Smart Polymeric Nanocarriers for Drug Delivery

Abstract: Smart polymeric nanocarriers are an important emerging area in drug delivery research. They are capable of releasing their payload in response to a specific stimulus, either present in the body or externally applied. We review the most important and extensively studied stimuli-responsive carriers, with special focus on their in vitro/in vivo preclinical evaluation. The most frequently studied stimuli include endogenous pH, enzymes and redox potential. Other emerging applications of externally applied stimuli such as temperature, magnetic field, ultrasound and light are also discussed. Finally, we close with an overall conclusion of the current state of the art and a look towards expected future breakthroughs using this type of nanocarrier.

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