Chapter 26 – Miniaturization and microfluidics

This short chapter provides an excursion into the microfluidics for separations, basic introduction into methods of fabrication, and brief overview of some of the commercial systems.

[1]  Xingyu Jiang,et al.  Nanomaterials for Ultrasensitive Protein Detection , 2013, Advanced materials.

[2]  D. Marshall,et al.  Microfluidics for single cell analysis. , 2012, Current opinion in biotechnology.

[3]  Gabriel P López,et al.  Microfluidic cell sorting: a review of the advances in the separation of cells from debulking to rare cell isolation. , 2015, Lab on a chip.

[4]  Petr Smejkal,et al.  Microfluidic isotachophoresis: A review , 2013, Electrophoresis.

[5]  G. Whitesides,et al.  Microfabrication meets microbiology , 2007, Nature Reviews Microbiology.

[6]  D. DeVoe,et al.  Bonding of thermoplastic polymer microfluidics , 2009 .

[7]  J. Justin Gooding,et al.  Recent Advances in Paper-Based Sensors , 2012, Sensors.

[8]  P. Blainey The future is now: single-cell genomics of bacteria and archaea. , 2013, FEMS microbiology reviews.

[9]  M. Macka,et al.  Surface-area expansion with monolithic open tubular columns , 2015 .

[10]  D. Di Carlo,et al.  Rapid prototyping polymers for microfluidic devices and high pressure injections. , 2011, Lab on a chip.

[11]  Frantisek Foret,et al.  Droplet microfluidics in (bio)chemical analysis. , 2015, The Analyst.

[12]  Christopher S. Chen,et al.  Microcontact printing: A tool to pattern. , 2007, Soft matter.

[13]  M. Ursem,et al.  Instrumental requirements for nanoscale liquid chromatography. , 1996, Analytical chemistry.

[14]  K. Otsuka,et al.  Recent progress in microchip electrophoresis-mass spectrometry. , 2011, Journal of pharmaceutical and biomedical analysis.

[15]  Guihua Yue,et al.  On-line 1D and 2D porous layer open tubular/LC-ESI-MS using 10-microm-i.d. poly(styrene-divinylbenzene) columns for ultrasensitive proteomic analysis. , 2007, Analytical chemistry.

[16]  Dmitriy A. Khodakov,et al.  Surface modification for PDMS‐based microfluidic devices , 2012, Electrophoresis.

[17]  Ali Kemal Yetisen,et al.  Paper-based microfluidic point-of-care diagnostic devices. , 2013, Lab on a chip.

[18]  A. Manz,et al.  Miniaturized total chemical analysis systems: A novel concept for chemical sensing , 1990 .

[19]  Ke Liu,et al.  Thermoplastic microfluidic devices and their applications in protein and DNA analysis. , 2011, The Analyst.

[20]  G. Whitesides,et al.  Understanding wax printing: a simple micropatterning process for paper-based microfluidics. , 2009, Analytical chemistry.

[21]  I. Lazar,et al.  Microfabricated devices: A new sample introduction approach to mass spectrometry. , 2006, Mass spectrometry reviews.

[22]  Holger Becker,et al.  Polymer microfabrication technologies for microfluidic systems , 2008, Analytical and bioanalytical chemistry.

[23]  A. Höltzel,et al.  Impact of conduit geometry and bed porosity on flow and dispersion in noncylindrical sphere packings. , 2007, Analytical chemistry.

[24]  A. Cappiello,et al.  Variable-gradient generator for micro- and nano-HPLC. , 2003, Analytical chemistry.

[25]  Angeliki Tserepi,et al.  Hierarchical micro and nano structured, hydrophilic, superhydrophobic and superoleophobic surfaces incorporated in microfluidics, microarrays and lab on chip microsystems , 2015 .

[26]  Wolfgang Wiechert,et al.  Single-cell microfluidics: opportunity for bioprocess development. , 2014, Current opinion in biotechnology.

[27]  František Foret,et al.  Microdevices in Mass Spectrometry , 2007, European journal of mass spectrometry.

[28]  Kyung-A Hyun,et al.  Microfluidic devices for the isolation of circulating rare cells: A focus on affinity‐based, dielectrophoresis, and hydrophoresis , 2013, Electrophoresis.

[29]  N. Nguyen,et al.  Fundamentals and Applications of Microfluidics , 2002 .

[30]  C. Kim,et al.  Electrowetting and electrowetting-on-dielectric for microscale liquid handling , 2002 .

[31]  J. Jorgenson Capillary liquid chromatography at ultrahigh pressures. , 2010, Annual review of analytical chemistry.

[32]  F. Regnier Microfabricated Monolith Columns for Liquid Chromatography. Sculpting Supports for Liquid Chromatography , 2000 .

[33]  Hong Chen,et al.  Two‐dimensional protein separation in microfluidic devices , 2009, Electrophoresis.

[34]  Wei Duan,et al.  Lab-on-a-chip: a component view , 2010 .

[35]  M. Sepaniak,et al.  Nanotechnology and chip level systems for pressure driven liquid chromatography and emerging analytical separation techniques: a review. , 2011, Analytica chimica acta.

[36]  A. Woolley,et al.  Ultra-high-speed DNA fragment separations using microfabricated capillary array electrophoresis chips. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[37]  Darwin R. Reyes,et al.  Micro total analysis systems. 1. Introduction, theory, and technology. , 2002, Analytical chemistry.

[38]  Daniel T. Chiu,et al.  Chemistry and biology in femtoliter and picoliter volume droplets. , 2009, Accounts of chemical research.

[39]  Antoine Pallandre,et al.  Recent innovations in protein separation on microchips by electrophoretic methods: An update , 2010, Electrophoresis.

[40]  K. Nakanishi,et al.  Octadecylsilylated porous silica rods as separation media for reversed-phase liquid chromatography. , 1996, Analytical chemistry.

[41]  I. Ali,et al.  Microchip-Based Nano Chromatography and Nano Capillary Electrophoresis in Genomics and Proteomics , 2009 .

[42]  Shoji Takeuchi,et al.  Microtechnologies for membrane protein studies , 2008, Analytical and bioanalytical chemistry.

[43]  Gwo-Bin Lee,et al.  Miniaturization of molecular biological techniques for gene assay. , 2010, The Analyst.

[44]  Sebastian J Maerkl,et al.  Next generation microfluidic platforms for high-throughput protein biochemistry. , 2011, Current opinion in biotechnology.

[45]  Weijia Wen,et al.  Extraction, amplification and detection of DNA in microfluidic chip-based assays , 2014, Microchimica Acta.

[46]  A. Levchenko,et al.  Lab-on-a-chip devices as an emerging platform for stem cell biology. , 2010, Lab on a chip.

[47]  N. Morgan,et al.  Electrochemical immunosensors for detection of cancer protein biomarkers. , 2012, ACS nano.

[48]  R. Kostiainen,et al.  Microchip technology in mass spectrometry. , 2009, Mass spectrometry reviews.

[49]  Salvatore Fanali,et al.  Recent applications in nanoliquid chromatography. , 2007, Journal of separation science.

[50]  D. Beebe,et al.  Physics and applications of microfluidics in biology. , 2002, Annual review of biomedical engineering.

[51]  John D Brennan,et al.  Printing silicone-based hydrophobic barriers on paper for microfluidic assays using low-cost ink jet printers. , 2014, The Analyst.

[52]  S. Lindström,et al.  Miniaturization of biological assays -- overview on microwell devices for single-cell analyses. , 2011, Biochimica et biophysica acta.

[53]  Syed A Hashsham,et al.  Miniaturized nucleic acid amplification systems for rapid and point-of-care diagnostics: a review. , 2012, Analytica chimica acta.

[54]  Youyuan Peng,et al.  Recent innovations in protein separation on microchips by electrophoretic methods , 2008, Electrophoresis.

[55]  Yasushi Ishihama,et al.  Proteomic LC-MS systems using nanoscale liquid chromatography with tandem mass spectrometry. , 2005, Journal of chromatography. A.

[56]  Fei Li,et al.  Advances in paper-based point-of-care diagnostics. , 2014, Biosensors & bioelectronics.

[57]  Nantana Nuchtavorn,et al.  A novel highly flexible, simple, rapid and low-cost fabrication tool for paper-based microfluidic devices (μPADs) using technical drawing pens and in-house formulated aqueous inks. , 2016, Analytica chimica acta.

[58]  Valentin Romanov,et al.  A critical comparison of protein microarray fabrication technologies. , 2014, The Analyst.

[59]  Terence G. Henares,et al.  Paper-based inkjet-printed microfluidic analytical devices. , 2015, Angewandte Chemie.

[60]  T. Hankemeier,et al.  Lab-on-a-Chip hyphenation with mass spectrometry: strategies for bioanalytical applications. , 2015, Current opinion in biotechnology.

[61]  Chee Meng Benjamin Ho,et al.  3D printed microfluidics for biological applications. , 2015, Lab on a chip.

[62]  Kevin W Plaxco,et al.  Integrated electrochemical microsystems for genetic detection of pathogens at the point of care. , 2015, Accounts of chemical research.