Abstract: Subjective and Objective Facial Dynamics Using Dermal Fillers Formulated for Facial Movement Adaptation

METHODS: An open-label, non-comparative 12 week prospective study conducted in 4 U.S. centers evaluated the safety and effectiveness of SPHAL in conjunction with a blunt-tipped cannula. Adverse events (AEs) were collected throughout the study. Subjects reported predefined, expected post-treatment injection site reactions during the first 2 weeks post-treatment via diary. Effectiveness assessments at 4 and 12 weeks post-treatment included treating invesitgatorand subject-reported Global Aesthetic Improvement Sclae (GAIS) scores and treating investigator-reported evaluations using the Medicis Lip Fullness Scale (MLFS).1