Toward Calibration-Free Continuous Glucose Monitoring Sensors: Bayesian Calibration Approach Applied to Next-Generation Dexcom Technology

Abstract Background: Continuous glucose monitoring (CGM) sensors need to be calibrated twice/day by using self-monitoring of blood glucose (SMBG) samples. Recently, to reduce the calibration frequency, we developed an online calibration algorithm based on a multiple-day model of sensor time variability and Bayesian parameter estimation. When applied to Dexcom G4 Platinum (DG4P) sensor data, the algorithm allowed the frequency of calibrations to be reduced to one-every-four-days without significant worsening of sensor accuracy. The aim of this study is to assess the same methodology on raw CGM data acquired by a next-generation Dexcom CGM sensor prototype and compare the results with that obtained on DG4P. Methods: The database consists of 55 diabetic subjects monitored for 10 days by a next-generation Dexcom CGM sensor prototype. The new calibration algorithm is assessed, retrospectively, by simulating an online procedure using progressively fewer SMBG samples until zero. Accuracy is evaluated with mean a...

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