Granisetron reduces the need for uterotonics but not sympathomimetics during cesarean delivery

To assess the effect of a 5‐hydroxytryptamine‐3 receptor antagonist (granisetron) on the use of sympathomimetic (cafedrine/theodrenaline) and uterotonic (oxytocin) agents after spinal anesthesia during cesarean delivery.

[1]  M. Delgado-Rodríguez,et al.  Systematic review and meta-analysis. , 2017, Medicina intensiva.

[2]  Chengmao Zhou,et al.  Efficacy of ondansetron for spinal anesthesia during cesarean section: a meta-analysis of randomized trials , 2017, The Journal of international medical research.

[3]  A. Papaioannou,et al.  Granisetron: a review of pharmacokinetics and clinical experience in chemotherapy induced - nausea and vomiting , 2017 .

[4]  R. Rodseth,et al.  Prophylactic Phenylephrine Infusions to Reduce Severe Spinal Anesthesia Hypotension During Cesarean Delivery in a Resource-Constrained Environment , 2017, Anesthesia and analgesia.

[5]  W. N. Ngan Kee,et al.  Norepinephrine Intermittent Intravenous Boluses to Prevent Hypotension During Spinal Anesthesia for Cesarean Delivery: A Sequential Allocation Dose-Finding Study , 2017, Anesthesia and analgesia.

[6]  W. N. Ngan Kee,et al.  Closed-Loop Feedback Computer-Controlled Phenylephrine for Maintenance of Blood Pressure During Spinal Anesthesia for Cesarean Delivery: A Randomized Trial Comparing Automated Boluses Versus Infusion , 2017, Anesthesia and analgesia.

[7]  Ning Zhang,et al.  Level of sensory block after spinal anesthesia as a predictor of hypotension in parturient , 2017, Medicine.

[8]  B. Bein,et al.  Cafedrine/Theodrenaline (20:1) Is an Established Alternative for the Management of Arterial Hypotension in Germany—a Review Based on a Systematic Literature Search , 2017, Front. Pharmacol..

[9]  M. Columb,et al.  Cardiac output changes with phenylephrine and ephedrine infusions during spinal anesthesia for cesarean section: A randomized, double-blind trial. , 2017, Journal of clinical anesthesia.

[10]  Y. Wan,et al.  Stimulation of contractions in pregnant human myometrium is associated with 5-HT3 receptors. , 2016, International journal of obstetric anesthesia.

[11]  R. Rossaint,et al.  Prevention of Spinal Anesthesia-Induced Hypotension During Cesarean Delivery by 5-Hydroxytryptamine-3 Receptor Antagonists: A Systematic Review and Meta-analysis and Meta-regression , 2016, Anesthesia and analgesia.

[12]  J. M. Calvo Vecino,et al.  Colloids versus crystalloids in the prevention of hypotension induced by spinal anesthesia in elective cesarean section. A systematic review and meta-analysis. , 2015, Minerva anestesiologica.

[13]  I. Mcconachie Preloading before spinal anaesthesia for Caesarean delivery? , 2015, British journal of anaesthesia.

[14]  Y. Amr,et al.  Intravenous granisetron attenuates hypotension during spinal anesthesia in cesarean delivery: A double-blind, prospective randomized controlled study , 2015, Journal of anaesthesiology, clinical pharmacology.

[15]  M. Wujtewicz,et al.  The influence of intravenous ondansetron on maternal blood haemodynamics after spinal anaesthesia for caesarean section: a double-blind, placebo-controlled study. , 2015, Ginekologia polska.

[16]  A. Terkawi,et al.  Ondansetron Does Not attenuate Hemodynamic Changes in Patients Undergoing Elective Cesarean Delivery Using Subarachnoid Anesthesia: A Double-Blind, Placebo-Controlled, Randomized Trial , 2015, Regional Anesthesia & Pain Medicine.

[17]  I. Osazuwa,et al.  CRYSTALLOID PRELOAD SHOWS TRANSIENT SUPERIORITY OVER COLLOID, OR THEIR COMBINATION IN SPINAL ANAESTHESIA-INDUCED HYPOTENSION PROPHYLAXIS FOR CAESAREAN SECTION. , 2015, Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria.

[18]  I. Labbene,et al.  Effect of Ondansetron on the Occurrence of Hypotension and on Neonatal Parameters during Spinal Anesthesia for Elective Caesarean Section: A Prospective, Randomized, Controlled, Double-Blind Study , 2015, Anesthesiology research and practice.

[19]  L. Zhuo,et al.  Efficacy of prophylactic intravenous ondansetron on the prevention of hypotension during cesarean delivery: a dose-dependent study. , 2014, International journal of clinical and experimental medicine.

[20]  M. Jarraya,et al.  Prévention de l’hypotension induite par la rachianesthésie au cours de la césarienne programmée : coremplissage par HEA 130/0,4 vs sérum salé isotonique , 2014 .

[21]  R. Rossaint,et al.  Prophylactic phenylephrine for caesarean section under spinal anaesthesia: systematic review and meta‐analysis , 2014, Anaesthesia.

[22]  S. Ben Marzouk,et al.  [Prevention of hypotension during spinal anesthesia for elective caesarean section: coloading with HAE 130/0.4 vs normal saline solution]. , 2014, Annales francaises d'anesthesie et de reanimation.

[23]  G. J. Crystal,et al.  The Bainbridge and the “Reverse” Bainbridge Reflexes: History, Physiology, and Clinical Relevance , 2012, Anesthesia and analgesia.

[24]  K. E. Clemens,et al.  Impact of cafedrine/theodrenaline (Akrinor® ) on therapy of maternal hypotension during spinal anesthesia for Cesarean delivery: a retrospective study. , 2010, Minerva Ginecologica.

[25]  L. Arnaout,et al.  [Effects of maternal analgesia and anesthesia on the fetus and the newborn]. , 2008, Journal de gynecologie, obstetrique et biologie de la reproduction.

[26]  K. Miyata,et al.  Characteristics of inhibitory effects of serotonin (5-HT)3-receptor antagonists, YM060 and YM114 (KAE-393), on the von Bezold-Jarisch reflex induced by 2-Methyl-5-HT, veratridine and electrical stimulation of vagus nerves in anesthetized rats. , 1995, Japanese journal of pharmacology.

[27]  J. Pritchard Ondansetron metabolism and pharmacokinetics. , 1992, Seminars in oncology.