Microsatellite instability in sporadic mucinous colorectal carcinomas: relationship to clinico‐pathological variables

A series of 44 sporadic mucinous colorectal carcinomas was analysed for microsatellite instability; 30 consecutive sporadic non‐mucinous colorectal cancers served as controls. Mucinous carcinomas showed microsatellite instability more frequently than non‐mucinous cancers: 26/44 and 8/30, respectively (P=0·005); the difference was higher for cancers with two or more microsatellite alterations: 12 of the 44 mucinous carcinomas versus one of the 30 non‐mucinous carcinomas (P=0·007). On comparing the clinico‐pathological features of mucinous carcinomas with and without microsatellite instabilities, no differences were found with respect to the following variables: sex ratio, tumour localization, tumour size, peritumoural lymphocytic infiltration, Crohn's‐like lymphoid reaction, peritumoural fibrosis, Dukes' stage, and relationship with adenoma. Mucinous cancers with DNA replication errors were characterized by three features: onset in younger patients (P<0·05); exophytic gross shape (P=0·03); and an expanding pattern of growth (P=0·003). Of the 12 mucinous carcinomas with instability in two or more microsatellites, ten (83·3 per cent) exhibited an expanding pattern of growth, while mucinous cancers with instability in one microsatellite or without genomic instability showed no distinctive growth pattern. This study confirms the relationship between microsatellite instabilities and mucin production in colorectal carcinomas, but shows that replication error RER‐positive and RER‐negative mucinous cancers differ in few clinico‐pathological features. These differences are only in part similar to those previously reported in RER‐positive colorectal carcinomas. These data indicate that mucinous carcinoma of the large bowel could represent a histological subset separate from other histotypes. © 1997 John Wiley & Sons, Ltd.

[1]  T. Iwama,et al.  Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. , 1996, Gastroenterology.

[2]  W. Bodmer,et al.  CLINICO‐PATHOLOGICAL FEATURES AND p53 EXPRESSION IN LEFT‐SIDED SPORADIC COLORECTAL CANCERS WITH AND WITHOUT MICROSATELLITE INSTABILITY , 1996, The Journal of pathology.

[3]  J. Rüschoff,et al.  GENOMIC INSTABILITY IN COLORECTAL CARCINOMAS: COMPARISON OF DIFFERENT EVALUATION METHODS AND THEIR BIOLOGICAL SIGNIFICANCE , 1996, The Journal of pathology.

[4]  S. Merajver,et al.  Clinical and pathological significance of microsatellite instability in sporadic endometrial carcinoma. , 1996, The American journal of pathology.

[5]  M. Watatani,et al.  Allelic loss of chromosome 17p, mutation of the p53 gene, and microsatellite instability in right‐ and left‐sided colorectal cancer , 1996, Cancer.

[6]  T. Uchida,et al.  Genomic instability of microsatellite repeats in prostate cancer: relationship to clinicopathological variables. , 1995, Cancer research.

[7]  R. vander Zwaag,et al.  Impact of the Crohn's-like lymphoid reaction on staging of right-sided colon cancer: results of multivariate analysis. , 1995, Human pathology.

[8]  A. Chapelle,et al.  Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability , 1995, Nature Genetics.

[9]  R. Fleischmann,et al.  Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer , 1994, Nature.

[10]  M. Fukayama,et al.  Microsatellite instability in the progression of gastric carcinoma. , 1994, Cancer research.

[11]  T. Uchida,et al.  Genomic instability of microsatellite repeats and mutations of H-, K-, and N-ras, and p53 genes in renal cell carcinoma. , 1994, Cancer research.

[12]  B. Vogelstein,et al.  Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. , 1994, The American journal of pathology.

[13]  R. vander Zwaag,et al.  From Dukes through Jass: pathological prognostic indicators in rectal cancer. , 1994, Human pathology.

[14]  D. Ward,et al.  Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer , 1994, Nature.

[15]  Robin J. Leach,et al.  Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer , 1993, Cell.

[16]  Bert Vogelstein,et al.  Hypermutability and mismatch repair deficiency in RER+ tumor cells , 1993, Cell.

[17]  L. Aaltonen,et al.  Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. , 1993, Cancer research.

[18]  N. Copeland,et al.  The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer , 1993, Cell.

[19]  D. Sidransky,et al.  Microsatellite instability in bladder cancer. , 1993, Cancer research.

[20]  Y. Nakamura,et al.  Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer. , 1993, Cancer research.

[21]  Darryl Shibata,et al.  Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis , 1993, Nature.

[22]  S N Thibodeau,et al.  Microsatellite instability in cancer of the proximal colon. , 1993, Science.

[23]  K. Kinzler,et al.  Clues to the pathogenesis of familial colorectal cancer. , 1993, Science.

[24]  C. Boland,et al.  Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review. , 1993, Gastroenterology.

[25]  B. Vogelstein,et al.  A genetic model for colorectal tumorigenesis , 1990, Cell.

[26]  Appelman Hd,et al.  Crohn's-like lymphoid reaction and colorectal carcinoma: a potential histologic prognosticator. , 1990 .

[27]  J. Jass,et al.  A NEW PROGNOSTIC CLASSIFICATION OF RECTAL CANCER , 1987, The Lancet.

[28]  C. Dukes,et al.  The classification of cancer of the rectum , 1980 .