Small-Cell Carcinoma of Nasopharynx: A Case Report of Unusual Localization

Neuroendocrine tumors are a spectrum of rare and highly heterogeneous neoplasms with distinct functional and biological behavior in relation to location, tumor size, and histological differentiation. Neuroendocrine tumors arise from the neuroendocrine cells of the diffuse neuroendocrine system located in almost every organ. Neuroendocrine tumors in the head and neck district are usually reported in sinonasal cavities and larynx. We present the case of a nasopharyngeal small-cell neuroendocrine carcinoma, which, as far as we know, is the 16th case reported in literature.

[1]  Jing Liu,et al.  Epstein–Barr Virus-Positive Large Cell Neuroendocrine Carcinoma of the Nasopharynx: Report of One Case and Review of the Literature , 2018, Head and Neck Pathology.

[2]  D. Irugu,et al.  Small Cell Neuroendocrine Carcinoma: A Rare Nasopharyngeal Malignancy with Aggressive Clinical Course , 2018, Indian Journal of Otolaryngology and Head & Neck Surgery.

[3]  W. D. de Herder,et al.  The Evolution of Neuroendocrine Tumor Treatment Reflected by ENETS Guidelines , 2018, Neuroendocrinology.

[4]  A. Colao.  Neuroendocrine Tumors in Real Life , 2018, Springer International Publishing.

[5]  S. Zappavigna,et al.  Aggressiveness pattern and second primary tumor risk associated with basaloid squamous cell carcinoma of the larynx , 2017, Oncotarget.

[6]  E. Rios,et al.  Small cell neuroendocrine carcinoma of the nasopharynx: a rare case report , 2017, Autopsy & case reports.

[7]  H. Errihani,et al.  Small-Cell Neuroendocrine Carcinoma Of Nasopharynx: A Case Report - , 2017 .

[8]  H. Errihani,et al.  AGGRESSIVE MULTIPLE MYELOMA IN A YOUNG ADULT: A CASE REPORT , 2017 .

[9]  M. Caraglia,et al.  Role of perineural invasion as a prognostic factor in laryngeal cancer. , 2016, Oncology letters.

[10]  G. de Rosa,et al.  Neuroendocrine tumours in rare sites: differences in nomenclature and diagnostics—a rare and ubiquitous histotype , 2016, Journal of Clinical Pathology.

[11]  D. Tafuri,et al.  Cavernous hemangioma of rhinopharynx: our experience and review of literature , 2015, Open medicine.

[12]  E. Monteiro,et al.  Small-Cell Neuroendocrine Carcinoma Originating From the Nasopharynx: Report of a Rare Case , 2015 .

[13]  R. Haba,et al.  Accelerated hyperfractionated radiotherapy for small cell carcinoma of the nasopharynx , 2015, Head & neck.

[14]  I. Arun,et al.  Reporting of a primary sinonasal neuroendocrine small cell carcinoma in the paediatric age group , 2014 .

[15]  H. Morgenstern,et al.  Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium , 2013, European Journal of Epidemiology.

[16]  A. Goyal,et al.  Small-Cell Neuroendocrine Carcinoma of Nasopharynx , 2012 .

[17]  S. Subha.  NEUROENDOCRINE CARCINOMA OF THE NASOPHARYNX - A CASE REPORT , 2011 .

[18]  Li‐yu Lee,et al.  Small-Cell Neuroendocrine Carcinoma of the Nasopharynx: Report of a Rare Case Lacking Association With Epstein-Barr Virus , 2011, International journal of surgical pathology.

[19]  S. Chiosea,et al.  Large Cell Neuroendocrine Carcinoma of the Larynx: Definition of an Entity , 2010, Head and neck pathology.

[20]  Chien-Heng Lin,et al.  Primary Small Cell Neuroendocrine Carcinoma of the Nasal Cavity After Successful Curative Therapy of Nasopharyngeal Carcinoma: A Case Report , 2009, The Kaohsiung journal of medical sciences.

[21]  C. Takita,et al.  Small cell carcinoma of the head and neck: the university of Miami experience. , 2008, International journal of radiation oncology, biology, physics.

[22]  A. Emami,et al.  Nasopharyngeal neuroendocrine carcinoma: a case report. , 2008, Ear, nose, & throat journal.

[23]  S. Deviprasad,et al.  Small-cell neuroendocrine carcinoma originating from the lateral nasopharyngeal wall. , 2008, Ear, nose, & throat journal.

[24]  E. Babin,et al.  Small cell neuroendocrine carcinoma of the nasal cavity and paranasal sinuses , 2006, The Journal of Laryngology & Otology.

[25]  J. A. Sánchez-Calzado,et al.  Sinonasal Neuroendocrine Carcinoma Presenting as a Nasopharyngeal Mass , 2001, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[26]  G. Wolf,et al.  Small cell carcinoma of the head and neck. , 1986, Head & neck surgery.