Oxidative Stress-Induced Signaling Pathways Implicated in the Pathogenesis of Parkinson’s Disease
暂无分享,去创建一个
[1] Xinglong Wang,et al. Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease. , 2013, Free radical biology & medicine.
[2] Xiaochun Chen,et al. Astaxanthin Suppresses MPP+-Induced Oxidative Damage in PC12 Cells through a Sp1/NR1 Signaling Pathway , 2013, Marine drugs.
[3] Hey-kyeong Jeong,et al. PINK1 Deficiency Enhances Inflammatory Cytokine Release from Acutely Prepared Brain Slices , 2013, Experimental neurobiology.
[4] Y. Kitagishi,et al. Function and Characteristics of PINK1 in Mitochondria , 2013, Oxidative medicine and cellular longevity.
[5] S. Gonfloni,et al. Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress , 2013, International journal of molecular sciences.
[6] S. Cardoso,et al. Mitochondria drive autophagy pathology via microtubule disassembly , 2013, Autophagy.
[7] X. Zhuang,et al. Characterization of PINK1 (PTEN-induced Putative Kinase 1) Mutations Associated with Parkinson Disease in Mammalian Cells and Drosophila* , 2013, The Journal of Biological Chemistry.
[8] L. Martins,et al. Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease , 2013, Cell Death and Disease.
[9] U. Landegren,et al. Elevated MARK2-dependent phosphorylation of Tau in Alzheimer's disease. , 2013, Journal of Alzheimer's disease : JAD.
[10] Yong-jun Wang,et al. Human neuromelanin: an endogenous microglial activator for dopaminergic neuron death. , 2013, Frontiers in bioscience.
[11] Y. Michotte,et al. Oxidative Stress in Genetic Mouse Models of Parkinson's Disease , 2012, Oxidative medicine and cellular longevity.
[12] I. Novak,et al. Mitophagy: a complex mechanism of mitochondrial removal. , 2012, Antioxidants & redox signaling.
[13] G. Cesareni,et al. Oxidative Stress, DNA Damage, and c-Abl Signaling: At the Crossroad in Neurodegenerative Diseases? , 2012, International journal of cell biology.
[14] Carol S. Lim,et al. Selective Targeting of c-Abl via a Cryptic Mitochondrial Targeting Signal Activated by Cellular Redox Status in Leukemic and Breast Cancer Cells , 2012, Pharmaceutical Research.
[15] Jianhua Zhang,et al. Genetically engineered mouse models of Parkinson's disease , 2012, Brain Research Bulletin.
[16] O. Elemento,et al. Concordant Signaling Pathways Produced by Pesticide Exposure in Mice Correspond to Pathways Identified in Human Parkinson's Disease , 2012, PloS one.
[17] David S. Park,et al. Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment , 2012, EMBO reports.
[18] S. Pluchino,et al. Plasticity of Subventricular Zone Neuroprogenitors in MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) Mouse Model of Parkinson's Disease Involves Cross Talk between Inflammatory and Wnt/β-Catenin Signaling Pathways: Functional Consequences for Neuroprotection and Repair , 2012, The Journal of Neuroscience.
[19] E. Mandelkow,et al. Microtubule Affinity-regulating Kinase 2 (MARK2) Turns on Phosphatase and Tensin Homolog (PTEN)-induced Kinase 1 (PINK1) at Thr-313, a Mutation Site in Parkinson Disease , 2012, The Journal of Biological Chemistry.
[20] N. Hattori,et al. PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria , 2012, Nature Communications.
[21] R. Uitti,et al. Autosomal dominant Parkinson's disease. , 2012, Parkinsonism & related disorders.
[22] A. Brice,et al. Role of mendelian genes in "sporadic" Parkinson's disease. , 2012, Parkinsonism & related disorders.
[23] Hey-kyeong Jeong,et al. Spatial and temporal correlation in progressive degeneration of neurons and astrocytes in contusion-induced spinal cord injury , 2012, Journal of Neuroinflammation.
[24] D. Surmeier,et al. The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's disease , 2011, Neuroscience.
[25] F. Costantini,et al. Downregulation of Wnt/β-catenin signaling causes degeneration of hippocampal neurons in vivo , 2011, Neurobiology of Aging.
[26] H. Reichmann. View point: Etiology in Parkinson's disease. Dual hit or spreading intoxication , 2011, Journal of the Neurological Sciences.
[27] Christine Van Broeckhoven,et al. Parkinson disease: Insights in clinical, genetic and pathological features of monogenic disease subtypes , 2011, Journal of Chemical Neuroanatomy.
[28] A. Brice,et al. What genetics tells us about the causes and mechanisms of Parkinson's disease. , 2011, Physiological reviews.
[29] S. Lipton,et al. Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics, and neuronal synaptic damage in neurodegenerative diseases , 2011, Cell Death and Differentiation.
[30] S. Pluchino,et al. A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection , 2011, Molecular Neurodegeneration.
[31] G. Martino,et al. Corrigendum to “Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease” [Neurobiol. Dis. 41/2 (2011) 508–527] , 2011, Neurobiology of Disease.
[32] D. Selkoe,et al. The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking , 2011, Journal of neurochemistry.
[33] A. Mahadevan,et al. Evaluation of Markers of Oxidative Stress, Antioxidant Function and Astrocytic Proliferation in the Striatum and Frontal Cortex of Parkinson’s Disease Brains , 2011, Neurochemical Research.
[34] R. Rodenburg,et al. Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance , 2011, Journal of Cell Science.
[35] M. Beal,et al. Molecular insights into Parkinson's disease , 2011, F1000 medicine reports.
[36] R. Huber,et al. HTRA proteases: regulated proteolysis in protein quality control , 2011, Nature Reviews Molecular Cell Biology.
[37] J. Siegenthaler,et al. Wnt Signaling Regulates Neuronal Differentiation of Cortical Intermediate Progenitors , 2011, The Journal of Neuroscience.
[38] E. Melamed,et al. Wnt signaling pathway overcomes the disruption of neuronal differentiation of neural progenitor cells induced by oligomeric amyloid β‐peptide , 2011, Journal of neurochemistry.
[39] G. Martino,et al. Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease , 2011, Neurobiology of Disease.
[40] Philip L De Jager,et al. Parkinson's disease: genetics and pathogenesis. , 2011, Annual review of pathology.
[41] R. Akundi,et al. Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice , 2011, PloS one.
[42] A. J. Valente,et al. Novel Regulation of Parkin Function through c-Abl-Mediated Tyrosine Phosphorylation: Implications for Parkinson's Disease , 2011, The Journal of Neuroscience.
[43] Jian-ning Zhang,et al. The Wnt /β‐catenin signaling pathway in the adult neurogenesis , 2011, The European journal of neuroscience.
[44] A. Whitworth,et al. PINK1 cleavage at position A103 by the mitochondrial protease PARL , 2010, Human molecular genetics.
[45] S. Prabhakar,et al. Altered oxidative stress levels in Indian Parkinson's disease patients with PARK2 mutations. , 2011, Acta biochimica Polonica.
[46] M. Sakaguchi,et al. A New Cytosolic Pathway from a Parkinson Disease-associated Kinase, BRPK/PINK1 , 2010, The Journal of Biological Chemistry.
[47] E. Medina,et al. Phosphatidylinositol 3-Kinase Activation Attenuates the TLR2-Mediated Macrophage Proinflammatory Cytokine Response to Francisella tularensis Live Vaccine Strain , 2010, The Journal of Immunology.
[48] Paul T. Schumacker,et al. Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1 , 2010, Nature.
[49] B. Li,et al. Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases , 2010, Cell Death and Differentiation.
[50] Hey-kyeong Jeong,et al. Inflammatory Responses Are Not Sufficient to Cause Delayed Neuronal Death in ATP-Induced Acute Brain Injury , 2010, PloS one.
[51] Robert A. Smith,et al. Toxicological and pathophysiological roles of reactive oxygen and nitrogen species. , 2010, Toxicology.
[52] Xin Sun,et al. Tetrahydroxystilbene glucoside attenuates MPP+-induced apoptosis in PC12 cells by inhibiting ROS generation and modulating JNK activation , 2010, Neuroscience Letters.
[53] M. Horowitz,et al. Gene–Environment Interactions in Parkinson's Disease: The Importance of Animal Modeling , 2010, Clinical pharmacology and therapeutics.
[54] J. Troncoso,et al. Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function , 2010, Proceedings of the National Academy of Sciences.
[55] L. Yin,et al. Terminal differentiation of chronic myelogenous leukemia cells is induced by targeting of the MUC1-C oncoprotein , 2010, Cancer biology & therapy.
[56] C. Tirolo,et al. Glia as a turning point in the therapeutic strategy of Parkinson's disease. , 2010, CNS & neurological disorders drug targets.
[57] D. Nicholls. Mitochondrial ion circuits. , 2010, Essays in biochemistry.
[58] Ted M. Dawson,et al. Genetic Animal Models of Parkinson's Disease , 2010, Neuron.
[59] M. Cookson,et al. Parkinson's disease: insights from pathways. , 2010, Human molecular genetics.
[60] S. Dubey,et al. Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: Implications for Parkinson's disease. , 2010, Bioorganic & medicinal chemistry.
[61] L. Feng,et al. Gene Therapy in Parkinson’s Disease , 2010, CNS drugs.
[62] S. Lipton,et al. Preventing Ca2+-mediated nitrosative stress in neurodegenerative diseases: possible pharmacological strategies. , 2010, Cell calcium.
[63] E. Arenas,et al. Emerging roles of Wnts in the adult nervous system , 2010, Nature Reviews Neuroscience.
[64] L. Chin,et al. Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling. , 2010, Human molecular genetics.
[65] Atsushi Tanaka,et al. PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin , 2010, PLoS biology.
[66] P Jeffrey Conn,et al. Glutamate receptors as therapeutic targets for Parkinson's disease. , 2009, CNS & neurological disorders drug targets.
[67] Hua Yu,et al. STATs in cancer inflammation and immunity: a leading role for STAT3 , 2009, Nature Reviews Cancer.
[68] M. Yin,et al. Antioxidative and anti-inflammatory neuroprotective effects of astaxanthin and canthaxanthin in nerve growth factor differentiated PC12 cells. , 2009, Journal of food science.
[69] Gene W. Yeo,et al. Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis , 2009, Nature Neuroscience.
[70] H. Büeler. Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease , 2009, Experimental Neurology.
[71] D. Standaert,et al. Targets for neuroprotection in Parkinson's disease. , 2009, Biochimica et biophysica acta.
[72] N. Wood,et al. PINK1 function in health and disease , 2009, EMBO molecular medicine.
[73] D. Sulzer,et al. Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons , 2009, Neuron.
[74] E. Hirsch,et al. Neuroinflammation in Parkinson's disease: a target for neuroprotection? , 2009, The Lancet Neurology.
[75] A. Whitworth,et al. Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin , 2009, Cell Death and Differentiation.
[76] E. Masliah,et al. Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson’s disease by disturbing calcium flux , 2009, Journal of neurochemistry.
[77] Xuebo Liu,et al. Astaxanthin inhibits reactive oxygen species-mediated cellular toxicity in dopaminergic SH-SY5Y cells via mitochondria-targeted protective mechanism , 2009, Brain Research.
[78] P. Kapahi,et al. Loss-of-Function Analysis Suggests That Omi/HtrA2 Is Not an Essential Component of the pink1/parkin Pathway In Vivo , 2008, The Journal of Neuroscience.
[79] N. Wood,et al. What Have PINK1 and HtrA2 Genes Told Us about the Role of Mitochondria in Parkinson's Disease? , 2008, Annals of the New York Academy of Sciences.
[80] S. Przedborski,et al. Oxidative Stress in Parkinson's Disease , 2008, Annals of the New York Academy of Sciences.
[81] M. Beal,et al. Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis , 2008, Nature Clinical Practice Neurology.
[82] A. Whitworth,et al. Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson’s disease factors Pink1 and Parkin , 2008, Disease Models & Mechanisms.
[83] E. Schon,et al. The kinase domain of mitochondrial PINK1 faces the cytoplasm , 2008, Proceedings of the National Academy of Sciences.
[84] A. Toulouse,et al. Progress in Parkinson's disease—Where do we stand? , 2008, Progress in Neurobiology.
[85] J. Trojanowski,et al. Neuroinflammation and Oxidation/Nitration of α-Synuclein Linked to Dopaminergic Neurodegeneration , 2008, The Journal of Neuroscience.
[86] S. Tabrizi,et al. PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons , 2008, PloS one.
[87] D. Mochly‐Rosen,et al. The PKCδ -Abl complex communicates ER stress to the mitochondria – an essential step in subsequent apoptosis , 2008, Journal of Cell Science.
[88] D H Geschwind,et al. Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation , 2008, Molecular Psychiatry.
[89] Hey-kyeong Jeong,et al. Resident microglia die and infiltrated neutrophils and monocytes become major inflammatory cells in lipopolysaccharide‐injected brain , 2007, Glia.
[90] E. Alnemri. HtrA2 and Parkinson's disease: think PINK? , 2007, Nature Cell Biology.
[91] Chaya Brodie,et al. The phosphorylation of tyrosine 332 is necessary for the caspase 3-dependent cleavage of PKCdelta and the regulation of cell apoptosis. , 2007, Cellular signalling.
[92] Hitoshi Takahashi,et al. The Lewy body in Parkinson's disease: Molecules implicated in the formation and degradation of α‐synuclein aggregates , 2007, Neuropathology : official journal of the Japanese Society of Neuropathology.
[93] J. Downward,et al. The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1 , 2007, Nature Cell Biology.
[94] J. Olzmann,et al. PINK1 Protects against Oxidative Stress by Phosphorylating Mitochondrial Chaperone TRAP1 , 2007, PLoS biology.
[95] P S Whitton,et al. Inflammation as a causative factor in the aetiology of Parkinson's disease , 2007, British journal of pharmacology.
[96] B. Bean,et al. Roles of Subthreshold Calcium Current and Sodium Current in Spontaneous Firing of Mouse Midbrain Dopamine Neurons , 2007, The Journal of Neuroscience.
[97] C. Olanow,et al. Ubiquitin–proteasome system and Parkinson's disease , 2006, Movement disorders : official journal of the Movement Disorder Society.
[98] Wolfgang Wurst,et al. A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo , 2006, Development.
[99] A. Graybiel. The basal ganglia: learning new tricks and loving it , 2005, Current Opinion in Neurobiology.
[100] B. Marchetti,et al. To be or not to be (inflamed)--is that the question in anti-inflammatory drug therapy of neurodegenerative disorders? , 2005, Trends in pharmacological sciences.
[101] Andreas Hald,et al. Oxidative stress and inflammation in Parkinson's disease: is there a causal link? , 2005, Experimental Neurology.
[102] C. Marsden,et al. Alterations in the distribution of glutathione in the substantia nigra in Parkinson's disease , 2005, Journal of Neural Transmission.
[103] E. Alnemri,et al. Regulation of HAX-1 Anti-apoptotic Protein by Omi/HtrA2 Protease during Cell Death* , 2004, Journal of Biological Chemistry.
[104] Sebastian Brandner,et al. Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Targeted Deletion in Mice , 2004, Molecular and Cellular Biology.
[105] R. Nusse,et al. The Wnt signaling pathway in development and disease. , 2004, Annual review of cell and developmental biology.
[106] A. Członkowska,et al. Dexamethasone protects against dopaminergic neurons damage in a mouse model of Parkinson's disease. , 2004, International immunopharmacology.
[107] Ke Cui,et al. Role of oxidative stress in neurodegeneration: recent developments in assay methods for oxidative stress and nutraceutical antioxidants , 2004, Progress in Neuro-Psychopharmacology and Biological Psychiatry.
[108] J. Andersen,et al. Oxidative stress in neurodegeneration: cause or consequence? , 2004, Nature Reviews Neuroscience.
[109] Alberto Gatti,et al. The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[110] R. Nussbaum,et al. Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1 , 2004, Science.
[111] Colin L. Masters,et al. Neurodegenerative diseases and oxidative stress , 2004, Nature Reviews Drug Discovery.
[112] Daniel Strickland,et al. Parkinson's prevalence estimated by a state registry , 2004, Movement disorders : official journal of the Movement Disorder Society.
[113] M. Kitazawa,et al. Proteolytic Activation of Proapoptotic Kinase PKCδ Is Regulated by Overexpression of Bcl‐2 , 2003 .
[114] S. Srinivasula,et al. Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice , 2003, Nature.
[115] M. Beal. Mitochondria, Oxidative Damage, and Inflammation in Parkinson's Disease , 2003, Annals of the New York Academy of Sciences.
[116] Roberto Colombo,et al. Protein carbonylation in human diseases. , 2003, Trends in molecular medicine.
[117] D. Lahiri,et al. Proteolytic activation of proapoptotic kinase PKCdelta is regulated by overexpression of Bcl-2: implications for oxidative stress and environmental factors in Parkinson's disease. , 2003, Annals of the New York Academy of Sciences.
[118] J. Yabut,et al. Glutathione depletion and oxidative stress. , 2002, Parkinsonism & related disorders.
[119] E. Esposito,et al. A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes , 2002, Neurobiology of Aging.
[120] Emad S. Alnemri,et al. Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi , 2002, Nature Structural Biology.
[121] E. Masliah,et al. α-Synuclein is phosphorylated in synucleinopathy lesions , 2002, Nature Cell Biology.
[122] Patrik Brundin,et al. Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein. , 2002, Nature reviews. Neuroscience.
[123] E. Masliah,et al. alpha-Synuclein is phosphorylated in synucleinopathy lesions. , 2002, Nature cell biology.
[124] David Blum,et al. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease , 2001, Progress in Neurobiology.
[125] E. Melamed,et al. Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier , 2001, Neuropharmacology.
[126] D. Kufe,et al. The ARG Tyrosine Kinase Interacts with Siva-1 in the Apoptotic Response to Oxidative Stress* , 2001, The Journal of Biological Chemistry.
[127] E. Joe,et al. Thrombin Induces NO Release from Cultured Rat Microglia via Protein Kinase C, Mitogen-activated Protein Kinase, and NF-κB* , 2000, The Journal of Biological Chemistry.
[128] Shinsei Minoshima,et al. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase , 2000, Nature Genetics.
[129] H. Braak,et al. Pathoanatomy of Parkinson’s disease , 2000, Journal of Neurology.
[130] Y. Naguib. Antioxidant activities of astaxanthin and related carotenoids. , 2000, Journal of agricultural and food chemistry.
[131] D. Kufe,et al. Interaction between Protein Kinase C δ and the c-Abl Tyrosine Kinase in the Cellular Response to Oxidative Stress* , 2000, The Journal of Biological Chemistry.
[132] M. Selley. (E)-4-hydroxy-2-nonenal may be involved in the pathogenesis of Parkinson's disease. , 1998, Free radical biology & medicine.
[133] E. Joe,et al. Mitogen‐activated protein kinases activated by lipopolysaccharide and β‐amyloid in cultured rat microglia , 1998 .
[134] C D Marsden,et al. Oxidative DNA Damage in the Parkinsonian Brain: An Apparent Selective Increase in 8‐Hydroxyguanine Levels in Substantia Nigra , 1997, Journal of neurochemistry.
[135] A. Schapira. OXIDATIVE STRESS IN PARKINSONS-DISEASE , 1995 .
[136] L. Forno. The Lewy body in Parkinson's disease. , 1987, Advances in neurology.
[137] J. Langston,et al. 1-Methyl-4-phenylpyridinium ion (MPP+): Identification of a metabolite of MPTP, a toxin selective to the substantia nigra , 1984, Neuroscience Letters.
[138] J. Mussini,et al. [Immunology of multiple sclerosis]. , 1982, La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris.