Successful management of an equine carpal chip fracture by intra-articularly injected adipose-derived stromal vascular fraction after arthroscopic removal.

Carpal chip fractures are common causes of lameness in racehorses. Due to disadvantages in surgical management, adjuvant treatment modalities are usually necessary. Adipose-derived stem cells (ADSCs) have the potential to differentiate into other cell types including bone and cartilage cells. Adipose-derived stromal vascular fraction (SVF) is produced during ADSCs isolation from adipose tissue. The purpose of this report was to present the successful management of a grade III chip fracture in the right carpus of a 5-year-old Thoroughbred gelding by intra-articularly injected autologous SVF one month after the arthroscopic removal of the fracture. This treatment resulted in lameness improvement and short rehabilitation period to previous racing activities. High performance levels and no recurrent injuries were recorded during a twenty month follow-up period.

[1]  O. Lepage,et al.  Biologic Strategies for Intra-articular Treatment and Cartilage Repair , 2015 .

[2]  M. Fini,et al.  Adipose-derived mesenchymal stem cells for cartilage tissue engineering: state-of-the-art in in vivo studies. , 2014, Journal of biomedical materials research. Part A.

[3]  N. Sofat,et al.  Future directions for the management of pain in osteoarthritis , 2014, International journal of clinical rheumatology.

[4]  L. Galuppo,et al.  Autologous point-of-care cellular therapies variably induce equine mesenchymal stem cell migration, proliferation and cytokine expression. , 2013, Equine veterinary journal.

[5]  P. Zuk.  Adipose-Derived Stem Cells in Tissue Regeneration: A Review , 2013 .

[6]  A. Oikonomou,et al.  Stem cell therapy for idiopathic pulmonary fibrosis: a protocol proposal , 2011, Journal of Translational Medicine.

[7]  F. Guilak,et al.  Concise Review: Adipose‐Derived Stromal Vascular Fraction Cells and Stem Cells: Let's Not Get Lost in Translation , 2011, Stem cells.

[8]  C. Kawcak,et al.  Evaluation of adipose‐derived stromal vascular fraction or bone marrow‐derived mesenchymal stem cells for treatment of osteoarthritis , 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[9]  Yilin Cao,et al.  Repair of articular cartilage defect in non-weight bearing areas using adipose derived stem cells loaded polyglycolic acid mesh. , 2009, Biomaterials.

[10]  M. Dauner,et al.  Chondrogenesis of adipose-derived adult stem cells in a poly-lactide-co-glycolide scaffold. , 2009, Tissue engineering. Part A.

[11]  B. Zheng,et al.  Mouse adipose-derived stem cells undergo multilineage differentiation in vitro but primarily osteogenic and chondrogenic differentiation in vivo. , 2006, Tissue engineering.

[12]  Farshid Guilak,et al.  Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo. , 2002, Biochemical and biophysical research communications.

[13]  J. J. Foerner,et al.  Osteochondritis dissecans of the tarsocrural joint: results of treatment with arthroscopic surgery. , 1991, Equine veterinary journal.

[14]  C. McIlwraith,et al.  Arthroscopic surgery for the treatment of osteochondral chip fractures in the equine carpus. , 1987, Journal of the American Veterinary Medical Association.

[15]  M. Helder,et al.  Freshly isolated stromal cells from the infrapatellar fat pad are suitable for a one-step surgical procedure to regenerate cartilage tissue. , 2009, Cytotherapy.

[16]  C. McIlwraith.  Chapter Four – Diagnostic and surgical arthroscopy of the carpal joints , 2005 .