The control of epidemics taking place in complex networks has been an increasingly active topic in public health management. In this article, we propose an efficient networked epidemic control system, where a modified susceptible-exposed-infected-vigilant (SEIV) model is first built to simulate epidemic spreading. Then, different from existing continuous resource models which abstractly map resources to parameters of epidemic models, a concrete resource description model is built to simulate real-world goods/services and their allocation. Based on the two models, a cost-constraint subset selection problem in epidemic control is identified. To solve the problem, a swarm-based stochastic optimization policy is proposed, where each particle in the swarm can determine its own solutions according to the guidance of its superior peers and historical searching experience of the whole swarm, without extra problem-relative information. Theoretical proof about system equilibrium is provided, which is consistent with experimental observations. The competitive performance of the proposed optimizer is validated by theoretical analysis and comparison experiments. Finally, an application case is provided to illustrate the practicability.