mTOR and the control of whole body metabolism.

[1]  J. Avruch,et al.  Amino acid regulation of TOR complex 1. , 2009, American journal of physiology. Endocrinology and metabolism.

[2]  K. Esser,et al.  Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesis. , 2009, Journal of applied physiology.

[3]  Michael Karin,et al.  p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling , 2009, Cell.

[4]  D. Alessi,et al.  mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). , 2008, The Biochemical journal.

[5]  Hiraku Ono,et al.  Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis. , 2008, Cell metabolism.

[6]  Hua Tang,et al.  Re-evaluating the Roles of Proposed Modulators of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling* , 2008, Journal of Biological Chemistry.

[7]  Zhigang He,et al.  Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway , 2008, Science.

[8]  E. Casanova,et al.  Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. , 2008, Cell metabolism.

[9]  J. Auwerx,et al.  Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. , 2008, Cell metabolism.

[10]  J. Rovira,et al.  Effect of mTOR inhibitor on body weight: from an experimental rat model to human transplant patients , 2008, Transplant international : official journal of the European Society for Organ Transplantation.

[11]  X. Bai,et al.  The Switch I Region of Rheb Is Critical for Its Interaction with FKBP38* , 2008, Journal of Biological Chemistry.

[12]  Mustafa Sahin,et al.  Tuberous sclerosis complex proteins control axon formation. , 2008, Genes & development.

[13]  Il-Jin Kim,et al.  FBXW7 Targets mTOR for Degradation and Cooperates with PTEN in Tumor Suppression , 2008, Science.

[14]  A. Wittinghofer,et al.  Biochemical characterisation of TCTP questions its function as a guanine nucleotide exchange factor for Rheb , 2008, FEBS letters.

[15]  P. Pandolfi,et al.  Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. , 2008, The Journal of clinical investigation.

[16]  K. Inoki,et al.  Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling , 2008 .

[17]  A. Newton,et al.  The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C , 2008, The EMBO journal.

[18]  K. Inoki,et al.  Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling , 2008, The EMBO journal.

[19]  S. Woods,et al.  The Role of Hypothalamic Mammalian Target of Rapamycin Complex 1 Signaling in Diet-Induced Obesity , 2008, The Journal of Neuroscience.

[20]  M. Gambello,et al.  Disruption of Tsc2 in pancreatic β cells induces β cell mass expansion and improved glucose tolerance in a TORC1-dependent manner , 2008, Proceedings of the National Academy of Sciences.

[21]  T. P. Neufeld,et al.  Regulation of TORC1 by Rag GTPases in nutrient response , 2008, Nature Cell Biology.

[22]  D. Kwiatkowski,et al.  mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation. , 2008, Molecular cell.

[23]  David M. Sabatini,et al.  The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1 , 2008, Science.

[24]  J. Ting,et al.  Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. , 2008, Genes & development.

[25]  T. P. Neufeld,et al.  The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila , 2008, The Journal of cell biology.

[26]  M. Rubart,et al.  Cardiac Restricted Overexpression of Kinase-dead Mammalian Target of Rapamycin (mTOR) Mutant Impairs the mTOR-mediated Signaling and Cardiac Function* , 2008, Journal of Biological Chemistry.

[27]  F. Natt,et al.  Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. , 2008, Cell metabolism.

[28]  M. Drummond,et al.  Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis , 2008, Current opinion in clinical nutrition and metabolic care.

[29]  B. Turk,et al.  AMPK phosphorylation of raptor mediates a metabolic checkpoint. , 2008, Molecular cell.

[30]  B. Hemmings,et al.  PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival. , 2008, Molecular cell.

[31]  J. Blenis,et al.  SKAR Links Pre-mRNA Splicing to mTOR/S6K1-Mediated Enhanced Translation Efficiency of Spliced mRNAs , 2008, Cell.

[32]  B. Manning,et al.  The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2 , 2008, Molecular and Cellular Biology.

[33]  Christophe Magnan,et al.  mTOR Inhibition by Rapamycin Prevents β-Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes , 2008, Diabetes.

[34]  Y. Uchijima,et al.  Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice. , 2008, American journal of physiology. Endocrinology and metabolism.

[35]  M. Sahin,et al.  Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. , 2008, Molecular cell.

[36]  Y. Kido,et al.  Biphasic Response of Pancreatic β-Cell Mass to Ablation of Tuberous Sclerosis Complex 2 in Mice , 2008, Molecular and Cellular Biology.

[37]  A. Paradiso,et al.  Synergic antiproliferative and antiangiogenic effects of EGFR and mTor inhibitors on pancreatic cancer cells. , 2008, Biochemical pharmacology.

[38]  C. Ricordi,et al.  Rapamycin impairs beta-cell proliferation in vivo. , 2008, Transplantation proceedings.

[39]  E. Jacinto,et al.  TOR regulation of AGC kinases in yeast and mammals. , 2008, The Biochemical journal.

[40]  D. Sgroi,et al.  Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. , 2008, Genes & development.

[41]  T. Lange,et al.  Tel2 Regulates the Stability of PI3K-Related Protein Kinases , 2007, Cell.

[42]  V. Mootha,et al.  mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex , 2007, Nature.

[43]  N. Sonenberg,et al.  Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53 , 2007, The EMBO journal.

[44]  Adiel Cohen,et al.  PRAS40 and PRR5-Like Protein Are New mTOR Interactors that Regulate Apoptosis , 2007, PloS one.

[45]  N. Sonenberg,et al.  Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. , 2007, Cancer research.

[46]  X. Bai,et al.  Rheb Activates mTOR by Antagonizing Its Endogenous Inhibitor, FKBP38 , 2007, Science.

[47]  J. Murray,et al.  mVps34 is Activated by an Acute Bout of Resistance Exercise , 2007, Biochemical Society transactions.

[48]  John C. Lawrence,et al.  Muscle-Specific Deletion of Rictor Impairs Insulin-Stimulated Glucose Transport and Enhances Basal Glycogen Synthase Activity , 2007, Molecular and Cellular Biology.

[49]  P. Iynedjian,et al.  Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes. , 2007, Biochemical and biophysical research communications.

[50]  B. Spiegelman,et al.  Skeletal Muscle Fiber-type Switching, Exercise Intolerance, and Myopathy in PGC-1α Muscle-specific Knock-out Animals* , 2007, Journal of Biological Chemistry.

[51]  T. Griffin,et al.  PRR5, a Novel Component of mTOR Complex 2, Regulates Platelet-derived Growth Factor Receptor β Expression and Signaling* , 2007, Journal of Biological Chemistry.

[52]  C. Proud,et al.  PRAS40 Is a Target for Mammalian Target of Rapamycin Complex 1 and Is Required for Signaling Downstream of This Complex* , 2007, Journal of Biological Chemistry.

[53]  G. Hortobagyi,et al.  IKKβ Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mTOR Pathway , 2007, Cell.

[54]  D. Alessi,et al.  Identification of Protor as a novel Rictor-binding component of mTOR complex-2. , 2007, The Biochemical journal.

[55]  K. Guan,et al.  Expanding mTOR signaling , 2007, Cell Research.

[56]  A. Nakashima,et al.  The Proline-rich Akt Substrate of 40 kDa (PRAS40) Is a Physiological Substrate of Mammalian Target of Rapamycin Complex 1* , 2007, Journal of Biological Chemistry.

[57]  David M Sabatini,et al.  Defining the role of mTOR in cancer. , 2007, Cancer cell.

[58]  R. Roth,et al.  PRAS40 Regulates mTORC1 Kinase Activity by Functioning as a Direct Inhibitor of Substrate Binding* , 2007, Journal of Biological Chemistry.

[59]  H. Yang-Yen,et al.  A knockout mouse approach reveals that TCTP functions as an essential factor for cell proliferation and survival in a tissue- or cell type-specific manner. , 2007, Molecular biology of the cell.

[60]  P. Bénit,et al.  S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase. , 2007, Cell metabolism.

[61]  A. Levine,et al.  The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. , 2007, Cancer research.

[62]  V. Mieulet,et al.  A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling. , 2007, The Biochemical journal.

[63]  S. Carr,et al.  PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. , 2007, Molecular cell.

[64]  F. Liu,et al.  Adiponectin Sensitizes Insulin Signaling by Reducing p70 S6 Kinase-mediated Serine Phosphorylation of IRS-1* , 2007, Journal of Biological Chemistry.

[65]  Mingyao Liu,et al.  Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase , 2007, Nature.

[66]  Timothy J. Griffin,et al.  Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40 , 2007, Nature Cell Biology.

[67]  N. Sonenberg,et al.  Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. , 2007, The Journal of clinical investigation.

[68]  D. Guertin,et al.  Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. , 2006, Developmental cell.

[69]  K. Inoki,et al.  Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. , 2006, Genes & development.

[70]  J. Qin,et al.  SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity , 2006, Cell.

[71]  J. Woo,et al.  Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. , 2006, Developmental cell.

[72]  J. P. McCoy,et al.  The Mammalian Target of Rapamycin (mTOR) Pathway Regulates Mitochondrial Oxygen Consumption and Oxidative Capacity* , 2006, Journal of Biological Chemistry.

[73]  Ming You,et al.  TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth , 2006, Cell.

[74]  G. Korbutt,et al.  The impact of the mTOR inhibitor sirolimus on the proliferation and function of pancreatic islets and ductal cells , 2006, Diabetologia.

[75]  George Thomas,et al.  Hypothalamic mTOR Signaling Regulates Food Intake , 2006, Science.

[76]  K. Inoki,et al.  TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[77]  M. Hall,et al.  TOR Signaling in Growth and Metabolism , 2006, Cell.

[78]  Alexandros Tzatsos,et al.  Nutrients Suppress Phosphatidylinositol 3-Kinase/Akt Signaling via Raptor-Dependent mTOR-Mediated Insulin Receptor Substrate 1 Phosphorylation , 2006, Molecular and Cellular Biology.

[79]  Robbie Loewith,et al.  The TOR signalling network from yeast to man. , 2006, The international journal of biochemistry & cell biology.

[80]  R. DePinho,et al.  The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin , 2005, Science.

[81]  F. Natt,et al.  Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[82]  James T. Murray,et al.  hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase* , 2005, Journal of Biological Chemistry.

[83]  Yuval Dor,et al.  Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. , 2005, Genes & development.

[84]  A. Levine,et al.  The coordinate regulation of the p53 and mTOR pathways in cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[85]  D. Guertin,et al.  Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex , 2005, Science.

[86]  D. Theisen,et al.  Regulation of mTOR by amino acids and resistance exercise in skeletal muscle , 2005, European Journal of Applied Physiology.

[87]  G. Thomas,et al.  Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development , 2004, Molecular and Cellular Biology.

[88]  Laura A. Solt,et al.  The PP2A-Associated Protein α4 Is an Essential Inhibitor of Apoptosis , 2004, Science.

[89]  Johan Auwerx,et al.  Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity , 2004, Nature.

[90]  M. Murakami,et al.  mTOR Is Essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells , 2004, Molecular and Cellular Biology.

[91]  D. Attaix,et al.  Class III phosphoinositide 3-kinase--Beclin1 complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes. , 2003, The Biochemical journal.

[92]  R. Moon,et al.  The Tuberin-Hamartin Complex Negatively Regulates β-Catenin Signaling Activity* , 2003, The Journal of Biological Chemistry.

[93]  R. Moon,et al.  The tuberin-hamartin complex negatively regulates beta-catenin signaling activity. , 2003, The Journal of biological chemistry.

[94]  A. Prescott,et al.  Inhibition of Autophagy in Mitotic Animal Cells , 2002, Traffic.

[95]  Takeshi Noda,et al.  Two Distinct Vps34 Phosphatidylinositol 3–Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting inSaccharomyces cerevisiae , 2001, The Journal of cell biology.

[96]  R. Burcelin,et al.  Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice , 2000, Nature.