The Science of Resilience: Implications for the Prevention and Treatment of Depression

Human responses to stress and trauma vary widely. Some people develop trauma-related psychological disorders, such as posttraumatic stress disorder (PTSD) and depression; others develop mild to moderate psychological symptoms that resolve rapidly; still others report no new psychological symptoms in response to traumatic stress. Individual variability in how animals and humans respond to stress and trauma depends on numerous genetic, developmental, cognitive, psychological, and neurobiological risk and protective factors.

[1]  S. Southwick,et al.  Resilience and Mental Health: Challenges Across the Lifespan , 2013 .

[2]  Mark Ragins,et al.  Resilience: The Science of Mastering Life’s Greatest Challenges , 2013 .

[3]  Margit Burmeister,et al.  Serotonin transporter gene, stress and raphe–raphe interactions: a molecular mechanism of depression , 2012, Trends in Neurosciences.

[4]  R. Davidson,et al.  Social influences on neuroplasticity: stress and interventions to promote well-being , 2012, Nature Neuroscience.

[5]  R. Rende.  Behavioral resilience in the post-genomic era: emerging models linking genes with environment , 2012, Front. Hum. Neurosci..

[6]  Bruce S. McEwen,et al.  Psychobiological allostasis: resistance, resilience and vulnerability , 2011, Trends in Cognitive Sciences.

[7]  M. Seligman,et al.  Beyond Depression: Towards a Process-Based Approach to Research, Diagnosis, and Treatment. , 2011, Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association.

[8]  C. Beevers,et al.  Neural mechanisms of the cognitive model of depression , 2011, Nature Reviews Neuroscience.

[9]  K. Shedden,et al.  The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. , 2011, Archives of general psychiatry.

[10]  A. Ferguson-Smith,et al.  Epigenetic regulation of the neural transcriptome: the meaning of the marks , 2010, Nature Neuroscience.

[11]  Ahmad R. Hariri,et al.  Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. , 2010, The American journal of psychiatry.

[12]  Giovanni A Fava,et al.  Increasing psychological well-being and resilience by psychotherapeutic methods. , 2009, Journal of personality.

[13]  Eric S. Kim,et al.  A meta-analytic review of the Penn Resiliency Program's effect on depressive symptoms. , 2009, Journal of consulting and clinical psychology.

[14]  E. Nestler,et al.  Psychobiology and molecular genetics of resilience , 2009, Nature Reviews Neuroscience.

[15]  S. Maddi.  The courage and strategies of hardiness as helpful in growing despite major, disruptive stresses. , 2008, The American psychologist.

[16]  J. Krystal,et al.  Brain-Derived Neurotrophic Factor–5-HTTLPR Gene Interactions and Environmental Modifiers of Depression in Children , 2006, Biological Psychiatry.

[17]  Michael D Matthews,et al.  Comprehensive soldier fitness: building resilience in a challenging institutional context. , 2011, The American psychologist.