To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis.

The term functionalized isocyanides refers to all those isocyanides in which a neighbouring functional group can finely tune the reactivity of the isocyano group or can be exploited in post-functionalization processes. In this manuscript, we have reviewed all the isocyanides in which the pendant functional group causes either deviation from or reinforces the normal reactivity of the isocyano group and categorized them to highlight their common features and differences. An analysis of their synthetic potential and the possible unexplored directions for future research studies is also addressed.

[1]  R. Orru,et al.  Trityl Isocyanide as a Mechanistic Probe in Multicomponent Chemistry: Walking the Line between Ugi- and Strecker-type Reactions. , 2016, Chemistry.

[2]  Q. Wang,et al.  Synthesis of Vinyl Isocyanides and Development of a Convertible Isonitrile. , 2016, Organic letters.

[3]  R. Orru,et al.  2-Bromo-6-isocyanopyridine as a Universal Convertible Isocyanide for Multicomponent Chemistry. , 2016, Organic letters.

[4]  C. Hutton,et al.  Total Synthesis of Ustiloxin D Utilizing an Ammonia-Ugi Reaction. , 2015, The Journal of organic chemistry.

[5]  M. Fontani,et al.  Chimica e chimici a Firenze : dall'ultimo dei Medici al padre del Centro europeo di risonanze magnetiche , 2015 .

[6]  E. Novellino,et al.  Exploiting the Electrophilic and Nucleophilic Dual Role of Nitrile Imines: One-Pot, Three-Component Synthesis of Furo[2,3-d]pyridazin-4(5H)-ones. , 2015, Organic letters.

[7]  F. Hahn,et al.  Complexes with protic (NH,NH and NH,NR) N-heterocyclic carbene ligands , 2015 .

[8]  Tanpreet Kaur,et al.  Arylsulfonylmethyl isocyanides: a novel paradigm in organic synthesis , 2015 .

[9]  A. Studer,et al.  Recent advances in the synthesis of nitrogen heterocycles via radical cascade reactions using isonitriles as radical acceptors. , 2015, Chemical Society reviews.

[10]  N. Kumagai,et al.  Direct Catalytic Asymmetric Mannich‐Type Reaction of Benzyl Isocyanide: Stereoselective Synthesis of 1,2‐Diarylethylenediamines , 2015 .

[11]  Constantinos G. Neochoritis,et al.  Efficient isocyanide-less isocyanide-based multicomponent reactions. , 2015, Organic letters.

[12]  Mei-Xiang Wang,et al.  Multicomponent reactions in organic synthesis , 2014 .

[13]  K. Khoury,et al.  A Universal Isocyanide for Diverse Heterocycle Syntheses , 2014, Organic letters.

[14]  Bin Xu,et al.  Mn(II)/O2-promoted oxidative annulation of vinyl isocyanides with boronic acids: synthesis of multi-substituted isoquinolines. , 2014, Chemical communications.

[15]  H. Hirao,et al.  Tandem insertion-cyclization reaction of isocyanides in the synthesis of 1,4-diaryl-1H-imidazoles: presence of N-arylformimidate intermediate. , 2014, The Journal of organic chemistry.

[16]  Shun-Yi Wang,et al.  Chemoselective synthesis of polycyclic spiroindolines and polysubstituted pyrroles via the domino reaction of 2-isocyanoethylindoles. , 2014, The Journal of organic chemistry.

[17]  M. Finze,et al.  Carba-closo-dodecaborate anions with two functional groups: [1-R-12-HC≡C-closo-1-CB₁₁H₁₀]⁻ (R = CN, NC, CO₂H, C(O)NH₂, NHC(O)H). , 2014, Inorganic chemistry.

[18]  L. Legras,et al.  Pyrrolidinone and Piperidinone Isocyanides from Isocyano Esters , 2014 .

[19]  K. Kozhikhova,et al.  Synthesis of water-soluble chitosan derivatives and their use for the stabilization of liposomal suspensions , 2014, Russian Chemical Bulletin.

[20]  E. Novellino,et al.  Reaction between (Z)-arylchlorooximes and α-isocyanoacetamides: a procedure for the synthesis of aryl-α-ketoamide amides. , 2014, The Journal of organic chemistry.

[21]  J. Yang,et al.  A free radical cascade cyclization of isocyanides with simple alkanes and alcohols. , 2014, Organic letters.

[22]  C. Hulme,et al.  Novel succinct routes to Quinoxalines and 2-Benzimidazolylquinoxalines via the Ugi reaction. , 2014, Tetrahedron letters.

[23]  A. Dömling,et al.  Application of cyclic ketones in MCR: Ugi/amide coupling based synthesis of fused tetrazolo[1,5-a][1,4]benzodiazepines , 2014 .

[24]  Chengjian Zhu,et al.  Radical arylalkoxycarbonylation of 2-isocyanobiphenyl with carbazates: dual C-C bond formation toward phenanthridine-6-carboxylates. , 2014, The Journal of organic chemistry.

[25]  V. Nenajdenko,et al.  Azidoisocyanides, New Bifunctional Reagents for Multicomponent Reactions and Biomolecule Modifications , 2014, Chemistry of Natural Compounds.

[26]  Qiang Zhu,et al.  Arylative cyclization of 2-isocyanobiphenyls with anilines: one-pot synthesis of 6-arylphenanthridines via competitive reaction pathways. , 2014, Organic letters.

[27]  Zhigang Xu,et al.  Synthesis of fused benzimidazole–quinoxalinones via UDC strategy and following the intermolecular nucleophilic substitution reaction , 2014 .

[28]  Lei Wang,et al.  The benzoyl peroxide promoted dual C-C bond formation via dual C-H bond cleavage: α-phenanthridinylation of ether by isocyanide. , 2014, Organic letters.

[29]  R. Paton,et al.  Phase-transfer-catalysed synthesis of pyrroloindolines and pyridoindolines by a hydrogen-bond-assisted isocyanide cyclization cascade. , 2014, Chemistry.

[30]  A. Dömling,et al.  Towards a facile and convenient synthesis of highly functionalized indole derivatives based on multi-component reactions. , 2014, Organic & biomolecular chemistry.

[31]  A. Studer,et al.  2-Trifluoromethylated indoles via radical trifluoromethylation of isonitriles. , 2014, Organic letters.

[32]  K. Harms,et al.  Regioselective Passerini and Passerini–Knoevenagel Reactions with vic‐Diketo Amides , 2014 .

[33]  A. Studer,et al.  6-Phosphorylated phenanthridines from 2-isocyanobiphenyls via radical C-P and C-C bond formation. , 2014, Organic letters.

[34]  A. Ramazani,et al.  Novel, fast and efficient one-pot sonochemical synthesis of 2-aryl-1,3,4-oxadiazoles. , 2014, Ultrasonics sonochemistry.

[35]  Shouyun Yu,et al.  Synthesis of 6-alkylated phenanthridine derivatives using photoredox neutral somophilic isocyanide insertion. , 2013, Angewandte Chemie.

[36]  Jieping Zhu,et al.  Catalytic enantioselective Michael addition of α-aryl-α-isocyanoacetates to vinyl selenone: synthesis of α,α-disubstituted α-amino acids and (+)- and (-)-trigonoliimine A. , 2013, Angewandte Chemie.

[37]  A. Studer,et al.  6-Aroylated phenanthridines via base promoted homolytic aromatic substitution (BHAS). , 2013, Organic letters.

[38]  Shouyun Yu,et al.  Isocyanide insertion: de novo synthesis of trifluoromethylated phenanthridine derivatives. , 2013, Organic letters.

[39]  J. Rudick.  Innovative macromolecular syntheses via isocyanide multicomponent reactions , 2013 .

[40]  Jesús Díaz,et al.  Elusive 2-aminofuran Diels-Alder substrates for a straightforward synthesis of polysubstituted anilines. , 2013, Organic & biomolecular chemistry.

[41]  S. Pronin,et al.  Stereoinversion of tertiary alcohols to tertiary-alkyl isonitriles and amines , 2013, Nature.

[42]  Jieping Zhu,et al.  Tertiary amines as synthetic equivalents of vinyl cations: zinc bromide promoted coupling of propargylamines with α-isocyanoacetamides to give 2,4,5-trisubstituted oxazoles initiated by an internal redox process. , 2013, Chemistry.

[43]  Lei Zhou,et al.  PhI(OAc)2-mediated synthesis of 6-(trifluoromethyl)phenanthridines by oxidative cyclization of 2-isocyanobiphenyls with CF3SiMe3 under metal-free conditions. , 2013, Organic letters.

[44]  Y. Ishikawa,et al.  1-Hydroxy-2-methyl-2-propyl Isocyanide (HMPI) as a New Convertible Isocyanide for the Ugi Four-Component-Coupling Reaction , 2013 .

[45]  A. Schimmer,et al.  α-Boryl isocyanides enable facile preparation of bioactive boropeptides. , 2013, Angewandte Chemie.

[46]  R. Fröhlich,et al.  Isocyanide Cyclization Reactions: 4‐Methylene‐4H‐benzo[d][1,3]oxazine, 3‐Benzyl‐4‐methylene‐3,4‐dihydroquinazolines and 3‐(4‐Benzyl)‐3H‐quinazolin‐4‐ones – Experiment and Theory , 2013 .

[47]  Siddhartha Sharma,et al.  Odorless isocyanide chemistry: an integrated microfluidic system for a multistep reaction sequence. , 2013, Angewandte Chemie.

[48]  C. Tsukano,et al.  Synthesis of 3-acyl-2-arylindole via palladium-catalyzed isocyanide insertion and oxypalladation of alkyne. , 2013, Organic letters.

[49]  Chuan He,et al.  Synthesis of pyrroles by click reaction: silver-catalyzed cycloaddition of terminal alkynes with isocyanides. , 2013, Angewandte Chemie.

[50]  Q. Zhang,et al.  Silver-catalyzed isocyanide-alkyne cycloaddition: a general and practical method to oligosubstituted pyrroles. , 2013, Angewandte Chemie.

[51]  Shun-Yi Wang,et al.  Isocyanide-based multicomponent reactions: catalyst-free stereoselective construction of polycyclic spiroindolines. , 2013, Organic letters.

[52]  M. Rahimi‐Nasrabadi,et al.  A Simple Synthesis of 2‐{(Arylmethylidene)hydrazinylidene]‐3‐hydroxy‐4H‐furo[3,2‐c]pyran‐4(3H)‐ones , 2013 .

[53]  K. Vanka,et al.  Synthesis of palmyrolide A and its cis-isomer and mechanistic insight into trans-cis isomerisation of the enamide macrocycle. , 2013, Chemical communications.

[54]  Xiaochuan Chen,et al.  Catalytic Ugi-type condensation of α-isocyanoacetamide and chiral cyclic imine: access to asymmetric construction of several heterocycles. , 2013, The Journal of organic chemistry.

[55]  A. Evdokimov,et al.  Synthesis of Tetrazole-substituted Spirocyclic γ-lactams by One-pot Azido-Ugi Reaction–cyclization , 2013 .

[56]  F. Hahn.  Substrate Recognition and Regioselective Catalysis with Complexes Bearing NR,NH‐NHC Ligands , 2013 .

[57]  T. Torroba,et al.  Complementary regioselectivity in the synthesis of iminohydantoins: remarkable effect of amide substitution on the cyclization. , 2013, Organic & biomolecular chemistry.

[58]  H. Veisi,et al.  A General Simple Methodology for Synthesis of Isonitriles Using Benzene- 1,3-disulfonyl Dichloride , 2013 .

[59]  N. Chatani,et al.  Modular synthesis of phenanthridine derivatives by oxidative cyclization of 2-isocyanobiphenyls with organoboron reagents. , 2012, Angewandte Chemie.

[60]  L. Wessjohann,et al.  4-Isocyanopermethylbutane-1,1,3-triol (IPB): a convertible isonitrile for multicomponent reactions , 2012 .

[61]  Jieping Zhu,et al.  Organocatalytic enantioselective one-pot four-component ugi-type multicomponent reaction for the synthesis of epoxy-tetrahydropyrrolo[3,4-b]pyridin-5-ones. , 2012, Chemistry.

[62]  C. Hulme,et al.  Ugi/aldol sequence: expeditious entry to several families of densely substituted nitrogen heterocycles. , 2012, Angewandte Chemie.

[63]  R. Borisov,et al.  Synthesis of tetrazolodiazepines by a five-centered four-component azide Ugi reaction. Scope and limitations , 2012, Russian Chemical Bulletin.

[64]  C. Tsukano,et al.  Palladium-catalyzed cascade process consisting of isocyanide insertion and benzylic C(sp3)-H activation: concise synthesis of indole derivatives. , 2012, Organic letters.

[65]  E. J. Sorensen,et al.  A chemical synthesis of 11-methoxy mitragynine pseudoindoxyl featuring the interrupted Ugi reaction. , 2012, Chemical science.

[66]  D. Moderhack.  N-Isocyanides—Synthesis and Reactions , 2012 .

[67]  T. Hashimoto,et al.  A catalytic asymmetric Ugi-type reaction with acyclic azomethine imines. , 2012, Angewandte Chemie.

[68]  C. Hulme,et al.  General one-pot, two-step protocol accessing a range of novel polycyclic heterocycles with high skeletal diversity. , 2012, ACS combinatorial science.

[69]  K. R. Mann,et al.  Nonisomorphous X-Ray Structures of Tritylnitrile and Tritylisonitrile , 2012, Journal of Chemical Crystallography.

[70]  S. Danishefsky,et al.  Enhancing the scope of the Diels-Alder reaction through isonitrile chemistry: emergence of a new class of acyl-activated dienophiles. , 2012, Journal of the American Chemical Society.

[71]  Wei Wang,et al.  Chemistry and biology of multicomponent reactions. , 2012, Chemical reviews.

[72]  C. Hulme,et al.  Applications of ortho-phenylisonitrile and ortho-N-Boc aniline for the two-step preparation of novel bis-heterocyclic chemotypes , 2012, Molecular Diversity.

[73]  J. Sello,et al.  Use of a Multicomponent Reaction for Chemoselective Derivatization of Multiple Classes of Metabolites , 2012, Chembiochem : a European journal of chemical biology.

[74]  P. Hiberty,et al.  A valence bond view of isocyanides' electronic structure , 2012 .

[75]  Takashi Okitsu,et al.  Tandem migration-carboalkoxylation of o-isocyanophenyl acetals leading to benzoxazoles. , 2012, Organic letters.

[76]  R. Sarpong,et al.  Synthetic studies toward lapidilectine-type Kopsia alkaloids. , 2012, Organic letters.

[77]  R. Orru,et al.  Concise Synthesis of Highly Substituted Benzo[a]quinolizines by a Multicomponent Reaction/Allylation/Heck Reaction Sequence , 2012 .

[78]  Justin D Dietrich,et al.  Facile, novel two-step syntheses of benzimidazoles, bis-benzimidazoles, and bis-benzimidazole-dihydroquinoxalines , 2012, Molecular Diversity.

[79]  J. Sello,et al.  Investigation of the configurational stabilities of chiral isocyanoacetates in multicomponent reactions. , 2011, The Journal of organic chemistry.

[80]  J. Guillemin,et al.  Microwave spectrum and conformational composition of 2-chloroethylisocyanide. , 2011, The journal of physical chemistry. A.

[81]  Hui Yu,et al.  A novel one-pot synthesis of α-keto-1,3,4-oxadiazole derivatives based on isocyanide-Nef reaction , 2011 .

[82]  F. Hahn,et al.  Synthesis and coordination chemistry of macrocyclic ligands featuring NHC donor groups. , 2011, Dalton transactions.

[83]  Éric A. Cohen,et al.  Synthesis of unsymmetrical 3,4-diaryl-3-pyrrolin-2-ones utilizing pyrrole Weinreb amides. , 2011, The Journal of organic chemistry.

[84]  Ying Cheng,et al.  Reaction of β-lactam carbenes with 2-pyridyl isonitriles: a one-pot synthesis of 2-carbonyl-3-(pyridylamino)imidazo[1,2-a]pyridines useful as fluorescent probes for mercury ion. , 2011, The Journal of organic chemistry.

[85]  R. Fröhlich,et al.  Stepwise formation of a molecular square with bridging NH,O-substituted dicarbene building blocks. , 2011, Journal of the American Chemical Society.

[86]  B. Ganem,et al.  A practical and inexpensive ‘convertible’ isonitrile for use in multicomponent reactions , 2011 .

[87]  A. Ogawa,et al.  Photoinduced intramolecular cyclization of o-ethenylaryl isocyanides with organic disulfides mediated by diphenyl ditelluride. , 2011, The Journal of organic chemistry.

[88]  G. Laconde,et al.  A facile and rapid synthesis of N-benzyl-2-substituted piperazines , 2011 .

[89]  A. Ramazani,et al.  Synthesis of sterically congested 1,3,4-oxadiazole derivatives from aromatic carboxylic acids, N,N-dicyclohexylcarbodiimide and (N-isocyanimino)triphenylphosphorane , 2011, Molecular Diversity.

[90]  M. Adib,et al.  Reaction between N-Isocyaniminotriphenylphosphorane, Aldimines, Meldrum's Acid and Water: Diastereoselective Synthesis of 3,4-Disubstituted N-Aminopyrrolidine-2,5-diones , 2011 .

[91]  G. Tron,et al.  A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates. , 2011, Organic & biomolecular chemistry.

[92]  K. Jørgensen,et al.  Synthesis of 1,2,4-triazolines: base-catalyzed hydrazination/cyclization cascade of α-isocyano esters and amides. , 2011, Organic letters.

[93]  Dawei Zhang,et al.  Double isocyanide cyclization: a synthetic strategy for two-carbon-tethered pyrrole/oxazole pairs. , 2011, Journal of the American Chemical Society.

[94]  A. Ogawa,et al.  Synthesis of 2,4-diiodoquinolines via the photochemical cyclization of o-alkynylaryl isocyanides with iodine. , 2011, The Journal of organic chemistry.

[95]  Jieping Zhu,et al.  Exploiting the divergent reactivity of α-isocyanoacetate: multicomponent synthesis of 5-alkoxyoxazoles and related heterocycles. , 2011, Chemistry.

[96]  M. Erion,et al.  Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase. , 2011, Journal of medicinal chemistry.

[97]  V. Nenajdenko,et al.  α-Acidic Isocyanides in Multicomponent Chemistry , 2011 .

[98]  M. Adib,et al.  An Efficient Three-Component Synthesis of 3-(5-Alkyl/aryl-1,3,4-oxadiazol-2-yl) -3-hydroxy-1,3-dihydro-2H-indol-2-ones. , 2010 .

[99]  Qiang Zhu,et al.  Synthesis of 2-alkoxy(aroxy)-3-substituted quinolines by DABCO-promoted cyclization of o-alkynylaryl isocyanides. , 2010, The Journal of organic chemistry.

[100]  Kazuhiro Kobayashi,et al.  Synthesis of 3-substituted 3H-indol-3-ols by the reaction of 2-isocyanophenyl ketones with Grignard reagents , 2010 .

[101]  Kazuhiro Kobayashi,et al.  Synthesis of 2,4,8‐Trisubstituted 1,7‐Naphthyridines by the Reaction of 4‐(1‐Aryl‐2‐methoxyethenyl)‐3‐isocyanopyridines with Excess Organolithiums , 2010 .

[102]  J. Nelissen,et al.  Synthesis of pyridodiazepinediones by using the Ugi multicomponent reaction , 2010 .

[103]  E. González-Zamora,et al.  Synthesis of a tetracyclic lactam system of Nuevamine by four-component reaction and free radical cyclization , 2010 .

[104]  Xiao-rong Wang,et al.  Dimerization of 2-pyridylisonitriles produces π-extended fused heteroarenes useful as highly selective colorimetric and optical probes for copper ion , 2010 .

[105]  J. Wildeman,et al.  Synthesis of 1‐(arylthio)alkenyl isocyanides , 2010 .

[106]  A. Tzschach,et al.  Zur Synthese der 1,3‐Azaphospholine‐1 , 2010 .

[107]  R. Borisov,et al.  Concise approach toward tetrazolo[1,5-a][1,4]benzodiazepines via a novel multicomponent isocyanide-based condensation. , 2010, Organic letters.

[108]  Chetna Madaan,et al.  Towards molecular diversity: dealkylation of tert-butyl amine in Ugi-type multicomponent reaction product establishes tert-butyl isocyanide as a useful convertible isonitrile. , 2010, Organic & biomolecular chemistry.

[109]  V. Nenajdenko,et al.  Isocyanoacetate derivatives: synthesis, reactivity, and application. , 2010, Chemical reviews.

[110]  N. Gianneschi,et al.  Facile procedure for generating side chain functionalized poly(alpha-hydroxy acid) copolymers from aldehydes via a versatile Passerini-type condensation. , 2010, Organic letters.

[111]  M. Sonoda,et al.  Synthesis of 2-Halogenated Quinolines by Halide-Mediated Intramolecular Cyclization of o-Alkynylaryl Isocyanides , 2010 .

[112]  A. Basso,et al.  A highly convergent synthesis of tricyclic N-heterocycles coupling an Ugi reaction with a tandem S(N)2'-Heck double cyclization. , 2010, The Journal of organic chemistry.

[113]  A. Ramazani,et al.  Novel one-pot, four-component condensation reaction: an efficient approach for the synthesis of 2,5-disubstituted 1,3,4-oxadiazole derivatives by a Ugi-4CR/aza-Wittig sequence. , 2010, Organic letters.

[114]  Kazuhiro Kobayashi,et al.  Synthesis of 4-alkylidene-2-(dimethylamino)methyl-4H-3,1-benzoxazines by the reaction of alkyl 2-isocyanophenyl ketones with Eschenmoser's salt , 2010 .

[115]  B. Tan,et al.  Chiral Brønsted acid catalyzed enantioselective addition of alpha-isocyanoacetamides to aldehydes. , 2010, Organic letters.

[116]  M. Adib,et al.  A multi-component synthesis of 3-aryl-1-(arylmethylideneamino)pyrrolidine-2,5-diones , 2010 .

[117]  M. Adib,et al.  An Efficient Three-Component Synthesis of 3-(1-Hydroxyalkyl)[1,2,4]-triazolo [4,3-c] quinazolines , 2010 .

[118]  S. Tkachenko,et al.  General Multicomponent Strategy for the Synthesis of 2‐Amino‐1,4‐diazaheterocycles: Scope, Limitations, and Utility , 2010 .

[119]  Wei Wang,et al.  (-)-Bacillamide C: the convergent approach. , 2010, Organic & biomolecular chemistry.

[120]  G. Tron,et al.  Efficient synthesis of alpha-ketoamides via 2-acyl-5-aminooxazoles by reacting acyl chlorides and alpha-isocyanoacetamides. , 2010, Organic letters.

[121]  Wei Wang,et al.  Polycyclic indole alkaloid-type compounds by MCR. , 2010, Chemical communications.

[122]  T. Kawasaki,et al.  Total syntheses of (-)-fructigenine A and (-)-5-N-acetylardeemin. , 2010, The Journal of organic chemistry.

[123]  A. Meijere,et al.  Synthesis of 1-Substituted Benzimidazoles from o-Bromophenyl Isocyanide and Amines† , 2009 .

[124]  De‐Xian Wang,et al.  Catalytic asymmetric Passerini-type reaction: chiral aluminum-organophosphate-catalyzed enantioselective alpha-addition of isocyanides to aldehydes. , 2009, The Journal of organic chemistry.

[125]  L. Grimaud,et al.  One-pot synthesis of oxazoles using isocyanide surrogates , 2009 .

[126]  A. Dömling,et al.  Efficient and diverse synthesis of indole derivatives. , 2009, The Journal of organic chemistry.

[127]  M. Thompson,et al.  Ugi reactions with ammonia offer rapid access to a wide range of 5-aminothiazole and oxazole derivatives. , 2009, The Journal of organic chemistry.

[128]  De‐Xian Wang,et al.  Brønsted acid catalyzed enantioselective three-component reaction involving the alpha addition of isocyanides to imines. , 2009, Angewandte Chemie.

[129]  R. Orru,et al.  The efficient one-pot reaction of up to eight components by the union of multicomponent reactions. , 2009, Angewandte Chemie.

[130]  L. Grimaud,et al.  “Isocyanide-free” Ugi reactions , 2009 .

[131]  A. Spek,et al.  A multicomponent reaction towards N-(cyanomethyl)amides. , 2009, Chemistry.

[132]  S. Matsunaga,et al.  A heterobimetallic Ga/Yb-Schiff base complex for catalytic asymmetric alpha-addition of isocyanides to aldehydes. , 2009, Journal of the American Chemical Society.

[133]  A. de Meijere,et al.  Reactions of ortho-lithiophenyl (-hetaryl) isocyanides with carbonyl compounds: rearrangements of 2-metalated 4H-3,1-benzoxazines. , 2009, The Journal of organic chemistry.

[134]  U. Kazmaier,et al.  Straightforward Synthesis of Chiral Hydroxy Isocyanides , 2009 .

[135]  Tannya R. Ibarra-Rivera,et al.  Multicomponent reactions of convertible isonitriles. , 2009, The Journal of organic chemistry.

[136]  K. Bukhryakov,et al.  Imidazo[1,2-a]quinoxalines accessed via two sequential isocyanide-based multicomponent reactions. , 2009, Journal of Organic Chemistry.

[137]  Kazuhiro Kobayashi,et al.  Synthesis of 4-Alkylidene-4H-3,1-benzoxazine Derivatives by Acid-Catalyzed Cyclizationof 2-Isocyanophenyl Ketones in the Presence of a Vinyl Ether , 2009 .

[138]  Jieping Zhu,et al.  Synthesis of pyrroles by consecutive multicomponent reaction/[4 + 1] cycloaddition of alpha-iminonitriles with isocyanides. , 2009, Organic letters.

[139]  S. Danishefsky,et al.  On the Preparation of Enantiomerically Pure Isonitriles from Amino Acid Esters and Peptides. , 2009, Tetrahedron letters.

[140]  A. Spek,et al.  Synthesis of conformationally constrained peptidomimetics using multicomponent reactions. , 2009, The Journal of organic chemistry.

[141]  A. de Meijere,et al.  ortho-Lithiophenyl isocyanide: a versatile precursor for 3H-quinazolin-4-ones and 3H-quinazolin-4-thiones. , 2009, Organic letters.

[142]  A. Spek,et al.  A novel three-component reaction toward dihydrooxazolopyridines. , 2009, Organic letters.

[143]  Mikhail Nikulnikov,et al.  tert-Butyl isocyanide revisited as a convertible reagent in the Groebke–Blackburn reaction , 2008 .

[144]  M. Krasavin,et al.  Greater variety in Groebke–Blackburn type 3-arylaminoimidazo[1,2-a]azines accessed via Pd-catalyzed arylation of a primary amine precursor , 2008 .

[145]  F. Hahn,et al.  Template Synthesis of Platinum Complexes with Benzoxazolin‐2‐ylidene Ligands , 2008 .

[146]  M. Thompson,et al.  Versatile assembly of 5-aminothiazoles based on the Ugi four-component coupling , 2008 .

[147]  R. Orru,et al.  Selective formation of 2-imidazolines and 2-substituted oxazoles by using a three-component reaction. , 2008, Chemistry.

[148]  Yoshihisa Kobayashi,et al.  2-nitrophenyl isocyanide as a versatile convertible isocyanide: rapid access to a fused gamma-lactam beta-lactone bicycle. , 2008, The Journal of organic chemistry.

[149]  Yoshihisa Kobayashi,et al.  Total synthesis of (+/-)-dysibetaine. , 2008, Organic letters.

[150]  A. Basso,et al.  Polyfunctionalized pyrrolidines by Ugi multicomponent reaction followed by palladium-mediated SN2' cyclizations. , 2008, The Journal of organic chemistry.

[151]  T. Bach,et al.  Diversity oriented synthesis of benzoxazoles and benzothiazoles , 2007 .

[152]  E. González-Zamora,et al.  Lithium bromide-promoted three-component synthesis of oxa-bridged tetracyclic tetrahydroisoquinolines , 2007 .

[153]  R. Orru,et al.  A flexible six-component reaction to access constrained depsipeptides based on a dihydropyridinone core. , 2007, The Journal of organic chemistry.

[154]  G. Tron,et al.  Ammonium chloride promoted three-component synthesis of 5-iminooxazoline and its subsequent transformation to macrocyclodepsipeptide. , 2007, Organic letters.

[155]  V. Nenajdenko,et al.  The first example of a diastereoselective thio-Ugi reaction: a new synthetic approach to chiral imidazole derivatives. , 2007, The Journal of organic chemistry.

[156]  M. Sonoda,et al.  Photoinduced thiotelluration of isocyanides by using a (PhS)2–(PhTe)2 mixed system, and its application to bisthiolation via radical cyclization , 2007 .

[157]  De‐Xian Wang,et al.  Chiral salen-aluminum complex as a catalyst for enantioselective alpha-addition of isocyanides to aldehydes: asymmetric synthesis of 2-(1-hydroxyalkyl)-5-aminooxazoles. , 2007, Organic letters.

[158]  Yoshihisa Kobayashi,et al.  New entry to convertible isocyanides for the Ugi reaction and its application to the stereocontrolled formal total synthesis of the proteasome inhibitor omuralide. , 2007, Organic letters.

[159]  R. Orru,et al.  A resource-efficient and highly flexible procedure for a three-component synthesis of 2-imidazolines. , 2007, The Journal of organic chemistry.

[160]  A. Ramazani,et al.  The reaction of (N-isocyanimino)triphenylphosphorane with dialkyl acetylenedicarboxylates in the presence of 1,3-diphenyl-1,3-propanedione: a novel three-component reaction for the stereoselective synthesis of dialkyl (Z)-2-(5,7-diphenyl-1,3,4-oxadiazepin-2-yl)-2-butenedioates , 2007 .

[161]  Jieping Zhu,et al.  Modulating the reactivity of alpha-isocyanoacetates: multicomponent synthesis of 5-methoxyoxazoles and furopyrrolones. , 2007, Angewandte Chemie.

[162]  A. Ramazani,et al.  The reaction of (N-isocyanimino)triphenylphosphorane with benzoic acid derivatives : A novel synthesis of 2 -aryl -1,3,4 -oxadiazole derivatives , 2007 .

[163]  A. Spek,et al.  Diastereoselective multicomponent synthesis of dihydropyridones with an isocyanide functionality. , 2006, Organic letters.

[164]  M. Pirrung,et al.  Versatile, fragrant, convertible isonitriles. , 2006, Journal of the American Chemical Society.

[165]  E. Pelkey,et al.  Regiocontrolled synthesis of pyrrole-2-carboxaldehydes and 3-pyrrolin-2-ones from pyrrole Weinreb amides. , 2006, The Journal of organic chemistry.

[166]  ItoYoshihiko,et al.  Indole Syntheses Utilizing o-Methylphenyl Isocyanides , 2006 .

[167]  A. Dömling,et al.  1-Isocyanomethylbenzotriazole and 2,2,4,4-tetramethylbutylisocyanide-cleavable isocyanides useful for the preparation of α-aminomethyl tetrazoles , 2006 .

[168]  U. Kazmaier,et al.  A new, modular approach towards 2-(1-hydroxyalkyl)oxazolines, effective bidentate chiral ligands , 2006 .

[169]  G. Stephenson,et al.  Sequential Ugi/Strecker reactions via microwave assisted organic synthesis: novel 3-center-4-component and 3-center-5-component multi-component reactions , 2006 .

[170]  Sébastien Gonnard,et al.  A new and versatile Ugi/SNAr synthesis of fused 4,5-dihydrotetrazolo[1,5-a]quinoxalines , 2006 .

[171]  Y. Izumi,et al.  Synthesis of 11H-indolo[3,2-c]quinoline derivatives carrying a substituent at the 6-position , 2005 .

[172]  Jieping Zhu,et al.  Multicomponent synthesis of epoxy-tetrahydronaphthyridine and structural diversification by subsequent fragmentation , 2005 .

[173]  G. Gouhier,et al.  On the use of boronates in the Petasis reaction , 2005 .

[174]  G. Giacomelli,et al.  Synthesis of 1-alkyl-4-imidazolecarboxylates: a catch and release strategy. , 2005, Journal of combinatorial chemistry.

[175]  F. Hahn,et al.  Template synthesis of tungsten complexes with saturated N-heterocyclic carbene ligands. , 2005, Chemical communications.

[176]  Jieping Zhu,et al.  Exploiting the dual reactivity of o-isocyanobenzamide: three-component synthesis of 4-imino-4H-3,1-benzoxazines. , 2005, Organic letters.

[177]  A. de Meijere,et al.  Versatile direct synthesis of oligosubstituted pyrroles by cycloaddition of alpha-metalated isocyanides to acetylenes. , 2005, Angewandte Chemie.

[178]  U. Kazmaier,et al.  A straightforward approach towards thiazoles and endothiopeptides via Ugi reaction. , 2005, Organic & biomolecular chemistry.

[179]  P. Parsons,et al.  Multicomponent cascade reactions: sequential [1 + 4] and [2 + 3] cycloadditions for the generation of heterocyclic ring systems. , 2005, Organic Letters.

[180]  Yoshinori Yamamoto,et al.  Copper- or phosphine-catalyzed reaction of alkynes with isocyanides. Regioselective synthesis of substituted pyrroles controlled by the catalyst. , 2005, Journal of the American Chemical Society.

[181]  Jieping Zhu,et al.  Mild oxidative one-carbon homologation of aldehyde to amide. , 2005, Journal of the American Chemical Society.

[182]  R. E. Robinson,et al.  Five Possible Isocyanoazulenes and Electron-Rich Complexes Thereof: A Quantitative Organometallic Approach for Probing Electronic Inhomogeneity of the Azulenic Framework , 2005 .

[183]  R. Bon,et al.  Multicomponent synthesis of 2-imidazolines. , 2005, The Journal of organic chemistry.

[184]  G. Giacomelli,et al.  Microwave-assisted synthesis of isonitriles: a general simple methodology. , 2005, The Journal of organic chemistry.

[185]  Jieping Zhu,et al.  Three-component synthesis of polysubstituted 6-azaindolines and its tricyclic derivatives. , 2005, Organic letters.

[186]  Kazuhiro Kobayashi,et al.  A convenient synthesis of quinolines by reactions of o-isocyano-β-methoxystyrenes with nucleophiles , 2004 .

[187]  Jieping Zhu,et al.  Ammonium chloride promoted Ugi four-component, five-center reaction of alpha-substituted alpha-isocyano acetic acid: a strong solvent effect. , 2004, Organic letters.

[188]  U. Kazmaier,et al.  An improved protocol for the synthesis of allylated isonitriles , 2004 .

[189]  W. Hiller,et al.  Synthesis of tetrazolopiperazine building blocks by a novel multi-component reaction , 2004 .

[190]  V. Mokrushin,et al.  Ugi Reaction with Isocyanoindoles , 2004 .

[191]  A. Leusen,et al.  Synthetic Uses of Tosylmethyl Isocyanide (TosMIC) , 2004 .

[192]  Kazuhiro Kobayashi,et al.  An efficient synthesis of 2,4-disubstituted quinolines by electrophile-mediated cyclization reactions of 2-isocyanostyrene derivatives , 2004 .

[193]  Jieping Zhu,et al.  Synthesis of polysubstituted 4,5,6,7-tetrahydrofuro[2,3-c]pyridines by a novel multicomponent reaction. , 2004, Organic letters.

[194]  Eberhardt Herdtweck,et al.  A Versatile Synthesis of 6-Oxo-1,4,5,6-tetrahydro-pyrazine-2-carboxylic Acid Methyl Esters via MCR Chemistry , 2004 .

[195]  A. Dömling,et al.  New MCRs: The first 4-component reaction leading to 2,4-disubstituted thiazoles , 2004, Molecular Diversity.

[196]  A. Basso,et al.  Passerini reaction – Amine Deprotection – Acyl Migration (PADAM): a convenient strategy for the solid-phase preparation of peptidomimetic compounds , 2004, Molecular Diversity.

[197]  A. Dömling,et al.  Convergent multicomponent assembly of 2-acyloxymethyl thiazoles , 2003 .

[198]  A. Spek,et al.  Novel multicomponent reaction for the combinatorial synthesis of 2-imidazolines. , 2003, Organic letters.

[199]  Carmen Almansa,et al.  Synthesis and Structure−Activity Relationship of a New Series of COX-2 Selective Inhibitors: 1,5-Diarylimidazoles , 2003 .

[200]  H. Umakoshi,et al.  Synthesis of 3-methoxyquinolines via cyclization of 1-isocyano-2-(2-lithio-2-methoxyethenyl)benzenes , 2003 .

[201]  J. Ichikawa,et al.  Ring-fluorinated isoquinoline and quinoline synthesis: intramolecular cyclization of o-cyano- and o-isocyano-beta,beta-difluorostyrenes. , 2003, Organic letters.

[202]  R. Menon,et al.  [4 + 1] Cycloaddition reactions of o-thioquinones with isocyanides: novel syntheses of 2-imino-1,3-oxathioles , 2003 .

[203]  Jieping Zhu,et al.  A one-pot four-component (ABC2) synthesis of macrocycles. , 2003, Angewandte Chemie.

[204]  F. Hahn,et al.  Template synthesis of benzannulated N-heterocyclic carbene ligands. , 2003, Chemistry.

[205]  C. Hulme,et al.  "Multi-component reactions : emerging chemistry in drug discovery" 'from xylocain to crixivan'. , 2003, Current medicinal chemistry.

[206]  M. Mozzon,et al.  Synthesis, coordination and reactivity of 2-(trimethylsiloxymethyl)phenyl- and 2-(hydroxymethyl)phenyl isocyanides , 2002 .

[207]  Jieping Zhu,et al.  A five-component synthesis of hexasubstituted benzene. , 2002, Angewandte Chemie.

[208]  Christopher J. Helal,et al.  A concise and regioselective synthesis of 1-alkyl-4-imidazolecarboxylates. , 2002, Organic letters.

[209]  Jieping Zhu,et al.  Rapid access to tetracyclic ring system of lennoxamine type natural product by combined use of a novel three-component reaction and Pummerer cyclization. , 2002, Chemical communications.

[210]  Jieping Zhu,et al.  Synthesis of furoquinolines by a multicomponent domino process. , 2002, Angewandte Chemie.

[211]  V. Nair,et al.  Diisopropylaminoisocyanide and DMAD in multiple component reactions (MCRs): novel synthesis of substituted 1-amino-3-pyrrolin-2-ones by reaction with aldehydes and dicarbonyl compounds , 2002 .

[212]  Yoshinori Yamamoto,et al.  Synthesis of allyl cyanamides and N-cyanoindoles via the palladium-catalyzed three-component coupling reaction. , 2002, Journal of the American Chemical Society.

[213]  K. Onitsuka,et al.  A novel route to 2,3-disubstituted indoles via palladium-catalyzed three-component coupling of aryl iodide, o-alkenylphenyl isocyanide and amine , 2002 .

[214]  R. Neidlein,et al.  2‐Cyano‐2‐isocyanoalkanoates in Multicomponent Reactions , 2002 .

[215]  T. Kan,et al.  Total synthesis of ecteinascidin 743. , 2002, Journal of the American Chemical Society.

[216]  B. Ganem,et al.  Metal-promoted variants of the Passerini reaction leading to functionalized heterocycles. , 2002, Organic letters.

[217]  Jieping Zhu,et al.  Ammonium chloride-promoted four-component synthesis of pyrrolo[3,4-b]pyridin-5-one. , 2002, Journal of the American Chemical Society.

[218]  Takashi Matsumoto,et al.  Synthesis of Pyrrolo[1,2-a]quinoxaline Derivatives by Lewis Acid-Catalyzed Reactions of 1-(2-Isocyanophenyl)pyrroles , 2001 .

[219]  Takashi Matsumoto,et al.  Synthesis of 4-(1-Dialkylaminoalkyl)pyrrolo[1,2-a]quinoxalines , 2001 .

[220]  H. Bienaymé,et al.  A novel multicomponent synthesis of polysubstituted 5-aminooxazole and its new scaffold-generating reaction to pyrrolo[3,4-b]pyridine. , 2001, Organic letters.

[221]  J. Simon.  Studies on the Reactivity of 1-Cyano-1-isocyanoalkylphosphonic Acid Esters , 2001 .

[222]  K. Chiba,et al.  Highly Efficient Conversion of Alcohols to Isocyanides , 2001 .

[223]  Kazuhiro Kobayashi,et al.  Synthesis of 2,2′-Biquinolines from o-Isocyanostyrenes , 2001 .

[224]  V. Mokrushin,et al.  New synthesis of indoles containing the isocyanide group , 2001 .

[225]  E. González-Zamora,et al.  Three component synthesis of oxa-bridged tetracyclic tetrahydroquinolines. , 2001, Chemical communications.

[226]  I. Ugi,et al.  Multicomponent Reactions with Isocyanides. , 2000, Angewandte Chemie.

[227]  A. Dömling,et al.  One-pot synthesis and biological evaluation of aspergillamides and analogues. , 2000, Bioorganic & medicinal chemistry letters.

[228]  W. Maison,et al.  Multicomponent synthesis of novel amino acid-nucleobase chimeras: a versatile approach to PNA-monomers. , 2000, Bioorganic & medicinal chemistry.

[229]  E. Vedejs,et al.  Progress toward synthesis of diazonamide A. Preparation of a 3-(oxazol-5-yl)-4-trifluoromethyl-sulfonyloxyindole and its use in biaryl coupling reactions. , 2000, Organic letters.

[230]  C. Blackburn,et al.  A novel dealkylation affording 3-aminoimidazo[1,2-a]pyridines: access to new substitution patterns by solid-phase synthesis† , 2000 .

[231]  R. Neidlein,et al.  Synthesen und chemische Reaktionen von 1-Cyano-1-isocyanoalkylphosphonsäureestern , 2000 .

[232]  T. Fukuda,et al.  New access to 2,3-disubstituted quinolines through cyclization of o-alkynylisocyanobenzenes , 1999 .

[233]  J. Rainier,et al.  An isonitrile-alkyne cascade to di-substituted indoles , 1999 .

[234]  I. Ugi,et al.  A new class of convertible isocyanides in the Ugi four-component reaction , 1999 .

[235]  R. Neidlein,et al.  Studies on the Reactivity ofα-Cyano-α-isocyanoalkanoates - Versatile Synthons for the Assembly of Imidazoles , 1999 .

[236]  K. Chi,et al.  SYNTHESIS, STRUCTURE, AND REACTIVITY OF RHENIUM N-ISOCYANIDE COMPLEXES REBR(CO)3(CNR)(CNNPPH3) , 1999 .

[237]  W. Maison,et al.  Modified PNAs: a simple method for the synthesis of monomeric building blocks. , 1999, Bioorganic & medicinal chemistry letters.

[238]  R. Grigg,et al.  Silver acetate catalysed cycloadditions of isocyanoacetates , 1999 .

[239]  L. Dai,et al.  A novel double addition of isocyanoacetamide to N-sulfonylimines for the synthesis of trisubstituted oxazoles , 1998 .

[240]  R. Neidlein,et al.  An Efficient Approach to Novel 5,5-Disubstituted Dithiohydantoins via α-Cyano-α-(dihalogenomethyleneamino)alkanoic Acid Esters , 1998 .

[241]  H. Bienaymé.  “Reagent explosion”: an efficient method to increase library size and diversity , 1998 .

[242]  T. Matsumoto,et al.  Synthesis of Pyrrolo[1,2-a]quinoxaline and Its 4-(1-Hydroxyalkyl) Derivatives by Lewis Acid-Catalyzed Reactions of 1-(2-Isocyanophenyl)pyrrole , 1998 .

[243]  H. Bienaymé,et al.  SYNTHESIS OF RIGID HYDROPHOBIC TETRAZOLES USING AN UGI MULTI-COMPONENT HETEROCYCLIC CONDENSATION , 1998 .

[244]  L. E. Kaim,et al.  A New Straightforward Formation of Aminoisoxazoles from Isocyanides , 1997 .

[245]  A. Katritzky,et al.  Syntheses of imidazoles and pyrroles: betmic and tosmic as complementary reagents , 1997 .

[246]  P. Sheldrake,et al.  An efficient method for the synthesis of substituted TosMIC precursors , 1996 .

[247]  R. Neidlein,et al.  Synthesen und chemische Reaktionen von α-Cyano-α-isocyanoalkansäureestern , 1996 .

[248]  T. Torroba,et al.  Studies on Isocyanides and Related Compounds. Synthesis of 1-Aryl-2-(tosylamino)-1H-imidazoles, a Novel Class of Imidazole Derivatives , 1996 .

[249]  T. Torroba,et al.  Studies on Isocyanides. 2-Isocyanothioanisole, a Synthetic Equivalent of the Benzothiazol-2-yl Anion , 1996 .

[250]  T. Fukui,et al.  Synthesis of 5-Substituted Methyl 1-Hydroxyimidazole-4-carboxylates and 5-Substituted Methyl 1-Aminoimidazole-4-carboxylates Using 3-Bromo-2-isocyanoacrylates (BICA) , 1995 .

[251]  C. Rizzoli,et al.  Radical annulations and cyclisations with isonitriles: the fate of the intermediate imidoyl and cyclohexadienyl radicals , 1995 .

[252]  Robert W. Armstrong,et al.  Molecular Diversity via a Convertible Isocyanide in the Ugi Four-Component Condensation , 1995 .

[253]  A. Leusen,et al.  ON THE SYNTHESIS OF BORON-SUBSTITUTED METHYL ISOCYANIDES - 2-ISOCYANOMETHYL-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE , 1995 .

[254]  M. Artico,et al.  4-Substituted 2-Phenyl- and 2-Phenyl-3-Aryl Pyrroles by Reaction of Tosyl Benzyl Isocyanide (TosBIC) with Michael Acceptors , 1995 .

[255]  T. Fukui,et al.  A NOVEL SYNTHESIS OF METHYL 5-SUBSTITUTED THIAZOLE-4-CARBOXYLATES USING 3-BROMO-2-ISOCYANOACRYLATES (BICA) , 1995 .

[256]  A. Katritzky,et al.  Comprehensive organic functional group transformations II , 1995 .

[257]  T. Fukui,et al.  A Novel Synthesis of Methyl 1,5-Disubstituted Imidazole-4-carboxylates Using 3-Bromo-2-isocyanoacrylates (BICA) , 1994 .

[258]  P. Paoli,et al.  Studies on isocyanides and related compounds. An unusual synthesis of imidazolyloxazolones , 1994 .

[259]  T. Fukuyama,et al.  A Novel Tin-Mediated Indole Synthesis , 1994 .

[260]  S. Marcaccini,et al.  Studies on isocyanides and related compounds. A convenient synthesis of 2,3-disubstituted spiroimidazolones , 1994 .

[261]  P. Paoli,et al.  Synthesis of N,N′-Diaryldipeptide Amides by Multi-Component Condensation Utilizing Potassium Isocyanoacetate , 1994 .

[262]  A. Köckritz,et al.  α-Substituted phosphonates. 64. Phosphono-Substituted Imidazoles and other heterocycles from diethyl [(2,2-dichloro-1-isocyano)-ethenyl]phosphonate† , 1994 .

[263]  S. Marcaccini,et al.  Studies on Isocyanides and Related Compounds. A Facile Synthesis of Imidazo[1,5-a]imidazoles , 1993 .

[264]  F. Hahn.  The Coordination Chemistry of Multidentate Isocyanide Ligands , 1993 .

[265]  P. Paoli,et al.  Studies on isocyanides and related compounds. Investigation on the reaction between (Z)-alkyl 3-dimethylamino-2-isocyanoacrylates and acyl chlorides , 1993 .

[266]  F. Hahn,et al.  Facile synthesis of (1,2-dihydrobenzoxazol-2-ylidene)tetracarbonyliron complexes from 2-trimethylsiloxyphenyl isocyanide , 1993 .

[267]  A. Katritzky,et al.  Synthesis of a-Amino Isocyanides and a-Alkylthio Isocyanides , 1993 .

[268]  T. Livinghouse,et al.  Acylnitrilium ion-initiated heteroannulations in alkaloid synthesis. An efficient, stereocontrolled, total synthesis of the Orchidaceae alkaloid (.+-.)-dendrobine , 1992 .

[269]  A. Leusen,et al.  CHEMISTRY OF N,P-ACETALS - APPLICATION TO THE SYNTHESIS OF 20-KETOSTEROIDS , 1992 .

[270]  Michael Schmittel,et al.  Neue Synthesen für isomerenreine Allyl‐ und Propargylcyanide durch Isocyanid‐Cyanid‐Umlagerung[1] , 1992 .

[271]  P. Paoli,et al.  Studies on isocyanides and related compounds. – Synthesis and cyclization of N‐substituted 1‐isocyano‐1‐cycloalkanecarboxamides , 1991 .

[272]  J. Pakusch,et al.  The Isocyanide–Cyanide Rearrangement; Mechanism and Preparative Applications , 1991 .

[273]  A. Leusen,et al.  A SHORT STEREOSELECTIVE SYNTHESIS OF ERBSTATIN , 1990 .

[274]  T. Torroba,et al.  A facile synthesis of 1-aryl-2-artylthio-1H-imidazoles , 1990 .

[275]  A. Katritzky,et al.  Benzotriazol-1-ylalkyl isocyanides: versatile synthons for preparation of unsymmetrical formamidines , 1990 .

[276]  M. Muratori,et al.  Studies on alkyl isocyanoacetates and related compounds. Synthesis of 6-arylthio-8-ethoxycarbonyl-4-ethoxycarbonyl-methylaminoimidazo[5,1-b][1,3,5]thiadiazine-2-thiones , 1990 .

[277]  T. Torroba,et al.  Synthesis of 2,4-diarylthio-5-N-alkyl-N-phenylaminooxazoles. A novel class of oxazole derivatives , 1989 .

[278]  T. Torroba,et al.  Synthesis of 1-arylthiocarbonyl-4-isopropylamino-2,5-dihydro-1H-imidazole-2-thiones, a novel class of imidazole derivatives , 1989 .

[279]  A. Katritzky,et al.  Benzotriazol-1-ylmethyl isocyanide, a new synthon for CHNC transfer. Syntheses of α-hydroxyaldehydes, 4-ethoxy-2-oxazolines and oxazoles , 1989 .

[280]  G. Valle,et al.  A novel synthetic route to imidazole derivatives: synthesis of mesoionic 3-alkyl-2-arylthio-1,3-diazolium-4-olates , 1989 .

[281]  R. Nolte,et al.  Screw Sense Selective Polymerization of Achiral Isocyanides Catalyzed by Optically-Active Nickel(Ii) Complexes , 1988 .

[282]  G. Adam,et al.  Scope and limitations of the TiCl4‐mediated additions of isocyanides to aldehydes and ketones with formation of α‐hydroxycarboxylic acid amides , 1988 .

[283]  M. Sawamura,et al.  Asymmetric aldol reaction of α-isocyanoacetamides with aldehydes catalyzed by a chiral ferrocenylphosphine-gold(I) complex , 1988 .

[284]  M. Sawamura,et al.  Asymmetric synthesis of β-hydroxy-α-alkylamino acids by asymmetric aldol reaction of α-isocyanocarboxylates catalyzed by chiral ferrocenylphosphine-gold(I) complexes , 1988 .

[285]  Kazuo Matsumoto,et al.  Synthesis of β-functionalized α, β-dehydroamino acid derivatives , 1988 .

[286]  W. P. Fehlhammer,et al.  Metallkomplexe funktioneller Isocyanide: XV. [3 + 2]-Cycloadditionen von freiem und komplexgebundenem Isocyanmethylenphosphoran mit Heteroallenen☆ , 1987 .

[287]  M. Imoto,et al.  Effective synthesis of erbstatin and its analogs. , 1987, The Journal of antibiotics.

[288]  Y. Takahashi,et al.  Total synthesis of indisocin and N-methylindisocin. , 1987, The Journal of antibiotics.

[289]  H. Naganawa,et al.  One-pot preparation of 1-chlorovinylisocyanides from carbonyl compounds. , 1987, The Journal of antibiotics.

[290]  R. Cotton,et al.  Lipophilic 5,6,7,8-tetrahydropterin substrates for phenylalanine hydroxylase (monkey brain), tryptophan hydroxylase (rat brain) and tyrosine hydroxylase (rat brain) , 1987 .

[291]  T. Livinghouse,et al.  Acylnitrilium ion cyclizations in heterocycle synthesis. A convergent method for the preparation of 2-acylpyrrolines via the intramolecular acylation of silyloxyalkenes with .alpha.-keto imidoyl chlorides , 1987 .

[292]  C. Rüchardt,et al.  The Synthetic Potential of the Isocyanide‐Cyanide Rearrangement , 1987 .

[293]  D. Braga,et al.  Functionalized isocyanides as ligands. 4. Base-promoted cyclization reactions of free and platinum(II)-coordinated o-(phosphoniomethyl)phenyl isocyanide tetrafluoroborates, o-(BF4-R3PCH2)C6H4NC. Synthesis and spectroscopic characterization of 1- and 2-platinum(II)-substituted indole derivatives and , 1986 .

[294]  B. Foxman,et al.  Direct synthesis of low-valent acyl isocyanide metal complexes. Preparation, structure and properties of (.eta.5-C5H5)Co(CNCOR)2 complexes formed via reaction of (.eta.5-C5H5)Co(CO)2 with acyl isocyanides , 1986 .

[295]  A. Leusen,et al.  An Improved Synthesis of Trimethylsilylmethyl Isocyanide , 1986 .

[296]  B. Jones,et al.  .beta.-Eliminations in isonitriles , 1986 .

[297]  Richard D. Smith,et al.  A convergent approach to heterocycle synthesis via silver ion mediated .alpha.-ketoimidoyl halide-arene cyclizations. An application to the synthesis of the erythrinane skeleton , 1986 .

[298]  A. Leusen,et al.  A NEW SYNTHETIC APPROACH TO THE BENZAZOLE RING-SYSTEM - SYNTHESIS AND ELECTROCYCLIC RING-CLOSURE OF DIALKENYL AND ALKENYL-ARYL SUBSTITUTED PYRROLES, IMIDAZOLES AND OXAZOLES , 1986 .

[299]  R. Herrmann,et al.  A Practical Synthesis o f 2-Azidophenylisocyanide , 1986 .

[300]  I. Ugi,et al.  Isocyanide Synthesis with Phosphoryl Chloride and Diisopropylamine , 1985 .

[301]  W. P. Fehlhammer,et al.  Metallkomplexe funktioneller Isocyanide, X. Über (Hydroxyalkyl)isocyanide und ihre Stabilisierung in Metallkomplexen , 1985 .

[302]  W. P. Fehlhammer,et al.  Metallkomplexe funktioneller Isocyanide. IX: N-Isocyanimine: Synthesen und Reaktionen am Komplex , 1985 .

[303]  W. P. Fehlhammer,et al.  Metallkomplexe funktioneller Isocyanide, VIII. (Isocyanimino)triphenylphosphoran-Metallkomplexe , 1985 .

[304]  T. Livinghouse,et al.  Alkaloid synthesis via the intramolecular imidate methylide 1,3-dipolar cycloaddition reaction , 1985 .

[305]  R. Michelin,et al.  Functionalized isocyanides as ligands. Synthesis of 2-(chloromethyl)- and 2-(iodomethyl)phenyl isocyanides and their transition-metal complexes , 1984 .

[306]  H. Lau,et al.  Synthesen mit α-metallierten Isocyaniden, LII. Synthesen mit α-metallierten Isocyaniden, LII. Synthese von 2-Alkyl- und 2-Acyl-1-methylimidazol-4-carbon-säuremethylestern aus (Z)-β-Dimethylamino-α-isocyanacrylsäure-methylester und Alkyl- oder Acylhalogeniden , 1982 .

[307]  P. G. Gassman,et al.  Opening of epoxides with trimethylsilyl cyanide to produce .beta.-hydroxy isonitriles. A general synthesis of oxazolines and .beta.-amino alcohols , 1982 .

[308]  M. Otsuka,et al.  An efficient synthesis of 5-diethoxymethylimidazole-4-carboxylate, a potential precursor for various imidazole derivatives , 1982 .

[309]  M. Jawdosiuk,et al.  β-Elimination of the isonitrile group in alkylation reactions of C–H acids activated by the isonitrile function , 1982 .

[310]  C. Wentrup,et al.  Isocyanoamines, R-NH-NC , 1981 .

[311]  U. Schöllkopf,et al.  (Diphenylphosphinyl)isocyanessigsäure‐tert‐butylester und seine Verwendung in der Wittig‐Horner‐Reaktion mit Aldehyden , 1981 .

[312]  M. Joullié,et al.  Total synthesis of (+)-furanomycin and stereoisomers , 1980 .

[313]  J. Chupp,et al.  Heterocycles from substituted amides. IX. 4,5‐dihydro‐1,2,4‐triazin‐6‐(1H)ones from 2‐isocyanoacetates and hydrazine , 1980 .

[314]  Y. Mizuno,et al.  Studies on the Chemical Synthesis of Potential Antimetabolites. XXV. Synthesis of (±)-Isowillardiine by Application of a Four-Component Condensation involving 2-Picolylamine 1-Oxide and 2-Picolyl Isocyanide 1-Oxide , 1980 .

[315]  J. Chupp,et al.  Heterocycles from substituted amides. VIII Oxazole derivatives from reaction of isocyanates with 2-isocyanoacetamides†‡ , 1980 .

[316]  U. Schöllkopf,et al.  Synthesen von 5‐Alkoxy‐ und 5‐Alkylthio‐4‐alkylimidazolen sowie 4‐Alkyl‐5‐aminothiazolen , 1979 .

[317]  T. Saegusa,et al.  AN ONE-POT SYNTHESIS OF 3-ALKYLINDOLES FROM o-TOLYL ISOCYANIDES , 1979 .

[318]  H. Lau,et al.  Synthesen mit α‐metallierten Isocyaniden, XLIV. Notiz über β‐Dimethylamino‐α‐isocyanacrylsäureester und ihre Verwendung in der Heterocyclenchemie , 1979 .

[319]  U. Schöllkopf,et al.  Synthesen mit α‐metallierten Isocyaniden, XLII. Bi‐, Ter‐ und Quateroxazole aus α‐anionisierten Isocyaniden und Acylierungsmitteln; α‐Aminoketone und α,α‐Diaminoketone , 1979 .

[320]  P. Jacobi,et al.  An unusually facile ring opening of 5-alkoxyoxazoles. Application to the synthesis of dimethoxy-.alpha.-methyldopa , 1979 .

[321]  N. Yoneda,et al.  Synthesis of heterocyclic compounds using isocyano compounds. 5. One-step synthesis of 1-oxo-1,2-dihydroisoquinoline-3-carboxylic acid derivatives , 1979 .

[322]  Kazuo Matsumoto,et al.  An Improved Stereoselective Synthesis of threo-β-Hydroxyamino Acids , 1979 .

[323]  Kazuo Matsumoto,et al.  A Facile Synthesis of 1-Oxo-1,2-dihydroisoquinoline-3-carboxylate and 2-Pyridone-6-carboxylate Derivatives , 1978 .

[324]  A. Albini,et al.  Photochemistry of quinoxaline 1-oxide and some of its derivatives , 1978 .

[325]  T. Saegusa,et al.  A new synthesis of 4,5-dihydro-3,1-benzoxazepine and 4H-5,6-dihydro-3,1-benzoxazocine derivatives , 1978 .

[326]  O. Possel,et al.  CHEMISTRY OF SULFONYLMETHYL ISOCYANIDES .16. TOSYLMETHYL ISOCYANIDE EMPLOYED IN A NOVEL SYNTHESIS OF KETONES - NEW MASKED FORMALDEHYDE REAGENT , 1978 .

[327]  N. Wibeŕg,et al.  Über Derivate des Hydrazins, VII Zur Reaktivität von Bis(trimethylsilyl)aminoisocyanid / On Derivatives of Hydrazine, VII Reactivity of Bis(trimethylsilyl)aminoisocyanide , 1977 .

[328]  U. Schöllkopf.  Recent Applications of α‐Metalated Isocyanides in Organic Synthesis , 1977 .

[329]  J. Anselme.  Isodiazomethane revisited. N-aminoisonitriles , 1977 .

[330]  G. Höfle,et al.  N‐Acyl Isocyanides , 1977 .

[331]  T. Saegusa,et al.  An efficient synthesis of indole , 1977 .

[332]  Kazuo Matsumoto,et al.  Alkylation of α-Isocyanoacetamides; Synthesis of 1,4,4-Trisubstituted 5-Oxo-4,5-dihydroimidazoles1 , 1977 .

[333]  O. Possel,et al.  Tosylmethyl isocyanide employed in a novel synthesis of ketones. A new masked formaldehyde reagent , 1977 .

[334]  R. Harms,et al.  Synthesen mit α‐metallierten Isocyaniden, XXXIII. Kettenverlängerung primärer Amine mit Epoxiden und Oxetan über α‐metallierte Isocyanide. Neue Synthese von 3‐ und 4‐Amino‐alkoholen, 5,6‐Dihydro‐4H‐1,3‐oxazinen und 4,5,6,7‐Tetrahydro‐1,3‐oxazepinen , 1976 .

[335]  N. Wibeŕg,et al.  Über Derivate des Hydrazins, VII Darstellung und Charakterisierung von Bis(trimethylsilyl)aminoisocyanid. , 1976 .

[336]  J. S. Thayer,et al.  Normal-iso rearrangement in cyanotrialkylsilanes , 1976 .

[337]  I. Hoppe,et al.  Cycloaddition von “Isocyanketen” an Benzophenonanil und Thioimidsäureester zu β‐Lactamen , 1976 .

[338]  A. Leusen,et al.  REACTION OF THIOMETHYL ISOCYANIDES WITH NITRILES - SYNTHESIS OF 4(5)-THIOIMIDAZOLES , 1976 .

[339]  A. Holm,et al.  N-Isocyanoimines. Preparation and Characterisation. , 1976 .

[340]  M. Tomie,et al.  A New Synthesis of 1-Aryl-1H-1, 2, 4-triazole-3-carboxylic Acid Esters , 1975 .

[341]  U. Schöllkopf,et al.  Synthesen mit α-metallierten Isocyaniden, XXX1) 2-Oxazolin-4-carbonitrile aus α-Isocyannitrilen und Carbonylverbindungen , 1975 .

[342]  U. Schöllkopf,et al.  Synthesen mit α-metallierten Isocyaniden, XXVIII1) In 2-Stellung unsubstituierte Oxazole aus α-metallierten Isocyaniden und Acylierungsreagenzien , 1975 .

[343]  G. Höfle.  α‐Acyloxy‐isocyanide („O‐Acyl‐isocyanhydrine”︁) , 1974 .

[344]  A. Leusen,et al.  Synthesis of Stereochemistry of 4-ethoxy-2-oxazolines , 1974 .

[345]  J. Fleury,et al.  Heterocyclisation des α-acylaminoamides—IV , 1974 .

[346]  A. Leusen,et al.  PREPARATION OF THIOMETHYLISOCYANIDES AND THEIR USE IN HETEROCYCLIC SYNTHESES , 1973 .

[347]  R. Stephany,et al.  Propargyl and Allenyl Isocyanide and Some of Their Copper(I)Complexes , 1973 .

[348]  U. Schöllkopf,et al.  Synthesen mit α-metallierten Isocyaniden, XX , 1973 .

[349]  F. Millich.  Polymerization of isocyanides , 1972 .

[350]  H. Walborsky,et al.  Synthesis of isonitriles , 1972 .

[351]  R. King,et al.  Novel reactions of vinyl isocyanide with organophosphorus and organoarsenic compounds , 1971 .

[352]  W. Kliegel,et al.  Hydroxylamin-Derivate, XXXVII. Hydroxylamine in der Vierkomponenten-Kondensation nach Ugi , 1969 .

[353]  L. Malatesta.  Isocyanide complexes of metals , 1969 .

[354]  R. A. Bailey,et al.  The electronic character of vinyl isocyanide , 1968 .

[355]  E. Müller,et al.  Untersuchungen an Diazomethanen, XXVI1) Isodiazomethan Knallsäureamid N‐Isocyan‐amin , 1968 .

[356]  J. Casanova,et al.  The Isonitrile—Nitrile Isomerization1 , 1966 .

[357]  K. Hartke.  Über Carbodiimide, IV. Eliminierung von Schwefelwasserstoff mit acylierten Carbodiimiden , 1966 .

[358]  H. Bredereck,et al.  Reaktionen der N-Isocyan-dialkylamine , 1965 .

[359]  H. Bredereck,et al.  Über N‐Isocyan‐dialkylamine , 1965 .

[360]  K. Offermann,et al.  Neuere Methoden der präparativen organischen Chemie IV. Isonitril‐Synthesen , 1965 .

[361]  W. Beck,et al.  Über Triorganometallfulminate von Silicium, Germanium, Zinn und Blei , 1964 .

[362]  I. Ugi,et al.  Isonitrile, XV. Δ1‐Cyclohexenyl‐isocyanid , 1963 .

[363]  M. Hanack,et al.  Rearrangements of Δ2‐Cyclopentenylmethane Derivatives , 1962 .

[364]  H. Meerwein,et al.  Über Säureamidacetale, Harnstoffacetale und Lactamacetale , 1961 .

[365]  I. Hagedorn,et al.  Darstellung von α.β‐ungesättigten und β‐Ketoisonitrilen , 1961 .

[366]  B. Bak,et al.  The structure of tertiary butyl isocyanide , 1958 .

[367]  E. Müller,et al.  Untersuchungen an Diazomethanen, III. Mitteil.: Herstellung von Isodiazomethan und seine Umlagerung zu Diazomethan , 1954 .

[368]  S. T. Henderson,et al.  Molecular structure and physical properties of prussic acid. Part I. —Refractive dispersion of prussic acid and its homologues , 1932 .

[369]  A. Dadieu.  Raman‐Effekt und Konstitutions‐Probleme, II. Mitteil.: Cyanverbindungen , 1931 .

[370]  H. Lindemann,et al.  Über die Konstitution der Verbindungen mit „zweiwertigem”︁ Kohlenstoff , 1930 .

[371]  J. Nef.  Ueber das zweiwerthige Kohlenstoffatom , 1892 .

[372]  A. Gautier.  Ueber die Einwirkung des Chlorwasserstoffs u. a. auf das Aethyl‐ und Methylcyanür , 1867 .