Progress and problems in the application of focused ultrasound for blood-brain barrier disruption.

[1]  Kullervo Hynynen,et al.  Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium. , 2008, Ultrasound in medicine & biology.

[2]  K. Hynynen,et al.  Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption. , 2008, Ultrasound in medicine & biology.

[3]  K. Hynynen,et al.  Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index. , 2008, Ultrasound in medicine & biology.

[4]  N. Vykhodtseva,et al.  6A-4 Focused Ultrasound Potential to Initiate Spreading Depression for Disruption of Blood Brain Barrier , 2007, 2007 IEEE Ultrasonics Symposium Proceedings.

[5]  Kullervo Hynynen,et al.  Cavitation threshold of microbubbles in gel tunnels by focused ultrasound. , 2007, Ultrasound in medicine & biology.

[6]  Natalia Vykhodtseva,et al.  Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI‐guided focused ultrasound , 2007, International journal of cancer.

[7]  D. Salvadori,et al.  Tomato-oleoresin supplement prevents doxorubicin-induced cardiac myocyte oxidative DNA damage in rats. , 2007, Mutation research.

[8]  G. Mantovani,et al.  A multicenter phase II study of pegylated liposomal doxorubicin and oxaliplatin in recurrent ovarian cancer. , 2007, Gynecologic oncology.

[9]  S. Pignata,et al.  A multicentre phase II study of carboplatin plus pegylated liposomal doxorubicin as first-line chemotherapy for patients with advanced or recurrent endometrial carcinoma: the END-1 study of the MITO (Multicentre Italian Trials in Ovarian Cancer and Gynecologic Malignancies) group , 2007, British Journal of Cancer.

[10]  N. Pimpinelli,et al.  Pegylated liposomal doxorubicin in the treatment of primary cutaneous T-cell lymphomas. , 2007, Haematologica.

[11]  M. Gilbert,et al.  Molecularly targeted therapies for malignant gliomas: advances and challenges , 2007, Expert review of anticancer therapy.

[12]  K. Itoh,et al.  Peptide-based immunotherapeutic approaches to glioma: a review , 2007, Expert opinion on biological therapy.

[13]  K. Hynynen,et al.  Use of ultrasound pulses combined with Definity for targeted blood-brain barrier disruption: a feasibility study. , 2007, Ultrasound in medicine & biology.

[14]  R. Berardi,et al.  Chemotherapy for advanced gastric cancer: across the years for a standard of care , 2007, Expert opinion on pharmacotherapy.

[15]  M. Lesniak,et al.  Convection enhanced drug delivery of novel therapeutic agents to malignant brain tumors. , 2007, Current drug delivery.

[16]  D. Gerber,et al.  Emerging monoclonal antibody therapies for malignant gliomas , 2007, Expert opinion on investigational drugs.

[17]  G. Takemura,et al.  Doxorubicin-induced cardiomyopathy from the cardiotoxic mechanisms to management. , 2007, Progress in cardiovascular diseases.

[18]  G. von Minckwitz Docetaxel/anthracycline combinations for breast cancer treatment , 2007, Expert opinion on pharmacotherapy.

[19]  K. Hynynen,et al.  Modular design for in vivo optical imaging and ultrasound treatment in the murine brain , 2007, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[20]  K. Hynynen,et al.  Multiphoton Imaging of Ultrasound/Optison Mediated Cerebrovascular Effects in vivo , 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[21]  Bhawna Gupta,et al.  Monoclonal antibody 2C5-modified doxorubicin-loaded liposomes with significantly enhanced therapeutic activity against intracranial human brain U-87 MG tumor xenografts in nude mice , 2007, Cancer Immunology, Immunotherapy.

[22]  W. Scheithauer,et al.  Phase II trial of pegylated liposomal doxorubicin (Caelyx™) plus Gemcitabine in chemotherapeutically pretreated patients with advanced breast cancer , 2007, Acta oncologica.

[23]  C. Palmieri,et al.  AIDS-related non-Hodgkin's lymphoma in the first decade of highly active antiretroviral therapy. , 2006, QJM : monthly journal of the Association of Physicians.

[24]  Yi Ai,et al.  Point source concentration of GDNF may explain failure of phase II clinical trial , 2006, Experimental Neurology.

[25]  Katherine W Ferrara,et al.  Acoustic response of compliable microvessels containing ultrasound contrast agents , 2006, Physics in medicine and biology.

[26]  O. Hamill,et al.  Twenty odd years of stretch-sensitive channels , 2006, Pflügers Archiv.

[27]  Y. Tabata,et al.  Local delivery of doxorubicin for malignant glioma by a biodegradable PLGA polymer sheet. , 2006, Anticancer research.

[28]  Kullervo Hynynen,et al.  Brain arterioles show more active vesicular transport of blood-borne tracer molecules than capillaries and venules after focused ultrasound-evoked opening of the blood-brain barrier. , 2006, Ultrasound in medicine & biology.

[29]  T. Wallimann,et al.  New insights into doxorubicin-induced cardiotoxicity: the critical role of cellular energetics. , 2006, Journal of molecular and cellular cardiology.

[30]  Natalia Vykhodtseva,et al.  Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery. , 2006, Journal of neurosurgery.

[31]  D D Allen,et al.  The blood-brain barrier and brain drug delivery. , 2006, Journal of nanoscience and nanotechnology.

[32]  R. Livingston,et al.  Capecitabine therapy for refractory metastatic thyroid carcinoma: a case series. , 2006, Thyroid : official journal of the American Thyroid Association.

[33]  W. Pardridge Molecular Trojan horses for blood-brain barrier drug delivery. , 2006, Discovery medicine.

[34]  Kullervo Hynynen,et al.  Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain--a primate study. , 2006, European journal of radiology.

[35]  Manabu Kinoshita,et al.  Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[36]  N. Vykhodtseva,et al.  Steady Potential Changes and Spreading Depression in Rat Brains Produced by Focused Ultrasound , 2006 .

[37]  W. Hall,et al.  Osmotic blood–brain barrier disruption chemotherapy for diffuse pontine gliomas , 2006, Journal of Neuro-Oncology.

[38]  Jianying Cui,et al.  Bubble pulsations between parallel plates. , 2006, The Journal of the Acoustical Society of America.

[39]  A. Jemal,et al.  Cancer Statistics, 2006 , 2006, CA: a cancer journal for clinicians.

[40]  K. Hynynen,et al.  Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound. , 2006, Biochemical and biophysical research communications.

[41]  K. Hynynen,et al.  Targeted disruption of the blood–brain barrier with focused ultrasound: association with cavitation activity , 2006, Physics in medicine and biology.

[42]  Paul A. Dayton,et al.  Microbubble oscillation in tubes with diameters of 12, 25, and 195 microns , 2006 .

[43]  S. Roman,et al.  Adrenocortical carcinoma , 2006, Current opinion in oncology.

[44]  E. Winer,et al.  Isolated central nervous system metastases in patients with HER2-overexpressing advanced breast cancer treated with first-line trastuzumab-based therapy. , 2005, Annals of oncology : official journal of the European Society for Medical Oncology.

[45]  Natalia Vykhodtseva,et al.  MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits. , 2005, Ultrasound in medicine & biology.

[46]  I. Nagata,et al.  Induced Spreading Depression Activates Persistent Neurogenesis in the Subventricular Zone, Generating Cells With Markers for Divided and Early Committed Neurons in the Caudate Putamen and Cortex , 2005, Stroke.

[47]  Kullervo Hynynen,et al.  A numerical study of transcranial focused ultrasound beam propagation at low frequency , 2005, Physics in medicine and biology.

[48]  W. K. Cullen,et al.  Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo , 2005, Nature Medicine.

[49]  M. Dietlein,et al.  Imaging of central nervous system lymphomas with iodine‐123 labeled rituximab , 2005, European journal of haematology.

[50]  C. Milstein,et al.  Pillars Article: Continuous cultures of fused cells secreting antibody of predefined specificity. Nature, 1975, 256 (5517): 495–497. , 2005 .

[51]  Ferenc A. Jolesz,et al.  Local and reversible blood–brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications , 2005, NeuroImage.

[52]  M. Mayberg,et al.  The cerebral vasculature as a therapeutic target for neurological disorders and the role of shear stress in vascular homeostatis and pathophysiology , 2004, Neurological research.

[53]  Wen-Zhi Chen,et al.  Extracorporeal High Intensity Focused Ultrasound Ablation in the Treatment of Patients with Large Hepatocellular Carcinoma , 2004, Annals of Surgical Oncology.

[54]  M Mazumdar,et al.  Neo-adjuvant chemotherapy for primary high-grade extremity soft tissue sarcoma. , 2004, Annals of oncology : official journal of the European Society for Medical Oncology.

[55]  Gunnar P. H. Dietz,et al.  Delivery of bioactive molecules into the cell: the Trojan horse approach , 2004, Molecular and Cellular Neuroscience.

[56]  Geoffrey S Ginsburg,et al.  Targeted therapies for cancer 2004. , 2004, American journal of clinical pathology.

[57]  Kenichi Murao,et al.  Spreading depression induces long-lasting brain protection against infarcted lesion development via BDNF gene-dependent mechanism , 2004, Brain Research.

[58]  Nico de Jong,et al.  Micromanipulation of endothelial cells: ultrasound-microbubble-cell interaction. , 2004, Ultrasound in medicine & biology.

[59]  K. Hynynen,et al.  Resonance frequency of microbubbles in small blood vessels: a numerical study , 2004, IEEE Ultrasonics Symposium, 2004.

[60]  Willem Boogerd,et al.  Modulation of the blood-brain barrier in oncology: therapeutic opportunities for the treatment of brain tumours? , 2004, Cancer treatment reviews.

[61]  K. Hynynen,et al.  Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles. , 2004, Ultrasound in medicine & biology.

[62]  Natalia Vykhodtseva,et al.  500‐element ultrasound phased array system for noninvasive focal surgery of the brain: A preliminary rabbit study with ex vivo human skulls , 2004, Magnetic resonance in medicine.

[63]  R. Bukowski,et al.  The promise of targeted therapy: cancer drugs become more specific. , 2004, Cleveland Clinic journal of medicine.

[64]  W. Pardridge Intravenous, non-viral RNAi gene therapy of brain cancer , 2004, Expert opinion on biological therapy.

[65]  M. Haluska,et al.  Osmotic blood-brain barrier modification for the treatment of malignant brain tumors. , 2004, Clinical journal of oncology nursing.

[66]  Hongwei Jin,et al.  Cortical spreading depression activates and upregulates MMP-9. , 2004, The Journal of clinical investigation.

[67]  M. Harris Monoclonal antibodies as therapeutic agents for cancer. , 2004, The Lancet. Oncology.

[68]  Gregory T. Clement,et al.  The feasibility of noninvasive image‐guided treatments of brain disorders by focused ultrasound , 2004 .

[69]  L. Curiel,et al.  Local recurrence of prostate cancer after external beam radiotherapy: early experience of salvage therapy using high-intensity focused ultrasonography. , 2004, Urology.

[70]  Cheri X Deng,et al.  Ultrasound-induced cell membrane porosity. , 2004, Ultrasound in medicine & biology.

[71]  Emil-Alexandru Brujan,et al.  The role of cavitation microjets in the therapeutic applications of ultrasound. , 2004, Ultrasound in medicine & biology.

[72]  Roy W. Martin,et al.  Liver Hemostasis With High‐Intensity Ultrasound , 2004, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[73]  Wen-zhi Chen,et al.  A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer , 2003, British Journal of Cancer.

[74]  D. Hawkins,et al.  Pattern of disease recurrence and prognostic factors in patients with osteosarcoma treated with contemporary chemotherapy , 2003, Cancer.

[75]  D. Gianfelice,et al.  MR Imaging-guided Focused Ultrasound Surgery of Breast Cancer: Correlation of Dynamic Contrast-enhanced MRI with Histopathologic Findings , 2003, Breast Cancer Research and Treatment.

[76]  E. Neuwelt,et al.  BR96–DOX Immunoconjugate Targeting of Chemotherapy in Brain Tumor Models , 2003, Journal of Neuro-Oncology.

[77]  Volker Sturm,et al.  Imaging‐guided convection‐enhanced delivery and gene therapy of glioblastoma , 2003, Annals of neurology.

[78]  M Pernot,et al.  High power transcranial beam steering for ultrasonic brain therapy. , 2003, Physics in medicine and biology.

[79]  R. J. Cersosimo,et al.  Monoclonal antibodies in the treatment of cancer, Part 1. , 2003, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

[80]  Shahram Vaezy,et al.  High-intensity focused US: a potential new treatment for GI bleeding. , 2003, Gastrointestinal endoscopy.

[81]  Yi Ai,et al.  Intraputamenal infusion of GDNF in aged rhesus monkeys: Distribution and dopaminergic effects , 2003, The Journal of comparative neurology.

[82]  E. Winer,et al.  Central nervous system metastases in women who receive trastuzumab‐based therapy for metastatic breast carcinoma , 2003, Cancer.

[83]  E. Lower,et al.  Increased rate of brain metastasis with trastuzumab therapy not associated with impaired survival. , 2003, Clinical breast cancer.

[84]  W. Pardridge Blood-brain barrier drug targeting: the future of brain drug development. , 2003, Molecular interventions.

[85]  Kullervo Hynynen,et al.  MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study. , 2003, Radiology.

[86]  K. Hynynen,et al.  The threshold for brain damage in rabbits induced by bursts of ultrasound in the presence of an ultrasound contrast agent (Optison). , 2003, Ultrasound in medicine & biology.

[87]  M Tanter,et al.  Experimental demonstration of noninvasive transskull adaptive focusing based on prior computed tomography scans. , 2003, The Journal of the Acoustical Society of America.

[88]  W. Pardridge Neurotrophins, neuroprotection and the blood-brain barrier. , 2002, Current opinion in investigational drugs.

[89]  G. Jurkovich,et al.  Spleen hemostasis using high-intensity ultrasound: survival and healing. , 2002, The Journal of trauma.

[90]  W. Pardridge,et al.  Drug and Gene Delivery to the Brain The Vascular Route , 2002, Neuron.

[91]  Wen-zhi Chen,et al.  [High intensity focused ultrasound in the treatment of primary malignant bone tumor]. , 2002, Zhonghua zhong liu za zhi [Chinese journal of oncology].

[92]  Shahram Vaezy,et al.  An image-guided high intensity focused ultrasound device for uterine fibroids treatment. , 2002, Medical physics.

[93]  R. Bell What Can We Learn from Herceptin® Trials in Metastatic Breast Cancer? , 2002, Oncology.

[94]  K. Possinger,et al.  Chemotherapy for Breast Cancer Brain Metastases , 2002, Oncology Research and Treatment.

[95]  G. Giaccone,et al.  Standard versus intensified chemotherapy with granulocyte colony-stimulating factor support in small-cell lung cancer: a prospective European Organization for Research and Treatment of Cancer-Lung Cancer Group Phase III Trial-08923. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[96]  Peter Alken,et al.  High intensity focused ultrasound as noninvasive therapy for multilocal renal cell carcinoma: case study and review of the literature. , 2002, The Journal of urology.

[97]  Gregory T. Clement,et al.  A non-invasive method for focusing ultrasound through the human skull. , 2002, Physics in medicine and biology.

[98]  R. Coleman,et al.  Phase II trial of murine (131)I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomas. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[99]  H. Winn,et al.  High-intensity focused ultrasound selectively disrupts the blood-brain barrier in vivo. , 2002, Ultrasound in medicine & biology.

[100]  W. Pardridge,et al.  Drug and gene targeting to the brain with molecular trojan horses , 2002, Nature Reviews Drug Discovery.

[101]  Jifeng Feng,et al.  A Phase II Study of Etoposide, Doxorubicin, and Carboplatin in the Treatment of Advanced Gastric Cancer , 2002, American journal of clinical oncology.

[102]  B. Anderson,et al.  A new method for the investigation of capillary structure , 2002, Journal of Neuroscience Methods.

[103]  E. Lo,et al.  Drug delivery to damaged brain , 2001, Brain Research Reviews.

[104]  W. Pardridge Brain drug targeting and gene technologies. , 2001, Japanese journal of pharmacology.

[105]  K. Hynynen,et al.  Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits. , 2001, Radiology.

[106]  J. Ridet,et al.  Recombinant proteins for neurodegenerative diseases: the delivery issue , 2001, Trends in Neurosciences.

[107]  G. Somjen Mechanisms of spreading depression and hypoxic spreading depression-like depolarization. , 2001, Physiological reviews.

[108]  L. Crum,et al.  Therapeutic Ultrasound, Part II * . High Intensity Focused Ultrasound: A Method of Hemostasis , 2001 .

[109]  G. Haar,et al.  High Intensity Focused Ultrasound for the Treatment of Tumors , 2001, Echocardiography.

[110]  J. Kreuter,et al.  Nanoparticulate systems for brain delivery of drugs. , 2001, Advanced drug delivery reviews.

[111]  Ennis,et al.  Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. , 2001, The New England journal of medicine.

[112]  W L Nyborg,et al.  Biological effects of ultrasound: development of safety guidelines. Part II: general review. , 2001, Ultrasound in medicine & biology.

[113]  Ralph A. Nixon,et al.  Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease , 2000, Nature.

[114]  W L Nyborg,et al.  Biological effects of ultrasound: development of safety guidelines. Part I: personal histories. , 2000, Ultrasound in medicine & biology.

[115]  F A Jolesz,et al.  MRI detection of the thermal effects of focused ultrasound on the brain. , 2000, Ultrasound in medicine & biology.

[116]  David Fortin,et al.  Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood‐brain barrier for the treatment of patients with malignant brain tumors , 2000, Cancer.

[117]  Ajay,et al.  Designing libraries with CNS activity. , 1999, Journal of medicinal chemistry.

[118]  Jennifer K. Sun,et al.  Phased array development for noninvasive focused ultrasound therapy of brain and liver , 1999, Proceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society (Cat. N.

[119]  J. Kreuter,et al.  Significant Transport of Doxorubicin into the Brain with Polysorbate 80-Coated Nanoparticles , 1999, Pharmaceutical Research.

[120]  S. Schwarze,et al.  In vivo protein transduction: delivery of a biologically active protein into the mouse. , 1999, Science.

[121]  J. Borredon,et al.  Dynamic In Vivo Measurement of Erythrocyte Velocity and Flow in Capillaries and of Microvessel Diameter in the Rat Brain by Confocal Laser Microscopy , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[122]  K Hynynen,et al.  Ultrasound technology for hyperthermia. , 1999, Ultrasound in medicine & biology.

[123]  Alexander Sasha Rabchevsky,et al.  Peripheral injections of Freund's adjuvant in mice provoke leakage of serum proteins through the blood–brain barrier without inducing reactive gliosis , 1999, Brain Research.

[124]  M. Singh,et al.  Transferrin As A targeting ligand for liposomes and anticancer drugs. , 1999, Current pharmaceutical design.

[125]  K Hynynen,et al.  The potential of transskull ultrasound therapy and surgery using the maximum available skull surface area. , 1999, The Journal of the Acoustical Society of America.

[126]  N. Fisk,et al.  Vascular occlusion using focused ultrasound surgery for use in fetal medicine. , 1999, European journal of ultrasound : official journal of the European Federation of Societies for Ultrasound in Medicine and Biology.

[127]  A. Stan,et al.  Doxorubicin-induced cell death in highly invasive human gliomas. , 1999, Anticancer research.

[128]  J. Chapelon,et al.  Treatment of localised prostate cancer with transrectal high intensity focused ultrasound. , 1999, European journal of ultrasound : official journal of the European Federation of Societies for Ultrasound in Medicine and Biology.

[129]  W. Pardridge,et al.  Non-invasive drug delivery to the human brain using endogenous blood-brain barrier transport systems. , 1999, Pharmaceutical science & technology today.

[130]  K. Hynynen,et al.  Focusing of therapeutic ultrasound through a human skull: a numerical study. , 1998, The Journal of the Acoustical Society of America.

[131]  V. Perry,et al.  CXC chemokines generate age-related increases in neutrophil-mediated brain inflammation and blood–brain barrier breakdown , 1998, Current Biology.

[132]  V. Perry,et al.  Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood–brain barrier breakdown in vivo , 1998, Neuroscience.

[133]  A. Prosperetti,et al.  Physics of acoustic cavitation in liquids: H. G. Flynn’s review 35 years later , 1998 .

[134]  Keith L Black,et al.  Intracarotid low dose bradykinin infusion selectively increases tumor permeability through activation of bradykinin B2 receptors in malignant gliomas , 1998, Brain Research.

[135]  E. Neuwelt,et al.  Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means. , 1998, Neurosurgery.

[136]  P. Kornblith Outwitting the Blood-Brain Barrier for Therapeutic Purposes: Osmotic Opening and Other Means , 1998 .

[137]  F A Jolesz,et al.  Demonstration of potential noninvasive ultrasound brain therapy through an intact skull. , 1998, Ultrasound in medicine & biology.

[138]  K. Chew,et al.  HER2/Neu and the Ets transcription activator PEA3 are coordinately upregulated in human breast cancer , 1997, Oncogene.

[139]  D. Trombetta,et al.  Changes in the permeability of the blood-brain barrier following sodium dodecyl sulphate administration in the rat , 1997, Experimental Brain Research.

[140]  A. Lindemann,et al.  Chemotherapeutic induction of long-term remission in metastatic medulloblastoma , 1997, Journal of Neuro-Oncology.

[141]  J. Huwyler,et al.  Brain drug delivery of small molecules using immunoliposomes. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[142]  J. Katz,et al.  Jets from collapsing bubbles , 1996, Proceedings of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences.

[143]  W. Mark Saltzman,et al.  Chemotherapeutic Drugs Released from Polymers: Distribution of 1,3-bis(2-chloroethyl)-l-nitrosourea in the Rat Brain , 1996, Pharmaceutical Research.

[144]  T. Leighton,et al.  The one-dimensional bubble: an unusual oscillator, with applications to human bioeffects of underwater sound , 1995 .

[145]  W. Mark Saltzman,et al.  Distribution of nerve growth factor following direct delivery to brain interstitium , 1995, Brain Research.

[146]  B. Öztaş,et al.  Intracarotid hypothermic saline infusion: a new method for reversible blood-brain barrier disruption in anesthetized rats , 1995, Neuroscience Letters.

[147]  P. Mcnaughton,et al.  Plasma albumin is a potent trigger of calcium signals and DNA synthesis in astrocytes. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[148]  W. Pardridge,et al.  Transport of Human Recombinant Brain-Derived Neurotrophic Factor (BDNF) Through the Rat Blood−Brain Barrier in Vivo Using Vector-Mediated Peptide Drug Delivery , 1994, Pharmaceutical Research.

[149]  M. Radeke,et al.  Distribution of Intracerebral Ventricularly Administered Neurotrophins in Rat Brain and Its Correlation with Trk Receptor Expression , 1994, Experimental Neurology.

[150]  T. Leighton The Acoustic Bubble , 1994 .

[151]  U. Bickel,et al.  Delivery of peptides and proteins through the blood-brain barrier. , 1993, Advanced drug delivery reviews.

[152]  P. Riesz,et al.  Free radical formation induced by ultrasound and its biological implications. , 1992, Free radical biology & medicine.

[153]  W. Pardridge Advances in cell biology of blood-brain barrier transport. , 1991, Seminars in cell biology.

[154]  E. Russell Ritenour,et al.  Ultrasound: Its Chemical, Physical, and Biological Effects , 1989 .

[155]  K. Suslick Ultrasound: Its Chemical, Physical, and Biological Effects , 1988 .

[156]  D. Miller,et al.  A review of the ultrasonic bioeffects of microsonation, gas-body activation, and related cavitation-like phenomena. , 1987, Ultrasound in medicine & biology.

[157]  S. Larson,et al.  Increased delivery of tumor-specific monoclonal antibodies to brain after osmotic blood-brain barrier modification in patients with melanoma metastatic to the central nervous system. , 1987, Neurosurgery.

[158]  Protection,et al.  Ultrasound: Medical Applications, Biological Effects, and Hazard Potential , 1987 .

[159]  J. Minna,et al.  Osmotic blood-brain barrier modification: monoclonal antibody, albumin, and methotrexate delivery to cerebrospinal fluid and brain. , 1985, Neurosurgery.

[160]  P. Edmonds,et al.  Evidence for free radical production by ultrasonic cavitation in biological media. , 1983, Ultrasound in medicine & biology.

[161]  H. G. Flynn Generation of transient cavities in liquids by microsecond pulses of ultrasound , 1982 .

[162]  M. Salcman,et al.  Morphologic effect of dimethyl sulfoxide on the blood-brain barrier. , 1982, Science.

[163]  R. Apfel Acoustic cavitation: a possible consequence of biomedical uses of ultrasound. , 1982, The British journal of cancer. Supplement.

[164]  L. Gavrilov,et al.  [Use of focused ultrasound for local destruction of different brain structures]. , 1976, Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova.

[165]  C. Milstein,et al.  Continuous cultures of fused cells secreting antibody of predefined specificity , 1975, Nature.

[166]  W. T. Coakley,et al.  Acoustical Detection of Single Cavitation Events in a Focused Field in Water at 1 MHz , 1971 .

[167]  J. Pond,et al.  Trackless lesions in nervous tissues produced by high intensity focused ultrasound (high-frequency mechanical waves). , 1968, Journal of anatomy.

[168]  Allan D. Pierce,et al.  Physical acoustics : principles and methods , 1965 .

[169]  P. P. Lele,et al.  A simple method for production of trackless focal lesions with focused ultrasound: statistical evaluation of the effects of irradiation on the central nervous system of the cat , 1962, The Journal of physiology.

[170]  Belle,et al.  An experimental neuropathological study of the effects of high-frequency focused ultrasound on the brain of the cat. , 1961, Journal of neuropathology and experimental neurology.

[171]  Milton S. Plesset,et al.  Theory of Rectified Diffusion of Mass into Gas Bubbles , 1961 .

[172]  E. Bell,et al.  Progress and problems in the neurological applications of focused ultrasound. , 1960, Journal of neurosurgery.

[173]  L. Bakay,et al.  Ultrasonically produced changes in the blood-brain barrier. , 1956, A.M.A. archives of neurology and psychiatry.

[174]  W. Fry,et al.  Effects of high intensity ultrasound on the central nervous system of the cat , 1955, The Journal of comparative neurology.

[175]  A. A. P. Leo,et al.  PIAL CIRCULATION AND SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEX , 1944 .

[176]  W. Pardridge The blood-brain barrier: Bottleneck in brain drug development , 2005, NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics.

[177]  T. Buchholz,et al.  Inflammatory breast cancer: current concepts in local management. , 2005, Breast disease.

[178]  J. Voges,et al.  Liposome-mediated suicide gene therapy in humans. , 2005, Methods in enzymology.

[179]  D. Goldenberg,et al.  Perspectives on cancer therapy with radiolabeled monoclonal antibodies. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[180]  M. Zalutsky Current status of therapy of solid tumors: brain tumor therapy. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[181]  D. Alberts,et al.  Role of pegylated liposomal doxorubicin in ovarian cancer. , 2005, Gynecologic oncology.

[182]  W. K. Cullen,et al.  Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. , 2005, Nature medicine.

[183]  K. Naresh,et al.  Consolidation radiation after complete remission in Hodgkin's disease following six cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine chemotherapy: is there a need? , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[184]  Henry Brem,et al.  Recent Advances in Brain Tumor Therapy: Local Intracerebral Drug Delivery by Polymers , 2004, Investigational New Drugs.

[185]  K. Hynynen,et al.  Forced linear oscillations of microbubbles in blood capillaries. , 2004, The Journal of the Acoustical Society of America.

[186]  G. Gerhardt,et al.  Intracranial delivery of proteins and peptides as a therapy for neurodegenerative diseases. , 2003, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.

[187]  F A Jolesz,et al.  Non-invasive opening of BBB by focused ultrasound. , 2003, Acta neurochirurgica. Supplement.

[188]  W. Hall,et al.  Importance of dose intensity in neuro-oncology clinical trials: summary report of the Sixth Annual Meeting of the Blood-Brain Barrier Disruption Consortium. , 2001, Neuro-oncology.

[189]  P. Zhong,et al.  Dynamics of bubble oscillation in constrained media and mechanisms of vessel rupture in SWL. , 2001, Ultrasound in medicine & biology.

[190]  S. Vaezy,et al.  High intensity focused ultrasound: a method of hemostasis. , 2001, Echocardiography.

[191]  P. S. St George-Hyslop,et al.  A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. , 2000, Nature.

[192]  A. Ghose,et al.  A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases. , 1999, Journal of combinatorial chemistry.

[193]  M. Küçük,et al.  Reversible blood-brain barrier dysfunction after intracarotid hyperthermic saline infusion. , 1998, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[194]  N. Riley Acoustic Streaming , 1998 .

[195]  K Hynynen,et al.  Noninvasive arterial occlusion using MRI-guided focused ultrasound. , 1996, Ultrasound in medicine & biology.

[196]  Morton W. Miller,et al.  A review of in vitro bioeffects of inertial ultrasonic cavitation from a mechanistic perspective. , 1996, Ultrasound in medicine & biology.

[197]  W. Saltzman,et al.  Stabilization of nerve growth factor in controlled release polymers and in tissue. , 1996, Journal of biomaterials science. Polymer edition.

[198]  K Hynynen,et al.  Histologic effects of high intensity pulsed ultrasound exposure with subharmonic emission in rabbit brain in vivo. , 1995, Ultrasound in medicine & biology.

[199]  R. M. Thomas,et al.  Ultrasound contrast agents nucleate inertial cavitation in vitro. , 1995, Ultrasound in medicine & biology.

[200]  Timothy G. Leighton,et al.  Applications of one-dimensional bubbles to lithotripsy, and to diver response to low frequency sound , 1995 .

[201]  P F Morrison,et al.  High-flow microinfusion: tissue penetration and pharmacodynamics. , 1994, The American journal of physiology.

[202]  E. Kano,et al.  Free radical formation induced by ultrasound and its effects on strand breaks in DNA of cultured FM3A cells. , 1993, Free radical research communications.

[203]  S. Vallabhajosula,et al.  Effect of blood-brain barrier and blood-tumor barrier modification on central nervous system liposomal uptake. , 1993, Cancer investigation.

[204]  W. Wilson,et al.  Melphalan penetration of the blood-brain barrier via the neutral amino acid transporter in tumor-bearing brain. , 1992, Cancer research.

[205]  H. Wachtel,et al.  Temporally-specific modification of myelinated axon excitability in vitro following a single ultrasound pulse. , 1990, Ultrasound in medicine & biology.

[206]  R F Heimburger,et al.  Ultrasound and the blood-brain barrier. , 1990, Advances in experimental medicine and biology.

[207]  M. Gautherie,et al.  Methods of External Hyperthermic Heating , 1990, Clinical Thermology.

[208]  K. Hynynen Biophysics and Technology of Ultrasound Hyperthermia , 1990 .

[209]  H. Wachtel,et al.  Transient modification of nerve excitability in vitro by single ultrasound pulses. , 1990, Biomedical sciences instrumentation.

[210]  N. Dubrawsky Cancer statistics , 1989, CA: a cancer journal for clinicians.

[211]  Padmakar P. Lele,et al.  Effects of Ultrasound on “Solid” Mammalian Tissues and Tumors In Vivo , 1987 .

[212]  G. Nussbaum Physical aspects of hyperthermia , 1982 .

[213]  L. Crum Acoustic Cavitation , 1982 .

[214]  W. McGuire,et al.  Breast Cancer 4 , 1981, Springer US.

[215]  Wesley Le Mars Nyborg,et al.  11 - Acoustic Streaming , 1965 .