Dihydromyricetin: A review on identification and quantification methods, biological activities, chemical stability, metabolism and approaches to enhance its bioavailability

[1]  Zhiguo Yu,et al.  Simultaneous determination of bioactive flavonoids of Hoveniae Semen in rat plasma by LC-MS/MS: Application to a comparative pharmacokinetic study. , 2019, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[2]  Dong Xiang,et al.  Uptake and Transport Mechanism of Dihydromyricetin Across Human Intestinal Caco-2 Cells. , 2018, Journal of food science.

[3]  Leiming Sun,et al.  Combined Analysis of the Fruit Metabolome and Transcriptome Reveals Candidate Genes Involved in Flavonoid Biosynthesis in Actinidia arguta , 2018, International journal of molecular sciences.

[4]  Chao-Mei Ma,et al.  Pharmacokinetic study of the major chemical constituents in Xanthoceras sorbifolia wood after oral administration of methanol extract, wood powder, and single constituents , 2018 .

[5]  Dan Liu,et al.  Effect of dihydromyricetin on proline metabolism of Vibrio parahaemolyticus: Inhibitory mechanism and interaction with molecular docking simulation , 2018 .

[6]  Tamara Ius,et al.  Role of Microenvironment in Glioma Invasion: What We Learned from In Vitro Models , 2018, International journal of molecular sciences.

[7]  M. Elliott,et al.  The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer , 2017 .

[8]  V. Křen,et al.  Quercetin and its analogues: optical and acido-basic properties. , 2017, Physical chemistry chemical physics : PCCP.

[9]  M. Ghoul,et al.  Effect of heat processing on thermal stability and antioxidant activity of six flavonoids , 2017 .

[10]  M. Chono,et al.  Flavonoid compounds related to seed coat color of wheat , 2017, Bioscience, biotechnology, and biochemistry.

[11]  A. Dalpiaz,et al.  Can pharmaceutical co-crystals provide an opportunity to modify the biological properties of drugs? , 2017, Drug discovery today.

[12]  P. Gomes,et al.  Anti biofilm effect of dihydromyricetin-loaded nanocapsules on urinary catheter infected by Pseudomonas aeruginosa. , 2017, Colloids and surfaces. B, Biointerfaces.

[13]  Zh Feng,et al.  Dihydromyricetin attenuated Ang II induced cardiac fibroblasts proliferation related to inhibitory of oxidative stress , 2017, European journal of pharmacology.

[14]  Chen Zhou,et al.  [Determination of 8 components in healthy food for anti-hangover and hepatoprotection by high performance liquid chromatography]. , 2017, Wei sheng yan jiu = Journal of hygiene research.

[15]  Haiyan Xiang,et al.  Antioxidant profiling of vine tea (Ampelopsis grossedentata): Off-line coupling heart-cutting HSCCC with HPLC-DAD-QTOF-MS/MS. , 2017, Food chemistry.

[16]  He-dong Lang,et al.  Dihydromyricetin prevents obesity-induced slow-twitch-fiber reduction partially via FLCN/FNIP1/AMPK pathway. , 2017, Biochimica et biophysica acta. Molecular basis of disease.

[17]  W. Xiong,et al.  Tissue Distribution, Excretion, and Metabolic Profile of Dihydromyricetin, a Flavonoid from Vine Tea (Ampelopsis grossedentata) after Oral Administration in Rats. , 2017, Journal of agricultural and food chemistry.

[18]  T. Liu,et al.  Dihydromyricetin ameliorates atherosclerosis in LDL receptor deficient mice. , 2017, Atherosclerosis.

[19]  Hai-ying Sun,et al.  Dihydromyricetin induces apoptosis and cytoprotective autophagy through ROS-NF-κB signalling in human melanoma cells , 2017, Free radical research.

[20]  Xiaojie Huang,et al.  Dihydromyricetin Reduces TGF-β Via P53 Activation-dependent Mechanism in Hepatocellular Carcinoma HepG2 Cells. , 2017, Protein and peptide letters.

[21]  Meiwan Chen,et al.  Dihydromyricetin Induces Apoptosis and Reverses Drug Resistance in Ovarian Cancer Cells by p53-mediated Downregulation of Survivin , 2017, Scientific Reports.

[22]  M. Murahari,et al.  Complexation of phytochemicals with cyclodextrin derivatives - An insight. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[23]  Wei-Jiunn Lee,et al.  Suppression of reactive oxygen species‐mediated ERK and JNK activation sensitizes dihydromyricetin‐induced mitochondrial apoptosis in human non‐small cell lung cancer , 2017, Environmental toxicology.

[24]  M. Zong,et al.  Highly Efficient Enzymatic Acylation of Dihydromyricetin by the Immobilized Lipase with Deep Eutectic Solvents as Cosolvent. , 2017, Journal of agricultural and food chemistry.

[25]  Hong Gao,et al.  A dual antibacterial mechanism involved in membrane disruption and DNA binding of 2R,3R-dihydromyricetin from pine needles of Cedrus deodara against Staphylococcus aureus. , 2017, Food chemistry.

[26]  M. Samsonowicz,et al.  Spectroscopic study of molecular structure, antioxidant activity and biological effects of metal hydroxyflavonol complexes. , 2017, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[27]  Xiaohong Zhang,et al.  Dihydromyricetin induces mitochondria-mediated apoptosis in HepG2 cells through down-regulation of the Akt/Bad pathway. , 2017, Nutrition research.

[28]  Dong Xiang,et al.  Gastrointestinal stability of dihydromyricetin, myricetin, and myricitrin: an in vitro investigation , 2017, International journal of food sciences and nutrition.

[29]  He-dong Lang,et al.  Dihydromyricetin delays the onset of hyperglycemia and ameliorates insulin resistance without excessive weight gain in Zucker diabetic fatty rats , 2017, Molecular and Cellular Endocrinology.

[30]  Wei Wang,et al.  Protection of oxidative stress induced apoptosis in osteosarcoma cells by dihydromyricetin through down-regulation of caspase activation and up-regulation of BcL-2 , 2016, Saudi journal of biological sciences.

[31]  Xiaohua Li,et al.  Determination of dihydromyricetin in rat plasma by LC-MS/MS and its application to a pharmacokinetic study , 2016, Pharmaceutical biology.

[32]  Xiaoxiong Zeng,et al.  Food macromolecule based nanodelivery systems for enhancing the bioavailability of polyphenols , 2016, Journal of food and drug analysis.

[33]  Ajazuddin,et al.  Recent expansion of pharmaceutical nanotechnologies and targeting strategies in the field of phytopharmaceuticals for the delivery of herbal extracts and bioactives. , 2016, Journal of controlled release : official journal of the Controlled Release Society.

[34]  Jiye Cai,et al.  Dihydromyricetin suppresses inflammatory responses in vitro and in vivo through inhibition of IKKβ activity in macrophages. , 2016, Scanning.

[35]  Tsong-Min Chang,et al.  Dihydromyricetin from Ampelopsis grossedentata inhibits melanogenesis through down-regulation of MAPK, PKA and PKC signaling pathways. , 2016, Chemico-biological interactions.

[36]  Lizhi Lv,et al.  Dihydromyricetin protects against liver ischemia/reperfusion induced apoptosis via activation of FOXO3a-mediated autophagy , 2016, Oncotarget.

[37]  J. Li,et al.  Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTOR signal pathway , 2016, Oncotarget.

[38]  Juan Ma,et al.  Dihydromyricetin suppresses TNF-α-induced NF-κB activation and target gene expression , 2016, Molecular and Cellular Biochemistry.

[39]  Xiaohui Chen,et al.  Effects of phospholipid complexes of total flavonoids from Persimmon (Diospyros kaki L.) leaves on experimental atherosclerosis rats. , 2016, Journal of ethnopharmacology.

[40]  W. Xiong,et al.  Solid-state characterization of optically pure (+)Dihydromyricetin extracted from Ampelopsis grossedentata leaves. , 2016, International journal of pharmaceutics.

[41]  Dan Liu,et al.  An insight into the inhibitory activity of dihydromyricetin against Vibrio parahaemolyticus , 2016 .

[42]  Dhara D. Bavishi,et al.  Spring and parachute: How cocrystals enhance solubility , 2016 .

[43]  Yuan Zhang,et al.  Preventive Effect of Dihydromyricetin against Cisplatin-Induced Nephrotoxicity In Vitro and In Vivo , 2016, Evidence-based complementary and alternative medicine : eCAM.

[44]  Hou Xiaolong,et al.  Enhancing Bioavailability of Dihydromyricetin through Inhibiting Precipitation of Soluble Cocrystals by a Crystallization Inhibitor , 2016 .

[45]  L. Bu,et al.  Dihydromyricetin promotes autophagy and apoptosis through ROS-STAT3 signaling in head and neck squamous cell carcinoma , 2016, Oncotarget.

[46]  R. Upton,et al.  A Quantitative Review and Meta-models of the Variability and Factors Affecting Oral Drug Absorption—Part II: Gastrointestinal Transit Time , 2016, The AAPS Journal.

[47]  Caifeng Xie,et al.  Dihydromyricetin ameliorates oleic acid-induced lipid accumulation in L02 and HepG2 cells by inhibiting lipogenesis and oxidative stress. , 2016, Life sciences.

[48]  Jian Shi,et al.  In Vivo Exposure of Kaempferol Is Driven by Phase II Metabolic Enzymes and Efflux Transporters , 2016, The AAPS Journal.

[49]  Xue-chu Zhen,et al.  Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson's disease by suppressing glycogen synthase kinase-3 beta activity , 2016, Acta Pharmacologica Sinica.

[50]  Ning Li,et al.  A magnetic biocatalyst based on mussel-inspired polydopamine and its acylation of dihydromyricetin , 2016 .

[51]  G. Jerz,et al.  Flavonoids from the flowers of Impatiens glandulifera Royle isolated by high performance countercurrent chromatography. , 2016, Phytochemical analysis : PCA.

[52]  P. Jiao,et al.  Protective Effect of Dihydromyricetin Against Lipopolysaccharide-Induced Acute Kidney Injury in a Rat Model , 2016, Medical science monitor : international medical journal of experimental and clinical research.

[53]  W. Gao,et al.  Development of Improved Process with Treatment of Cellulase for Isolation of Ampelopsin from Dried Fruits of Ampelopsis grossedentata , 2016 .

[54]  M. K. Kim,et al.  Myricetin: biological activity related to human health , 2016, Applied Biological Chemistry.

[55]  R. Lodder,et al.  BSN723T Prevents Atherosclerosis and Weight Gain in ApoE Knockout Mice Fed a Western Diet , 2015, WebmedCentral.

[56]  X. Fang,et al.  Dihydromyricetin induces cell apoptosis via a p53-related pathway in AGS human gastric cancer cells. , 2015, Genetics and molecular research : GMR.

[57]  I. Antal,et al.  Multiple ABC Transporters Efflux Baicalin , 2015, Phytotherapy research : PTR.

[58]  Zhi-min Qi,et al.  Simultaneous quantification of ten constituents of Xanthoceras sorbifolia Bunge using UHPLC-MS methods and evaluation of their radical scavenging, DNA scission protective, and α-glucosidase inhibitory activities. , 2015, Chinese journal of natural medicines.

[59]  X. Liu,et al.  Determination of dihydromyricetin in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. , 2015, Journal of pharmaceutical and biomedical analysis.

[60]  P. Liu,et al.  Dihydromyricetin stimulates irisin secretion partially via the PGC-1α pathway , 2015, Molecular and Cellular Endocrinology.

[61]  P. Liu,et al.  Dihydromyricetin improves glucose and lipid metabolism and exerts anti-inflammatory effects in nonalcoholic fatty liver disease: A randomized controlled trial. , 2015, Pharmacological research.

[62]  S. Guterres,et al.  Improving drug biological effects by encapsulation into polymeric nanocapsules. , 2015, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[63]  S. Rehman,et al.  HPLC Determination of Bioactive Flavonoids in Hovenia dulcis Fruit Extracts. , 2015, Journal of chromatographic science.

[64]  W. Xiong,et al.  Suppression of Inflammatory Responses by Dihydromyricetin, a Flavonoid from Ampelopsis grossedentata, via Inhibiting the Activation of NF-κB and MAPK Signaling Pathways. , 2015, Journal of natural products.

[65]  M. Mi,et al.  Dihydromyricetin improves skeletal muscle insulin resistance by inducing autophagy via the AMPK signaling pathway , 2015, Molecular and Cellular Endocrinology.

[66]  S. Cutler,et al.  Sulfated phenolic compounds from Limonium caspium: Isolation, structural elucidation, and biological evaluation. , 2015, Fitoterapia.

[67]  W. Xiong,et al.  Dihydromyricetin protects endothelial cells from hydrogen peroxide-induced oxidative stress damage by regulating mitochondrial pathways. , 2015, Life sciences.

[68]  Cheng-Yang Huang.  Inhibition of a Putative Dihydropyrimidinase from Pseudomonas aeruginosa PAO1 by Flavonoids and Substrates of Cyclic Amidohydrolases , 2015, PloS one.

[69]  B. Liu,et al.  Dihydromyricetin alleviates carbon tetrachloride-induced acute liver injury via JNK-dependent mechanism in mice. , 2015, World journal of gastroenterology.

[70]  M. Mi,et al.  Dihydromyricetin improves skeletal muscle insulin sensitivity by inducing autophagy via the AMPK-PGC-1α-Sirt3 signaling pathway , 2015, Endocrine.

[71]  Yen‐Hua Huang,et al.  Inhibition of Staphylococcus aureus PriA Helicase by Flavonol Kaempferol , 2015, The Protein Journal.

[72]  Pingping Wu,et al.  Investigation of in vitro and in vivo antioxidant activities of flavonoids rich extract from the berries of Rhodomyrtus tomentosa(Ait.) Hassk. , 2015, Food chemistry.

[73]  Wenyong Lou,et al.  Highly efficient and regioselective synthesis of dihydromyricetin esters by immobilized lipase. , 2015, Journal of biotechnology.

[74]  S. O'keefe,et al.  Antioxidant activities of Vine Tea (Ampelopsis grossedentata) extract and its major component dihydromyricetin in soybean oil and cooked ground beef. , 2015, Food chemistry.

[75]  Hongyan Zhu,et al.  Attenuating effects of dihydromyricetin on angiotensin II-induced rat cardiomyocyte hypertrophy related to antioxidative activity in a NO-dependent manner , 2015, Pharmaceutical biology.

[76]  Runzhi Zhu,et al.  A reduction in reactive oxygen species contributes to dihydromyricetin-induced apoptosis in human hepatocellular carcinoma cells , 2014, Scientific Reports.

[77]  B. Liu,et al.  Dihydromyricetin induces mouse hepatoma Hepal-6 cell apoptosis via the transforming growth factor-β pathway , 2014, Molecular medicine reports.

[78]  Jinghong Qiu,et al.  A potent antibrowning agent from pine needles of Cedrus deodara: 2R,3R-dihydromyricetin. , 2014, Journal of food science.

[79]  B. Liu,et al.  Dihydromyricetin inhibits migration and invasion of hepatoma cells through regulation of MMP-9 expression. , 2014, World journal of gastroenterology.

[80]  Yuanzhong Wu,et al.  Dihydromyricetin Activates AMP-Activated Protein Kinase and P38MAPK Exerting Antitumor Potential in Osteosarcoma , 2014, Cancer Prevention Research.

[81]  B. Liu,et al.  Dihydromyricetin induces cell cycle arrest and apoptosis in melanoma SK-MEL-28 cells. , 2014, Oncology reports.

[82]  Bin Liu,et al.  Dihydromyricetin induces autophagy in HepG2 cells involved in inhibition of mTOR and regulating its upstream pathways. , 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[83]  Tong Zhang,et al.  Simultaneous determination of dihydromyricetin and resveratrol in Ampelopsis sinica (Miq.) W.T. Wang by high-performance liquid chromatography coupled with a diode array detection method. , 2014, Journal of chromatographic science.

[84]  R. Olsen,et al.  Dihydromyricetin Prevents Fetal Alcohol Exposure-Induced Behavioral and Physiological Deficits: The Roles of GABAA Receptors in Adolescence , 2014, Neurochemical Research.

[85]  Ruo Huang,et al.  Isolation and NMR Spectral Studies of Dihydromyricetin , 2013 .

[86]  Haili Huang,et al.  Dihydromyricetin suppresses the proliferation of hepatocellular carcinoma cells by inducing G2/M arrest through the Chk1/Chk2/Cdc25C pathway. , 2013, Oncology reports.

[87]  Qingquan Guo,et al.  Effects of Solubility, Thermal Stability and Antioxidant Properties of Acylating Dihydromyricetin , 2013 .

[88]  Ajazuddin,et al.  Recent advances and future prospects of phyto-phospholipid complexation technique for improving pharmacokinetic profile of plant actives. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[89]  K. Sekimizu,et al.  Antimicrobial action mechanism of flavonoids from Dorstenia species. , 2013, Drug discoveries & therapeutics.

[90]  Ning Chen,et al.  Pharmacological potential of ampelopsin in Rattan tea , 2012 .

[91]  Chao Yuan,et al.  CHARACTERIZATION, STABILITY AND ANTIOXIDANT ACTIVITY OF THE INCLUSION COMPLEX OF DIHYDROMYRICETIN WITH HYDROXYPROPYL-β-CYCLODEXTRIN , 2012 .

[92]  Jian Zhao,et al.  Empirical, thermodynamic and quantum-chemical investigations of inclusion complexation between flavanones and (2-hydroxypropyl)-cyclodextrins. , 2012, Food chemistry.

[93]  S. Solanki,et al.  Microemulsion Drug Delivery System: For Bioavailability Enhancement of Ampelopsin , 2012, ISRN pharmaceutics.

[94]  Yu Zhan,et al.  Dihydromyricetin Inhibits Cell Invasion and Down-regulates MMP-2/-9 Protein Expression Levels in Human Breast Cancer Cells*: Dihydromyricetin Inhibits Cell Invasion and Down-regulates MMP-2/-9 Protein Expression Levels in Human Breast Cancer Cells* , 2012 .

[95]  H. Abdolmaleky,et al.  Flavonoid Ampelopsin Inhibits the Growth and Metastasis of Prostate Cancer In Vitro and in Mice , 2012, PloS one.

[96]  Qun Sun,et al.  Antibacterial activity of water-soluble extract from pine needles of Cedrus deodara. , 2012, International journal of food microbiology.

[97]  R. Olsen,et al.  Dihydromyricetin As a Novel Anti-Alcohol Intoxication Medication , 2012, The Journal of Neuroscience.

[98]  Koichi Wada,et al.  Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications. , 2011, International journal of pharmaceutics.

[99]  Robert A. Weinberg,et al.  Tumor Metastasis: Molecular Insights and Evolving Paradigms , 2011, Cell.

[100]  Irina Volf,et al.  A critical review of methods for characterisation of polyphenolic compounds in fruits and vegetables. , 2011, Food chemistry.

[101]  Chun-Sen Wu,et al.  Study on Antioxidant Activity of Dihydromyricetin-Zinc(II) Complex , 2011 .

[102]  Zheng-xiang Ning,et al.  Characterization and antioxidant activity of flavonoid-rich extracts from leaves of Ampelopsis grossedentata. , 2009 .

[103]  Jie Zeng,et al.  Characterization and antioxidant activity of dihydromyricetin–lecithin complex , 2009 .

[104]  Carmen González-Barreiro,et al.  A review on the use of cyclodextrins in foods , 2009 .

[105]  Hui Li,et al.  Comparison of refluxing, ultrasonic- and microwave-assisted extraction of dihydromyricetin from Ampelopsis grossedentata. , 2008, Journal of AOAC International.

[106]  H. Schipper,et al.  Oxidative stress in diseases of the human cornea. , 2008, Free radical biology & medicine.

[107]  Y. Kwon,et al.  Cytotoxic constituents from the bark of Salix hulteni , 2008, Archives of pharmacal research.

[108]  M. Malumbres,et al.  Emerging cancer therapeutic opportunities by inhibiting mitotic kinases. , 2008, Current opinion in pharmacology.

[109]  N. Neamati,et al.  Small molecules anti-HIV therapeutics targeting CXCR4. , 2008, Current pharmaceutical design.

[110]  Zheng-xiang Ning,et al.  Izdvajanje dihidromiricetina iz lišća biljke Ampelopsis grossedentata mikrovalnom i višefaznom protustrujnom ekstrakcijom , 2007 .

[111]  B. Sarmento,et al.  Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs. , 2007, Drug discovery today.

[112]  Yu-ying Zhao,et al.  Isolation and identification of metabolites from dihydromyricetin , 2007, Magnetic resonance in chemistry : MRC.

[113]  S. Elmore.  Apoptosis: A Review of Programmed Cell Death , 2007, Toxicologic pathology.

[114]  Fereidoon Shahidi,et al.  Phenolics in cereals, fruits and vegetables: occurrence, extraction and analysis. , 2006, Journal of pharmaceutical and biomedical analysis.

[115]  Jacques Turgeon,et al.  The ATP-Binding Cassette Transporters and Their Implication in Drug Disposition: A Special Look at the Heart , 2006, Pharmacological Reviews.

[116]  G. Cordell,et al.  Prediction of human absorption of natural compounds by the non-everted rat intestinal sac model. , 2006, European journal of medicinal chemistry.

[117]  A. Hoffmann,et al.  Circuitry of nuclear factor κB signaling , 2006 .

[118]  Jin-Hyun Kim,et al.  Recovery and pre-purification of (+)-dihydromyricetin from Hovenia dulcis , 2006 .

[119]  Andrew J Lamb,et al.  Antimicrobial activity of flavonoids , 2005, International Journal of Antimicrobial Agents.

[120]  Boyang Yu,et al.  Improving the solubility of ampelopsin by solid dispersions and inclusion complexes. , 2005, Journal of pharmaceutical and biomedical analysis.

[121]  D. Kingston,et al.  Anticancer Agents from Natural Products , 2005 .

[122]  Junmei Wang,et al.  Threshold dissociation and molecular modeling of transition metal complexes of flavonoids , 2005, Journal of the American Society for Mass Spectrometry.

[123]  S. Singh,et al.  Anti-HIV and cytotoxic ruthenium(II) complexes containing flavones: biochemical evaluation in mice. , 2004, Indian journal of experimental biology.

[124]  Jin-Peng Yan,et al.  Ampelopsin, a small molecule inhibitor of HIV-1 infection targeting HIV entry. , 2004, Biomedical and environmental sciences : BES.

[125]  Liliana Jiménez,et al.  Polyphenols: food sources and bioavailability. , 2004, The American journal of clinical nutrition.

[126]  Colin L. Masters,et al.  Neurodegenerative diseases and oxidative stress , 2004, Nature Reviews Drug Discovery.

[127]  Hongwei Wang,et al.  Flavonoids: Promising anticancer agents , 2003, Medicinal research reviews.

[128]  H. Vezin,et al.  The splanchnic metabolism of flavonoids highly differed according to the nature of the compound. , 2003, American journal of physiology. Gastrointestinal and liver physiology.

[129]  Hui Wu,et al.  Antioxidation properties and mechanism of action of dihydromyricetin from Ampelopsis grossedentata. , 2003, Yao xue xue bao = Acta pharmaceutica Sinica.

[130]  Ming Xia,et al.  Purification of (+)-dihydromyricetin from leaves extract of Ampelopsis grossedentata using high-speed countercurrent chromatograph with scale-up triple columns. , 2002, Journal of chromatography. A.

[131]  W. Oleszek,et al.  Antioxidant and antiradical activities of flavonoids. , 2001, Journal of agricultural and food chemistry.

[132]  E. Middleton,et al.  The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. , 2000, Pharmacological reviews.

[133]  C. Skibola,et al.  Guest Editors: Enrique Cadenas and Kelvin J. A. Davies POTENTIAL HEALTH IMPACTS OF EXCESSIVE FLAVONOID INTAKE , 2000 .

[134]  J Dressman,et al.  Improving drug solubility for oral delivery using solid dispersions. , 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[135]  G. Pei,et al.  [Determination of total flavonoids and dihydromyricetin in Ampelopsis grossedentala (Hand-Mazz) W. T. Wang]. , 2000, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.

[136]  T. Jacks,et al.  The cell cycle and cancer. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[137]  S. Sahu,et al.  Pro-oxidant activity of flavonoids: effects on glutathione and glutathione S-transferase in isolated rat liver nuclei. , 1996, Cancer letters.

[138]  B. Levet-Trafit,et al.  Estimation of oral drug absorption in man based on intestine permeability in rats. , 1996, Life sciences.

[139]  M. Omata,et al.  Modulation of vascular calcium channel activity in response to acute volume expansion in rats. , 1995, Life sciences.

[140]  J. Crison,et al.  A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability , 1995, Pharmaceutical Research.

[141]  K. Schaumburg,et al.  Isolation of dihydromyricetin and dihydroquercetin from bark of pinus contorta , 1985 .

[142]  Longhuo Wu,et al.  2 Evidence-Based Complementary and Alternative Medicine , 2017 .

[143]  Xiaoqing Chen,et al.  At-line hyphenation of high-speed countercurrent chromatography with Sephadex LH-20 column chromatography for bioassay-guided separation of antioxidants from vine tea (Ampelopsis grossedentata). , 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[144]  R. Upton,et al.  A Quantitative Review and Meta-Models of the Variability and Factors Affecting Oral Drug Absorption—Part I: Gastrointestinal pH , 2016, The AAPS Journal.

[145]  V. Rai,et al.  Emerging need to use phytopharmaceuticals in the treatment of HIV , 2013 .

[146]  L. Luo,et al.  Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-κB signaling pathways. , 2012, International immunopharmacology.

[147]  Z. Fang.  Dihydromyricetin Inhibits Cell Invasion and Down-regulates MMP-2/-9 Protein Expression Levels in Human Breast Cancer Cells , 2012 .

[148]  刘本国.  Empirical, thermodynamic and quantum-chemical investigations of inclusion complexation between flavanones and (2-hydroxypropyl)-cyclodextrins , 2012 .

[149]  F. Liu,et al.  Apoptosis induced by the inclusion complex of dihydromyricetin with hydroxypropyl--cyclodextrin in Human Hep G2 cells , 2011 .

[150]  Zheng-xiang Ning,et al.  International Journal of Food Engineering Microwave Assisted Multi-Stage Countercurrent Extraction of Dihydromyricetin from Ampelopsis grossedentataa , 2011 .

[151]  A. Elaissari,et al.  Nanotechnology olymer-based nanocapsules for drug delivery , 2009 .

[152]  Wu Min-chen.  Study on Biological Efficacy of Dihydromyricetin , 2008 .

[153]  Yan Gao,et al.  Microwave Multi-Stage Countercurrent Extraction of Dihydromyricetin from Ampelopsis grossedentata , 2007 .

[154]  Ning Zheng-xiang.  The Antioxidation Activity of DMYL in Lard System , 2005 .

[155]  Zhong Zheng.  The Rat Chronic Toxicity Test of Total Flavone of Ampelopsis grossedentata from Guangxi , 2003 .

[156]  T. Shen.  Dihydromyricetin in Ampelopsis grossedentataby Reversed-Phase High Performance Liquid Chromatograpohy , 2002 .

[157]  Yousheng Zhang,et al.  Basic constituent of Ampelopsis grossedentata , 2001 .

[158]  S. Tahara,et al.  Ampelopsin, a major antifungal constituent from Salix sachalinensis, and its methyl ethers , 2001 .

[159]  M. Lawrence,et al.  Microemulsion-based media as novel drug delivery systems. , 2000, Advanced drug delivery reviews.

[160]  M. W. Brenner,et al.  Food Tannins Measurement, Determination of Food Tannins by Ultraviolet Spectrophotometry , 1958 .