NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

[1]  J. Power,et al.  Synaptic NMDA receptors in basolateral amygdala principal neurons are triheteromeric proteins: physiological role of GluN2B subunits. , 2013, Journal of neurophysiology.

[2]  R. Malinow,et al.  Metabotropic NMDA receptor function is required for β-amyloid–induced synaptic depression , 2013, Proceedings of the National Academy of Sciences.

[3]  R. Nicoll,et al.  Diversity in NMDA Receptor Composition , 2013, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[4]  Michael D Hill,et al.  Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial , 2012, The Lancet Neurology.

[5]  D. Purpura,et al.  REST-dependent epigenetic remodeling promotes the in vivo developmental switch in NMDA receptors , 2012, Nature Neuroscience.

[6]  P. Calabresi,et al.  Targeting NR2A-containing NMDA receptors reduces L-DOPA-induced dyskinesias , 2012, Neurobiology of Aging.

[7]  Arne V. Blackman,et al.  Target-Specific Expression of Presynaptic NMDA Receptors in Neocortical Microcircuits , 2012, Neuron.

[8]  S. Oliet,et al.  Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists , 2012, Cell.

[9]  S. Traynelis,et al.  GluN1 splice variant control of GluN1/GluN2D NMDA receptors , 2012, The Journal of physiology.

[10]  S. Lipton,et al.  Genetic Deletion of NR3A Accelerates Glutamatergic Synapse Maturation , 2012, PloS one.

[11]  Min Goo Lee,et al.  Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function , 2012, Nature.

[12]  Anne-Marie Le Sourd,et al.  Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2 , 2012, Nature.

[13]  R. Malinow.  New developments on the role of NMDA receptors in Alzheimer's disease , 2012, Current Opinion in Neurobiology.

[14]  David L. Hunt,et al.  Synaptic plasticity of NMDA receptors: mechanisms and functional implications , 2012, Current Opinion in Neurobiology.

[15]  G. Hardingham,et al.  Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist , 2012, British journal of pharmacology.

[16]  Stéphane Dieudonné,et al.  NMDA Receptors with Incomplete Mg2+ Block Enable Low-Frequency Transmission through the Cerebellar Cortex , 2012, The Journal of Neuroscience.

[17]  P. Kind,et al.  The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults , 2012, Neuron.

[18]  S. Traynelis,et al.  Subunit-Selective Allosteric Inhibition of Glycine Binding to NMDA Receptors , 2012, The Journal of Neuroscience.

[19]  F. Georges,et al.  Disrupted surface cross-talk between NMDA and Ephrin-B2 receptors in anti-NMDA encephalitis. , 2012, Brain : a journal of neurology.

[20]  J. Tsien,et al.  Genetic Overexpression of NR2B Subunit Enhances Social Recognition Memory for Different Strains and Species , 2012, PloS one.

[21]  P. Paoletti,et al.  An Alternating GluN1-2-1-2 Subunit Arrangement in Mature NMDA Receptors , 2012, PloS one.

[22]  R. Safadi,et al.  1418 A PHASE-2, RANDOMIZED, DOUBLE BLIND, PLACEBO-CONTROLLED TRIAL OF ARAMCHOL FOR THE TREATMENT OF NON ALCOHOLIC FATTY LIVER DISEASE (NAFLD) , 2012 .

[23]  M. Hollmann,et al.  GluN3 subunit-containing NMDA receptors: not just one-trick ponies , 2012, Trends in Neurosciences.

[24]  D. J. Cook,et al.  Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain , 2012, Nature.

[25]  Nils Brose,et al.  CaMKII binding to GluN2B is critical during memory consolidation , 2012, The EMBO journal.

[26]  S. Raghavachari,et al.  Mechanisms of CaMKII action in long-term potentiation , 2012, Nature Reviews Neuroscience.

[27]  B. Orser,et al.  Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases , 2012, The EMBO journal.

[28]  S. Floresco,et al.  NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear , 2012, Neuropharmacology.

[29]  M. Cenci,et al.  Glutamatergic mechanisms in the dyskinesias induced by pharmacological dopamine replacement and deep brain stimulation for the treatment of Parkinson's disease , 2012, Progress in Neurobiology.

[30]  Jon W. Johnson,et al.  A single GluN2 subunit residue controls NMDA receptor channel properties via intersubunit interaction , 2011, Nature Neuroscience.

[31]  Bita Moghaddam,et al.  From Revolution to Evolution: The Glutamate Hypothesis of Schizophrenia and its Implication for Treatment , 2012, Neuropsychopharmacology.

[32]  Anirvan Ghosh,et al.  A Critical Role for GluN2B-Containing NMDA Receptors in Cortical Development and Function , 2011, Neuron.

[33]  K. Reymann,et al.  Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors , 2011, Neurobiology of Aging.

[34]  L. Raymond,et al.  Mechanisms underlying NMDA receptor synaptic/extrasynaptic distribution and function , 2011, Molecular and Cellular Neuroscience.

[35]  C. Lüscher,et al.  In utero exposure to cocaine delays postnatal synaptic maturation of glutamatergic transmission in the VTA , 2011, Nature Neuroscience.

[36]  M. Mayer.  Emerging models of glutamate receptor ion channel structure and function. , 2011, Structure.

[37]  D. Jane,et al.  Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo , 2011, Molecular Neurodegeneration.

[38]  R. Nicoll,et al.  Distinct Modes of AMPA Receptor Suppression at Developing Synapses by GluN2A and GluN2B: Single-Cell NMDA Receptor Subunit Deletion In Vivo , 2011, Neuron.

[39]  L. Wollmuth,et al.  Arrangement of Subunits in Functional NMDA Receptors , 2011, The Journal of Neuroscience.

[40]  Laetitia Mony,et al.  Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines , 2011, The EMBO journal.

[41]  P. Paoletti,et al.  Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit , 2011, Nature Neuroscience.

[42]  E. Kavalali,et al.  NMDA Receptor Blockade at Rest Triggers Rapid Behavioural Antidepressant Responses , 2011, Nature.

[43]  Hiro Furukawa,et al.  Subunit Arrangement and Phenylethanolamine Binding in GluN1/GluN2B NMDA Receptors , 2011, Nature.

[44]  Christophe Blanchet,et al.  NMDA receptor–dependent metaplasticity at hippocampal mossy fiber synapses , 2011, Nature Neuroscience.

[45]  Shaomin Li,et al.  Soluble Aβ Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors , 2011, The Journal of Neuroscience.

[46]  Y. T. Wang,et al.  Stroke intervention pathways: NMDA receptors and beyond. , 2011, Trends in molecular medicine.

[47]  J. Isaac,et al.  mGluR5 and NMDA Receptors Drive the Experience- and Activity-Dependent NMDA Receptor NR2B to NR2A Subunit Switch , 2011, Neuron.

[48]  P. Paoletti.  Molecular basis of NMDA receptor functional diversity , 2011, The European journal of neuroscience.

[49]  A. Barria,et al.  NMDA receptor subunit composition controls synaptogenesis and synapse stabilization , 2011, Proceedings of the National Academy of Sciences.

[50]  G. Kohr,et al.  NR2A subunit of the N-methyl d-aspartate receptors are required for potentiation at the mossy fiber to granule cell synapse and vestibulo-cerebellar motor learning , 2011, Neuroscience.

[51]  S. Traynelis,et al.  Structural and Mechanistic Determinants of a Novel Site for Noncompetitive Inhibition of GluN2D-Containing NMDA Receptors , 2011, The Journal of Neuroscience.

[52]  S. Lipton,et al.  NR3A-containing NMDARs promote neurotransmitter release and spike timing–dependent plasticity , 2011, Nature Neuroscience.

[53]  M. Zhuo,et al.  Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain , 2009, Neurotherapeutics.

[54]  G. Köhr,et al.  Triheteromeric NR1/NR2A/NR2B Receptors Constitute the Major N-Methyl-d-aspartate Receptor Population in Adult Hippocampal Synapses , 2010, The Journal of Biological Chemistry.

[55]  K. Ashe,et al.  Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration , 2010, Neuron.

[56]  A. Capelli,et al.  Identification and Characterization of Novel NMDA Receptor Antagonists Selective for NR2A- over NR2B-Containing Receptors , 2010, Journal of Pharmacology and Experimental Therapeutics.

[57]  A. Buisson,et al.  Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-β Production , 2010, The Journal of Neuroscience.

[58]  H. Ropers,et al.  Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes , 2010, Nature Genetics.

[59]  B. Imperiali,et al.  Dynamic and specific interaction between synaptic NR2-NMDA receptor and PDZ proteins , 2010, Proceedings of the National Academy of Sciences.

[60]  D. Liotta,et al.  A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. , 2010, Nature communications.

[61]  H. Bading,et al.  Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders , 2010, Nature Reviews Neuroscience.

[62]  G. Collingridge,et al.  Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95 , 2010, Nature Neuroscience.

[63]  J. Isaac,et al.  Casein Kinase 2 Regulates the NR2 Subunit Composition of Synaptic NMDA Receptors , 2010, Neuron.

[64]  Masahiko Watanabe,et al.  Impairment of CaMKII activation and attenuation of neuropathic pain in mice lacking NR2B phosphorylated at Tyr1472 , 2010, The European journal of neuroscience.

[65]  D. Attwell,et al.  The receptor subunits generating NMDA receptor mediated currents in oligodendrocytes , 2010, The Journal of physiology.

[66]  R. Dingledine,et al.  Glutamate Receptor Ion Channels: Structure, Regulation, and Function , 2010, Pharmacological Reviews.

[67]  S. Lipton,et al.  Excitatory Glycine Responses of CNS Myelin Mediated by NR1/NR3 “NMDA” Receptor Subunits , 2010, The Journal of Neuroscience.

[68]  Nanxin Li,et al.  mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists , 2010, Science.

[69]  S. Lipton,et al.  Memantine Preferentially Blocks Extrasynaptic over Synaptic NMDA Receptor Currents in Hippocampal Autapses , 2010, The Journal of Neuroscience.

[70]  Jürgen Götz,et al.  Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models , 2010, Cell.

[71]  S. Sakoda,et al.  Activation of NR2A Receptors Induces Ischemic Tolerance through CREB Signaling , 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[72]  Michael D. Ehlers,et al.  Metaplasticity at Single Glutamatergic Synapses , 2010, Neuron.

[73]  B. Philpot,et al.  Influence of the NR3A subunit on NMDA receptor functions , 2010, Progress in Neurobiology.

[74]  R. Petralia,et al.  Organization of NMDA receptors at extrasynaptic locations , 2010, Neuroscience.

[75]  Xiaoyu Peng,et al.  Cellular and Synaptic Mechanisms of Anti-NMDA Receptor Encephalitis , 2010, The Journal of Neuroscience.

[76]  Adam G. Carter,et al.  GABAB Receptors Modulate NMDA Receptor Calcium Signals in Dendritic Spines , 2010, Neuron.

[77]  K. Nakazawa,et al.  Loss of GluN2B-Containing NMDA Receptors in CA1 Hippocampus and Cortex Impairs Long-Term Depression, Reduces Dendritic Spine Density, and Disrupts Learning , 2010, The Journal of Neuroscience.

[78]  M. Sheng,et al.  Distinct Roles of NR2A and NR2B Cytoplasmic Tails in Long-Term Potentiation , 2010, The Journal of Neuroscience.

[79]  L. Raymond,et al.  Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice , 2010, Neuron.

[80]  M. M. Soundarapandian,et al.  DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke , 2010, Cell.

[81]  K. Magnusson,et al.  Selective Vulnerabilities of N-methyl-D-aspartate (NMDA) Receptors During Brain Aging , 2010, Front. Ag. Neurosci..

[82]  W. Lu,et al.  Distinct trafficking and expression mechanisms underlie LTP and LTD of NMDA receptor‐mediated synaptic responses , 2009, Hippocampus.

[83]  K. Nakazawa,et al.  Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes , 2010, Nature Neuroscience.

[84]  E. Gouaux,et al.  X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor , 2009, Nature.

[85]  R. Anwyl,et al.  Glun2b Subunit-containing Nmda Receptor Antagonists Prevent A␤-mediated Synaptic Plasticity Disruption in Vivo Abrogation of A␤-mediated Disruption of Hippocampal Synaptic Plasticity in Vivo by Antagonists Selective for Glun2b-containing , 2022 .

[86]  J. Tsien,et al.  Genetic Enhancement of Memory and Long-Term Potentiation but Not CA1 Long-Term Depression in NR2B Transgenic Rats , 2009, PloS one.

[87]  S. Traynelis,et al.  Control of NMDA Receptor Function by the NR2 Subunit Amino-Terminal Domain , 2009, The Journal of Neuroscience.

[88]  C. Jahr,et al.  Selective Expression of Ligand-Gated Ion Channels in L5 Pyramidal Cell Axons , 2009, The Journal of Neuroscience.

[89]  Boris Barbour,et al.  Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule , 2009, Proceedings of the National Academy of Sciences.

[90]  John F. Wesseling,et al.  Downregulation of NR3A-Containing NMDARs Is Required for Synapse Maturation and Memory Consolidation , 2009, Neuron.

[91]  J. Kew,et al.  Allosteric modulators of NR2B‐containing NMDA receptors: molecular mechanisms and therapeutic potential , 2009, British journal of pharmacology.

[92]  Wei Lu,et al.  Metaplastic Regulation of Long-Term Potentiation/Long-Term Depression Threshold by Activity-Dependent Changes of NR2A/NR2B Ratio , 2009, The Journal of Neuroscience.

[93]  Mark T. Harnett,et al.  Burst-Timing-Dependent Plasticity of NMDA Receptor-Mediated Transmission in Midbrain Dopamine Neurons , 2009, Neuron.

[94]  Shaomin Li,et al.  Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake , 2009, Neuron.

[95]  C. Gebhardt,et al.  Both NR2A and NR2B subunits of the NMDA receptor are critical for long-term potentiation and long-term depression in the lateral amygdala of horizontal slices of adult mice. , 2009, Learning & memory.

[96]  Jon W. Johnson,et al.  Mechanism of differential control of NMDA receptor activity by NR2 subunits , 2009, Nature.

[97]  R. Wenthold,et al.  Different Roles of C-terminal Cassettes in the Trafficking of Full-length NR1 Subunits to the Cell Surface* , 2009, Journal of Biological Chemistry.

[98]  J. Tsien,et al.  In Vivo Evidence for NMDA Receptor-Mediated Excitotoxicity in a Murine Genetic Model of Huntington Disease , 2009, The Journal of Neuroscience.

[99]  Jon W. Johnson,et al.  Mg2+ Imparts NMDA Receptor Subtype Selectivity to the Alzheimer's Drug Memantine , 2009, The Journal of Neuroscience.

[100]  W. Abraham,et al.  Mechanisms of group I mGluR-dependent long-term depression of NMDA receptor-mediated transmission at Schaffer collateral-CA1 synapses. , 2009, Journal of neurophysiology.

[101]  P. Calabresi,et al.  Decreased NR2B Subunit Synaptic Levels Cause Impaired Long-Term Potentiation But Not Long-Term Depression , 2009, The Journal of Neuroscience.

[102]  J. Diamond,et al.  Subunit- and Pathway-Specific Localization of NMDA Receptors and Scaffolding Proteins at Ganglion Cell Synapses in Rat Retina , 2008, The Journal of Neuroscience.

[103]  J. Rawlins,et al.  Contribution of Hippocampal and Extra-Hippocampal NR2B-Containing NMDA Receptors to Performance on Spatial Learning Tasks , 2008, Neuron.

[104]  Masahiko Watanabe,et al.  Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors , 2008, Proceedings of the National Academy of Sciences.

[105]  D. Feldman,et al.  Presynaptic NMDA Receptors: Newly Appreciated Roles in Cortical Synaptic Function and Plasticity , 2008, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[106]  Benjamin D. Philpot,et al.  Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity , 2008, Neuropharmacology.

[107]  Xiaoyu Peng,et al.  Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies , 2008, The Lancet Neurology.

[108]  R. Anwyl,et al.  Extrasynaptic NR2D-Containing NMDARs Are Recruited to the Synapse during LTP of NMDAR-EPSCs , 2008, The Journal of Neuroscience.

[109]  Z. Xiong,et al.  Differential Roles of NMDA Receptor Subtypes in Ischemic Neuronal Cell Death and Ischemic Tolerance , 2008, Stroke.

[110]  Masahiko Watanabe,et al.  Functional contributions of synaptically localized NR2B subunits of the NMDA receptor to synaptic transmission and long‐term potentiation in the adult mouse CNS , 2008, The Journal of physiology.

[111]  David J. Sanderson,et al.  NMDA Receptor Subunit NR2A Is Required for Rapidly Acquired Spatial Working Memory But Not Incremental Spatial Reference Memory , 2008, The Journal of Neuroscience.

[112]  D. Feldman,et al.  Synapse-Specific Expression of Functional Presynaptic NMDA Receptors in Rat Somatosensory Cortex , 2008, The Journal of Neuroscience.

[113]  F. Gage,et al.  Mechanisms and Functional Implications of Adult Neurogenesis , 2008, Cell.

[114]  D. Jane,et al.  NR2B‐ and NR2D‐containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones , 2008, The Journal of physiology.

[115]  Jon W. Johnson,et al.  Structural Rearrangements of NR1/NR2A NMDA Receptors during Allosteric Inhibition , 2008, Neuron.

[116]  R. Cunha,et al.  Adenosine A2A Receptors Are Essential for Long-Term Potentiation of NMDA-EPSCs at Hippocampal Mossy Fiber Synapses , 2008, Neuron.

[117]  Hyung-Bae Kwon,et al.  Long-Term Potentiation Selectively Expressed by NMDA Receptors at Hippocampal Mossy Fiber Synapses , 2008, Neuron.

[118]  M. Constantine‐Paton,et al.  NR2A−/− Mice Lack Long-Term Potentiation But Retain NMDA Receptor and L-Type Ca2+ Channel-Dependent Long-Term Depression in the Juvenile Superior Colliculus , 2007, The Journal of Neuroscience.

[119]  J. Partridge,et al.  Long-lasting NMDA receptor-mediated EPSCs in mouse striatal medium spiny neurons. , 2007, Journal of neurophysiology.

[120]  Chris G. Parsons,et al.  Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse , 2007, Neuropharmacology.

[121]  Alexander Z. Harris,et al.  Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices , 2007, The Journal of physiology.

[122]  Roger A. Nicoll,et al.  Rapid Bidirectional Switching of Synaptic NMDA Receptors , 2007, Neuron.

[123]  T. Veenstra,et al.  NMDA Di-Heteromeric Receptor Populations and Associated Proteins in Rat Hippocampus , 2007, The Journal of Neuroscience.

[124]  V. Pawlak,et al.  Excitotoxicity in vitro by NR2A- and NR2B-containing NMDA receptors , 2007, Neuropharmacology.

[125]  D. Purpura,et al.  NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders , 2007, Nature Reviews Neuroscience.

[126]  Ann Marie Craig,et al.  NMDA Receptor Subunits Have Differential Roles in Mediating Excitotoxic Neuronal Death Both In Vitro and In Vivo , 2007, The Journal of Neuroscience.

[127]  J. Tsien,et al.  Maintenance of superior learning and memory function in NR2B transgenic mice during ageing , 2007, The European journal of neuroscience.

[128]  Khaleel Bhaukaurally,et al.  Glutamate exocytosis from astrocytes controls synaptic strength , 2007, Nature Neuroscience.

[129]  Mark F. Bear,et al.  Obligatory Role of NR2A for Metaplasticity in Visual Cortex , 2007, Neuron.

[130]  M. Bear,et al.  Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression , 2007, Neuropharmacology.

[131]  David Lodge,et al.  Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus , 2007, Neuropharmacology.

[132]  P. Seeburg,et al.  The role of NMDAR subtypes and charge transfer during hippocampal LTP induction , 2007, Neuropharmacology.

[133]  Karel Svoboda,et al.  Activity-Dependent Plasticity of the NMDA-Receptor Fractional Ca2+ Current , 2007, Neuron.

[134]  D. Choquet,et al.  NMDA receptor surface mobility depends on NR2A-2B subunits , 2006, Proceedings of the National Academy of Sciences.

[135]  A. Lüthi,et al.  Insufficient Sleep Reversibly Alters Bidirectional Synaptic Plasticity and NMDA Receptor Function , 2006, The Journal of Neuroscience.

[136]  D. Wyllie,et al.  Equilibrium Constants for (R)-[(S)-1-(4-Bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic Acid (NVP-AAM077) Acting at Recombinant NR1/NR2A and NR1/NR2B N-Methyl-d-aspartate Receptors: Implications for Studies of Synaptic Transmission , 2006, Molecular Pharmacology.

[137]  M. Ehlers,et al.  Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1 , 2006, Nature Neuroscience.

[138]  Rafael Yuste,et al.  Protein kinase A regulates calcium permeability of NMDA receptors , 2006, Nature Neuroscience.

[139]  P. Calabresi,et al.  A Critical Interaction between NR2B and MAGUK in l-DOPA Induced Dyskinesia , 2006, The Journal of Neuroscience.

[140]  A. Holmes,et al.  Genetic Inactivation of the NMDA Receptor NR2A Subunit has Anxiolytic- and Antidepressant-Like Effects in Mice , 2006, Neuropsychopharmacology.

[141]  D. Luckenbaugh,et al.  A double-blind, placebo-controlled study of memantine in the treatment of major depression. , 2006, The American journal of psychiatry.

[142]  P. Paoletti,et al.  Relating NMDA Receptor Function to Receptor Subunit Composition: Limitations of the Pharmacological Approach , 2006, The Journal of Neuroscience.

[143]  T. Bártfai,et al.  A Specific Role for NR2A-Containing NMDA Receptors in the Maintenance of Parvalbumin and GAD67 Immunoreactivity in Cultured Interneurons , 2006, The Journal of Neuroscience.

[144]  E. Gouaux,et al.  Subunit arrangement and function in NMDA receptors , 2005, Nature.

[145]  R. Malinow,et al.  NMDA Receptor Subunit Composition Controls Synaptic Plasticity by Regulating Binding to CaMKII , 2005, Neuron.

[146]  Kai Chang,et al.  The Synaptic Localization of NR2B-Containing NMDA Receptors Is Controlled by Interactions with PDZ Proteins and AP-2 , 2005, Neuron.

[147]  D. Lovinger,et al.  Activation of NR2A-Containing NMDA Receptors Is Not Obligatory for NMDA Receptor-Dependent Long-Term Potentiation , 2005, The Journal of Neuroscience.

[148]  P. Greengard,et al.  Regulation of NMDA receptor trafficking by amyloid-β , 2005, Nature Neuroscience.

[149]  J. Montgomery,et al.  Dynamin-dependent NMDAR endocytosis during LTD and its dependence on synaptic state , 2005, BMC Neuroscience.

[150]  V. Pawlak,et al.  Lack of NMDA Receptor Subtype Selectivity for Hippocampal Long-Term Potentiation , 2005, The Journal of Neuroscience.

[151]  Wade Morishita,et al.  Distinct triggering and expression mechanisms underlie LTD of AMPA and NMDA synaptic responses , 2005, Nature Neuroscience.

[152]  Theodore C. Dumas,et al.  Developmental regulation of cognitive abilities: Modified composition of a molecular switch turns on associative learning , 2005, Progress in Neurobiology.

[153]  P. Paoletti,et al.  Modulation of Triheteromeric NMDA Receptors by N-Terminal Domain Ligands , 2005, Neuron.

[154]  E. Bézard,et al.  Alterations of striatal NMDA receptor subunits associated with the development of dyskinesia in the MPTP-lesioned primate model of Parkinson's disease , 2005, Neuropharmacology.

[155]  Stephen F Traynelis,et al.  Subunit‐specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles , 2005, The Journal of physiology.

[156]  P. Paoletti,et al.  The Micromolar Zinc-Binding Domain on the NMDA Receptor Subunit NR2B , 2005, The Journal of Neuroscience.

[157]  S. Dravid,et al.  Protons Trap NR1/NR2B NMDA Receptors in a Nonconducting State , 2005, The Journal of Neuroscience.

[158]  J. Meador-Woodruff,et al.  NR3A NMDA receptor subunit mRNA expression in schizophrenia, depression and bipolar disorder , 2004, Schizophrenia Research.

[159]  Yan Hua Huang,et al.  Regulation of the NMDA Receptor Complex and Trafficking by Activity-Dependent Phosphorylation of the NR2B Subunit PDZ Ligand , 2004, The Journal of Neuroscience.

[160]  S. Cull-Candy,et al.  Role of Distinct NMDA Receptor Subtypes at Central Synapses , 2004, Science's STKE.

[161]  G. Collingridge,et al.  Differential Roles of NR2A and NR2B-Containing NMDA Receptors in Cortical Long-Term Potentiation and Long-Term Depression , 2004, The Journal of Neuroscience.

[162]  T. Woo,et al.  Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorder. , 2004, Archives of general psychiatry.

[163]  M. Sheng,et al.  Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity , 2004, Science.

[164]  Michael Häusser,et al.  A proportional but slower NMDA potentiation follows AMPA potentiation in LTP , 2004, Nature Neuroscience.

[165]  Michael W. Salter,et al.  Src kinases: a hub for NMDA receptor regulation , 2004, Nature Reviews Neuroscience.

[166]  Yehezkel Ben-Ari,et al.  The NMDA Receptor Is Coupled to the ERK Pathway by a Direct Interaction between NR2B and RasGRF1 , 2003, Neuron.

[167]  John R Huguenard,et al.  Pathway-Specific Differences in Subunit Composition of Synaptic NMDA Receptors on Pyramidal Neurons in Neocortex , 2003, The Journal of Neuroscience.

[168]  K. Roche,et al.  Differential binding of the AP-2 adaptor complex and PSD-95 to the C-terminus of the NMDA receptor subunit NR2B regulates surface expression , 2003, Neuropharmacology.

[169]  M. Ehlers,et al.  Activity-Dependent mRNA Splicing Controls ER Export and Synaptic Delivery of NMDA Receptors , 2003, Neuron.

[170]  Hiroshi Baba,et al.  The Role of N-Methyl-d-Aspartate (NMDA) Receptors in Pain: A Review , 2003, Anesthesia and analgesia.

[171]  P. Sah,et al.  Development and Subunit Composition of Synaptic NMDA Receptors in the Amygdala: NR2B Synapses in the Adult Central Amygdala , 2003, The Journal of Neuroscience.

[172]  Z. Fu,et al.  Association of NR3A with the N-methyl-D-aspartate receptor NR1 and NR2 subunits. , 2002, Molecular pharmacology.

[173]  Yitao Liu,et al.  Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor- PSD-95 Protein Interactions , 2002, Science.

[174]  Roberto Malinow,et al.  Subunit-Specific NMDA Receptor Trafficking to Synapses , 2002, Neuron.

[175]  P. Bickford,et al.  A Hippocampal NR2B Deficit Can Mimic Age-Related Changes in Long-Term Potentiation and Spatial Learning in the Fischer 344 Rat , 2002, The Journal of Neuroscience.

[176]  G. Westbrook,et al.  Mobile NMDA Receptors at Hippocampal Synapses , 2002, Neuron.

[177]  C. McBain,et al.  Distinct NMDA Receptors Provide Differential Modes of Transmission at Mossy Fiber-Interneuron Synapses , 2002, Neuron.

[178]  Hiroto Takahashi,et al.  Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits , 2002, Nature.

[179]  S. Coultrap,et al.  LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1 , 2002, Nature Neuroscience.

[180]  R. S. Jones,et al.  NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons. , 2001, Journal of neurophysiology.

[181]  Alison L. Barth,et al.  NMDAR EPSC kinetics do not regulate the critical period for LTP at thalamocortical synapses , 2001, Nature Neuroscience.

[182]  M. Bear,et al.  Visual Experience and Deprivation Bidirectionally Modify the Composition and Function of NMDA Receptors in Visual Cortex , 2001, Neuron.

[183]  G. Rumbaugh,et al.  Exon 5 and spermine regulate deactivation of NMDA receptor subtypes. , 2000, Journal of neurophysiology.

[184]  J. Hell,et al.  A Developmental Change in NMDA Receptor-Associated Proteins at Hippocampal Synapses , 2000, The Journal of Neuroscience.

[185]  E. Shimizu,et al.  Genetic enhancement of learning and memory in mice , 1999, Nature.

[186]  Marc G Caron,et al.  Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia , 1999, Cell.

[187]  P. V. Rayudu,et al.  Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A , 1998, Nature.

[188]  S. Vicini,et al.  Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors. , 1998, Journal of neurophysiology.

[189]  Richard F. Thompson,et al.  Importance of the Intracellular Domain of NR2 Subunits for NMDA Receptor Function In Vivo , 1998, Cell.

[190]  A. Wenzel,et al.  Synapse‐specific localization of NMDA and GABAA receptor subunits revealed by antigen‐retrieval immunohistochemistry , 1998, The Journal of comparative neurology.

[191]  P. Ascher,et al.  High-Affinity Zinc Inhibition of NMDA NR1–NR2A Receptors , 1997, The Journal of Neuroscience.

[192]  Robert C. Malenka,et al.  Independent mechanisms for long-term depression of AMPA and NMDA responses , 1995, Neuron.

[193]  T. Yagi,et al.  Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit , 1995, Nature.

[194]  S. Nakanishi,et al.  Differential expression of five N‐methyl‐D‐aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats , 1994, The Journal of comparative neurology.

[195]  H. Wigström,et al.  Long‐term Depression in the Hippocampal CA1 Region is Associated with Equal Changes in AMPA and NMDA Receptor‐mediated Synaptic Potentials , 1994, The European journal of neuroscience.

[196]  P. Seeburg,et al.  Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[197]  Y. Jan,et al.  Changing subunit composition of heteromeric NMDA receptors during development of rat cortex , 1994, Nature.

[198]  B. Sakmann,et al.  Developmental and regional expression in the rat brain and functional properties of four NMDA receptors , 1994, Neuron.

[199]  U. Sieben,et al.  STRUCTURE, REGULATION AND FUNCTION OF NF-1d3 , 1994 .

[200]  K. Sakimura,et al.  Developmental changes in distribution of NMDA receptor channel subunit mRNAs. , 1992, Neuroreport.

[201]  G. Collingridge,et al.  Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus , 1991, Nature.

[202]  G Lynch,et al.  Long-term potentiation differentially affects two components of synaptic responses in hippocampus. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[203]  R. Nicoll,et al.  A persistent postsynaptic modification mediates long-term potentiation in the hippocampus , 1988, Neuron.

[204]  Robert C. Wolpert,et al.  A Review of the , 1985 .