Biological Activity of 1,24(R)-Dihydroxyvitamin 3 and 1,24(S)-Dihydroxyvitamin D3 in the Rat 1

Abstract The activities of 1,24(R)-dihydroxyvitamin D3 and 1,24(S)-dihydroxyvitamin D3 have been compared with that of 1,25-dihydroxyvitamin D3 in the stimulation of intestinal calcium transport, mobilization of bone calcium, elevation of serum inorganic phosphorus concentration, and in healing rickets in vitamin D-deficient rats. The 1α-hydroxyvitamin D3 was also compared with the 1,24-dihydroxyvitamin D3 compounds in antirachitic activity. In all parameters 1,25-dihydroxyvitamin D3 is about 10 times more active than either 1,24(R)-dihydroxyvitamin D3 and 1,24(S)-dihydroxyvitamin D3. In antirachitic activity 1,25-dihydroxyvitamin D3 is about two times more active than 1α-hydroxyvitamin D3 which in turn is two times more active than 1,24(R)-dihydroxyvitamin D3. The 1,24(R)-dihydroxy-vitamin D3 and 1,24(S)-dihydroxyvitamin D3 compounds are equally active except in the healing of rickets where the 1,24(S)-dihydroxyvitamin D3 elicits weak biological activity.

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