A Novel DNMT3B Splice Variant Expressed in Tumor and Pluripotent Cells Modulates Genomic DNA Methylation Patterns and Displays Altered DNA Binding
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Keith D Robertson | Naohiro Terada | Philip H Schwartz | K. Robertson | N. Terada | Beth O. Van Emburgh | J. Vieweg | J. Shan | P. Schwartz | T. Hamazaki | Johannes Vieweg | Jixiu Shan | Suhasni Gopalakrishnan | Z. Su | C. R. Fields | Takashi Hamazaki | C Robert Fields | Suhasni Gopalakrishnan | Zhen Su | Beth O Van Emburgh
[1] I. Suetake,et al. DNMT3L Stimulates the DNA Methylation Activity of Dnmt3a and Dnmt3b through a Direct Interaction* , 2004, Journal of Biological Chemistry.
[2] S. Hirohashi,et al. DNA methyltransferase expression and DNA methylation of CPG islands and peri‐centromeric satellite regions in human colorectal and stomach cancers , 2001, International journal of cancer.
[3] C. Allis,et al. DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA , 2007, Nature.
[4] T. Chevassut,et al. Severe Global DNA Hypomethylation Blocks Differentiation and Induces Histone Hyperacetylation in Embryonic Stem Cells , 2004, Molecular and Cellular Biology.
[5] Peter A. Jones,et al. Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus , 1999, Oncogene.
[6] S. Baylin,et al. Dnmt3a and Dnmt3b Are Transcriptional Repressors That Exhibit Unique Localization Properties to Heterochromatin* , 2001, The Journal of Biological Chemistry.
[7] M. Ehrlich,et al. Immunodeficiency, centromeric region instability, facial anomalies syndrome (ICF) , 2006, Orphanet journal of rare diseases.
[8] M. Lieber,et al. The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[9] K. Robertson,et al. Preferential Methylation of Unmethylated DNA by Mammaliande Novo DNA Methyltransferase Dnmt3a* , 2002, The Journal of Biological Chemistry.
[10] T. Bestor,et al. Eukaryotic cytosine methyltransferases. , 2005, Annual review of biochemistry.
[11] H. Leonhardt,et al. Interactions within the mammalian DNA methyltransferase family , 2003, BMC Molecular Biology.
[12] S. Hirohashi,et al. Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[13] J. Venables,et al. Multiple alternative splicing markers for ovarian cancer. , 2008, Cancer research.
[14] Xiaodong Cheng,et al. Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation , 2007, Nature.
[15] H. Leonhardt,et al. A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei , 1992, Cell.
[16] S. Baylin,et al. Hypomethylation of pericentromeric DNA in breast adenocarcinomas , 1998, International journal of cancer.
[17] J. Aubin,et al. cDNA fingerprinting of osteoprogenitor cells to isolate differentiation stage-specific genes. , 1999, Nucleic acids research.
[18] J. Fackenthal,et al. Aberrant RNA splicing and its functional consequences in cancer cells , 2008, Disease Models & Mechanisms.
[19] R. Jaenisch,et al. Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. , 2007, Genes & development.
[20] A. Feinberg. Phenotypic plasticity and the epigenetics of human disease , 2007, Nature.
[21] Bert Vogelstein,et al. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells , 2002, Nature.
[22] Peter A. Jones,et al. Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation. , 2004, Molecular cancer research : MCR.
[23] C. Wijmenga,et al. The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[24] S. Jang,et al. A novel DNMT3B subfamily, DeltaDNMT3B, is the predominant form of DNMT3B in non-small cell lung cancer. , 2006, International journal of oncology.
[25] K. Robertson,et al. DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions. , 2009, Human molecular genetics.
[26] S. Yamanaka,et al. Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors , 2006, Cell.
[27] Gil Ast,et al. Insights into the connection between cancer and alternative splicing. , 2008, Trends in genetics : TIG.
[28] Diane D. Liu,et al. Expression of ΔDNMT3B Variants and Its Association with Promoter Methylation of p16 and RASSF1A in Primary Non–Small Cell Lung Cancer , 2006 .
[29] Xiaodong Cheng,et al. The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds , 2002, Nature Structural Biology.
[30] M. Robert,et al. An Essential Role for DNA Methyltransferase DNMT3B in Cancer Cell Survival* , 2002, The Journal of Biological Chemistry.
[31] K. Robertson,et al. The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. , 1999, Nucleic acids research.
[32] E. Li,et al. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases , 1998, Nature Genetics.
[33] N. Tommerup,et al. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene , 1999, Nature.
[34] S. Vandenberg,et al. Genome-wide hypomethylation in human glioblastomas associated with specific copy number alteration, methylenetetrahydrofolate reductase allele status, and increased proliferation. , 2006, Cancer research.
[35] Qian Tao,et al. DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function. , 2008, Human molecular genetics.
[36] M. L. Beau,et al. Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins , 2007, Oncogene.
[37] H Ishii,et al. Expression of mRNA for DNA methyltransferases and methyl‐CpG–binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis , 2001, Hepatology.
[38] E. Li,et al. Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome , 2006, Development.
[39] D. Haber,et al. DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development , 1999, Cell.
[40] G. Felsenfeld,et al. Vezf1 regulates genomic DNA methylation through its effects on expression of DNA methyltransferase Dnmt3b. , 2008, Genes & development.
[41] D. Bourc’his,et al. α-Satellite DNA methylation in normal individuals and in ICF patients: heterogeneous methylation of constitutive heterochromatin in adult and fetal tissues , 1997, Human Genetics.
[42] E. Li,et al. The PWWP Domain of Dnmt3a and Dnmt3b Is Required for Directing DNA Methylation to the Major Satellite Repeats at Pericentric Heterochromatin , 2004, Molecular and Cellular Biology.
[43] Gangning Liang,et al. Cooperativity between DNA Methyltransferases in the Maintenance Methylation of Repetitive Elements , 2002, Molecular and Cellular Biology.