Signaling by the phosphoinositide 3-kinase family in immune cells.
暂无分享,去创建一个
[1] David K. Finlay,et al. PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells , 2012, The Journal of experimental medicine.
[2] Roger L. Williams,et al. G Protein–Coupled Receptor–Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness , 2012, Science Signaling.
[3] K. Okkenhaug,et al. The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases , 2012, The open rheumatology journal.
[4] M. Gold,et al. Selective inhibitors of phosphoinositide 3-kinase delta: modulators of B-cell function with potential for treating autoimmune inflammatory diseases and B-cell malignancies , 2012, Front. Immun..
[5] A. Ferrando,et al. HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes. , 2012, Blood.
[6] A. Marshall,et al. The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions , 2012, Front. Immun..
[7] L. R. Perumalsamy,et al. Distinct Spatial and Molecular Features of Notch Pathway Assembly in Regulatory T Cells , 2012, Science Signaling.
[8] S. Feske,et al. Ion channels , 2013, Thorax.
[9] Dalya R. Soond,et al. Pten Loss in CD4 T Cells Enhances Their Helper Function but Does Not Lead to Autoimmunity or Lymphoma , 2012, The Journal of Immunology.
[10] L. Turka,et al. Regulation of T Cell Homeostasis and Responses by Pten , 2012, Front. Immun..
[11] S. Ward,et al. Pharmacological Targeting of Phosphoinositide Lipid Kinases and Phosphatases in the Immune System: Success, Disappointment, and New Opportunities , 2012, Front. Immun..
[12] M. Shlomchik,et al. B Cell Receptor Signal Transduction in the GC Is Short-Circuited by High Phosphatase Activity , 2012, Science.
[13] A. Bolino,et al. Myotubularin phosphoinositide phosphatases: cellular functions and disease pathophysiology. , 2012, Trends in molecular medicine.
[14] Dalya R. Soond,et al. Does the PI3K pathway promote or antagonize regulatory T cell development and function? , 2012, Front. Immun..
[15] D. Fruman,et al. Akt and mTOR in B Cell Activation and Differentiation , 2012, Front. Immun..
[16] R. Flavell,et al. Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis , 2012, Proceedings of the National Academy of Sciences.
[17] M. Falasca,et al. Regulation and cellular functions of class II phosphoinositide 3-kinases. , 2012, The Biochemical journal.
[18] A. Hirao,et al. PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORγ. , 2021, Cell reports.
[19] A. Ferrando,et al. Targeting nonclassical oncogenes for therapy in T-ALL. , 2012, Cancer cell.
[20] A. Marshall,et al. p110δ Phosphoinositide 3-Kinase Represses IgE Switch by Potentiating BCL6 Expression , 2012, The Journal of Immunology.
[21] Guoxing Wang,et al. Receptor Signaling Lymphocyte-activation Molecule Family 1 (Slamf1) Regulates Membrane Fusion and NADPH Oxidase 2 (NOX2) Activity by Recruiting a Beclin-1/Vps34/Ultraviolet Radiation Resistance-associated Gene (UVRAG) Complex* , 2012, The Journal of Biological Chemistry.
[22] D. Sabatini,et al. mTOR Signaling in Growth Control and Disease , 2012, Cell.
[23] D. Hodson,et al. Regulation of lymphocyte development and function by RNA-binding proteins. , 2012, Current opinion in immunology.
[24] M. Horton,et al. Regulation of immune responses by mTOR. , 2012, Annual review of immunology.
[25] Qingsheng Li,et al. Transcription factor Foxo1 represses T-bet-mediated effector functions and promotes memory CD8(+) T cell differentiation. , 2012, Immunity.
[26] D. Fruman,et al. PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances. , 2012, The Biochemical journal.
[27] Markus Werner,et al. FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination , 2012, The Journal of experimental medicine.
[28] N. Ktistakis,et al. How phosphoinositide 3-phosphate controls growth downstream of amino acids and autophagy downstream of amino acid withdrawal. , 2012, Biochemical Society transactions.
[29] W. Zong,et al. Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function , 2012, Proceedings of the National Academy of Sciences.
[30] Ian Mcleod,et al. Macroautophagy in T Lymphocyte Development and Function , 2011, Front. Immun..
[31] C. Rommel,et al. PI3Kδ inhibitors in cancer: rationale and serendipity merge in the clinic. , 2011, Cancer discovery.
[32] Ian Mcleod,et al. The Class III Kinase Vps34 Promotes T Lymphocyte Survival through Regulating IL-7Rα Surface Expression , 2011, The Journal of Immunology.
[33] John E. Burke,et al. Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases , 2011, Science Signaling.
[34] G. Semenza,et al. Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1 , 2011, Cell.
[35] A. Iwasaki,et al. Autophagy in the control and pathogenesis of viral infection. , 2011, Current opinion in virology.
[36] Roger L. Williams,et al. Dynamics of the Phosphoinositide 3-Kinase p110δ Interaction with p85α and Membranes Reveals Aspects of Regulation Distinct from p110α , 2011, Structure.
[37] E. Hirsch,et al. The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions. , 2011, Blood.
[38] T. Ludwig,et al. The GTPase-activating protein ARAP3 regulates chemotaxis and adhesion-dependent processes in neutrophils. , 2011, Blood.
[39] D. Green,et al. HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells , 2011, The Journal of experimental medicine.
[40] S. Gygi,et al. Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling , 2011, Science.
[41] S. McColl,et al. PI3Kδ drives the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting effector T cell apoptosis and promoting Th17 differentiation. , 2011, Journal of autoimmunity.
[42] A. Toker,et al. Akt isoform-specific signaling in breast cancer , 2011, Cell adhesion & migration.
[43] Qingsheng Li,et al. A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity. , 2011, Immunity.
[44] K. Okkenhaug,et al. PI3Kβ Plays a Critical Role in Neutrophil Activation by Immune Complexes , 2011, Science Signaling.
[45] D. Sabatini,et al. The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling , 2011, Science.
[46] Roger L. Williams,et al. Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism , 2011, Molecular cell.
[47] Julian Downward,et al. RAS Interaction with PI3K: More Than Just Another Effector Pathway. , 2011, Genes & cancer.
[48] David K. Finlay,et al. Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell Metabolism , 2011, Immunity.
[49] D. Rappolee,et al. The Phosphoinositide Kinase PIKfyve Is Vital in Early Embryonic Development , 2011, The Journal of Biological Chemistry.
[50] David K. Finlay,et al. Metabolism, migration and memory in cytotoxic T cells , 2011, Nature Reviews Immunology.
[51] K. Anderson,et al. P-Rex1 and Vav1 Cooperate in the Regulation of Formyl-Methionyl-Leucyl-Phenylalanine–Dependent Neutrophil Responses , 2011, The Journal of Immunology.
[52] Xiaoping Zhou,et al. The Mammalian Class 3 PI3K (PIK3C3) Is Required for Early Embryogenesis and Cell Proliferation , 2011, PloS one.
[53] H. Virgin,et al. Autophagy in immunity and inflammation , 2011, Nature.
[54] R. Ulrich,et al. CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. , 2011, Blood.
[55] Y. Ohsumi,et al. PtdIns 3-Kinase Orchestrates Autophagosome Formation in Yeast , 2011, Journal of lipids.
[56] W. Kerr. Inhibitor and activator: dual functions for SHIP in immunity and cancer , 2011, Annals of the New York Academy of Sciences.
[57] P. Hawkins,et al. PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils. , 2010, Blood.
[58] G. Giles,et al. Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers , 2010, Proceedings of the National Academy of Sciences.
[59] D. Powell,et al. Requirement for Class II Phosphoinositide 3-Kinase C2α in Maintenance of Glomerular Structure and Function , 2010, Molecular and Cellular Biology.
[60] Mingming Jia,et al. COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer , 2010, Nucleic Acids Res..
[61] Dalya R. Soond,et al. Phosphoinositide 3-Kinase Activity in T Cells Regulates the Magnitude of the Germinal Center Reaction , 2010, The Journal of Immunology.
[62] M. Boes,et al. SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages , 2010, Nature Immunology.
[63] M. Janas,et al. Stromal cell-derived factor 1α and CXCR4: newly defined requirements for efficient thymic β-selection. , 2010, Trends in immunology.
[64] Melissa C. Hendershott,et al. mRNA Degradation Plays a Significant Role in the Program of Gene Expression Regulated by Phosphatidylinositol 3-Kinase Signaling , 2010, Molecular and Cellular Biology.
[65] Markus Werner,et al. Role of PI3K in the generation and survival of B cells , 2010, Immunological reviews.
[66] P. Vogt,et al. Cancer-derived mutations in the regulatory subunit p85α of phosphoinositide 3-kinase function through the catalytic subunit p110α , 2010, Proceedings of the National Academy of Sciences.
[67] K. Okkenhaug,et al. The PI3K Isoforms p110α and p110δ Are Essential for Pre–B Cell Receptor Signaling and B Cell Development , 2010, Science Signaling.
[68] A. Kiger,et al. Drosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functions , 2010, The Journal of cell biology.
[69] M. Merkenschlager,et al. PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors , 2010, The Journal of experimental medicine.
[70] R. DePinho,et al. Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells , 2010, Nature Immunology.
[71] B. Vanhaesebroeck,et al. Activity of any class IA PI3K isoform can sustain cell proliferation and survival , 2010, Proceedings of the National Academy of Sciences.
[72] G. Hortobagyi,et al. Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer. , 2010, Cancer research.
[73] M. Birnbaum,et al. AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species. , 2010, Blood.
[74] M. Birnbaum,et al. Akt1 and Akt2 promote peripheral B-cell maturation and survival. , 2010, Blood.
[75] D. Rigden,et al. Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation , 2010, Autophagy.
[76] B. Vanhaesebroeck,et al. The emerging mechanisms of isoform-specific PI3K signalling , 2010, Nature Reviews Molecular Cell Biology.
[77] R. Teasdale,et al. Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella , 2010, The EMBO journal.
[78] D. Sabatini,et al. Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids , 2010, Cell.
[79] K. Shokat,et al. Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34 , 2010, Science.
[80] Dalya R. Soond,et al. PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans. , 2010, Blood.
[81] S. Grinstein,et al. In vivo requirement for Atg5 in antigen presentation by dendritic cells. , 2010, Immunity.
[82] H. Guillou,et al. ARAP3 binding to phosphatidylinositol-(3,4,5)-trisphosphate depends on N-terminal tandem PH domains and adjacent sequences. , 2010, Cellular signalling.
[83] Qingsheng Li,et al. The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin. , 2010, Immunity.
[84] M. Turner,et al. Thymic development beyond β-selection requires phosphatidylinositol 3-kinase activation by CXCR4 , 2010, The Journal of experimental medicine.
[85] Yi Liu,et al. The p110δ crystal structure uncovers mechanisms for selectivity and potency of novel PI3K inhibitors , 2009, Nature chemical biology.
[86] S. Smerdon,et al. Function of the Nucleotide Exchange Activity of Vav1 in T Cell Development and Activation , 2009, Science Signaling.
[87] T. Mak,et al. Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase , 2009, Proceedings of the National Academy of Sciences.
[88] M. Girvin,et al. Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110α and are disrupted in oncogenic p85 mutants , 2009, Proceedings of the National Academy of Sciences.
[89] R. Rickert,et al. Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy. , 2009, Immunity.
[90] M. Gold,et al. Phosphoinositide 3-Kinase p110δ Regulates Natural Antibody Production, Marginal Zone and B-1 B Cell Function, and Autoantibody Responses1 , 2009, The Journal of Immunology.
[91] R. DePinho,et al. PI3 Kinase Signals BCR-Dependent Mature B Cell Survival , 2009, Cell.
[92] David K. Finlay,et al. Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes , 2009, The Journal of experimental medicine.
[93] Michael Loran Dustin,et al. The class II phosphatidylinositol 3 kinase C2beta is required for the activation of the K+ channel KCa3.1 and CD4 T-cells. , 2009, Molecular biology of the cell.
[94] S. Hedrick. The cunning little vixen: Foxo and the cycle of life and death , 2009, Nature Immunology.
[95] P. Pandolfi,et al. Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. , 2009, Cancer cell.
[96] K. Okkenhaug,et al. The p110δ Isoform of Phosphatidylinositol 3-Kinase Controls Susceptibility to Leishmania major by Regulating Expansion and Tissue Homing of Regulatory T Cells1 , 2009, The Journal of Immunology.
[97] B. Cubelos,et al. Essential function for the GTPase TC21 in homeostatic antigen receptor signaling , 2009, Nature Immunology.
[98] R. Ahmed,et al. mTOR regulates memory CD8 T cell differentiation , 2009, Nature.
[99] Daniel R. Beisner,et al. Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. , 2009, Nature immunology.
[100] K. Okkenhaug,et al. p110γ and p110δ isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease , 2009, Proceedings of the National Academy of Sciences.
[101] R. Gascoyne,et al. Selective ablation of the YxxM motif of IL-7Rα suppresses lymphomagenesis but maintains lymphocyte development , 2009, Oncogene.
[102] R. Michell,et al. Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function. , 2009, The Biochemical journal.
[103] R. Flavell,et al. An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance. , 2009, Immunity.
[104] D. Fruman,et al. Fine tuning the immune response with PI3K , 2009, Immunological reviews.
[105] M. Reth,et al. Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling , 2009, Nature Reviews Immunology.
[106] Daniel R. Beisner,et al. Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor , 2009, Nature Immunology.
[107] Y. Terauchi,et al. Critical role of class IA PI3K for c-Rel expression in B lymphocytes. , 2009, Blood.
[108] P. Hawkins,et al. CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks. , 2008, Blood.
[109] K. Shokat,et al. Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production. , 2008, The Journal of allergy and clinical immunology.
[110] R. DePinho,et al. Distinct roles for Foxo1 at multiple stages of B cell differentiation , 2008, Nature Immunology.
[111] P. Musiani,et al. Phosphoinositide 3-Kinase p110β Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development , 2008, Science Signaling.
[112] Jason S. Mitchell,et al. The p110γ isoform of phosphatidylinositol 3‐kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites , 2008, Journal of leukocyte biology.
[113] V. Lazar,et al. FOXO1 Regulates L-Selectin and a Network of Human T Cell Homing Molecules Downstream of Phosphatidylinositol 3-Kinase1 , 2008, The Journal of Immunology.
[114] Gareth Griffiths,et al. Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum , 2008, The Journal of cell biology.
[115] M. Loda,et al. Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis , 2008, Nature.
[116] K. Okkenhaug,et al. The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ , 2008, Proceedings of the National Academy of Sciences.
[117] David M. Sabatini,et al. The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1 , 2008, Science.
[118] David K. Finlay,et al. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR , 2008, Proceedings of the National Academy of Sciences.
[119] M. Schlissel,et al. Foxo1 directly regulates the transcription of recombination-activating genes during B cell development , 2008, Nature Immunology.
[120] R. DePinho,et al. SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway , 2008, Nature Immunology.
[121] K. Rittinger,et al. Crucial structural role for the PH and C1 domains of the Vav1 exchange factor , 2008, EMBO reports.
[122] Holger Gerhardt,et al. Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration , 2008, Nature.
[123] Tobias Meyer,et al. Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging. , 2008, Molecular cell.
[124] Michael G. Kharas,et al. KLF4 is a FOXO target gene that suppresses B cell proliferation. , 2008, International immunology.
[125] M. Juntilla,et al. Critical roles of the PI3K/Akt signaling pathway in T cell development. , 2008, Immunology letters.
[126] R. Rickert,et al. Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases , 2008, The Journal of experimental medicine.
[127] Li Zhao,et al. Helical domain and kinase domain mutations in p110α of phosphatidylinositol 3-kinase induce gain of function by different mechanisms , 2008, Proceedings of the National Academy of Sciences.
[128] John L Cleveland,et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes , 2008, Autophagy.
[129] J. Backer. The regulation and function of Class III PI3Ks: novel roles for Vps34. , 2008, The Biochemical journal.
[130] S. Jameson,et al. Selective Regulation of CD8 Effector T Cell Migration by the p110γ Isoform of Phosphatidylinositol 3-Kinase1 , 2008, The Journal of Immunology.
[131] K. Okkenhaug,et al. CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer. , 2008, Blood.
[132] M. Lemmon,et al. Membrane recognition by phospholipid-binding domains , 2008, Nature Reviews Molecular Cell Biology.
[133] P. Pandolfi,et al. The Effect of Deleting p110δ on the Phenotype and Function of PTEN-Deficient B Cells1 , 2008, The Journal of Immunology.
[134] Bert Vogelstein,et al. The Structure of a Human p110α/p85α Complex Elucidates the Effects of Oncogenic PI3Kα Mutations , 2007, Science.
[135] K. Okkenhaug,et al. Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation. , 2007, Blood.
[136] P. Hawkins,et al. PI3K Class IB Pathway , 2007, Science's STKE.
[137] B. Hemmings,et al. Deletion of PKBα/Akt1 Affects Thymic Development , 2007, PloS one.
[138] G. Prestwich,et al. Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase γ , 2007, Proceedings of the National Academy of Sciences.
[139] M. Birnbaum,et al. Akt1 and Akt2 are required for αβ thymocyte survival and differentiation , 2007, Proceedings of the National Academy of Sciences.
[140] Yuval Inbar,et al. Mechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit , 2007, Science.
[141] Lewis C. Cantley,et al. AKT/PKB Signaling: Navigating Downstream , 2007, Cell.
[142] David K. Finlay,et al. Notch-induced T cell development requires phosphoinositide-dependent kinase 1 , 2007, The EMBO journal.
[143] G. Stamp,et al. Binding of Ras to Phosphoinositide 3-Kinase p110α Is Required for Ras- Driven Tumorigenesis in Mice , 2007, Cell.
[144] D. Nemazee,et al. Basal B Cell Receptor-Directed Phosphatidylinositol 3-Kinase Signaling Turns Off RAGs and Promotes B Cell-Positive Selection1 , 2007, The Journal of Immunology.
[145] B. Vanhaesebroeck,et al. Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers , 2007, Proceedings of the National Academy of Sciences.
[146] T. Ludwig,et al. Unequal Contribution of Akt Isoforms in the Double-Negative to Double-Positive Thymocyte Transition1 , 2007, The Journal of Immunology.
[147] Michael G. Kharas,et al. T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling. , 2007, Blood.
[148] A. Iwasaki,et al. In Brief , 2007, Nature Reviews Immunology.
[149] C. Rommel,et al. PI3Kδ and PI3Kγ: partners in crime in inflammation in rheumatoid arthritis and beyond? , 2007, Nature Reviews Immunology.
[150] M. Turner,et al. Cutting Edge: The PI3K p110δ Is Required for Down-Regulation of RAG Expression in Immature B Cells1 , 2007, The Journal of Immunology.
[151] K. Okkenhaug,et al. Antigen receptor signalling: a distinctive role for the p110δ isoform of PI3K , 2007, Trends in immunology.
[152] K. Okkenhaug,et al. Role of the phosphoinositide 3‐kinase p110δ in generation of type 2 cytokine responses and allergic airway inflammation , 2007, European journal of immunology.
[153] S. Armstrong,et al. FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress , 2007, Cell.
[154] K. Okkenhaug,et al. Cutting Edge: The Phosphoinositide 3-Kinase p110δ Is Critical for the Function of CD4+CD25+Foxp3+ Regulatory T Cells1 , 2006, The Journal of Immunology.
[155] Hailing Cheng,et al. The p110α isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation , 2006, Proceedings of the National Academy of Sciences.
[156] K. Okkenhaug,et al. The p110δ Isoform of Phosphoinositide 3-Kinase Controls Clonal Expansion and Differentiation of Th Cells1 , 2006, The Journal of Immunology.
[157] P. Hawkins,et al. PtdIns3P binding to the PX domain of p40phox is a physiological signal in NADPH oxidase activation , 2006, The EMBO journal.
[158] L. Turka,et al. Cutting Edge: T Cell Requirement for CD28 Costimulation Is Due to Negative Regulation of TCR Signals by PTEN1 , 2006, The Journal of Immunology.
[159] K. Calame,et al. Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling. , 2006, Immunity.
[160] P. Hawkins,et al. Signalling through Class I PI3Ks in mammalian cells. , 2006, Biochemical Society transactions.
[161] J. Dixon,et al. Myotubularin phosphatases: policing 3-phosphoinositides. , 2006, Trends in cell biology.
[162] E. Skolnik,et al. Phosphatidylinositol-3 Phosphatase Myotubularin-Related Protein 6 Negatively Regulates CD4 T Cells , 2006, Molecular and Cellular Biology.
[163] Ji Luo,et al. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism , 2006, Nature Reviews Genetics.
[164] L. Cantley,et al. Ras, PI(3)K and mTOR signalling controls tumour cell growth , 2006, Nature.
[165] Xi C. He,et al. PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention , 2006, Nature.
[166] S. Morrison,et al. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells , 2006, Nature.
[167] Robbie Loewith,et al. A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling , 2006, Cell.
[168] K. Okkenhaug,et al. Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation , 2006, Nature.
[169] D. Sabatini,et al. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. , 2006, Molecular cell.
[170] W. Swat,et al. Essential role of PI3Kdelta and PI3Kgamma in thymocyte survival. , 2006, Blood.
[171] B. Vanhaesebroeck,et al. Oncogenic transformation induced by the p110β, -γ, and -δ isoforms of class I phosphoinositide 3-kinase , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[172] K. Okkenhaug,et al. Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells. , 2006, Blood.
[173] D. F. Barber,et al. Class IB-Phosphatidylinositol 3-Kinase (PI3K) Deficiency Ameliorates IA-PI3K-Induced Systemic Lupus but Not T Cell Invasion1 , 2006, The Journal of Immunology.
[174] P. Khavari,et al. The Class II Phosphoinositide 3-Kinase C2β Is Not Essential for Epidermal Differentiation , 2005, Molecular and Cellular Biology.
[175] E. Skolnik,et al. Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1. , 2005, Molecular biology of the cell.
[176] F. Natt,et al. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[177] S. Ruf,et al. Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells. , 2005, Immunity.
[178] M. Ciofani,et al. Notch promotes survival of pre–T cells at the β-selection checkpoint by regulating cellular metabolism , 2005, Nature Immunology.
[179] Emilio Hirsch,et al. Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis , 2005, Nature Medicine.
[180] E. Vigorito,et al. Cutting Edge: T Cell Development Requires the Combined Activities of the p110γ and p110δ Catalytic Isoforms of Phosphatidylinositol 3-Kinase1 , 2005, The Journal of Immunology.
[181] K. Okkenhaug,et al. Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. , 2005, Blood.
[182] E. Skolnik,et al. The Phosphatidylinositol 3-Phosphate Phosphatase Myotubularin- Related Protein 6 (MTMR6) Is a Negative Regulator of the Ca2+-Activated K+ Channel KCa3.1 , 2005, Molecular and Cellular Biology.
[183] Kong-Peng Lam,et al. Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells , 2005, PLoS biology.
[184] T. Tuschl,et al. Endogenous MHC Class II Processing of a Viral Nuclear Antigen After Autophagy , 2005, Science.
[185] Thijs J. Hagenbeek,et al. The Loss of PTEN Allows TCR αβ Lineage Thymocytes to Bypass IL-7 and Pre-TCR–mediated Signaling , 2004, The Journal of experimental medicine.
[186] C. Martínez-A,et al. Differential requirements for DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing. , 2004, Immunity.
[187] K. Okkenhaug,et al. Cutting Edge: Differential Roles for Phosphoinositide 3-Kinases, p110γ and p110δ, in Lymphocyte Chemotaxis and Homing1 , 2004, The Journal of Immunology.
[188] Y. Samuels,et al. Oncogenic mutations of PIK3CA in human cancers. , 2004, Current topics in microbiology and immunology.
[189] N. Rajewsky,et al. Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β Heterodimer , 2004, Cell.
[190] F. McCormick,et al. Signaling Specificity by Ras Family GTPases Is Determined by the Full Spectrum of Effectors They Regulate , 2004, Molecular and Cellular Biology.
[191] D. Alessi,et al. The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development , 2004, Nature Immunology.
[192] J. Ptak,et al. High Frequency of Mutations of the PIK3CA Gene in Human Cancers , 2004, Science.
[193] D. Fruman,et al. Phosphoinositide 3-kinase: diverse roles in immune cell activation. , 2004, Annual review of immunology.
[194] Oreste Acuto,et al. CD28-mediated co-stimulation: a quantitative support for TCR signalling , 2003, Nature Reviews Immunology.
[195] P. Hawkins,et al. Phosphoinositide 3‐kinase‐dependent activation of Rac , 2003, FEBS letters.
[196] S. Koyasu. The role of PI3K in immune cells , 2003, Nature Immunology.
[197] K. Okkenhaug,et al. PI3K in lymphocyte development, differentiation and activation , 2003, Nature Reviews Immunology.
[198] T. Mak,et al. Critical Roles of Pten in B Cell Homeostasis and Immunoglobulin Class Switch Recombination , 2003, The Journal of experimental medicine.
[199] D. Staunton,et al. Essential Role of Phosphoinositide 3-Kinase δ in Neutrophil Directional Movement , 2003, The Journal of Immunology.
[200] T. Behrens,et al. PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction , 2003, Nature Immunology.
[201] J. Ihle,et al. Essential, Nonredundant Role for the Phosphoinositide 3-Kinase p110δ in Signaling by the B-Cell Receptor Complex , 2002, Molecular and Cellular Biology.
[202] E. Vigorito,et al. A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation , 2002, The Journal of experimental medicine.
[203] T. Asano,et al. PI3K-mediated negative feedback regulation of IL-12 production in DCs , 2002, Nature Immunology.
[204] K. Okkenhaug,et al. Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice , 2002, Science.
[205] P. Lipp,et al. Phosphatidylinositol 3-phosphate is generated in phagosomal membranes , 2001, Current Biology.
[206] S. Grinstein,et al. Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation , 2001, The Journal of cell biology.
[207] S. Emr,et al. The role of phosphoinositides in membrane transport. , 2001, Current opinion in cell biology.
[208] Paul Tempst,et al. PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox , 2001, Nature Cell Biology.
[209] M. Yaffe,et al. The PX domains of p47phox and p40phox bind to lipid products of PI(3)K , 2001, Nature Cell Biology.
[210] T. Sasaki,et al. T cell-specific loss of Pten leads to defects in central and peripheral tolerance. , 2001, Immunity.
[211] Takeshi Noda,et al. Two Distinct Vps34 Phosphatidylinositol 3–Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting inSaccharomyces cerevisiae , 2001, The Journal of cell biology.
[212] M. Lemmon,et al. Signal-dependent membrane targeting by pleckstrin homology (PH) domains. , 2000, The Biochemical journal.
[213] W L Stanford,et al. Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. , 2000, Science.
[214] Dianqing Wu,et al. Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction , 2000 .
[215] Silvano Sozzani,et al. Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation , 2000 .
[216] Paul M. Allen,et al. Proline Residues in Cd28 and the Src Homology (Sh)3 Domain of Lck Are Required for T Cell Costimulation , 1999, The Journal of experimental medicine.
[217] Gillian E. Wu,et al. Modulation of the IL-7 dose-response threshold during pro-B cell differentiation is dependent on pre-B cell receptor expression. , 1998, Journal of immunology.
[218] J. Backer,et al. Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains. , 1998, The Journal of biological chemistry.
[219] Marino Zerial,et al. EEA1 links PI(3)K function to Rab5 regulation of endosome fusion , 1998, Nature.
[220] J. Backer,et al. Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit , 1998, Molecular and Cellular Biology.
[221] P. Hawkins,et al. Phosphatidylinositol 3-kinase-γ activates Bruton’s tyrosine kinase in concert with Src family kinases , 1997 .
[222] P. Parker,et al. Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis , 1997, Nature.
[223] K. Rajewsky,et al. In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death , 1997, Cell.
[224] L. Cantley,et al. A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains* , 1997, The Journal of Biological Chemistry.
[225] G. Panayotou,et al. Phosphoinositide 3-kinases: a conserved family of signal transducers. , 1997, Trends in biochemical sciences.
[226] M. Zvelebil,et al. p110δ, a novel phosphoinositide 3-kinase in leukocytes , 1997 .
[227] David R. Kaplan,et al. Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate , 1997, Science.
[228] M. Owen,et al. The interleukin‐7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis. , 1996, The EMBO journal.
[229] D. Tuveson,et al. CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase. , 1993, Science.
[230] S. Emr,et al. A membrane‐associated complex containing the Vps15 protein kinase and the Vps34 PI 3‐kinase is essential for protein sorting to the yeast lysosome‐like vacuole. , 1993, The EMBO journal.
[231] K. Takegawa,et al. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. , 1993, Science.
[232] I. Batty,et al. Distinct inactivation of PI3K signalling by PTEN and 5-phosphatases. , 2012, Advances in biological regulation.
[233] B. Vogelstein,et al. Structural effects of oncogenic PI3Kα mutations. , 2010, Current topics in microbiology and immunology.
[234] D. Fruman. Regulatory subunits of class IA PI3K. , 2010, Current topics in microbiology and immunology.
[235] K. Okkenhaug,et al. PI3Ks in lymphocyte signaling and development. , 2010, Current topics in microbiology and immunology.
[236] K. Okkenhaug,et al. This information is current as Signaling in CD 8 T Cells S 6 Phosphorylation to Control Metabolic Converge at the Level of Ribosomal Protein Mammalian Target of Rapamycin Pathways MAPK , Phosphatidylinositol 3-Kinase , and , 2009 .
[237] P. Schwartzberg,et al. Tec family kinases in T lymphocyte development and function. , 2005, Annual review of immunology.
[238] P. Lipp,et al. Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. , 2002, Molecular cell.