Serotonin Reuptake Inhibitors, Epilepsy and Myoclonus

Specific inhibitors of 5-HT reuptake are reported to have lower preconvulsive activity than other antidepressants. A patient with post-traumatic epilepsy who had remained fit-free for many years until she was given the 5-HT reuptake inhibitor fluvoxamine is reported. Changes in serotonergic function may play a more widespread role in the pathophysiology of seizure disorders than hitherto thought.

[1]  K. Rijckevorsel-Harmant,et al.  Fluvoxamine: an antidepressant with low (or no) epileptogenic effect , 1990, The Lancet.

[2]  L. Dupuis,et al.  Contact Lens Damage Due to Ribavirin Exposure , 1989, DICP : the annals of pharmacotherapy.

[3]  Weber Jj.  Seizure activity associated with fluoxetine therapy. , 1989 .

[4]  R. Squires,et al.  Antidepressants and metabolites that block GABAA receptors coupled to 35S-t-butylbicyclophosphorothionate binding sites in rat brain , 1988, Brain Research.

[5]  Wernicke Jf.  The side effect profile and safety of fluoxetine. , 1985 .

[6]  B. Nilsson.  Adverse reactions in connection with zimeldine treatment — a review , 1983, Acta psychiatrica Scandinavica. Supplementum.

[7]  M. Trimble.  New antidepressant drugs and the seizure threshold , 1980, Neuropharmacology.

[8]  C. Goetz,et al.  Levodopa-induced myoclonus. , 1975, Archives of neurology.

[9]  G. Omenn.  Serotonin in Down's Syndrome , 1975 .

[10]  W. Weiner,et al.  5-Hydroxytryptophan induced behavior in intact guinea pigs. , 1973, Research communications in chemical pathology and pharmacology.

[11]  H. Pope,et al.  Does Fluoxetine Prolong Electrically Induced Seizures? , 1989, Convulsive therapy.

[12]  J. J. Weber.  Seizure activity associated with fluoxetine therapy. , 1989, Clinical pharmacy.

[13]  D. Bradford,et al.  Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model. , 1984, Neuropsychobiology.

[14]  S Watkins,et al.  The epilepsies. , 1968, Nursing times.