Perpetual Secretory Dysfunction of Natural Killer-like Cells1.2

SUMMARY Sarcoidosis Is an Immunopathogenlc disorder of uncertain cause. Because the regula· tlon of monocyte mobilization and function may be critical to granuloma formation in this disease, wa evaluated production of the cell-dlrected Inhibitor of monocyte leukotaxls (CDI·MLx) by periph. eral blood and bronchoalveolar lavege mononuclear cells from these patients. Cells obtained from either source during clinically active disease spontaneously produced this leukotactlc regulator in "/tro In amounts comparable to those achieved with maximal mitogenic stimulation of normal cells. Plasma leukotactic Inhibitory activity and spontaneous Inhibitor production ware significantly associated. Plasma Inhibitory activity and CDI·MLx production ware normal In patients whose dis· ease was Inactive. Spontaneous production continued for at least 7 days /n "/tro and could not be attributed to alterations in the absolute numbers of specific mononuclear cell populations. Partl· tioning of peripheral blood mononuclear cells by a combination of E·rosettlng and Immunoadher· ence techniques indicated, howaver, that CDI·MLx was produced by a subpopulatlon of natural killer· like cells that formed E·rosettes and bore the OKMI and Leu 7 membrane antigens.

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