In search of the tumour-suppressor functions of BRCA1 and BRCA2

[1]  R. Scully,et al.  DNA polymerase stalling, sister chromatid recombination and the BRCA genes , 2000, Oncogene.

[2]  S. Elledge,et al.  Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. , 2000, Genes & development.

[3]  M. Perricaudet,et al.  BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells. , 2000, Cancer research.

[4]  V. Yamazaki,et al.  A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage , 2000, Current Biology.

[5]  Alexander Kinev,et al.  BRCA1 Is Associated with a Human SWI/SNF-Related Complex Linking Chromatin Remodeling to Breast Cancer , 2000, Cell.

[6]  S. Elledge,et al.  BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. , 2000, Genes & development.

[7]  S. Kowalczykowski Initiation of genetic recombination and recombination-dependent replication. , 2000, Trends in biochemical sciences.

[8]  Jong-Soo Lee,et al.  hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response , 2000, Nature.

[9]  C. Deng,et al.  Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation , 2000, Oncogene.

[10]  D. Baltimore,et al.  ATR disruption leads to chromosomal fragmentation and early embryonic lethality. , 2000, Genes & development.

[11]  M. King,et al.  Insights into the functions of BRCA1 and BRCA2. , 2000, Trends in genetics : TIG.

[12]  B. Koller,et al.  BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgene , 1999, Oncogene.

[13]  D. Livingston,et al.  Genetic analysis of BRCA1 function in a defined tumor cell line. , 1999, Molecular cell.

[14]  S. Elledge,et al.  Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. , 1999, Science.

[15]  Y. Shiloh,et al.  ATM: A mediator of multiple responses to genotoxic stress , 1999, Oncogene.

[16]  L. Guarente,et al.  Diverse and dynamic functions of the Sir silencing complex , 1999, Nature Genetics.

[17]  B. Koller,et al.  Brca1 controls homology-directed DNA repair. , 1999, Molecular cell.

[18]  S. Fang,et al.  RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[19]  J. Griffith,et al.  Analysis of DNA replication forks encountering a pyrimidine dimer in the template to the leading strand. , 1999, Journal of molecular biology.

[20]  I. Irminger-Finger,et al.  The Functions of Breast Cancer Susceptibility Gene 1 (BRCA1) Product and Its Associated Proteins , 1999, Biological chemistry.

[21]  F. Couch,et al.  Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. , 1998, Molecular cell.

[22]  B. Koller,et al.  BRCA1 required for transcription-coupled repair of oxidative DNA damage. , 1998, Science.

[23]  G. Smith,et al.  An entire functional mammary gland may comprise the progeny from a single cell. , 1998, Development.

[24]  B. Ponder,et al.  Involvement of Brca2 in DNA repair. , 1998, Molecular cell.

[25]  K. Lamborn,et al.  Second cancers following pediatric Hodgkin's disease. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[26]  Akira Shinohara,et al.  Rad51‐deficient vertebrate cells accumulate chromosomal breaks prior to cell death , 1998, The EMBO journal.

[27]  H. Ashe,et al.  Intergenic transcription and transinduction of the human beta-globin locus. , 1997, Genes & development.

[28]  Ralph Scully,et al.  Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage , 1997, Cell.

[29]  S. Henikoff Nuclear organization and gene expression: homologous pairing and long-range interactions. , 1997, Current opinion in cell biology.

[30]  Luke Hughes-Davies,et al.  Transcriptional activation functions in BRCA2 , 1997, Nature.

[31]  G. Eichele,et al.  Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 , 1997, Nature.

[32]  Yonghong Xiao,et al.  Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells , 1997, Cell.

[33]  Anne M. Bowcock,et al.  Identification of a RING protein that can interact in vivo with the BRCA1 gene product , 1996, Nature Genetics.

[34]  H. Hanafusa,et al.  Evidence for a transcriptional activation function of BRCA1 C-terminal region. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[35]  A. Carr,et al.  The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. , 1996, Genes & development.

[36]  I. Verma,et al.  Transcriptional activation by BRCA1 , 1996, Nature.

[37]  J. Rossant,et al.  The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse , 1996, Cell.

[38]  M. Osborne,et al.  The Role of Estrogen in Mammary Carcinogenesis a , 1995, Annals of the New York Academy of Sciences.

[39]  Steven E. Bayer,et al.  A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. , 1994, Science.

[40]  A. Fornace Recombination of parent and daughter strand DNA after UV-irradiation in mammalian cells , 1983, Nature.

[41]  S. Tokuoka,et al.  Malignant breast tumors among atomic bomb survivors, Hiroshima and Nagasaki, 1950-74. , 1979, Journal of the National Cancer Institute.

[42]  K. Kinzler,et al.  Cancer-susceptibility genes. Gatekeepers and caretakers. , 1997, Nature.