THEME 3 COGNITIVE AND PSYCHOLOGICAL ASSESSMENT AND SUPPORT

Discussion and conclusion: The M-ACE was useful for the detection of ALS FTD patients but did not differentiate between ALS pure and ALS plus groups. This was perhaps not surprising as ALS plus is currently defi ned according to behavioural symptomatology and executive dysfunction, both of which are not measured by the M-ACE. Interestingly, the severity of behavioural symptomatology did not differ between ALS plus and ALS FTD groups. This likely refl ects the heterogeneity of the ALS FTD sample whereby some individuals had prominent behavioural symptoms whereas language impairment predominates in others. The M-ACE and MiND-B combined detects ALS FTD patients, differentiates along the ALS continuum and offers insight into the progression of non-motor symptomatology in ALS.

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