Native pancreatic α‐cell adaptation in streptozotocin‐induced diabetic primates: importance for pig islet xenotransplantation

Abstract:  Background:  Metabolic compatibility between donor and recipient species is an important matter for pig islet xenotransplantation. Glucagon is a key hormone for the function of pig islets as well as control of hypoglycemia in the recipients of the islets. Because a discrepancy exists in the composition of glucagon cells of pig and human/primate islets, the present study was designed to determine the role of native recipient glucagon cells in the treatment of diabetes by islet transplantation in a “pig‐to‐primate” model.

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