Comparison of Safety and Efficacy ofMethadone vsMorphine for Treatment of Neonatal Abstinence Syndrome

DESIGN, SETTING, AND PARTICIPANTS In this randomized, double-blind, intention-to-treat trial, term infants from 8 US newborn units whose mothers received buprenorphine, methadone, or opioids for pain control during pregnancy were eligible. A total of 117 infants were randomized to receive methadone or morphine from February 9, 2014, to March 6, 2017. Mothers who declined randomization could consent to data collection and standard institutional treatment.

[1]  L. Jansson,et al.  The opioid-exposed newborn: assessment and pharmacologic management. , 2018, Journal of opioid management.

[2]  C. Hollenbeak,et al.  The economic burden of neonatal abstinence syndrome in the United States , 2017, Addiction.

[3]  A. Beckwith,et al.  Morphine Versus Methadone Treatment for Neonatal Withdrawal and Impact on Early Infant Development , 2017, Global pediatric health.

[4]  D. Fegley,et al.  Challenges and strategies to facilitate formulation development of pediatric drug products: Safety qualification of excipients. , 2017, International journal of pharmaceutics.

[5]  Inna Chervoneva,et al.  Buprenorphine for the Treatment of the Neonatal Abstinence Syndrome , 2017, The New England journal of medicine.

[6]  J. Davis,et al.  Neonatal abstinence syndrome: Pharmacologic strategies for the mother and infant. , 2016, Seminars in perinatology.

[7]  Jason R. Wiles,et al.  Pharmacokinetics of Oral Methadone in the Treatment of Neonatal Abstinence Syndrome: A Pilot Study. , 2015, The Journal of pediatrics.

[8]  Darrell Spurlock,et al.  Retrospective chart review comparing morphine and methadone in neonates treated for neonatal abstinence syndrome. , 2015, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

[9]  J. Meinzen-Derr,et al.  Cohort Analysis of a Pharmacokinetic-Modeled Methadone Weaning Optimization for Neonatal Abstinence Syndrome. , 2015, The Journal of pediatrics.

[10]  J. Davis,et al.  Opioids in pregnancy and neonatal abstinence syndrome. , 2015, Seminars in perinatology.

[11]  W. Cooper,et al.  Increasing incidence and geographic distribution of neonatal abstinence syndrome: United States 2009 to 2012 , 2015, Journal of Perinatology.

[12]  Matthew M Davis,et al.  Increasing Incidence and Geographic Distribution of Neonatal Abstinence Syndrome: United States 2009-2012 , 2015, Journal of Perinatology.

[13]  S. Lorch,et al.  Variation in treatment of neonatal abstinence syndrome in US Children's Hospitals, 2004–2011 , 2014, Journal of Perinatology.

[14]  Marie J. Hayes,et al.  Methadone versus morphine for treatment of neonatal abstinence syndrome: A prospective randomized clinical trial , 2014, Journal of Perinatology.

[15]  Karen C DʼApolito,et al.  Assessing Neonates for Neonatal Abstinence: Are You Reliable? , 2014, The Journal of perinatal & neonatal nursing.

[16]  Steven Edward Kern,et al.  The pharmacokinetics of methadone and its metabolites in neonates, infants, and children , 2014, Paediatric anaesthesia.

[17]  P. Visintainer,et al.  Efficacy of clonidine versus phenobarbital in reducing neonatal morphine sulfate therapy days for neonatal abstinence syndrome. A prospective randomized clinical trial , 2013, Journal of Perinatology.

[18]  H. Jones,et al.  Cigarette smoking in opioid-dependent pregnant women: neonatal and maternal outcomes. , 2013, Drug and alcohol dependence.

[19]  J. Mrozek,et al.  Neonatal drug withdrawal. , 2013, Minnesota medicine.

[20]  Amber M. Holbrook,et al.  Predicting treatment for neonatal abstinence syndrome in infants born to women maintained on opioid agonist medication. , 2012, Addiction.

[21]  H. Jones,et al.  Neonatal abstinence syndrome after methadone or buprenorphine exposure. , 2010, The New England journal of medicine.

[22]  H. Jeffery,et al.  Opiate treatment for opiate withdrawal in newborn infants. , 2010, The Cochrane database of systematic reviews.

[23]  A. Bertolini,et al.  Methadone--metabolism, pharmacokinetics and interactions. , 2004, Pharmacological research.