Summary This study demonstrates the feasibility of free-breathing phase-contrast CINE MRI without averaging. A new version of the CINE GRICS algorithm[1] was used to correct for motion. Background Phase-contrast MRI encodes speed and direction of moving spins by means of toggling a bipolar gradient. It is a valuable tool for assessing conditions affecting the vascular system by measuring the velocity of flowing blood[2]. Clinically, this sequence is performed in breath-hold or in free breathing but, in the latter case, using signal averaging. We propose to demonstrate the feasibility of free-breathing phase-contrast CINE MRI without averaging exploiting the acquisition redundancy by applying a new version of the CINE GRICS algorithm[1] to correct for motion. Methods Cardiac examination (approved by our local ethics committee) was performed on one normal volunteer during which three 2D phase-contrast CINE MRI sequences (common parameters: 256x128 acquisition matrix, 6 views per segment (vps), 32 reconstructed cardiac phases, 150 cm/sec VENC, slice direction velocity encoding, 5 mm slice thickness, 44 cm FOV, 62.5 kHz bandwidth, 3.05/8.08 ms TE/TR, 15° flip angle) were acquired on a 3T scanner (Signa HDxt, GE Healthcare, Milwaukee, WI) with a 8-element cardiac coil : (1) breath-held (2) averaged (3 NEX) in free breathing (3) in free breathing storing the raw data of 3 NEX to an external computer for offline processing. Signals from a respiratory belt were carried by a custom Maglife patient monitoring system (Schiller Medical, France) and recorded with a dedicated home-made hardware. Offline processing consisted of splitting the raw data from the 2 velocity encoding steps thus giving 2 sets of