Genetics of breast cancer bone metastasis: a sequential multistep pattern

[1]  Z. Wang,et al.  MCAM expression is associated with poor prognosis in non-small cell lung cancer , 2014, Clinical and Translational Oncology.

[2]  I. Fabregat,et al.  Overactivation of the TGF‐β pathway confers a mesenchymal‐like phenotype and CXCR4‐dependent migratory properties to liver tumor cells , 2013, Hepatology.

[3]  S. Jee,et al.  Induction of chemokine receptor CXCR4 expression by transforming growth factor-β1 in human basal cell carcinoma cells. , 2013, Journal of dermatological science.

[4]  E. Oliva,et al.  FGF18 as a prognostic and therapeutic biomarker in ovarian cancer. , 2013, The Journal of clinical investigation.

[5]  Andrew E. Sloan,et al.  Brain Tumor Initiating Cells Adapt to Restricted Nutrition through Preferential Glucose Uptake , 2013, Nature Neuroscience.

[6]  I. Mikhailenko,et al.  LRP1 Protects the Vasculature by Regulating Levels of Connective Tissue Growth Factor and HtrA1 , 2013, Arteriosclerosis, thrombosis, and vascular biology.

[7]  N. Crawford,et al.  WISP1/CCN4: A Potential Target for Inhibiting Prostate Cancer Growth and Spread to Bone , 2013, PloS one.

[8]  M. Cher,et al.  PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signaling , 2013, Molecular Cancer.

[9]  J. Iwata,et al.  CTGF Mediates Smad-Dependent Transforming Growth Factor β Signaling To Regulate Mesenchymal Cell Proliferation during Palate Development , 2013, Molecular and Cellular Biology.

[10]  Shiwu Zhang,et al.  Bone metastasis from breast cancer involves elevated IL-11 expression and the gp130/STAT3 pathway , 2013, Medical Oncology.

[11]  G. Kristiansen,et al.  Knockdown of prolyl‐4‐hydroxylase domain 2 inhibits tumor growth of human breast cancer MDA‐MB‐231 cells by affecting TGF‐β1 processing , 2013, International journal of cancer.

[12]  Hiroyuki Suzuki,et al.  Transforming Growth Factor-β Induces Transcription Factors MafK and Bach1 to Suppress Expression of the Heme Oxygenase-1 Gene* , 2013, The Journal of Biological Chemistry.

[13]  Lei Zhang,et al.  MiR-223/Ect2/p21 signaling regulates osteosarcoma cell cycle progression and proliferation. , 2013, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[14]  Yun-ye Ning,et al.  Overexpression of response gene to complement 32 (RGC32) promotes cell invasion and induces epithelial–mesenchymal transition in lung cancer cells via the NF-κB signaling pathway , 2013, Tumor Biology.

[15]  B. Behnam,et al.  Crosstalk between breast cancer stem cells and metastatic niche: emerging molecular metastasis pathway? , 2013, Tumor Biology.

[16]  K. Mohammad,et al.  RANKL/RANK/MMP-1 Molecular Triad Contributes to the Metastatic Phenotype of Breast and Prostate Cancer Cells In Vitro , 2013, PloS one.

[17]  D. Abraham,et al.  Connective tissue growth factor causes EMT-like cell fate changes in vivo and in vitro , 2013, Journal of Cell Science.

[18]  Chun-Yin Huang,et al.  CCN4 induces vascular cell adhesion molecule-1 expression in human synovial fibroblasts and promotes monocyte adhesion. , 2013, Biochimica et biophysica acta.

[19]  P. Billings,et al.  Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses. , 2013, Developmental biology.

[20]  Kaushal Joshi,et al.  Tumor‐Specific Activation of the C‐JUN/MELK Pathway Regulates Glioma Stem Cell Growth in a p53‐Dependent Manner , 2013, Stem cells.

[21]  R. Albulescu Elevated cyclin B2 expression in invasive breast carcinoma is associated with unfavorable clinical outcome. , 2013, Biomarkers in medicine.

[22]  C. Aalkjaer,et al.  Contribution of Na+,HCO3−‐cotransport to cellular pH control in human breast cancer: A role for the breast cancer susceptibility locus NBCn1 (SLC4A7) , 2013, International journal of cancer.

[23]  W. Guo,et al.  Differential Expression of the RANKL/RANK/OPG System Is Associated with Bone Metastasis in Human Non-Small Cell Lung Cancer , 2013, PloS one.

[24]  A. Mercurio,et al.  Estrogen receptor β sustains epithelial differentiation by regulating prolyl hydroxylase 2 transcription , 2013, Proceedings of the National Academy of Sciences.

[25]  Kaushal Joshi,et al.  MELK-Dependent FOXM1 Phosphorylation is Essential for Proliferation of Glioma Stem Cells , 2013, Stem cells.

[26]  A. Quintás-Cardama,et al.  Molecular Pathways: JAK/STAT Pathway: Mutations, Inhibitors, and Resistance , 2013, Clinical Cancer Research.

[27]  M. Aurrand-Lions,et al.  Soluble Melanoma Cell Adhesion Molecule (sMCAM/sCD146) Promotes Angiogenic Effects on Endothelial Progenitor Cells through Angiomotin* , 2013, The Journal of Biological Chemistry.

[28]  Kishore R. Sakharkar,et al.  Glycolytic enzymes PGK1 and PKM2 as novel transcriptional targets of PPARγ in breast cancer pathophysiology , 2013, Journal of drug targeting.

[29]  G. Berx,et al.  Regulatory networks defining EMT during cancer initiation and progression , 2013, Nature Reviews Cancer.

[30]  Xu Feng,et al.  IL-11 produced by breast cancer cells augments osteoclastogenesis by sustaining the pool of osteoclast progenitor cells , 2013, BMC Cancer.

[31]  J. Jung,et al.  Upregulation of CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cells , 2013, Oncogene.

[32]  Jia Fan,et al.  Enhanced production of CTGF and IL-11 from highly metastatic hepatoma cells under hypoxic conditions: an implication of hepatocellular carcinoma metastasis to bone , 2013, Journal of Cancer Research and Clinical Oncology.

[33]  M. Mimeault,et al.  Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells , 2013, Journal of cellular and molecular medicine.

[34]  A. Jemal,et al.  Cancer statistics, 2013 , 2013, CA: a cancer journal for clinicians.

[35]  M. Vincenti,et al.  Interleukin-1 beta and transforming growth factor-beta 3 cooperate to activate matrix metalloproteinase expression and invasiveness in A549 lung adenocarcinoma cells. , 2012, Cancer letters.

[36]  Y. Lim,et al.  Transcriptional regulation of the interleukin-11 gene by oncogenic Ras. , 2012, Carcinogenesis.

[37]  W. Lowry,et al.  Ptk7 Marks the First Human Developmental EMT In Vitro , 2012, PloS one.

[38]  G. Melino,et al.  Identification of NCF2/p67phox as a novel p53 target gene , 2012, Cell cycle.

[39]  P. Jung,et al.  Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation. , 2012, Cancer cell.

[40]  M. Eccles,et al.  Cohesin Is Required for Activation of MYC by Estradiol , 2012, PloS one.

[41]  Lingling Zhu,et al.  FHL family members suppress vascular endothelial growth factor expression through blockade of dimerization of HIF1α and HIF1β , 2012, IUBMB life.

[42]  Chih-Hsin Tang,et al.  Interleukin‐11 Increases Cell Motility and Up‐Regulates Intercellular Adhesion Molecule‐1 Expression in Human Chondrosarcoma Cells , 2012, Journal of cellular biochemistry.

[43]  A. Clark,et al.  The effects of transforming growth factor-β2 on the expression of follistatin and activin A in normal and glaucomatous human trabecular meshwork cells and tissues. , 2012, Investigative ophthalmology & visual science.

[44]  Yun Hee Kang,et al.  ESM-1 regulates cell growth and metastatic process through activation of NF-κB in colorectal cancer. , 2012, Cellular signalling.

[45]  Dongling Yang,et al.  CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis. , 2012, Blood.

[46]  M. Aurrand-Lions,et al.  CD146 Expression in Human Breast Cancer Cell Lines Induces Phenotypic and Functional Changes Observed in Epithelial to Mesenchymal Transition , 2012, PloS one.

[47]  T. Svitkina,et al.  Exo70 Stimulates the Arp2/3 Complex for Lamellipodia Formation and Directional Cell Migration , 2012, Current Biology.

[48]  J. Massagué,et al.  Molecular Pathways Molecular Pathways : VCAM-1 as a Potential Therapeutic Target in Metastasis , 2012 .

[49]  S. Kung,et al.  Transcriptional Network Analysis Identifies BACH1 as a Master Regulator of Breast Cancer Bone Metastasis , 2012, The Journal of Biological Chemistry.

[50]  J. Rutka,et al.  ECT2 and RASAL2 mediate mesenchymal-amoeboid transition in human astrocytoma cells. , 2012, The American journal of pathology.

[51]  James M. Allen,et al.  Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin , 2012, The Journal of cell biology.

[52]  F. Climent,et al.  RANK induces epithelial-mesenchymal transition and stemness in human mammary epithelial cells and promotes tumorigenesis and metastasis. , 2012, Cancer research.

[53]  E. Rosen,et al.  BRCA1 Regulates Follistatin Function in Ovarian Cancer and Human Ovarian Surface Epithelial Cells , 2012, PloS one.

[54]  J. Qin,et al.  The effect of NET-1 on the proliferation, migration and endocytosis of the SMMC-7721 HCC cell line. , 2012, Oncology reports.

[55]  Teppei Shimamura,et al.  Dynamic Change of Chromatin Conformation in Response to Hypoxia Enhances the Expression of GLUT3 (SLC2A3) by Cooperative Interaction of Hypoxia-Inducible Factor 1 and KDM3A , 2012, Molecular and Cellular Biology.

[56]  R. Vessella,et al.  DIAPH3 governs the cellular transition to the amoeboid tumour phenotype , 2012, EMBO molecular medicine.

[57]  T. Brabletz To differentiate or not — routes towards metastasis , 2012, Nature Reviews Cancer.

[58]  P. Hinds,et al.  Matrix Metalloprotease-1a Promotes Tumorigenesis and Metastasis* , 2012, The Journal of Biological Chemistry.

[59]  Cristin G. Print,et al.  Cyclin E2 Overexpression Is Associated with Endocrine Resistance but not Insensitivity to CDK2 Inhibition in Human Breast Cancer Cells , 2012, Molecular Cancer Therapeutics.

[60]  A. Jukkola-Vuorinen,et al.  Expressions of individual PHDs associate with good prognostic factors and increased proliferation in breast cancer patients , 2012, Breast Cancer Research and Treatment.

[61]  R. Pestell,et al.  Breast cancer stem cells. , 2012, The international journal of biochemistry & cell biology.

[62]  J. Shand,et al.  IGFBP5 induces cell adhesion, increases cell survival and inhibits cell migration in MCF-7 human breast cancer cells , 2012, Journal of Cell Science.

[63]  J. Gong,et al.  Bone morphogenetic protein 4 (BMP4) is required for migration and invasion of breast cancer , 2012, Molecular and Cellular Biochemistry.

[64]  Jia Han,et al.  TFF3 mediated induction of VEGF via hypoxia in human gastric cancer SGC-7901 cells , 2012, Molecular Biology Reports.

[65]  F. May,et al.  TFF3 is a normal breast epithelial protein and is associated with differentiated phenotype in early breast cancer but predisposes to invasion and metastasis in advanced disease. , 2012, The American journal of pathology.

[66]  S. Casimiro,et al.  Analysis of a bone metastasis gene expression signature in patients with bone metastasis from solid tumors , 2012, Clinical & Experimental Metastasis.

[67]  Carlo C. Maley,et al.  Clonal evolution in cancer , 2012, Nature.

[68]  J. Brooks,et al.  Increased expression of NuSAP in recurrent prostate cancer is mediated by E2F1 , 2012, Oncogene.

[69]  S. Cai,et al.  METCAM/MUC18 augments migration, invasion, and tumorigenicity of human breast cancer SK-BR-3 cells. , 2012, Gene.

[70]  J. Massagué,et al.  VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors. , 2011, Cancer cell.

[71]  Hong Peng,et al.  Interactions between cancer stem cells and their niche govern metastatic colonization , 2011, Nature.

[72]  Y. Jeng,et al.  Phosphorylation of NuSAP by Cdk1 regulates its interaction with microtubules in mitosis , 2011, Cell cycle.

[73]  C. Ricciardelli,et al.  The ADAMTS1 protease gene is required for mammary tumor growth and metastasis. , 2011, The American journal of pathology.

[74]  J. Massagué,et al.  Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. , 2011, Cancer cell.

[75]  L. Pannell,et al.  INCREASED VASCULARITY AND SPONTANEOUS METASTASIS OF BREAST CANCER BY HEDGEHOG SIGNALING MEDIATED UPREGULATION OF CYR61 , 2011, Oncogene.

[76]  Robert A. Weinberg,et al.  Tumor Metastasis: Molecular Insights and Evolving Paradigms , 2011, Cell.

[77]  C. Der,et al.  The ect2 rho Guanine nucleotide exchange factor is essential for early mouse development and normal cell cytokinesis and migration. , 2011, Genes & cancer.

[78]  W. Ding,et al.  Snail1 induces epithelial-to-mesenchymal transition and tumor initiating stem cell characteristics , 2011, BMC Cancer.

[79]  Lixin Wei,et al.  Epithelial-Mesenchymal Transition in tumor microenvironment , 2011, Cell & Bioscience.

[80]  Ruey-Bing Yang,et al.  Domain and functional analysis of a novel breast tumor suppressor protein, SCUBE2. , 2011, The Journal of biological chemistry.

[81]  R. Samant,et al.  Hedgehog Signaling: Networking to Nurture a Promalignant Tumor Microenvironment , 2011, Molecular Cancer Research.

[82]  E. Lam,et al.  FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer , 2011, Oncogene.

[83]  Mithat Gönen,et al.  The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors. , 2011, The Journal of clinical investigation.

[84]  P. Jose,et al.  Response gene to complement 32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells. , 2011, American journal of physiology. Cell physiology.

[85]  Sophia Hsin-Jung Li,et al.  Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast , 2011, Cell.

[86]  Chih-Hsin Tang,et al.  WISP-1 increases MMP-2 expression and cell motility in human chondrosarcoma cells. , 2011, Biochemical pharmacology.

[87]  Irmeli Barkefors,et al.  Exocyst Complex Component 3-like 2 (EXOC3L2) Associates with the Exocyst Complex and Mediates Directional Migration of Endothelial Cells* , 2011, The Journal of Biological Chemistry.

[88]  M. Gossen,et al.  Different roles of the human Orc6 protein in the replication initiation process , 2011, Cellular and Molecular Life Sciences.

[89]  R. Weinberg,et al.  A Perspective on Cancer Cell Metastasis , 2011, Science.

[90]  Yongmei Li,et al.  ShRNA-Targeted Centromere Protein A Inhibits Hepatocellular Carcinoma Growth , 2011, PloS one.

[91]  T. Mohr,et al.  Up‐regulation of the fibroblast growth factor 8 subfamily in human hepatocellular carcinoma for cell survival and neoangiogenesis , 2011, Hepatology.

[92]  B. Reina-San-Martin,et al.  Deficiency in trefoil factor 1 (TFF1) increases tumorigenicity of human breast cancer cells and mammary tumor development in TFF1-knockout mice , 2011, Oncogene.

[93]  R. Minchin,et al.  RNAi-Mediated Knock-Down of Arylamine N-acetyltransferase-1 Expression Induces E-cadherin Up-Regulation and Cell-Cell Contact Growth Inhibition , 2011, PloS one.

[94]  P. Seth,et al.  TGFβ-dependent induction of interleukin-11 and interleukin-8 involves SMAD and p38 MAPK pathways in breast tumor models with varied bone metastases potential , 2011, Cancer biology & therapy.

[95]  S. Sen,et al.  A Migration Signature and Plasma Biomarker Panel for Pancreatic Adenocarcinoma , 2010, Cancer Prevention Research.

[96]  Xin Lu,et al.  Hypoxia and Hypoxia-Inducible Factors: Master Regulators of Metastasis , 2010, Clinical Cancer Research.

[97]  Harald J. Maier,et al.  NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells. , 2010, Cancer letters.

[98]  A. Strongin,et al.  The Wnt/Planar Cell Polarity Protein-tyrosine Kinase-7 (PTK7) Is a Highly Efficient Proteolytic Target of Membrane Type-1 Matrix Metalloproteinase , 2010, The Journal of Biological Chemistry.

[99]  R. Zhao,et al.  Suppression of TSPAN1 by RNA Interference Inhibits Proliferation and Invasion of Colon Cancer Cells in Vitro , 2010, Tumori.

[100]  B. Vojtesek,et al.  The pro-metastatic protein anterior gradient-2 predicts poor prognosis in tamoxifen-treated breast cancers , 2010, Oncogene.

[101]  Beverly A. Teicher,et al.  CXCL12 (SDF-1)/CXCR4 Pathway in Cancer , 2010, Clinical Cancer Research.

[102]  Shikha Khatri,et al.  FOXO3a Regulates Glycolysis via Transcriptional Control of Tumor Suppressor TSC1* , 2010, The Journal of Biological Chemistry.

[103]  T. Harris,et al.  The Conserved Mitochondrial Twin Cx9C Protein Cmc2 Is a Cmc1 Homologue Essential for Cytochrome c Oxidase Biogenesis* , 2010, The Journal of Biological Chemistry.

[104]  R. Minchin,et al.  Small molecule inhibition of arylamine N-acetyltransferase Type I inhibits proliferation and invasiveness of MDA-MB-231 breast cancer cells. , 2010, Biochemical and biophysical research communications.

[105]  P. Kjellén,et al.  TOM1L Is Involved in a Novel Signaling Pathway Important for the IL-2 Production in Jurkat T Cells Stimulated by CD3/CD28 CoLigation , 2010, Mediators of inflammation.

[106]  In Gyu Kim,et al.  TSPYL5 is involved in cell growth and the resistance to radiation in A549 cells via the regulation of p21(WAF1/Cip1) and PTEN/AKT pathway. , 2010, Biochemical and biophysical research communications.

[107]  N. Turner,et al.  Fibroblast growth factor signalling: from development to cancer , 2010, Nature Reviews Cancer.

[108]  Annuska M Glas,et al.  Biological Functions of the Genes in the Mammaprint Breast Cancer Profile Reflect the Hallmarks of Cancer , 2010, Biomarker insights.

[109]  Larry Norton,et al.  Tumor Self-Seeding by Circulating Cancer Cells , 2009, Cell.

[110]  P. Bastiaens,et al.  VEGF autoregulates its proliferative and migratory ERK1/2 and p38 cascades by enhancing the expression of DUSP1 and DUSP5 phosphatases in endothelial cells. , 2009, American journal of physiology. Cell physiology.

[111]  S. Catalano,et al.  Akt2 Inhibition Enables the Forkhead Transcription Factor FoxO3a To Have a Repressive Role in Estrogen Receptor α Transcriptional Activity in Breast Cancer Cells , 2009, Molecular and Cellular Biology.

[112]  J. Arribas,et al.  The Cleavage of Semaphorin 3C Induced by ADAMTS1 Promotes Cell Migration* , 2009, The Journal of Biological Chemistry.

[113]  Y. Shiozawa,et al.  Expression of PGK1 by Prostate Cancer Cells Induces Bone Formation , 2009, Molecular Cancer Research.

[114]  T. Zhu,et al.  Trefoil factor-1 (TFF1) enhances oncogenicity of mammary carcinoma cells. , 2009, Endocrinology.

[115]  W. Hong,et al.  Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor , 2009, The EMBO journal.

[116]  P. Mehdipour,et al.  Prognostic implication of CDC25A and cyclin E expression on primary breast cancer patients , 2009, Cell biology international.

[117]  S. Morrison,et al.  Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution , 2009, Cell.

[118]  Qiongqing Wang,et al.  ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. , 2009, Genes & development.

[119]  Min Wu,et al.  Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humans. , 2009, The Biochemical journal.

[120]  D. Newgreen,et al.  Staurosporine augments EGF-mediated EMT in PMC42-LA cells through actin depolymerisation, focal contact size reduction and Snail1 induction – A model for cross-modulation , 2009, BMC Cancer.

[121]  Larry Norton,et al.  Latent bone metastasis in breast cancer tied to Src-dependent survival signals. , 2009, Cancer cell.

[122]  H. Zhang,et al.  Four and a half LIM domains 1 (FHL1) and receptor interacting protein of 140kDa (RIP140) interact and cooperate in estrogen signaling. , 2009, The international journal of biochemistry & cell biology.

[123]  A. Toker,et al.  FOXO3a Promotes Tumor Cell Invasion through the Induction of Matrix Metalloproteinases , 2009, Molecular and Cellular Biology.

[124]  M. Conaway,et al.  PTK7 is essential for polarized cell motility and convergent extension during mouse gastrulation , 2009, Development.

[125]  Howard Y. Chang,et al.  Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. , 2009, Cancer cell.

[126]  Raghu Kalluri,et al.  The basics of epithelial-mesenchymal transition. , 2009, The Journal of clinical investigation.

[127]  Y. H. Kim,et al.  Upregulation of the cycline kinase subunit CKS2 increases cell proliferation rate in gastric cancer , 2009, Journal of Cancer Research and Clinical Oncology.

[128]  T. Tan,et al.  CTGF enhances migration and MMP‐13 up‐regulation via αvβ3 integrin, FAK, ERK, and NF‐κB‐dependent pathway in human chondrosarcoma cells , 2009, Journal of Cellular Biochemistry.

[129]  J. Hoheisel,et al.  Neuromedin U is overexpressed in pancreatic cancer and increases invasiveness via the hepatocyte growth factor c-Met pathway. , 2009, Cancer letters.

[130]  Zhongmei Zhou,et al.  KLF5 Promotes Breast Cell Survival Partially through Fibroblast Growth Factor-binding Protein 1-pERK-mediated Dual Specificity MKP-1 Protein Phosphorylation and Stabilization* , 2009, The Journal of Biological Chemistry.

[131]  Yasuhiro Nakagami,et al.  The protein disulfide isomerase AGR2 is essential for production of intestinal mucus , 2009, Proceedings of the National Academy of Sciences.

[132]  Ming-Tzu Tsai,et al.  SCUBE2 suppresses breast tumor cell proliferation and confers a favorable prognosis in invasive breast cancer. , 2009, Cancer research.

[133]  H. Rus,et al.  RGC-32 Mediates Transforming Growth Factor-β-induced Epithelial-Mesenchymal Transition in Human Renal Proximal Tubular Cells* , 2009, Journal of Biological Chemistry.

[134]  Russell G. Jones,et al.  Tumor suppressors and cell metabolism: a recipe for cancer growth. , 2009, Genes & development.

[135]  F. Bertucci,et al.  Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. , 2009, Cancer research.

[136]  H. Zhang,et al.  Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway. , 2009, The Journal of clinical investigation.

[137]  Samy Lamouille,et al.  TGF-β-induced epithelial to mesenchymal transition , 2009, Cell Research.

[138]  F. Bertucci,et al.  CD146 expression is associated with a poor prognosis in human breast tumors and with enhanced motility in breast cancer cell lines , 2009, Breast Cancer Research.

[139]  B. Olsen,et al.  Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3. , 2008, Molecular biology of the cell.

[140]  K. Bayless,et al.  Molecular profile of endothelial invasion of three-dimensional collagen matrices: insights into angiogenic sprout induction in wound healing. , 2008, American journal of physiology. Cell physiology.

[141]  Liang Zhao,et al.  Blockade of SDF-1/CXCR4 signalling inhibits pancreatic cancer progression in vitro via inactivation of canonical Wnt pathway , 2008, British Journal of Cancer.

[142]  T. Katagiri,et al.  Involvement of elevated expression of multiple cell-cycle regulator, DTL/RAMP (denticleless/RA-regulated nuclear matrix associated protein), in the growth of breast cancer cells , 2008, Oncogene.

[143]  R. Geffers,et al.  Filopodia Formation Induced by Active Mdia2/drf3 1 , 2022 .

[144]  M. Young,et al.  TGF‐β1 and WISP‐1/CCN‐4 can regulate each other's activity to cooperatively control osteoblast function , 2008, Journal of cellular biochemistry.

[145]  M. Ittmann,et al.  Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting programmed cell death , 2008, International journal of cancer.

[146]  Jae-Won Jung,et al.  Soluble PTK7 inhibits tube formation, migration, and invasion of endothelial cells and angiogenesis. , 2008, Biochemical and biophysical research communications.

[147]  S. Spiegl-Kreinecker,et al.  FGF5 as an oncogenic factor in human glioblastoma multiforme: autocrine and paracrine activities , 2008, Oncogene.

[148]  Robert A. Weinberg,et al.  Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. , 2008, Developmental cell.

[149]  G. Sonenshein,et al.  NF‐κB and epithelial to mesenchymal transition of cancer , 2008, Journal of cellular biochemistry.

[150]  E. Wang,et al.  Elevated thymosin β15 expression is associated with progression and metastasis of non‐small cell lung cancer   , 2008 .

[151]  Wenjun Guo,et al.  The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells , 2008, Cell.

[152]  P. Chambon,et al.  Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling , 2008, Nature.

[153]  R. Bernards,et al.  Enabling personalized cancer medicine through analysis of gene-expression patterns , 2008, Nature.

[154]  Jing-jing Wu,et al.  DUSP1 Is Controlled by p53 during the Cellular Response to Oxidative Stress , 2008, Molecular Cancer Research.

[155]  Chiun Hsu,et al.  Forkhead box transcription factor FOXO3a suppresses estrogen-dependent breast cancer cell proliferation and tumorigenesis , 2008, Breast Cancer Research.

[156]  D. Radisky,et al.  Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development , 2008, Clinical & Experimental Metastasis.

[157]  G. Mills,et al.  ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation , 2008, Nature Cell Biology.

[158]  Kunihiro Tsuchida,et al.  Follistatin Suppresses the Production of Experimental Multiple-Organ Metastasis by Small Cell Lung Cancer Cells in Natural Killer Cell–Depleted SCID Mice , 2008, Clinical Cancer Research.

[159]  Zheng Wang,et al.  The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation. , 2008, Cancer research.

[160]  Paul S Mischel,et al.  Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells , 2008, Journal of neuroscience research.

[161]  X. Tong,et al.  Transforming Growth Factor- (cid:1) 1 Impairs Endothelin-1-Mediated Contraction of Brain Vessels by Inducing Mitogen-Activated Protein (MAP) Kinase Phosphatase-1 and Inhibiting p38 MAP Kinase , 2007 .

[162]  L. Nelles,et al.  Activation of NF-κB by Akt upregulates Snail expression and induces epithelium mesenchyme transition , 2007, Oncogene.

[163]  W. Berger,et al.  FGF18 in colorectal tumour cells: autocrine and paracrine effects. , 2007, Carcinogenesis.

[164]  C. Waterman-Storer,et al.  mDia2 regulates actin and focal adhesion dynamics and organization in the lamella for efficient epithelial cell migration , 2007, Journal of Cell Science.

[165]  Connie Wang,et al.  Transforming Growth Factor-β1 Induces an Epithelial-to-Mesenchymal Transition State in Mouse Hepatocytes in Vitro* , 2007, Journal of Biological Chemistry.

[166]  Brendan F Boyce,et al.  Biology of RANK, RANKL, and osteoprotegerin , 2007, Arthritis research & therapy.

[167]  King-Jen Chang,et al.  CTGF enhances the motility of breast cancer cells via an integrin-alphavbeta3-ERK1/2-dependent S100A4-upregulated pathway. , 2007, Journal of cell science.

[168]  King-Jen Chang,et al.  CTGF enhances the motility of breast cancer cells via an integrin-αvβ3–ERK1/2-dependent S100A4-upregulated pathway , 2007, Journal of Cell Science.

[169]  S. Keyse,et al.  Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases , 2007, Oncogene.

[170]  Paula D. Bos,et al.  Mediators of vascular remodelling co-opted for sequential steps in lung metastasis , 2007, Nature.

[171]  K. Shichijo,et al.  Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the invasive activity of human gastric carcinoma cells. , 2007, International journal of oncology.

[172]  Yusuke Nakamura,et al.  Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family , 2007, Breast Cancer Research.

[173]  H. Frierson,et al.  Neuromedin U is regulated by the metastasis suppressor RhoGDI2 and is a novel promoter of tumor formation, lung metastasis and cancer cachexia , 2007, Oncogene.

[174]  H. Hsu,et al.  L2dtl Is Essential for Cell Survival and Nuclear Division in Early Mouse Embryonic Development* , 2007, Journal of Biological Chemistry.

[175]  B. Tycko,et al.  Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2. , 2006, Molecular biology of the cell.

[176]  D. Jeoung,et al.  A Splice Variant of CD99 Increases Motility and MMP-9 Expression of Human Breast Cancer Cells through the AKT-, ERK-, and JNK-dependent AP-1 Activation Signaling Pathways* , 2006, Journal of Biological Chemistry.

[177]  Hung-Wei Pan,et al.  Role of L2DTL, Cell Cycle-Regulated Nuclear and Centrosome Protein, in Aggressive HepatocellularCarcinoma , 2006, Cell cycle.

[178]  H. Yoshida,et al.  Epithelial-mesenchymal transition induced by the stromal cell-derived factor-1/CXCR4 system in oral squamous cell carcinoma cells. , 2006, International journal of oncology.

[179]  A. Witteveen,et al.  Converting a breast cancer microarray signature into a high-throughput diagnostic test , 2006, BMC Genomics.

[180]  T. Nakayama,et al.  Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells. , 2006, International journal of oncology.

[181]  M. Noble,et al.  Cancer stem cells. , 2006, The New England journal of medicine.

[182]  Tomoaki Koga,et al.  The Transforming Growth Factor-β-Smad3/4 Signaling Pathway Acts as a Positive Regulator for TLR2 Induction by Bacteria via a Dual Mechanism Involving Functional Cooperation with NF-κB and MAPK Phosphatase 1-dependent Negative Cross-talk with p38 MAPK* , 2006, Journal of Biological Chemistry.

[183]  Soichiro Ibaragi,et al.  Pathogenic Role of Connective Tissue Growth Factor (CTGF/CCN2) in Osteolytic Metastasis of Breast Cancer , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[184]  Yi Zhang,et al.  Genes associated with breast cancer metastatic to bone. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[185]  J. Visvader,et al.  Socs2 and elf5 mediate prolactin-induced mammary gland development. , 2006, Molecular endocrinology.

[186]  P. Rudland,et al.  Significance of the metastasis-inducing protein AGR2 for outcome in hormonally treated breast cancer patients , 2006, British Journal of Cancer.

[187]  S. M. Sims,et al.  Regulation of cancer cell migration and bone metastasis by RANKL , 2006, Nature.

[188]  J. Quigley,et al.  Matrix metalloproteinases and tumor metastasis , 2006, Cancer and Metastasis Reviews.

[189]  P. ten Dijke,et al.  The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells. , 2006, Cancer research.

[190]  S. Rafii,et al.  VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche , 2005, Nature.

[191]  Alfonso Bellacosa,et al.  Epithelial–mesenchymal transition in development and cancer: role of phosphatidylinositol 3′ kinase/AKT pathways , 2005, Oncogene.

[192]  J. Massagué,et al.  TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. , 2005, Cancer cell.

[193]  J. Johnston,et al.  SOCS2 Can Enhance Interleukin-2 (IL-2) and IL-3 Signaling by Accelerating SOCS3 Degradation , 2005, Molecular and Cellular Biology.

[194]  D. Santini,et al.  Suppressor of cytokine signalling 2 (SOCS-2) expression in breast carcinoma , 2005, Journal of Clinical Pathology.

[195]  Thomas Kirchner,et al.  Migrating cancer stem cells — an integrated concept of malignant tumour progression , 2005, Nature Reviews Cancer.

[196]  M. Ratajczak,et al.  Trafficking of Normal Stem Cells and Metastasis of Cancer Stem Cells Involve Similar Mechanisms: Pivotal Role of the SDF‐1–CXCR4 Axis , 2005, Stem cells.

[197]  S. Werner,et al.  ADAMTS1 Proteinase Is Up-regulated in Wounded Skin and Regulates Migration of Fibroblasts and Endothelial Cells* , 2005, Journal of Biological Chemistry.

[198]  W. Jelkmann,et al.  Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element. , 2005, The Biochemical journal.

[199]  C. Marshall,et al.  Cdc42–MRCK and Rho–ROCK signalling cooperate in myosin phosphorylation and cell invasion , 2005, Nature Cell Biology.

[200]  Carlos L Arteaga,et al.  Dual role of transforming growth factor beta in mammary tumorigenesis and metastatic progression. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

[201]  R. Epstein The CXCL12–CXCR4 chemotactic pathway as a target of adjuvant breast cancer therapies , 2004, Nature Reviews Cancer.

[202]  L. Huang,et al.  Hypoxia-Inducible Factor-1 Transactivates Transforming Growth Factor-β3 in Trophoblast , 2004 .

[203]  Andreas Sommer,et al.  NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression , 2004 .

[204]  Y. Hara,et al.  Follistatin Restricts Bone Morphogenetic Protein (BMP)‐2 Action on the Differentiation of Osteoblasts in Fetal Rat Mandibular Cells , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[205]  M. Tessier-Lavigne,et al.  PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates , 2004, Nature.

[206]  D. Page,et al.  Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis , 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

[207]  I. Fabregat,et al.  Snail blocks the cell cycle and confers resistance to cell death. , 2004, Genes & development.

[208]  Ryuji Kobayashi,et al.  IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a , 2004, Cell.

[209]  G. Roodman Mechanisms of bone metastasis. , 2004, Discovery medicine.

[210]  Stephen S. Taylor,et al.  Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression , 2004, Journal of Cell Science.

[211]  S. Ashley,et al.  CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells , 2004, Oncogene.

[212]  Gen Sheng Wu,et al.  The Phosphatase MKP1 Is a Transcriptional Target of p53 Involved in Cell Cycle Regulation* , 2003, Journal of Biological Chemistry.

[213]  Ying E. Zhang,et al.  Smad-dependent and Smad-independent pathways in TGF-β family signalling , 2003, Nature.

[214]  J. Ellenberg,et al.  NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization , 2003, The Journal of cell biology.

[215]  G. Taraboletti,et al.  Matrix metalloproteinases (MMP9 and MMP2) induce the release of vascular endothelial growth factor (VEGF) by ovarian carcinoma cells: implications for ascites formation. , 2003, Cancer research.

[216]  H. Shin,et al.  Expression of osteoprotegerin and RANK ligand in breast cancer bone metastasis. , 2003, Journal of Korean medical science.

[217]  M. Katoh Trefoil factors and human gastric cancer (review). , 2003, International journal of molecular medicine.

[218]  T. Tomonaga,et al.  Overexpression and mistargeting of centromere protein-A in human primary colorectal cancer. , 2003, Cancer research.

[219]  M. Iruela-Arispe,et al.  ADAMTS1/METH1 Inhibits Endothelial Cell Proliferation by Direct Binding and Sequestration of VEGF165* , 2003, Journal of Biological Chemistry.

[220]  K. Alitalo,et al.  VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia , 2003, The Journal of cell biology.

[221]  N. Ferrara,et al.  The biology of VEGF and its receptors , 2003, Nature Medicine.

[222]  C. Cordon-Cardo,et al.  A multigenic program mediating breast cancer metastasis to bone. , 2003, Cancer cell.

[223]  S. Nomoto,et al.  ΔNp63α and TAp63α regulate transcription of genes with distinct biological functions in cancer and development , 2003 .

[224]  H. Grabsch,et al.  Overexpression of the mitotic checkpoint genes BUB1, BUBR1, and BUB3 in gastric cancer—association with tumour cell proliferation , 2003, The Journal of pathology.

[225]  R. Salunga,et al.  Gene expression profiles of human breast cancer progression , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[226]  近藤 誠二 Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases , 2003 .

[227]  M. Mareel,et al.  Trefoil peptides as proangiogenic factors in vivo and in vitro: implication of cyclooxygenase‐2 and EGF receptor signaling , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[228]  Marc Payton,et al.  Deregulation of Cyclin E2 expression and associated kinase activity in primary breast tumors , 2002, Oncogene.

[229]  Hua Yu,et al.  Roles of activated Src and Stat3 signaling in melanoma tumor cell growth , 2002, Oncogene.

[230]  M. Shibuya,et al.  MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis. , 2002, Cancer cell.

[231]  Jiahuai Han,et al.  Activation of p38α MAPK Enhances Collagenase-1 (Matrix Metalloproteinase (MMP)-1) and Stromelysin-1 (MMP-3) Expression by mRNA Stabilization* , 2002, The Journal of Biological Chemistry.

[232]  G. Mundy Metastasis: Metastasis to bone: causes, consequences and therapeutic opportunities , 2002, Nature Reviews Cancer.

[233]  A. Clark,et al.  Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues. , 2002, Molecular vision.

[234]  T. Hunter,et al.  PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone , 2002, The Journal of cell biology.

[235]  L. Lanningham-Foster,et al.  Overexpression of CRIP in transgenic mice alters cytokine patterns and the immune response. , 2002, American journal of physiology. Endocrinology and metabolism.

[236]  G. Moreno-Bueno,et al.  Correlation of Snail expression with histological grade and lymph node status in breast carcinomas , 2002, Oncogene.

[237]  Sara J. Prest,et al.  The estrogen‐regulated protein, TFF1, stimulates migration of human breast cancer cells , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[238]  Christopher C W Hughes,et al.  Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM. , 2002, Microvascular research.

[239]  M. Nieto,et al.  The snail superfamily of zinc-finger transcription factors , 2002, Nature Reviews Molecular Cell Biology.

[240]  Yudong D. He,et al.  Gene expression profiling predicts clinical outcome of breast cancer , 2002, Nature.

[241]  J. Peters,et al.  Scc1/Rad21/Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells. , 2001, Developmental cell.

[242]  A. Wellstein,et al.  Enhancement of Fibroblast Growth Factor (FGF) Activity by an FGF-binding Protein* , 2001, The Journal of Biological Chemistry.

[243]  R. Spang,et al.  Predicting the clinical status of human breast cancer by using gene expression profiles , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[244]  R. Tibshirani,et al.  Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[245]  J. Rossant,et al.  FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. , 2001, Developmental cell.

[246]  S. Ethier,et al.  Identification of gene expression profiles that predict the aggressive behavior of breast cancer cells. , 2001, Cancer research.

[247]  T. Mcclanahan,et al.  Involvement of chemokine receptors in breast cancer metastasis , 2001, Nature.

[248]  M. Mareel,et al.  Induction of scattering and cellular invasion by trefoil peptides in src‐ and RhoA‐transformed kidney and colonic epithelial cells , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[249]  Thomas Hawighorst,et al.  Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis , 2001, Nature Medicine.

[250]  Thiennu H. Vu,et al.  Matrix metalloproteinases: effectors of development and normal physiology. , 2000, Genes & development.

[251]  Christian A. Rees,et al.  Molecular portraits of human breast tumours , 2000, Nature.

[252]  Andrew V. Nguyen,et al.  Transforming growth factor beta3 induces cell death during the first stage of mammary gland involution. , 2000, Development.

[253]  Roy Garcia,et al.  STATs in oncogenesis , 2000, Oncogene.

[254]  R. Medema,et al.  AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1 , 2000, Nature.

[255]  A. Levine,et al.  WISP-1 is a Wnt-1- and β-catenin-responsive oncogene , 2000, Genes & Development.

[256]  Francisco Portillo,et al.  The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression , 2000, Nature Cell Biology.

[257]  D. Hanahan,et al.  The Hallmarks of Cancer , 2000, Cell.

[258]  Anita B. Roberts,et al.  Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response , 1999, Nature Cell Biology.

[259]  M. Iruela-Arispe,et al.  METH-1, a Human Ortholog of ADAMTS-1, and METH-2 Are Members of a New Family of Proteins with Angio-inhibitory Activity* , 1999, The Journal of Biological Chemistry.

[260]  Christian A. Rees,et al.  Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[261]  P. Cohen,et al.  Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B* , 1999, The Journal of Biological Chemistry.

[262]  L. Lau,et al.  The CCN family of angiogenic regulators: the integrin connection. , 1999, Experimental cell research.

[263]  Kiyoshi Ohtani,et al.  Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F , 1999, Oncogene.

[264]  M. Greenberg,et al.  Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor , 1999, Cell.

[265]  R Wieser,et al.  TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. , 1999, The Journal of clinical investigation.

[266]  Jin Hong Liu,et al.  Functional association of TGF-β receptor II with cyclin B , 1999, Oncogene.

[267]  L. Mao,et al.  Overexpression of cdc25A and cdc25B is frequent in primary non-small cell lung cancer but is not associated with overexpression of c-myc. , 1998, Cancer research.

[268]  W. Ansorge,et al.  The cdc25B phosphatase is essential for the G2/M phase transition in human cells. , 1998, Journal of cell science.

[269]  M. Kirschner,et al.  The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. , 1998, Genes & development.

[270]  M. Mattei,et al.  A New Member of the Rho Family, Rnd1, Promotes Disassembly of Actin Filament Structures and Loss of Cell Adhesion , 1998, The Journal of cell biology.

[271]  M. Korc,et al.  Fibroblast growth factor-5 stimulates mitogenic signaling and is overexpressed in human pancreatic cancer: evidence for autocrine and paracrine actions , 1997, Oncogene.

[272]  A. Fainsod,et al.  The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4 , 1997, Mechanisms of Development.

[273]  M. Loda,et al.  Thymosin β15: A novel regulator of tumor cell motility upregulated in metastatic prostate cancer , 1996, Nature Medicine.

[274]  Peipei Ping,et al.  Intracoronary gene transfer of fibroblast growth factor–5 increases blood flow and contractile function in an ischemic region of the heart , 1996, Nature Medicine.

[275]  D. Gomez,et al.  Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer. , 1996, Cancer research.

[276]  X. Graña,et al.  Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). , 1995, Oncogene.

[277]  C. Der,et al.  Aberrant function of the Ras signal transduction pathway in human breast cancer , 1995, Breast Cancer Research and Treatment.

[278]  M. Shibuya,et al.  Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. , 1994, The Journal of biological chemistry.

[279]  R. Birkenbihl,et al.  Cloning and characterization of rad21 an essential gene of Schizosaccharomyces pombe involved in DNA double-strand-break repair. , 1992, Nucleic acids research.

[280]  P. Watson,et al.  Inhibition of c-myc expression by phosphorothioate antisense oligonucleotide identifies a critical role for c-myc in the growth of human breast cancer. , 1991, Cancer research.

[281]  N. Ling,et al.  FOLLISTATIN BINDS TO BOTH ACTIVIN AND INHIBIN THROUGH THE COMMON BETA-SUBUNIT , 1991 .

[282]  R. Shiu,et al.  Stimulation of c-myc oncogene expression associated with estrogen-induced proliferation of human breast cancer cells. , 1987, Cancer research.

[283]  Massimo Cristofanilli,et al.  Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition , 2013 .

[284]  Xiaoyan Yang,et al.  Involvement of Ext1 and heparanase in migration of mouse FBJ osteosarcoma cells , 2012, Molecular and Cellular Biochemistry.

[285]  M. Roizen,et al.  Hallmarks of Cancer: The Next Generation , 2012 .

[286]  René Bernards,et al.  TSPYL5 suppresses p53 levels and function by physical interaction with USP7 , 2011, Nature Cell Biology.

[287]  X. Qiu,et al.  Elevated thymosin beta15 expression is associated with progression and metastasis of non-small cell lung cancer. , 2008, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[288]  R. Deberardinis,et al.  The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. , 2008, Cell metabolism.

[289]  荻野 広和,et al.  Follistatin suppresses the production of experimental multiple-organ metastasis by small cell lung cancer cells in natural killer cell-depleted SCID mice , 2008 .

[290]  Yu Wang,et al.  A glycolytic mechanism regulating an angiogenic switch in prostate cancer. , 2007, Cancer research.

[291]  X. Tong,et al.  Transforming growth factor-beta 1 impairs endothelin-1-mediated contraction of brain vessels by inducing mitogen-activated protein (MAP) kinase phosphatase-1 and inhibiting p38 MAP kinase. , 2007, Molecular pharmacology.

[292]  S. Lowe,et al.  Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. , 2007, Cancer cell.

[293]  A. Aigner,et al.  The fibroblast growth factor-binding protein FGF-BP. , 2006, The international journal of biochemistry & cell biology.

[294]  L. Ellis,et al.  Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells. , 2006, Cancer research.

[295]  M. Hendrix Intermediate filaments , 2004, Cancer and Metastasis Reviews.

[296]  H. Pehamberger,et al.  NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. , 2004, The Journal of clinical investigation.

[297]  Ryuji Kobayashi,et al.  IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. , 2004, Cell.

[298]  L. Huang,et al.  Hypoxia-inducible factor-1 transactivates transforming growth factor-beta3 in trophoblast. , 2004, Endocrinology.

[299]  S. Nomoto,et al.  DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development. , 2003, Cancer research.

[300]  R. Derynck,et al.  Smad-dependent and Smad-independent pathways in TGF-beta family signalling. , 2003, Nature.

[301]  A. Levine,et al.  WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. , 2002, Genes & development.

[302]  C. Stanners,et al.  Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation. , 2002, Neoplasia.

[303]  A. Levine,et al.  WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene. , 2000, Genes & development.

[304]  J. Djeu,et al.  Functional association of TGF-beta receptor II with cyclin B. , 1999, Oncogene.

[305]  M. Loda,et al.  Thymosin beta 15: a novel regulator of tumor cell motility upregulated in metastatic prostate cancer. , 1996, Nature medicine.

[306]  D. Moscatelli,et al.  The FGF family of growth factors and oncogenes. , 1992, Advances in cancer research.

[307]  N. Ling,et al.  Follistatin binds to both activin and inhibin through the common subunit. , 1991, Endocrinology.