OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection.

[1]  M. Bachmann,et al.  Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus. , 1999, Journal of immunology.

[2]  M. Debenedette,et al.  T cell co-stimulatory molecules other than CD28. , 1999, Current opinion in immunology.

[3]  M. Bachmann,et al.  Influenza virus: a novel method to assess viral and neutralizing antibody titers in vitro. , 1999, Journal of immunological methods.

[4]  C. Takahashi,et al.  Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal. , 1999, Journal of immunology.

[5]  M. Riedinger,et al.  CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40‐ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles , 1999, European journal of immunology.

[6]  R. Steinman,et al.  TRANCE, a Tumor Necrosis Factor Family Member Critical for CD40 Ligand–independent T Helper Cell Activation , 1999, The Journal of experimental medicine.

[7]  S. McDonald,et al.  Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein. , 1999, Journal of immunology.

[8]  M. Croft,et al.  Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses. , 1998, Journal of immunology.

[9]  M. Croft,et al.  OX-40: life beyond the effector T cell stage. , 1998, Seminars in immunology.

[10]  J. Borst,et al.  Tumor necrosis factor receptor family members in the immune system. , 1998, Seminars in immunology.

[11]  B. Kwon,et al.  Role of 4-1BB in immune responses. , 1998, Seminars in immunology.

[12]  Y. Tanaka,et al.  OX40 costimulation enhances interleukin-4 (IL-4) expression at priming and promotes the differentiation of naive human CD4(+) T cells into high IL-4-producing effectors. , 1998, Blood.

[13]  K. Toellner,et al.  CD4 T Cell Cytokine Differentiation: The B Cell Activation Molecule, OX40 Ligand, Instructs CD4 T Cells to Express Interleukin 4 and Upregulates Expression of the Chemokine Receptor, Blr-1 , 1998, The Journal of experimental medicine.

[14]  L. Tuosto,et al.  CD28 affects the earliest signaling events generated by TCR engagement , 1998, European journal of immunology.

[15]  R. Zinkernagel,et al.  Induction and Exhaustion of Lymphocytic Choriomeningitis Virus–specific Cytotoxic T Lymphocytes Visualized Using Soluble Tetrameric Major Histocompatibility Complex Class I–Peptide Complexes , 1998, The Journal of experimental medicine.

[16]  Takashi Uchiyama,et al.  Activation of OX40 Signal Transduction Pathways Leads to Tumor Necrosis Factor Receptor-associated Factor (TRAF) 2- and TRAF5-mediated NF-κB Activation* , 1998, The Journal of Biological Chemistry.

[17]  R. Steinman,et al.  TRANCE (Tumor Necrosis Factor [TNF]-related Activation-induced Cytokine), a New TNF Family Member Predominantly Expressed in T cells, Is a Dendritic Cell–specific Survival Factor , 1997, The Journal of experimental medicine.

[18]  R. Dubose,et al.  A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function , 1997, Nature.

[19]  Yuetsu Tanaka,et al.  Expression and function of OX40 ligand on human dendritic cells. , 1997, Journal of immunology.

[20]  P. Doherty,et al.  Effector CD4+ and CD8+ T‐cell mechanisms in the control of respiratory virus infections , 1997, Immunological reviews.

[21]  A. Aruffo,et al.  4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses , 1997, The Journal of experimental medicine.

[22]  M Aguet,et al.  The role of antibody concentration and avidity in antiviral protection. , 1997, Science.

[23]  F. Finkelman,et al.  CD28 dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response. , 1997, Journal of immunology.

[24]  I. Lefkovits.  Immunology Methods Manual: The Comprehensive Sourcebook of Techniques , 1997 .

[25]  R. Ahmed,et al.  CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection , 1996, Journal of virology.

[26]  Philip J. R. Goulder,et al.  Phenotypic Analysis of Antigen-Specific T Lymphocytes , 1996, Science.

[27]  W. Solbach,et al.  IL-4-deficient Balb/c mice resist infection with Leishmania major , 1996, The Journal of experimental medicine.

[28]  A. Barclay,et al.  OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand , 1996, European journal of immunology.

[29]  T. Mak,et al.  Duration of TCR stimulation determines costimulatory requirement of T cells. , 1996, Immunity.

[30]  J. Bluestone,et al.  CD28/B7 system of T cell costimulation. , 1996, Annual review of immunology.

[31]  P. Borrow,et al.  CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response , 1996, The Journal of experimental medicine.

[32]  R. Zinkernagel,et al.  Induction of long-lived germinal centers associated with persisting antigen after viral infection , 1996, The Journal of experimental medicine.

[33]  Yuetsu Tanaka,et al.  The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells , 1996, The Journal of experimental medicine.

[34]  R. Zinkernagel,et al.  CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4+ T cell functions , 1996, The Journal of experimental medicine.

[35]  W. Strober,et al.  The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response , 1996, The Journal of experimental medicine.

[36]  T. Mak,et al.  Skin allograft rejection in CD28-deficient mice. , 1996, Transplantation.

[37]  D. Bourdette,et al.  Selective depletion of myelin–reactive T cells with the anti–OX–40 antibody ameliorates autoimmune encephalomyelitis , 1996, Nature Medicine.

[38]  E. Reddy,et al.  Transducers of life and death: TNF receptor superfamily and associated proteins. , 1996, Oncogene.

[39]  H. P. Fell,et al.  Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. , 1995, Immunity.

[40]  M. Seldin,et al.  Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV‐1‐regulated protein gp34. , 1994, The EMBO journal.

[41]  R M Zinkernagel,et al.  Impairment and delay of neutralizing antiviral antibody responses by virus-specific cytotoxic T cells. , 1993, Journal of immunology.

[42]  H. P. Fell,et al.  Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions. , 1993, Journal of immunology.

[43]  K P Lee,et al.  Differential T cell costimulatory requirements in CD28-deficient mice. , 1993, Science.

[44]  D. Gray,et al.  Novel pathways of antigen presentation for the maintenance of memory. , 1991, International immunology.

[45]  D. Paterson,et al.  Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. , 1987, Molecular immunology.

[46]  R M Zinkernagel,et al.  Primary antibody responses to a well-defined and unique hapten are not enhanced by preimmunization with carrier: analysis in a viral model. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[47]  R. Flavell,et al.  CD40 and CD154 in cell-mediated immunity. , 1998, Annual review of immunology.

[48]  R. Zinkernagel,et al.  Neutralizing antiviral B cell responses. , 1997, Annual review of immunology.

[49]  M. Fbachmann.  Evaluation of lymphocytic choriomeningitis virus-specific cytotoxic T cell responses , 1996 .

[50]  M. Kopf.  Protocols for gene targeting , 1996 .

[51]  J Bajorath,et al.  Immune regulation by CD40 and its ligand GP39. , 1996, Annual review of immunology.