State of the art Raman techniques for biological applications.

Raman spectroscopy is a powerful tool for the elucidation of qualitative and quantitative information from biological systems and has huge potential in areas such as biotechnologies, drug discovery, agro-chemical research and clinical diagnostics. This report summarises the principal Raman techniques applied to biomedical systems and discusses the challenges that exist to the wide spread adoption of Raman spectroscopy.

[1]  Joseph P. Hornak,et al.  Encyclopedia of imaging science and technology , 2002 .

[2]  S. Lam,et al.  Development and preliminary results of an endoscopic Raman probe for potential in vivo diagnosis of lung cancers. , 2008, Optics letters.

[3]  Martin J T Milton,et al.  Primary methods for the measurement of amount of substance , 2001 .

[4]  Renato Zenobi,et al.  Tip-Enhanced Raman Spectroscopy Can See More: The Case of Cytochrome c , 2008 .

[5]  Wei-Chuan Shih,et al.  Intrinsic Raman spectroscopy for quantitative biological spectroscopy part I: theory and simulations. , 2008, Optics express.

[6]  H. Bruining,et al.  In vitro and in vivo Raman spectroscopy of human skin. , 1998, Biospectroscopy.

[7]  Conor L Evans,et al.  Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[8]  Mortazavi,et al.  Supporting Online Material Materials and Methods Figs. S1 to S13 Tables S1 to S3 References Label-free Biomedical Imaging with High Sensitivity by Stimulated Raman Scattering Microscopy , 2022 .

[9]  Jürgen Popp,et al.  Towards a detailed understanding of bacterial metabolism--spectroscopic characterization of Staphylococcus epidermidis. , 2007, Chemphyschem : a European journal of chemical physics and physical chemistry.

[10]  Volker Deckert,et al.  Tip-enhanced Raman spectroscopy of single RNA strands: towards a novel direct-sequencing method. , 2008, Angewandte Chemie.

[11]  J. Pawley,et al.  Handbook of Biological Confocal Microscopy , 1990, Springer US.

[12]  H. Tashiro,et al.  In Vivo Raman Study of the Living Rat Esophagus and Stomach Using a Micro-Raman Probe under an Endoscope , 2007, Applied spectroscopy.

[13]  Pavel Matousek,et al.  Use of picosecond Kerr-gated Raman spectroscopy to suppress signals from both surface and deep layers in bladder and prostate tissue. , 2005, Journal of biomedical optics.

[14]  P. Matousek,et al.  Recent advances in the development of Raman spectroscopy for deep non‐invasive medical diagnosis , 2013, Journal of biophotonics.

[15]  R. Zenobi,et al.  Full spectroscopic tip-enhanced Raman imaging of single nanotapes formed from β-amyloid(1-40) peptide fragments. , 2013, ACS nano.

[16]  Guihua Zeng,et al.  Periodic diffraction correlation imaging through strongly scattering mediums , 2013 .

[17]  Gerwin J Puppels,et al.  Studying the effectiveness of penetration enhancers to deliver retinol through the stratum cornum by in vivo confocal Raman spectroscopy. , 2009, Journal of controlled release : official journal of the Controlled Release Society.

[18]  X. Xie,et al.  Video-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering , 2010, Science.

[19]  Dieter Oelkrug,et al.  Quantitative Raman spectroscopy in turbid matter: reflection or transmission mode? , 2013, Analytical and Bioanalytical Chemistry.

[20]  R. Mendelsohn,et al.  Permeation of dimyristoylphosphatidylcholine into skin : Structural and spatial information from IR and Raman microscopic imaging , 2005 .

[21]  Michael D. Morris,et al.  Emerging Raman applications and techniques in biomedical and pharmaceutical fields , 2010 .

[22]  Girard,et al.  Computing the optical near-field distributions around complex subwavelength surface structures: A comparative study of different methods. , 1996, Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics.

[23]  Kazuyoshi Itoh,et al.  High-speed molecular spectral imaging of tissue with stimulated Raman scattering , 2012, Nature Photonics.

[24]  A. Goodship,et al.  Numerical Simulations of Subsurface Probing in Diffusely Scattering Media Using Spatially Offset Raman Spectroscopy , 2005, Applied spectroscopy.

[25]  R. Richards-Kortum,et al.  Near-Infrared Raman Spectroscopy for in vivo Detection of Cervical Precancers , 2001, Photochemistry and photobiology.

[26]  R. Stosch,et al.  Validation of isotope dilution surface‐enhanced Raman scattering (IDSERS) as a higher order reference method for clinical measurands employing international comparison schemes , 2013 .

[27]  S. Bell,et al.  Quantitative surface-enhanced Raman spectroscopy. , 2008, Chemical Society reviews.

[28]  N Stone,et al.  Assessment of fiberoptic near-infrared raman spectroscopy for diagnosis of bladder and prostate cancer. , 2005, Urology.

[29]  X. Xie,et al.  Imaging Lignin-Downregulated Alfalfa Using Coherent Anti-Stokes Raman Scattering Microscopy , 2010, BioEnergy Research.

[30]  R. Dasari,et al.  Raman microspectroscopic model of human breast tissue: implications for breast cancer diagnosis in vivo , 2002 .

[31]  Andrew G. Glen,et al.  APPL , 2001 .

[32]  Xiaohui Ni,et al.  Multicolor stimulated Raman scattering microscopy , 2012 .

[33]  M. Feld,et al.  Blood analysis by Raman spectroscopy. , 2002, Optics letters.

[34]  John T. Krug,et al.  Design of near-field optical probes with optimal field enhancement by finite difference time domain electromagnetic simulation , 2002 .

[35]  Wei Min,et al.  Highly specific label-free molecular imaging with spectrally tailored excitation stimulated Raman scattering (STE-SRS) microscopy. , 2011, Nature photonics.

[36]  M. Pelletier,et al.  Quantitative Analysis Using Raman Spectrometry , 2003, Applied spectroscopy.

[37]  Pavel Matousek,et al.  Novel Assessment of Bone Using Time‐Resolved Transcutaneous Raman Spectroscopy , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[38]  Pavel Matousek,et al.  Subsurface probing of calcifications with spatially offset Raman spectroscopy (SORS): future possibilities for the diagnosis of breast cancer. , 2007, The Analyst.

[39]  T. Gaylord,et al.  Rigorous coupled-wave analysis of planar-grating diffraction , 1981 .

[40]  S. Simpson,et al.  Scanning near-field optical microscopy of metallic features , 2005 .

[41]  Wei Min,et al.  Vibrational imaging of newly synthesized proteins in live cells by stimulated Raman scattering microscopy , 2013, Proceedings of the National Academy of Sciences.

[42]  Wei Zheng,et al.  Spectroscopic diagnosis of laryngeal carcinoma using near-infrared Raman spectroscopy and random recursive partitioning ensemble techniques. , 2009, The Analyst.

[43]  M. Windbergs,et al.  Towards drug quantification in human skin with confocal Raman microscopy. , 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[44]  Lukas Novotny,et al.  Tip‐enhanced Raman spectroscopy of carbon nanotubes , 2009 .

[45]  Sokki Sathaiah,et al.  Raman spectroscopy for diagnosis of atherosclerosis: a rapid analysis using neural networks. , 2005, Medical engineering & physics.

[46]  M. Teh,et al.  Diagnosis of gastric cancer using near-infrared Raman spectroscopy and classification and regression tree techniques. , 2008, Journal of biomedical optics.

[47]  Richard H Guy,et al.  Imaging drug delivery to skin with stimulated Raman scattering microscopy. , 2011, Molecular pharmaceutics.

[48]  Shao-Xin Li,et al.  Detection of nasopharyngeal cancer using confocal Raman spectroscopy and genetic algorithm technique , 2012, Journal of biomedical optics.

[49]  Eric C. Le Ru,et al.  Principles of Surface-Enhanced Raman Spectroscopy: And Related Plasmonic Effects , 2008 .

[50]  Brian W. Pogue,et al.  Multichannel diffuse optical Raman tomography for bone characterization in vivo: a phantom study , 2012, Biomedical optics express.

[51]  M. Ueda,et al.  Video-rate confocal microscopy for single-molecule imaging in live cells and superresolution fluorescence imaging. , 2012, Biophysical journal.

[52]  R. Stosch,et al.  Double isotope dilution surface-enhanced Raman scattering as a reference procedure for the quantification of biomarkers in human serum. , 2011, The Analyst.

[53]  Abigail S Haka,et al.  In vivo Raman spectral pathology of human atherosclerosis and vulnerable plaque. , 2006, Journal of biomedical optics.

[54]  Stefan W. Hell,et al.  Single-molecule STED microscopy with photostable organic fluorophores. , 2010, Small.

[55]  R. Leapman,et al.  Analysis of directly frozen macromolecules and tissues in the field‐emission STEM , 1991, Journal of microscopy.

[56]  Binghe Wang,et al.  Drug Delivery: Principles and Applications , 2005 .

[57]  Wei-Chuan Shih,et al.  Intrinsic Raman spectroscopy for quantitative biological spectroscopy part II: experimental applications. , 2008, Optics express.

[58]  Ganesh D. Sockalingum,et al.  Micro-Raman spectroscopy of mixed cancer cell populations , 2005 .

[59]  H. Rigneault,et al.  Background-free Coherent Raman Imaging: The CARS and SRS Contrast Mechanisms , 2012 .

[60]  Jingwei Shao,et al.  In Vivo Blood Glucose Quantification Using Raman Spectroscopy , 2012, PloS one.

[61]  Modelling topographical artifacts in scanning near-field optical microscopy , 2004 .

[62]  Feruz Ganikhanov,et al.  High-sensitivity vibrational imaging with frequency modulation coherent anti-Stokes Raman scattering (FM CARS) microscopy. , 2006, Optics letters.

[63]  M. Xiao,et al.  The role of propagating and evanescent waves in scanning near-field optical microscopy , 2006 .

[64]  D. Begley,et al.  Imaging cortical vasculature with stimulated Raman scattering and two‐photon photothermal lensing microscopy , 2012 .

[65]  Yin Zhang,et al.  Imaging with Raman spectroscopy. , 2010, Current pharmaceutical biotechnology.

[66]  H. Iwase,et al.  [Breast cancer]. , 2006, Nihon rinsho. Japanese journal of clinical medicine.

[67]  Srinjan Basu,et al.  Label-free live-cell imaging of nucleic acids using stimulated Raman scattering microscopy. , 2012, Chemphyschem : a European journal of chemical physics and physical chemistry.

[69]  C. Eliasson,et al.  Internal standard in surface-enhanced Raman spectroscopy. , 2004, Analytical chemistry.

[70]  M. Aronova,et al.  Development of electron energy-loss spectroscopy in the biological sciences , 2012, MRS bulletin.

[71]  David D. Cunningham,et al.  In Vivo Glucose Sensing , 2009 .

[72]  Jane A Dickerson,et al.  Current Applications of Liquid Chromatography / Mass Spectrometry in Pharmaceutical Discovery After a Decade of Innovation , 2008 .

[73]  Michael D Morris,et al.  Transcutaneous fiber optic Raman spectroscopy of bone using annular illumination and a circular array of collection fibers. , 2006, Journal of biomedical optics.

[74]  David N. Waters,et al.  Raman spectroscopy of powders : effects of light absorption and scattering , 1994 .

[75]  David I. Ellis,et al.  Metabolic fingerprinting in disease diagnosis: biomedical applications of infrared and Raman spectroscopy. , 2006, The Analyst.

[76]  Jürgen Popp,et al.  On the way to nanometer-sized information of the bacterial surface by tip-enhanced Raman spectroscopy. , 2006, Chemphyschem : a European journal of chemical physics and physical chemistry.

[77]  Ian W. Hunter,et al.  VOLUMETRIC RAMAN MICROSCOPY THROUGH A TURBID MEDIUM , 1996 .

[78]  Basic principles of ultrafast Raman loss spectroscopy# , 2012, Journal of Chemical Sciences.

[79]  R. Carlson,et al.  Predictors of local recurrence after breast-conservation therapy. , 2005, Clinical breast cancer.

[80]  B. Wood,et al.  Effects of pre‐processing of Raman spectra on in vivo classification of nutrient status of microalgal cells , 2006 .

[81]  Zhong Lin Wang,et al.  Shell-isolated nanoparticle-enhanced Raman spectroscopy , 2010, Nature.

[82]  Alán Aspuru-Guzik,et al.  Modeling Coherent Anti-Stokes Raman Scattering with Time-Dependent Density Functional Theory: Vacuum and Surface Enhancement , 2011 .

[83]  Detlef Schiel,et al.  Surface-enhanced Raman scattering based approach for quantitative determination of creatinine in human serum. , 2005, Analytical chemistry.

[84]  X. Xie,et al.  Label-free imaging of biomolecules in food products using stimulated Raman microscopy. , 2011, Journal of biomedical optics.

[85]  Ping Wang,et al.  Quantitative vibrational imaging by hyperspectral stimulated Raman scattering microscopy and multivariate curve resolution analysis. , 2013, Analytical chemistry.

[86]  R. Dasari,et al.  Diagnosing breast cancer by using Raman spectroscopy. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[87]  M S Patterson,et al.  Noninvasive measurement of fluorophore concentration in turbid media with a simple fluorescence /reflectance ratio technique. , 2001, Applied optics.

[88]  Pavel Matousek,et al.  Noninvasive Raman Spectroscopy of Human Tissue in vivo , 2006, Applied spectroscopy.

[89]  B. Dietzek,et al.  Raman and CARS microspectroscopy of cells and tissues. , 2009, The Analyst.

[90]  Matthew D. Keller,et al.  Development of a spatially offset Raman spectroscopy probe for breast tumor surgical margin evaluation. , 2011, Journal of biomedical optics.

[91]  Dan Fu,et al.  Quantitative chemical imaging with multiplex stimulated Raman scattering microscopy. , 2012, Journal of the American Chemical Society.

[92]  J Mertz,et al.  Single-molecule detection by two-photon-excited fluorescence. , 1995, Optics letters.

[93]  Zeng-Ping Chen,et al.  Quantitative Raman spectrometry: The accurate determination of analytes in solution phase of turbid media , 2013 .

[94]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[95]  P. Pudney,et al.  An In Vivo Confocal Raman Study of the Delivery of Trans-Retinol to the Skin , 2007, Applied spectroscopy.

[96]  X. Xie,et al.  Rapid, Label-Free Detection of Brain Tumors with Stimulated Raman Scattering Microscopy , 2013, Science Translational Medicine.

[97]  J Popp,et al.  Cell wall investigations utilizing tip‐enhanced Raman scattering , 2008, Journal of microscopy.

[98]  J. L. Yang,et al.  Chemical mapping of a single molecule by plasmon-enhanced Raman scattering , 2013, Nature.

[99]  Steven G. Johnson,et al.  Advances in FDTD Computational Electrodynamics: Photonics and Nanotechnology , 2013 .

[100]  Peter Lasch,et al.  Spectral pre-processing for biomedical vibrational spectroscopy and microspectroscopic imaging , 2012 .

[101]  George R. Littlejohn,et al.  Label-free chemically specific imaging in planta with stimulated Raman scattering microscopy. , 2013, Analytical chemistry.

[102]  D. Ben‐Amotz,et al.  External Raman standard for absolute intensity and concentration measurements , 2005 .

[103]  Zachary J Smith,et al.  Rejection of fluorescence background in resonance and spontaneous Raman microspectroscopy. , 2011, Journal of visualized experiments : JoVE.