Application of the scaling index method to &mgr;CT images of human trabecular bone for the characterization of biomechanical strength

Osteoporosis is a metabolic bone disorder characterized by the loss of bone mineral density (BMD) and the deterioration of the bone micro-architecture. Rarefied bone structures are more susceptible to fractures which are the worst complications of osteoporosis. Here, we apply a structure characterization method, namely the Scaling Index Method, to micro-computed tomographic (&mgr;-CT) images of the distal radius and extract 3D nonlinear structure measures to assess the biomechanical properties of trabecular bone. Biomechanical properties were quantified by the maximum compressive strength (MCS) obtained in a biomechanical test and bone mineral density (BMD) was calculated using dual X-ray absorptiometry (DXA). &mgr;-CT images allow for the application of two different modalities of the SIM which differ in the dimensional embedding of the image. Both representations lead to similar correlation coefficients with MCS which are significantly better than the ones obtained using standard 3D morphometric parameters and comparable to the result given by BMD. The analysis of &mgr;-CT images based on the SIM allows for a sharp distinction of the different structural elements which compose the trabecular bone network.

[1]  P. Rüegsegger,et al.  Direct Three‐Dimensional Morphometric Analysis of Human Cancellous Bone: Microstructural Data from Spine, Femur, Iliac Crest, and Calcaneus , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[2]  Roberto A. Monetti,et al.  Structural analysis of human proximal femur for the prediction of biomechanical strength in vitro: the locally adapted scaling vector method , 2005, SPIE Medical Imaging.

[3]  S. Majumdar,et al.  Local 3D Scaling Properties for the Analysis of Trabecular Bone Extracted from High-Resolution Magnetic Resonance Imaging of Human Trabecular Bone: Comparison with Bone Mineral Density in the Prediction of Biomechanical Strength In Vitro , 2003, Investigative radiology.

[4]  T. M. Link,et al.  The 3D-based scaling index algorithm: a new structure measure to analyze trabecular bone architecture in high-resolution MR images in vivo , 2006, Osteoporosis International.

[5]  Ernst J. Rummeny,et al.  Scaling index method: a novel nonlinear technique for the analysis of high-resolution MRI of human bones , 2003, SPIE Medical Imaging.

[6]  Ernst J. Rummeny,et al.  The 3D-based scaling index algorithm to optimize structure analysis of trabecular bone in postmenopausal women with and without osteoporotic spine fractures , 2004, SPIE Medical Imaging.

[7]  Ernst J. Rummeny,et al.  Assessing the biomechanical strength of trabecular bone in vitro using 3D anisotropic nonlinear texture measures: the scaling vector method , 2004, SPIE Medical Imaging.

[8]  Ernst J. Rummeny,et al.  Improving the textural characterization of trabecular bone structure to quantify its changes: the locally adapted scaling vector method , 2005, SPIE Medical Imaging.

[9]  M. Jergas,et al.  Assessment of prevalent and incident vertebral fractures in osteoporosis research , 2003, Osteoporosis International.

[10]  M. Hahn,et al.  Heterogeneity of the skeleton: Comparison of the trabecular microarchitecture of the spine, the iliac crest, the femur, and the calcaneus , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[11]  S. Majumdar,et al.  Correlation of Trabecular Bone Structure with Age, Bone Mineral Density, and Osteoporotic Status: In Vivo Studies in the Distal Radius Using High Resolution Magnetic Resonance Imaging , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.