Fluorescence detection of ethylmorphine through terbium complex

Abstract In this paper, new fluorescence assay was developed for ethylmorphine based on complex formation with terbium. Ethylmorphine is an opiate and it is prone to be abused. Therefore, it is one of the frequently tested analytes in screening tests. The developed assay can be used as a screening test for opiate alkaloids since it produces fluorescence ON response with a simple experiment, and it may be used for an alternative/additional test to avoid false negative/positive results in regular screening tests. The assay can also be used for the quantitative analysis of ethylmorphine.

[1]  Félix Sancenón,et al.  Chromogenic and Fluorogenic Probes for the Detection of Illicit Drugs , 2018, ChemistryOpen.

[2]  M. Ahel,et al.  Simultaneous analysis of opioid analgesics and their metabolites in municipal wastewaters and river water by liquid chromatography-tandem mass spectrometry. , 2018, Journal of chromatography. A.

[3]  P. Zavalij,et al.  Supramolecular Sensors for Opiates and Their Metabolites. , 2017, Journal of the American Chemical Society.

[4]  Y. Vander Heyden,et al.  Comparison of a triple-quadrupole and a quadrupole time-of-flight mass analyzer to quantify 16 opioids in human plasma. , 2016, Journal of pharmaceutical and biomedical analysis.

[5]  K. Eckart,et al.  Development of a new multi-analyte assay for the simultaneous detection of opioids in serum and other body fluids using liquid chromatography-tandem mass spectrometry. , 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[6]  P. Van Eenoo,et al.  Improved sensitivity by use of gas chromatography-positive chemical ionization triple quadrupole mass spectrometry for the analysis of drug related substances. , 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[7]  Woochang Lee,et al.  Influence of Vitamin C on Urine Dipstick Test Results. , 2015, Annals of clinical and laboratory science.

[8]  Yu Peng,et al.  A terbium(III)-complex-based on-off fluorescent chemosensor for phosphate anions in aqueous solution and its application in molecular logic gates. , 2015, ACS applied materials & interfaces.

[9]  N. Samyn,et al.  A quantitative, selective and fast ultra-high performance liquid chromatography tandem mass spectrometry method for the simultaneous analysis of 33 basic drugs in hair (amphetamines, cocaine, opiates, opioids and metabolites). , 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[10]  O. Spigset,et al.  Screening and quantitative determination of drugs of abuse in diluted urine by UPLC-MS/MS. , 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[11]  S. Dulaurent,et al.  Development and validation of a single LC-MS/MS assay following SPE for simultaneous hair analysis of amphetamines, opiates, cocaine and metabolites. , 2014, Forensic science international.

[12]  P. Douglas,et al.  Applied Photochemistry , 2013 .

[13]  Yanyan Wang,et al.  pH-mediated stacking in capillary electrophoresis for analysis of opiates in saliva , 2012 .

[14]  Donnell R. Christian,et al.  Basic Principles of Forensic Chemistry , 2011 .

[15]  A. Helland,et al.  Death of a 10‐Month‐Old Boy After Exposure to Ethylmorphine , 2010, Journal of forensic sciences.

[16]  J. Sessler,et al.  Algorithms for the determination of binding constants and enantiomeric excess in complex host : guest equilibria using optical measurements. , 2010, New journal of chemistry = Nouveau journal de chimie.

[17]  Thomas Berg,et al.  Determination of opiates and cocaine in urine by high pH mobile phase reversed phase UPLC-MS/MS. , 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[18]  Ó. Pozo,et al.  Development of a qualitative liquid chromatography/tandem mass spectrometric method for the detection of narcotics in urine relevant to doping analysis. , 2007, Rapid communications in mass spectrometry : RCM.

[19]  Ethylmorphine hydrochloride/rocuronium bromide/suxamethonium chloride , 2007 .

[20]  Thorfinnur Gunnlaugsson,et al.  Luminescent Eu(III) and Tb(III) Complexes: Developing Lanthanide Luminescent-Based Devices , 2005, Journal of Fluorescence.

[21]  H. Gjerde,et al.  A case of high opiate tolerance: Implications for drug analyses and interpretations , 2005, International Journal of Legal Medicine.