The Fas death factor

Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express Fas, whereas FasL is expressed predominantly in activated T cells. In the immune system, Fas and FasL are involved in down-regulation of immune reactions as well as in T cell-mediated cytotoxicity. Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction.

[1]  A. Ryan.  Russell , 1996 .

[2]  P. Krammer,et al.  Autocrine T-cell suicide mediated by APO-1/(Fas/CD95) , 1995, Nature.

[3]  S. Nagata,et al.  TCR/CD3 coupling to Fas-based cytotoxicity , 1995, The Journal of experimental medicine.

[4]  S. Nagata,et al.  Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody , 1995, The Journal of experimental medicine.

[5]  John Calvin Reed,et al.  Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity , 1995, Cell.

[6]  S. Nagata,et al.  Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disorders. , 1995, The EMBO journal.

[7]  C. Smith,et al.  Fas ligand mediates activation-induced cell death in human T lymphocytes , 1995, The Journal of experimental medicine.

[8]  E. Lacy,et al.  Massive upregulation of the Fas ligand in lpr and gld mice: implications for Fas regulation and the graft-versus-host disease-like wasting syndrome , 1995, The Journal of experimental medicine.

[9]  S. Nagata,et al.  Fas and Fas ligand: lpr and gld mutations. , 1995, Immunology today.

[10]  M. Boguski,et al.  A novel RING finger protein interacts with the cytoplasmic domain of CD40. , 1994, The Journal of biological chemistry.

[11]  I. Behrmann,et al.  Structure of the human APO‐1 gene , 1994, European journal of immunology.

[12]  S. Nagata,et al.  Fas-mediated apoptosis in primary cultured mouse hepatocytes. , 1994, Experimental cell research.

[13]  P. Kourilsky,et al.  The expansion of a CD4+ T cell population bearing a distinctive β chain in MRL lpr/lpr mice suggests a role for the fas protein in peripheral T cell selection , 1994, European journal of immunology.

[14]  Y. Laouar,et al.  In vivo CD4+ lymph node T cells from lpr mice generate CD4-CD8-B220+TCR-beta low cells. , 1994, Journal of immunology.

[15]  H. Gresham,et al.  Spontaneous elaboration of transforming growth factor beta suppresses host defense against bacterial infection in autoimmune MRL/lpr mice , 1994, The Journal of experimental medicine.

[16]  D. Newmeyer,et al.  Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria , 1994, Cell.

[17]  Z. Oltvai,et al.  Checkpoints of dueling dimers foil death wishes , 1994, Cell.

[18]  N. Oyaizu,et al.  Cross-linking of CD4 molecules upregulates Fas antigen expression in lymphocytes by inducing interferon-gamma and tumor necrosis factor-alpha secretion. , 1994, Blood.

[19]  S. Nagata,et al.  Increased Fas antigen expression in murine retrovirus‐induced immunodeficiency syndrome, MAIDS , 1994, European journal of immunology.

[20]  K. Schulze-Osthoff,et al.  Divergent signalling via APO‐1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death. , 1994, The EMBO journal.

[21]  F. Ramsdell,et al.  Differential ability of Th1 and Th2 T cells to express Fas ligand and to undergo activation-induced cell death. , 1994, International immunology.

[22]  P. Golstein,et al.  T cell receptor‐induced Fas ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A , 1994, European journal of immunology.

[23]  J. Inazawa,et al.  Human Fas ligand: gene structure, chromosomal location and species specificity. , 1994, International immunology.

[24]  R. Testi,et al.  Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase , 1994, The Journal of experimental medicine.

[25]  K. Schulze-Osthoff,et al.  Cell nucleus and DNA fragmentation are not required for apoptosis , 1994, The Journal of cell biology.

[26]  M. Krönke,et al.  Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling , 1994, Cell.

[27]  C. Walsh,et al.  The role of the Fas lytic pathway in a perforin-less CTL hybridoma. , 1994, Journal of immunology.

[28]  C. Goodnow,et al.  Effects of the lpr mutation on elimination and inactivation of self-reactive B cells. , 1994, Journal of immunology.

[29]  S. Nagata,et al.  No requirement of reactive oxygen intermediates in Fas‐mediated apoptosis , 1994, FEBS letters.

[30]  M. Seldin,et al.  Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV‐1‐regulated protein gp34. , 1994, The EMBO journal.

[31]  C. M. Eischen,et al.  Tyrosine kinase activation provides an early and requisite signal for Fas-induced apoptosis. , 1994, Journal of immunology.

[32]  D. Goeddel,et al.  A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor , 1994, Cell.

[33]  J. Tschopp,et al.  Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways , 1994, Nature.

[34]  I. N. Crisps,et al.  Fatal interactions: fas-induced apoptosis of mature T cells , 1994 .

[35]  K. Okumura,et al.  Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes. , 1994, Immunity.

[36]  A. Abbas,et al.  The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. , 1994, Immunity.

[37]  I. Stamenkovic,et al.  Fas and tumor necrosis factor receptor-mediated cell death: similarities and distinctions , 1994, The Journal of experimental medicine.

[38]  H Hengartner,et al.  Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. , 1994, Science.

[39]  Z. Darżynkiewicz,et al.  CD4 engagement induces Fas antigen‐dependent apoptosis of T cells in vivo , 1994, European journal of immunology.

[40]  P. Krammer,et al.  Activation induces sensitivity toward APO-1 (CD95)-mediated apoptosis in human B cells. , 1994, Journal of immunology.

[41]  S. Yonehara,et al.  Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[42]  A. Benner,et al.  High expression of APO-1 (CD95) on T lymphocytes from human immunodeficiency virus-1-infected children. , 1994, Blood.

[43]  S. Ju,et al.  Participation of target Fas protein in apoptosis pathway induced by CD4+ Th1 and CD8+ cytotoxic T cells. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[44]  R. Kolesnick,et al.  The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling , 1994, Cell.

[45]  Hans Hengartner,et al.  Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice , 1994, Nature.

[46]  M R Alderson,et al.  The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster. , 1994, Immunity.

[47]  C. Sidman,et al.  A specific intercellular pathway of apoptotic cell death is defective in the mature peripheral T cells of autoimmune lpr and gld mice , 1994, European journal of immunology.

[48]  B. Beutler,et al.  Unraveling function in the TNF ligand and receptor families. , 1994, Science.

[49]  F. Ramsdell,et al.  gld/gld mice are unable to express a functional ligand for Fas , 1994, European journal of immunology.

[50]  P. Golstein,et al.  Fas‐based lymphocyte‐mediated cytotoxicity against syngeneic activated lymphocytes: A regulatory pathway? , 1994, European journal of immunology.

[51]  M. Raff,et al.  Programmed cell death and Bcl‐2 protection in the absence of a nucleus. , 1994, The EMBO journal.

[52]  Matthew J. Brauer,et al.  Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. , 1994, Science.

[53]  Terry Farrah,et al.  The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death , 1994, Cell.

[54]  N. Jenkins,et al.  Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand , 1994, Cell.

[55]  Timothy J. Ley,et al.  Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells , 1994, Cell.

[56]  J. Mountz,et al.  Correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[57]  S. Nagata,et al.  Purification and characterization of the Fas-ligand that induces apoptosis , 1994, The Journal of experimental medicine.

[58]  D. Goeddel,et al.  Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways. , 1994, Journal of immunology.

[59]  P. Erb,et al.  Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity. , 1994, Journal of immunology.

[60]  M. Seldin,et al.  The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L- arginine , 1994, The Journal of experimental medicine.

[61]  H. Boehmer.  Positive selection of lymphocytes , 1994, Cell.

[62]  G. J. V. Nossal,et al.  Negative selection of lymphocytes , 1994, Cell.

[63]  J. Sprent,et al.  Expansion/deletion of mature T cells exposed to endogenous superantigens in vivo. , 1994, Journal of immunology.

[64]  S. Grant,et al.  Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[65]  N. Hayashi,et al.  Immunohistochemical detection of Fas antigen in liver tissue of patients with chronic hepatitis C , 1993, Hepatology.

[66]  E. Lacy,et al.  The onset of Fas expression parallels the acquisition of CD8 and CD4 in fetal and adult αβ thymocytes , 1994 .

[67]  S. Nagata,et al.  Fas and Fas ligand: a death factor and its receptor. , 1994, Advances in immunology.

[68]  Takashi Suda,et al.  Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family , 1993, Cell.

[69]  Junying Yuan,et al.  Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3 , 1993, Cell.

[70]  F. Chisari,et al.  Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis , 1993, The Journal of experimental medicine.

[71]  B. Barres,et al.  Programmed cell death and the control of cell survival: lessons from the nervous system. , 1993, Science.

[72]  R. Eisenberg,et al.  Selection of the T cell receptor repertoire in Lpr mice. , 1993, Journal of immunology.

[73]  Y. Lazebnik,et al.  Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis , 1993, The Journal of cell biology.

[74]  L. Tartaglia,et al.  A novel domain within the 55 kd TNF receptor signals cell death , 1993, Cell.

[75]  J. Russell,et al.  Autoimmune gld mutation uncouples suicide and cytokine/proliferation pathways in activated, mature T cells , 1993, European journal of immunology.

[76]  S. Nagata,et al.  Lethal effect of the anti-Fas antibody in mice , 1993, Nature.

[77]  Shuji Takahashi,et al.  Establishment of apoptosis‐inducing monoclonal antibody 2D1 and 2D1‐resistant variants of human T cell lines , 1993, European journal of immunology.

[78]  J. Mountz,et al.  Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene , 1993, The Journal of experimental medicine.

[79]  K. Elkon,et al.  The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn , 1993, The Journal of experimental medicine.

[80]  S. Nagata,et al.  Effect of bcl-2 on Fas antigen-mediated cell death. , 1993, Journal of immunology.

[81]  T. Pohl,et al.  Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes. , 1993, Immunology today.

[82]  P. Krammer,et al.  Activation interferes with the APO-1 pathway in mature human T cells. , 1993, International immunology.

[83]  S. Nagata,et al.  A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. , 1993, The Journal of biological chemistry.

[84]  C. Weaver,et al.  Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[85]  P. Marrack,et al.  Profound deletion of mature T cells in vivo by chronic exposure to exogenous superantigen. , 1993, Journal of immunology.

[86]  P. Möller,et al.  Coregulation of the APO-1 antigen with intercellular adhesion molecule-1 (CD54) in tonsillar B cells and coordinate expression in follicular center B cells and in follicle center and mediastinal B-cell lymphomas. , 1993, Blood.

[87]  T. Uede,et al.  Transcriptional repression and differential splicing of Fas mRNA by early transposon (ETn) insertion in autoimmune lpr mice. , 1993, Biochemical and biophysical research communications.

[88]  S. Nagata,et al.  Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[89]  P. Golstein,et al.  Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity , 1993, The Journal of experimental medicine.

[90]  T. Miyawaki,et al.  Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood. , 1992, Journal of immunology.

[91]  M. Seldin,et al.  Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci , 1992, The Journal of experimental medicine.

[92]  P. Möller,et al.  Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens. , 1992, Journal of immunology.

[93]  J. Inazawa,et al.  Assignment of the human Fas antigen gene (Fas) to 10q24.1. , 1992, Genomics.

[94]  J. Shiver,et al.  Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A , 1992, Cell.

[95]  P. Lichter,et al.  The human APO-1 (APT) antigen maps to 10q23, a region that is syntenic with mouse chromosome 19. , 1992, Genomics.

[96]  E. Jaffe,et al.  A novel lymphoproliferative/autoimmune syndrome resembling murine lpr/gld disease. , 1992, The Journal of clinical investigation.

[97]  G. Lenoir,et al.  Expression of the APO-1 antigen in Burkitt lymphoma cell lines correlates with a shift towards a lymphoblastoid phenotype. , 1992, Blood.

[98]  M. Pawlita,et al.  Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen. , 1992, The Journal of biological chemistry.

[99]  M. Raff,et al.  Social controls on cell survival and cell death , 1992, Nature.

[100]  N. Copeland,et al.  Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis , 1992, Nature.

[101]  L. Owen-Schaub,et al.  DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement. , 1992, Cellular immunology.

[102]  N. Copeland,et al.  The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. , 1992, Journal of immunology.

[103]  H. von Boehmer,et al.  Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice , 1992, European journal of immunology.

[104]  R. Aebersold,et al.  A natural killer cell granule protein that induces DNA fragmentation and apoptosis , 1992, The Journal of experimental medicine.

[105]  K. Rajewsky.  Early and late B-cell development in the mouse. , 1992 .

[106]  V. Fadok,et al.  Apoptosis and programmed cell death in immunity. , 1992, Annual review of immunology.

[107]  L. David Tomei,et al.  Apoptosis: The Molecular Basis of Cell Death , 1991 .

[108]  A. Sher,et al.  Diversity of Cytokine Synthesis and Function of Mouse CD4+ T Cells , 1991, Immunological reviews.

[109]  H. Macdonald,et al.  Clonal expansion precedes anergy and death of Vβ8+ peripheral T cells responding to staphylococcal enterotoxin B in vivo , 1991, European journal of immunology.

[110]  Atsushi Hase,et al.  The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis , 1991, Cell.

[111]  B. Rocha,et al.  Peripheral selection of the T cell repertoire. , 1991, Science.

[112]  R. Eisenberg,et al.  Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. , 1991, Annual review of immunology.

[113]  J. Sprent,et al.  Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity , 1990, Cell.

[114]  N. Yamamoto,et al.  Anti-Fas monoclonal antibody is cytocidal to human immunodeficiency virus-infected cells without augmenting viral replication. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[115]  J. D. Marshall,et al.  Differences defined by bone marrow transplantation suggest that lpr and gld are mutations of genes encoding an interacting pair of molecules. , 1990, The Journal of experimental medicine.

[116]  Ishiura Shoichi,et al.  Calcium is essential for both the membrane binding and lytic activity of pore-forming protein (perforin) from cytotoxic T-lymphocyte☆ , 1990 .

[117]  M. Egerton,et al.  Kinetics of mature T-cell development in the thymus. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[118]  T. Waldmann,et al.  Monoclonal-antibody-mediated apoptosis in adult T-cell leukaemia , 1990, The Lancet.

[119]  T. Katagiri,et al.  A new allele of the lpr locus, lprcg, that complements the gld gene in induction of lymphadenopathy in the mouse , 1990, The Journal of experimental medicine.

[120]  P. Möller,et al.  Monoclonal antibody-mediated tumor regression by induction of apoptosis. , 1989, Science.

[121]  S. Yonehara,et al.  A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor , 1989, The Journal of experimental medicine.

[122]  S. Jonjić,et al.  Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes , 1989, The Journal of experimental medicine.

[123]  D. Purves.  Body and Brain: A Trophic Theory of Neural Connections , 1988 .

[124]  J. D. Young,et al.  A calcium- and perforin-independent pathway of killing mediated by murine cytolytic lymphocytes , 1987, The Journal of experimental medicine.

[125]  M. Sitkovsky,et al.  Exocytosis of cytolytic granules may not be required for target cell lysis by cytotoxic T-lymphocytes , 1987, Nature.

[126]  J. D. Young,et al.  Dissociation of membrane binding and lytic activities of the lymphocyte pore-forming protein (perforin) , 1987, The Journal of experimental medicine.

[127]  H. Ostergaard,et al.  Cytotoxic T lymphocyte mediated lysis without release of serine esterase , 1987, Nature.

[128]  J. D. Young,et al.  Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[129]  G. Berke,et al.  T-Lymphocyte-mediated cytolysis as an excitatory process of the target. I. Evidence that the target cell may be the site of Ca2+ action. , 1985, Cellular immunology.

[130]  R. Balderas,et al.  Association of lpr gene with graft-vs.-host disease-like syndrome , 1985, The Journal of experimental medicine.

[131]  P. Henkart.  Mechanism of lymphocyte-mediated cytotoxicity. , 1985, Annual review of immunology.

[132]  E. Podack.  The molecular mechanism of lymphocyte-mediated tumor cell lysis. , 1985, Immunology today.

[133]  V. Kelley,et al.  Induction of various autoantibodies by mutant gene lpr in several strains of mice. , 1984, Journal of immunology.

[134]  E. Eicher,et al.  A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice , 1984, The Journal of experimental medicine.

[135]  I. Weissman,et al.  Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice , 1980, European journal of immunology.

[136]  I. Maclennan,et al.  Limited specific T-cell mediated cytolysis in the absence of extracellular Ca2+. , 1980, Immunology.

[137]  A. Theofilopoulos,et al.  Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains , 1978, The Journal of experimental medicine.