Origin of Life on Earth and Shannon's Theory of Communication

The genetic information system is segregated, linear and digital. It is astonishing that the technology of information theory and coding theory has been in place in biology for at least 3.850 billion years (Mojzsis, S.J., Kishnamurthy, Arrhenius, G., 1998. Before RNA and after: geological and geochemical constraints on molecular evolution 1-47. In: Gesteland, R.F. (Ed.), The RNA World: The Nature of Modern RNA Suggests a Prebiotic RNA, second ed. Cold Spring Harbor Laboratory Press, Boca Raton, FL). The genetic code performs a mapping between the sequences of the four nucleotides in mRNA to the sequences of the 20 amino acids in protein. It is highly relevant to the origin of life that the genetic code is constructed to confront and solve the problems of communication and recording by the same principles found both in the genetic information system and in modern computer and communication codes. There is nothing in the physico-chemical world that remotely resembles reactions being determined by a sequence and codes between sequences. The existence of a genome and the genetic code divides living organisms from non-living matter. If the historic process of the origin and evolution of life could be followed, it would prove to be a purely chemical process (Wächtershäuser, G., 1997. The origin of life and its methodological challenge. J. Theor. Biol. 187, 483-694). The question is whether this historic process or any reasonable part of it is available to human experiment and reasoning; there is no requirement that Nature's laws be plausible or even known to mankind. Bohr (Bohr, N., 1933. Light and life. Nature 308, 421-423, 456-459) argued that life is consistent with but undecidable by human reasoning from physics and chemistry. Perhaps scientists will come closer and closer to the riddle of how life emerged on Earth, but, like Zeno's Achilles, never achieve a complete solution.

[1]  B. McMillan.  The Basic Theorems of Information Theory , 1953 .

[2]  D. Deamer,et al.  The first living systems: a bioenergetic perspective , 1997, Microbiology and molecular biology reviews : MMBR.

[3]  R. Thorne,et al.  Phenetic and Phylogenetic Classification , 1964, Nature.

[4]  Richard W. Hamming,et al.  Coding and Information Theory , 2018, Feynman Lectures on Computation.

[5]  Gregory J. Chaitin,et al.  The Limits of Mathematics , 1995, J. Univers. Comput. Sci..

[6]  M. Eigen,et al.  The hypercycle. A principle of natural self-organization. Part A: Emergence of the hypercycle. , 1977, Die Naturwissenschaften.

[7]  When is random random? , 1990, Nature.

[8]  H. Yockey.  Walther Löb, Stanley L. Miller and Prebiotic "Building Blocks" in the Silent Electrical Discharge , 2015 .

[9]  L. Breiman.  The Individual Ergodic Theorem of Information Theory , 1957 .

[10]  W. Gilbert.  Origin of life: The RNA world , 1986, Nature.

[11]  J. Bové.  Wall-Less Prokaryotes of Plants , 1984 .

[12]  William Feller,et al.  An Introduction to Probability Theory and Its Applications , 1951 .

[13]  M. Kimura,et al.  The role of robustness and changeability on the origin and evolution of genetic codes. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[14]  W. Löb.  Über das Verhalten des Formamids unter der Wirkung der stillen Entladung Ein Beitrag zur Frage der Stickstoff-Assimilation , 1913 .

[15]  G Tononi,et al.  Measures of degeneracy and redundancy in biological networks. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[16]  W. Leinfelder,et al.  Gene for a novel tRNA species that accepts L-serine and cotranslationally inserts selenocysteine , 1988, Nature.

[17]  A. Lazcano,et al.  Oparin's ``Origin of Life'': Sixty Years Later , 1997, Journal of Molecular Evolution.

[18]  P. Diaconis,et al.  Matchings and phylogenetic trees. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[19]  Thomas L. Madden,et al.  Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. , 1997, Nucleic acids research.

[20]  P. Billingsley,et al.  Ergodic theory and information , 1966 .

[21]  Raymond F. Gesteland,et al.  Life Before DNA. (Book Reviews: The RNA World. The Nature of Modern RNA Suggests a Prebiotic RNA World.) , 1993 .

[22]  T. Cech,et al.  The intervening sequence RNA of Tetrahymena is an enzyme. , 1986, Science.

[23]  M H Freedman,et al.  Limit, logic, and computation , 1998, Proc. Natl. Acad. Sci. USA.

[24]  S. Fox,et al.  Experimental Retracement of Terrestrial Origin of an Excitable Cell: Was it Predictable? , 1996 .

[25]  Shōzō Ōsawa,et al.  Evolution of the genetic code , 1995 .

[26]  T. Jukes,et al.  Molecules and evolution , 1966 .

[27]  S J de Souza,et al.  Origin of genes. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[28]  C. Woese.  The universal ancestor. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[29]  L E Orgel,et al.  RNA catalysis and the origins of life. , 1986, Journal of theoretical biology.

[30]  R. Shapiro,et al.  Prebiotic cytosine synthesis: a critical analysis and implications for the origin of life. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[31]  L. Orgel,et al.  The maintenance of the accuracy of protein synthesis and its relevance to ageing. , 1963, Proceedings of the National Academy of Sciences of the United States of America.

[32]  L E Orgel,et al.  The maintenance of the accuracy of protein synthesis and its relevance to ageing: a correction. , 1970, Proceedings of the National Academy of Sciences of the United States of America.

[33]  A. Lazcano.  Chemical evolution and the primitive soup: did Oparin get it all right? , 1997, Journal of theoretical biology.

[34]  A. Brack.  The origin of life on Earth , 1991 .

[35]  W. Gilbert,et al.  The exon theory of genes. , 1987, Cold Spring Harbor symposia on quantitative biology.

[36]  C. Darwin.  On the Origin of Species by Means of Natural Selection: Or, The Preservation of Favoured Races in the Struggle for Life , 2019 .

[37]  S. Miller.  A production of amino acids under possible primitive earth conditions. , 1953, Science.

[38]  F. Cramer,et al.  Accuracy of protein biosynthesis: quasi-species nature of proteins and possibility of error catastrophes. , 1998, Journal of theoretical biology.

[39]  Hubert P. Yockey.  Information in bits and bytes. Reply to Lifson's review of ‘information theory and molecular biology’ , 1995 .

[40]  Cyril Ponnamperuma.  The Origin of Life in the Universe , 1964 .

[41]  Raymond M. Smullyan,et al.  Godel's Incompleteness Theorems , 1992 .

[42]  T. M. Sonneborn.  Degeneracy of the Genetic Code: Extent, Nature, and Genetic Implications , 1965 .

[43]  F H Crick,et al.  CODES WITHOUT COMMAS. , 1957, Proceedings of the National Academy of Sciences of the United States of America.

[44]  A. Shiryayev.  New Metric Invariant of Transitive Dynamical Systems and Automorphisms of Lebesgue Spaces , 1993 .

[45]  R. Miledi,et al.  Messenger RNA from human brain induces drug- and voltage-operated channels in Xenopus oocytes , 1984, Nature.

[46]  H. P. Yockey,et al.  Information Theory And Molecular Biology , 1992 .

[47]  A. Turing.  On Computable Numbers, with an Application to the Entscheidungsproblem. , 1937 .

[48]  S J Willson.  Measuring inconsistency in phylogenetic trees. , 1998, Journal of theoretical biology.

[49]  T. Cech,et al.  A model for the RNA-catalyzed replication of RNA. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[50]  S. Osawa,et al.  Recent evidence for evolution of the genetic code , 1992, Microbiological reviews.

[51]  V. Bryson,et al.  Evolving Genes and Proteins. , 1965, Science.

[52]  Maynard V. Olson.  A Time to Sequence , 1995, Science.

[53]  S. Pincus,et al.  Randomness and degrees of irregularity. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[54]  David P. Williamson,et al.  Approximation algorithms , 1997 .

[55]  M. Eigen,et al.  The Hypercycle: A principle of natural self-organization , 2009 .

[56]  G Tononi,et al.  A complexity measure for selective matching of signals by the brain. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[57]  G. Wächtershäuser,et al.  The origin of life and its methodological challenge. , 1997, Journal of theoretical biology.

[58]  J. Jungck,et al.  Experimental retracement of the origins of a protocell , 1995 .

[59]  P. Bork,et al.  Measuring genome evolution. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[60]  Claude E. Shannon,et al.  Prediction and Entropy of Printed English , 1951 .

[61]  C. E. SHANNON,et al.  A mathematical theory of communication , 1948, MOCO.

[62]  C. Darwin.  The Life and Letters of Charles Darwin , 1959, The Yale Journal of Biology and Medicine.

[63]  J. Smith,et al.  Biochemical evolution. I. Polymerization On internal, organophilic silica surfaces of dealuminated zeolites and feldspars. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[64]  Claude E. Shannon,et al.  The mathematical theory of communication , 1950 .

[65]  R. A. Fisher,et al.  The Genetical Theory of Natural Selection , 1931 .

[66]  H. P. Yockey,et al.  An application of information theory to the Central Dogma and the Sequence Hypothesis. , 1974, Journal of theoretical biology.

[67]  D. Ornstein.  Ergodic theory, randomness, and dynamical systems , 1974 .

[68]  F. Crick.  Central Dogma of Molecular Biology , 1970, Nature.

[69]  R. Sunde,et al.  Serine incorporation into the selenocysteine moiety of glutathione peroxidase. , 1987, The Journal of biological chemistry.

[70]  R E Kalman,et al.  Not all (possibly) "random" sequences are created equal. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[71]  R. Lemmon.  Chemical Evolution , 1972, Nature.

[72]  Nucleic acid enzymes: playing with a fuller deck. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[73]  T H Jukes,et al.  Evolutionary changes in the genetic code , 1990, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[74]  P. Shields.  The theory of Bernoulli shifts , 1973 .

[75]  N. Bohr.  Light and Life , 1933, Nature.

[76]  M. Levitt,et al.  A unified statistical framework for sequence comparison and structure comparison. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[77]  Vladimir A. Uspensky,et al.  Gödel's Incompleteness Theorem , 1989, Theor. Comput. Sci..

[78]  O. Baudisch.  Über Nitrat‐ und Nitritassimilation , 1913 .

[79]  I. Parsons,et al.  Biochemical evolution III: polymerization on organophilic silica-rich surfaces, crystal-chemical modeling, formation of first cells, and geological clues. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[80]  F. Crick.  Origin of the Genetic Code , 1967, Nature.

[81]  T. Mizutani,et al.  The conversion of phosphoserine residues to selenocysteine residues on an opal suppressor tRNA and casein , 1988, FEBS letters.

[82]  Friedrich Engels.  Dialectics of Nature , 1883 .

[83]  M. Levy,et al.  The stability of the RNA bases: implications for the origin of life. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[84]  Ernst Haeckel.  Generelle Morphologie der Organismen , 1866 .