Bioinformatics has become an important subject in computer science (CS). While it is an active research area, bioinformatics is still of infancy in CS education. E-learning labs are emerging as important educational tools for bioinformatics. We consider that it can be improved with case study and simulated virtual environment. In this study we present a dedicated case-study e-learning lab for bioinformatics (CELB). It is publicly accessible at http://bioinfo.hust.edu.cn:8080/blast4/. The evaluation results reveal that this e-learning lab is suitable for training students' problem-solving ability in bioinformatics.