Consumption of a buckwheat protein extract retards 7,12-dimethylbenz[alpha]anthracene-induced mammary carcinogenesis in rats.

Female rats were examined for the effects of feeding buckwheat protein extract (BWPE) on the development of mammary tumor caused by administration of 7,12-dimethylbenz[alpha]anthracene. The percentage of rats with palpable mammary tumors and serum estradiol were lower in the BWPE-fed animals than the casein-fed ones, implying that BWPE intake retarded the mammary carcinogenesis by lowering serum estradiol.

[1]  J. Meites.  Relation of prolactin and estrogen to mammary tumorigenesis in the rat. , 1972, Journal of the National Cancer Institute.

[2]  M. Eastwood.  The physiological effect of dietary fiber: an update. , 1992, Annual review of nutrition.

[3]  T. Morita,et al.  A rice protein isolate alters 7,12-dimethylbenz[alpha]anthracene-induced mammary tumor development in female rats. , 1996, Journal of nutritional science and vitaminology.

[4]  C. la Vecchia,et al.  Fibers and breast cancer risk. , 1997, Nutrition and cancer.

[5]  N. Asp,et al.  Determination of insoluble, soluble, and total dietary fiber in foods and food products: interlaboratory study. , 1988, Journal - Association of Official Analytical Chemists.

[6]  J. Kayashita,et al.  Consumption of buckwheat protein lowers plasma cholesterol and raises fecal neutral sterols in cholesterol-Fed rats because of its low digestibility. , 1997, The Journal of nutrition.

[7]  Y. Pomeranz.  Buckwheat: structure, composition, and utilization. , 1983, Critical reviews in food science and nutrition.

[8]  J. Milner,et al.  Effect of arginine on the carcinogenicity of 7,12-dimethylbenz[a]-anthracene and N-methyl-N-nitrosourea. , 1984, Carcinogenesis.

[9]  J. Kayashita,et al.  Feeding of buckwheat protein extract reduces hepatic triglyceride concentration, adipose tissue weight, and hepatic lipogenesis in rats , 1996 .

[10]  W. Blair,et al.  Dietary soybean isolate and methionine supplementation affect mammary tumor progression in rats. , 1991, The Journal of nutrition.

[11]  J. Kayashita,et al.  Hypocholesterolemic effect of buckwheat protein extract in rats fed cholesterol enriched diets , 1995 .

[12]  J. Kayashita,et al.  Buckwheat protein extract suppression of the growth depression in rats induced by feeding amaranth (Food Red No. 2). , 1996, Bioscience, biotechnology, and biochemistry.