A Review of Randomized Clinical Trials in Tinnitus

Objectives: Review reports of randomized clinical trials (RCTs) in tinnitus to identify well‐established treatments, promising developments, and opportunities for improvement in this area of clinical research.

[1]  F. Martin,et al.  Tinnitus: a double-blind crossover controlled trial to evaluate the use of lignocaine. , 1980, Clinical otolaryngology and allied sciences.

[2]  C. Sorkness,et al.  Antidepressants and chronicnonmalignant pain: A review , 1987 .

[3]  P. E. Hansen,et al.  Acupuncture treatment of chronic unilateral tinnitus--a double-blind cross-over trial. , 1982, Clinical otolaryngology and allied sciences.

[4]  C. B. Pedersen,et al.  Zinc in the Management of Tinnitus , 1991, The Annals of otology, rhinology, and laryngology.

[5]  M. Meikle,et al.  The Perceived Severity of Tinnitus: Some Observations Concerning a Large Population of Tinnitus Clinic Patients , 1984, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[6]  N. Roland,et al.  Electromagnetic stimulation as a treatment of tinnitus: a pilot study. , 1993, Clinical otolaryngology and allied sciences.

[7]  P. Wilson,et al.  Tinnitus reaction questionnaire: psychometric properties of a measure of distress associated with tinnitus. , 1991, Journal of speech and hearing research.

[8]  L. Duckert,et al.  Treatment of tinnitus with intravenous lidocaine: A double-blind randomized trial , 1983, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[9]  F K Kuk,et al.  The psychometric properties of a tinnitus handicap questionnaire. , 1990, Ear and hearing.

[10]  N. Marks,et al.  The effect of single doses of amylobarbitone sodium and carbamazepine in tinnitus , 1981, The Journal of Laryngology & Otology.

[11]  Richard S. Hallam,et al.  The effects of reassurance, relaxation training and distraction on chronic tinnitus sufferers. , 1986, Behaviour research and therapy.

[12]  D. Faraggi,et al.  Comparison between self-hypnosis, masking and attentiveness for alleviation of chronic tinnitus. , 1993, Audiology.

[13]  O. Vilholm,et al.  Effect of traditional Chinese acupuncture on severe tinnitus: a double-blind, placebo-controlled, clinical investigation with open therapeutic control. , 1998, British journal of audiology.

[14]  B. Stach,et al.  A double-blind placebo-controlled trial of baclofen in the treatment of tinnitus. , 1996, The American journal of otology.

[15]  A. Blayney,et al.  A sequential double blind cross-over trial of tocainide hydrochloride in tinnitus. , 1985, Clinical otolaryngology and allied sciences.

[16]  R. Dobie,et al.  Electrical Tinnitus Suppression: A Double-Blind Crossover Study , 1986, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[17]  D. Quine,et al.  Amino-oxyacetic acid as a palliative in tinnitus. , 1985, Archives of otolaryngology.

[18]  W. Rief,et al.  Meeting the expectations of chronic tinnitus patients: comparison of a structured group therapy program for tinnitus management with a problem-solving group. , 1998, Journal of psychosomatic research.

[19]  P. Lindberg,et al.  Treatment of tinnitus by external electrical stimulation. , 1986, Scandinavian audiology.

[20]  C. Fielder,et al.  Low-powered ultrasound in the treatment of tinnitus: a pilot study. , 1986, British journal of audiology.

[21]  J B Spitzer,et al.  Development of the Tinnitus Handicap Inventory. , 1996, Archives of otolaryngology--head & neck surgery.

[22]  L. Podoshin,et al.  Idiopathic subjective tinnitus treated by biofeedback, acupuncture and drug therapy. , 1991, Ear, nose, & throat journal.

[23]  Richard S. Hallam,et al.  Relaxation and cognitive therapy: A controlled trial in chronic tinnitus , 1995 .

[24]  R. Johnson,et al.  Use of alprazolam for relief of tinnitus. A double-blind study. , 1993, Archives of otolaryngology--head & neck surgery.

[25]  W. Katon,et al.  Disabling tinnitus. Association with affective disorder. , 1988, General hospital psychiatry.

[26]  C. Fankhauser,et al.  Prospective Crossover Evaluation of Four Methods of Clinical Management of Tinnitus , 1984, Otolaryngology Head & Neck Surgery.

[27]  N. Kay Oral chemotherapy in tinnitus. , 1981, British journal of audiology.

[28]  G. Carlsson,et al.  Effects of stomatognathic treatment on tinnitus: a retrospective study. , 1987, Cranio : the journal of craniomandibular practice.

[29]  A. Axelsson,et al.  Ginkgo biloba extract for the treatment of tinnitus. , 1994, Audiology : official organ of the International Society of Audiology.

[30]  G. Housley,et al.  Evaluation of Amino-Oxyacetic Acid as a Palliative in Tinnitus , 1990, The Annals of otology, rhinology, and laryngology.

[31]  Gordon H. Guyatt,et al.  Users' guides to the medical literature. II. How to use an article about therapy or prevention. A. Are the results of the study valid? Evidence-Based Medicine Working Group. , 1993, JAMA.

[32]  R. Lechtenberg,et al.  Benzodiazepines in the treatment of tinnitus , 1984, The Journal of Laryngology & Otology.

[33]  M. Gold Cost-effectiveness in health and medicine , 2016 .

[34]  G H Guyatt,et al.  USERS' GUIDES TO THE MEDICAL LITERATURE. II: HOW TO USE AN ARTICLE ABOUT THERAPY OR PREVENTION A. ARE THE RESULTS OF THE STUDY VALID ? , 1993 .

[35]  A. Ringdahl,et al.  Treatment of tinnitus: a controlled comparison of masking and placebo. , 1987, British journal of audiology.

[36]  Raleigh O. Jones,et al.  Cyclandelate in the Management of Tinnitus: A Randomized, Placebo-Controlled Study , 1998, Otolaryngology Head & Neck Surgery.

[37]  H. Silverstein,et al.  Effect of Melatonin on Tinnitus , 1998, The Laryngoscope.

[38]  J. Cathcart Assessment of the value of tocainide hydrochloride in the treatment of tinnitus , 1982, The Journal of Laryngology & Otology.

[39]  K. Thomas,et al.  Low-powered ultrasound in the inhibition of tinnitus. , 1987, British journal of audiology.

[40]  John E. Reinwall,et al.  The Tricyclic Trimipramine in the Treatment of Subjective Tinnitus , 1988, The Annals of otology, rhinology, and laryngology.

[41]  N. Marks,et al.  A controlled trial of hypnotherapy in tinnitus. , 1985, Clinical otolaryngology and allied sciences.

[42]  B. Kröner-Herwig,et al.  The management of chronic tinnitus--comparison of a cognitive-behavioural group training with yoga. , 1995, Journal of psychosomatic research.

[43]  C. Naranjo,et al.  Protracted tinnitus after discontinuation of long-term therapeutic use of benzodiazepines. , 1988, Journal of clinical psychopharmacology.

[44]  J. Butler,et al.  Client centred hypnotherapy in the management of tinnitus – is it better than counselling? , 1996, The Journal of Laryngology & Otology.

[45]  E. Fowler,et al.  The “Illusion of loudness” of tinnitus—Its etiology and treatment , 1942 .

[46]  P. Bradley,et al.  A trial of tinnitus therapy with ear-canal magnets. , 1991, Clinical otolaryngology and allied sciences.

[47]  H. Heinzl,et al.  Caroverine in tinnitus treatment. A placebo-controlled blind study. , 1997, Acta oto-laryngologica.

[48]  J. Tonndorf The analogy between tinnitus and pain: A suggestion for a physiological basis of chronic tinnitus , 1987, Hearing Research.

[49]  A. Axelsson,et al.  Acupuncture in the management of tinnitus: a placebo-controlled study. , 1994, Audiology : official organ of the International Society of Audiology.

[50]  P. Wilson,et al.  An evaluation of relaxation training in the treatment of tinnitus. , 1985, Behaviour research and therapy.

[51]  R. Coles,et al.  Epidemiology of tinnitus: (1) Prevalence , 1984, The Journal of Laryngology & Otology.

[52]  M. Hotz,et al.  Caroverine in tinnitus treatment. , 1998, Acta oto-laryngologica.

[53]  J. Henry,et al.  The Psychological Management of Tinnitus: Comparison of a Combined Cognitive Educational Program, Education Alone and a Waiting-List Control. , 1996, The international tinnitus journal.

[54]  W. Katon,et al.  Antidepressant treatment of tinnitus patients: report of a randomized clinical trial and clinical prediction of benefit. , 1993, The American journal of otology.

[55]  J. Shea Medical treatment of tinnitus. , 1984, The American journal of otology.

[56]  S. Stephens,et al.  A controlled study of tinnitus masking. , 1985, British journal of audiology.

[57]  I. Donaldson Tegretol: A double blind trial in tinnitus , 1981, The Journal of Laryngology & Otology.

[58]  B. Thedinger,et al.  Treatment of tinnitus with electrical stimulation: An evaluation of the audimax theraband , 1987, The Laryngoscope.

[59]  P. Lindberg,et al.  The psychological treatment of tinnitus: an experimental evaluation. , 1989, Behaviour research and therapy.

[60]  P. Vermeij,et al.  The value of tocainide in the treatment of tinnitus , 2004, Archives of oto-rhino-laryngology.

[61]  J. Hazell,et al.  Drug therapy and tinnitus: the UK experience , 1984, The Journal of Laryngology & Otology.

[62]  Ben-David,et al.  Idiopathic Subjective Tinnitus Treated by Amitriptyline Hydrochloride/Biofeedback. , 1995, The international tinnitus journal.

[63]  J. Emmett,et al.  Medical Treatment of Tinnitus , 1981, The Annals of otology, rhinology, and laryngology.

[64]  P. Vermeij,et al.  The value of flunarizine in the treatment of tinnitus. , 1986, ORL; journal for oto-rhino-laryngology and its related specialties.

[65]  W. Briner,et al.  Synthetic prostaglandin E1 misoprostol as a treatment for tinnitus. , 1993, Archives of otolaryngology--head & neck surgery.

[66]  T. Lenarz Treatment of tinnitus with lidocaine and tocainide. , 1986, Scandinavian audiology. Supplementum.

[67]  P. Vermeij,et al.  The value of carbamazepine in the treatment of tinnitus. , 1985, ORL; journal for oto-rhino-laryngology and its related specialties.

[68]  J. Bench,et al.  Managing tinnitus: a comparison of different approaches to tinnitus management training. , 1997, British journal of audiology.

[69]  J. H. Hulshof,et al.  The effect of iontophoresis of lignocaine in the treatment of tinnitus. , 1989, Clinical otolaryngology and allied sciences.

[70]  A Axelsson,et al.  Tinnitus--a study of its prevalence and characteristics. , 1989, British journal of audiology.

[71]  M Walger,et al.  Soft-laser/Ginkgo therapy in chronic tinnitus. A placebo-controlled study. , 1995, Advances in oto-rhino-laryngology.

[72]  S. Carlsson,et al.  Tinnitus: evaluation of biofeedback and stomatognathic treatment. , 1991, British journal of audiology.

[73]  P. Wilson,et al.  EMG biofeedback in the treatment of tinnitus: an experimental evaluation. , 1987, Behaviour research and therapy.