Mis‐estimation and bias of hyperpolarized apparent diffusion coefficient measurements due to slice profile effects

The purpose of this work was to explore the impact of slice profile effects on apparent diffusion coefficient (ADC) mapping of hyperpolarized (HP) substrates.

[1]  L Zhao,et al.  Gradientecho imaging considerations for hyperpolarized ^ Xe MR , 1996 .

[2]  A. Haase,et al.  Apparent rate constant mapping using hyperpolarized [1–13C]pyruvate , 2014, NMR in biomedicine.

[3]  P. Larson,et al.  Diffusion MR of hyperpolarized 13C molecules in solution. , 2013, The Analyst.

[4]  J. Kurhanewicz,et al.  Hyperpolarized 13 C-Pyruvate Magnetic Resonance Reveals Rapid Lactate Export in Metastatic Renal Cell Carcinomas , 2012 .

[5]  M. Merritt,et al.  Hyperpolarized Magnetic Resonance as a Sensitive Detector of Metabolic Function , 2014, Biochemistry.

[6]  D Chien,et al.  Signal strength in subsecond FLASH magnetic resonance imaging: the dynamic approach to steady state. , 1990, Medical physics.

[8]  Christoffer Laustsen,et al.  Assessment of early diabetic renal changes with hyperpolarized [1‐13C]pyruvate , 2013, Diabetes/metabolism research and reviews.

[9]  T. Foster,et al.  A review of normal tissue hydrogen NMR relaxation times and relaxation mechanisms from 1-100 MHz: dependence on tissue type, NMR frequency, temperature, species, excision, and age. , 1984, Medical physics.

[10]  Charles H Cunningham,et al.  Spectral–spatial excitation for rapid imaging of DNP compounds , 2011, NMR in biomedicine.

[11]  Florian Wiesinger,et al.  Saturation‐recovery metabolic‐exchange rate imaging with hyperpolarized [1‐13C] pyruvate using spectral‐spatial excitation , 2013, Magnetic resonance in medicine.

[12]  K. Brindle,et al.  Spin echo measurements of the extravasation and tumor cell uptake of hyperpolarized [1‐13C]lactate and [1‐13C]pyruvate , 2013, Magnetic resonance in medicine.

[13]  John Kurhanewicz,et al.  Metabolic Reprogramming and Validation of Hyperpolarized 13C Lactate as a Prostate Cancer Biomarker Using a Human Prostate Tissue Slice Culture Bioreactor , 2013, The Prostate.

[14]  F. Wiesinger,et al.  Direct design of 2D RF pulses using matrix inversion. , 2013, Journal of magnetic resonance.

[15]  J. Kurhanewicz,et al.  Hyperpolarized 13C-pyruvate magnetic resonance reveals rapid lactate export in metastatic renal cell carcinomas. , 2013, Cancer research.

[16]  A. Haase,et al.  Diffusion of hyperpolarized 13 C-metabolites in , 2012 .

[17]  K. Brindle,et al.  Detection of transgene expression using hyperpolarized 13C urea and diffusion‐weighted magnetic resonance spectroscopy , 2015, Magnetic resonance in medicine.

[18]  F. Sotgia,et al.  Using the “reverse Warburg effect” to identify high-risk breast cancer patients , 2012, Cell cycle.

[19]  Martin O. Leach,et al.  Model Free Approach to Kinetic Analysis of Real-Time Hyperpolarized 13C Magnetic Resonance Spectroscopy Data , 2013, PloS one.

[20]  P. Larson,et al.  Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1-13C]Pyruvate , 2013, Science Translational Medicine.

[21]  Jim M Wild,et al.  Slice profile effects in 2D slice-selective MRI of hyperpolarized nuclei. , 2010, Journal of magnetic resonance.

[22]  A. Haase,et al.  Diffusion of hyperpolarized 13C‐metabolites in tumor cell spheroids using real‐time NMR spectroscopy , 2013, NMR in biomedicine.

[23]  M. Holz,et al.  Biological applications of scanning tunnelling microscopy , 1993 .

[24]  M. Holz,et al.  Temperature-dependent self-diffusion coefficients of water and six selected molecular liquids for calibration in accurate 1H NMR PFG measurements , 2000 .

[25]  Jan Wolber,et al.  Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy , 2007, Nature Medicine.

[26]  P. Larson,et al.  Rapid in vivo apparent diffusion coefficient mapping of hyperpolarized 13C metabolites , 2015, Magnetic resonance in medicine.

[27]  Franz Schilling,et al.  In vivo measurement of apparent diffusion coefficients of hyperpolarized 13C‐labeled metabolites , 2014, NMR in biomedicine.

[28]  Albert P. Chen,et al.  Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading. , 2008, Cancer research.

[29]  J. Pauly,et al.  Parameter relations for the Shinnar-Le Roux selective excitation pulse design algorithm [NMR imaging]. , 1991, IEEE transactions on medical imaging.

[30]  J. Ardenkjær-Larsen,et al.  Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[31]  F. Jolesz,et al.  Gradient-Echo Imaging Considerations for Hyperpolarized 129Xe MR , 1996, Journal of magnetic resonance. Series B.