Lifelong exercise training promotes the remodelling of the immune system and prostate signalome in a rat model of prostate carcinogenesis

[1]  Michael J. Schlicht,et al.  The MNU Plus Testosterone Rat Model of Prostate Carcinogenesis , 2022, Toxicologic pathology.

[2]  Yicheng Han,et al.  CD3+CD4-CD8- (Double-Negative) T Cells in Inflammation, Immune Disorders and Cancer , 2022, Frontiers in Immunology.

[3]  E. Sierra-Diaz,et al.  Distribution and Effects of Estrogen Receptors in Prostate Cancer: Associated Molecular Mechanisms , 2022, Frontiers in Endocrinology.

[4]  Bruce D. Johnson,et al.  Exercise and the immune system: taking steps to improve responses to cancer immunotherapy , 2021, Journal for ImmunoTherapy of Cancer.

[5]  Heung Kyu Lee,et al.  Function of γδ T cells in tumor immunology and their application to cancer therapy , 2021, Experimental & Molecular Medicine.

[6]  C. Porto,et al.  Estrogen Receptor Signaling Pathways Involved in Invasion and Colony Formation of Androgen-Independent Prostate Cancer Cells PC-3 , 2021, International journal of molecular sciences.

[7]  C. Parker,et al.  Prostate Cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. , 2020, Annals of oncology : official journal of the European Society for Medical Oncology.

[8]  H. Thorpe,et al.  Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate , 2020, Lipids in health and disease.

[9]  Hipácia Werneck-Gomes,et al.  Targeting Wistar rat as a model for studying benign, premalignant and malignant lesions of the prostate. , 2019, Life sciences.

[10]  R. D. de Boer,et al.  A novel method optimizing the normalization of cardiac parameters in small animal models: the importance of dimensional indexing. , 2019, American journal of physiology. Heart and circulatory physiology.

[11]  H. Ahmed,et al.  The effects of testosterone replacement therapy on the prostate: a clinical perspective , 2019, F1000Research.

[12]  R. Laufer-Amorim,et al.  Association between decreased expression of estrogen receptor alpha, androgen receptor and phosphatase and tensin homolog immunoexpression in the canine prostate , 2019, Pesquisa Veterinária Brasileira.

[13]  Laurel M. Wentz,et al.  The compelling link between physical activity and the body's defense system , 2018, Journal of sport and health science.

[14]  R. Vitorino,et al.  Exercise Training Impacts Cardiac Mitochondrial Proteome Remodeling in Murine Urothelial Carcinoma , 2018, International journal of molecular sciences.

[15]  A. Jemal,et al.  Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries , 2018, CA: a cancer journal for clinicians.

[16]  S. Rogatto,et al.  Immunohistochemical panel to characterize canine prostate carcinomas according to aberrant p63 expression , 2018, PloS one.

[17]  K. Takayama,et al.  Estrogen and Androgen Blockade for Advanced Prostate Cancer in the Era of Precision Medicine , 2018, Cancers.

[18]  G. Castoria,et al.  Estrogens and Their Receptors in Prostate Cancer: Therapeutic Implications , 2018, Front. Oncol..

[19]  C. Niu,et al.  Gamma-delta (γδ) T cells: friend or foe in cancer development? , 2018, Journal of Translational Medicine.

[20]  M. Ljungman,et al.  Human prostate luminal cell differentiation requires NOTCH3 induction by p38-MAPK and MYC , 2017, Journal of Cell Science.

[21]  Minoru Kanehisa,et al.  KEGG: new perspectives on genomes, pathways, diseases and drugs , 2016, Nucleic Acids Res..

[22]  Martin H. Schaefer,et al.  HIPPIE v2.0: enhancing meaningfulness and reliability of protein–protein interaction networks , 2016, Nucleic Acids Res..

[23]  Y. Nordby,et al.  Estrogen receptors α and β and aromatase as independent predictors for prostate cancer outcome , 2016, Scientific Reports.

[24]  K. To,et al.  Importance of Estrogenic Signaling and Its Mediated Receptors in Prostate Cancer , 2016, International journal of molecular sciences.

[25]  L. Priskorn,et al.  Is Sedentary Lifestyle Associated With Testicular Function? A Cross-Sectional Study of 1,210 Men. , 2016, American journal of epidemiology.

[26]  R. Newton,et al.  Enhancing active surveillance of prostate cancer: the potential of exercise medicine , 2016, Nature Reviews Urology.

[27]  A. Piastowska-Ciesielska,et al.  Oestrogens and oestrogen receptors in prostate cancer , 2016, SpringerPlus.

[28]  Anushya Muruganujan,et al.  PANTHER version 10: expanded protein families and functions, and analysis tools , 2015, Nucleic Acids Res..

[29]  A. Alayev,et al.  mTORC1 directly phosphorylates and activates ERα upon estrogen stimulation , 2015, Oncogene.

[30]  M. Woźniewski,et al.  The effect of physical training on the N-methyl-N-nitrosourea-induced mammary carcinogenesis of Sprague–Dawley rats , 2015, Experimental biology and medicine.

[31]  R. Watson,et al.  Physical activity and its mechanistic effects on prostate cancer , 2015, Prostate Cancer and Prostatic Disease.

[32]  Juancarlos Chan,et al.  Gene Ontology Consortium: going forward , 2014, Nucleic Acids Res..

[33]  A. Crétual,et al.  Exercise training combined with antioxidant supplementation prevents the antiproliferative activity of their single treatment in prostate cancer through inhibition of redox adaptation. , 2014, Free radical biology & medicine.

[34]  V. Lafont,et al.  Plasticity of γδ T Cells: Impact on the Anti-Tumor Response , 2014, Front. Immunol..

[35]  P. Loprinzi,et al.  White Blood Cell Counts Mediate the Effects of Physical Activity on Prostate-Specific Antigen Levels , 2014, Research quarterly for exercise and sport.

[36]  J. Zajac,et al.  Androgens and prostate cancer; pathogenesis and deprivation therapy. , 2013, Best practice & research. Clinical endocrinology & metabolism.

[37]  Anushya Muruganujan,et al.  Large-scale gene function analysis with the PANTHER classification system , 2013, Nature Protocols.

[38]  Brad T. Sherman,et al.  DAVID-WS: a stateful web service to facilitate gene/protein list analysis , 2012, Bioinform..

[39]  Johannes Goll,et al.  Protein interaction data curation: the International Molecular Exchange (IMEx) consortium , 2012, Nature Methods.

[40]  F. Karpe,et al.  Physical activity and exercise in the regulation of human adipose tissue physiology. , 2012, Physiological reviews.

[41]  D. Vaamonde,et al.  Physically active men show better semen parameters and hormone values than sedentary men , 2012, European Journal of Applied Physiology.

[42]  W. Ricke,et al.  Androgens and estrogens in benign prostatic hyperplasia: past, present and future. , 2011, Differentiation; research in biological diversity.

[43]  Martin R. Lindley,et al.  The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease , 2011, Nature Reviews Immunology.

[44]  Wanjun Chen,et al.  Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression , 2011, International journal of biological sciences.

[45]  Stephen W Byers,et al.  Cross-regulation of signaling pathways: an example of nuclear hormone receptors and the canonical Wnt pathway. , 2010, Experimental cell research.

[46]  K. Esser,et al.  Physical activity reduces prostate carcinogenesis in a transgenic model , 2009, The Prostate.

[47]  J. Zoladz,et al.  Endurance Training of Moderate Intensity Increases Testosterone Concentration in Young, Healthy Men , 2009, International journal of sports medicine.

[48]  R. Matusik,et al.  Activation of β‐Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration , 2009, The Prostate.

[49]  G. Risbridger,et al.  The Dual, Opposing Roles of Estrogen in the Prostate , 2009, Annals of the New York Academy of Sciences.

[50]  G. Risbridger,et al.  Estrogen-regulated development and differentiation of the prostate. , 2008, Differentiation; research in biological diversity.

[51]  A. Conney,et al.  Inhibitory effect of voluntary running wheel exercise on the growth of human pancreatic Panc-1 and prostate PC-3 xenograft tumors in immunodeficient mice. , 2008, Oncology reports.

[52]  C. Ulrich,et al.  Effect of exercise on serum sex hormones in men: a 12-month randomized clinical trial. , 2008, Medicine and science in sports and exercise.

[53]  T. Shirai.  Significance of chemoprevention for prostate cancer development: Experimental in vivo approaches to chemoprevention , 2007, Pathology international.

[54]  M. Irigoyen,et al.  Maximal exercise test is a useful method for physical capacity and oxygen consumption determination in streptozotocin-diabetic rats , 2007, Cardiovascular diabetology.

[55]  J. Kreisberg,et al.  Cross-talk between the androgen receptor and the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer. , 2007, Current cancer drug targets.

[56]  J. Arunakaran,et al.  Chemoprevention of rat prostate carcinogenesis by diallyl disulfide, an organosulfur compound of garlic. , 2006, Biological & pharmaceutical bulletin.

[57]  J. Arunakaran,et al.  Chemoprevention of MNU and Testosterone induced prostate carcinogenesis by Calcitriol (vitamin D3) in adult male albino Wistar rats , 2006 .

[58]  William J. Kraemer,et al.  Hormonal Responses and Adaptations to Resistance Exercise and Training , 2005, Sports medicine.

[59]  Ajamete Kaykas,et al.  WNT and β-catenin signalling: diseases and therapies , 2004, Nature Reviews Genetics.

[60]  F. Taneli,et al.  SERUM TESTOSTERONE, GROWTH HORMONE, AND INSULIN-LIKE GROWTH FACTOR-1 LEVELS, MENTAL REACTION TIME, AND MAXIMAL AEROBIC EXERCISE IN SEDENTARY AND LONG-TERM PHYSICALLY TRAINED ELDERLY MALES , 2004, The International journal of neuroscience.

[61]  P. Shannon,et al.  Cytoscape: a software environment for integrated models of biomolecular interaction networks. , 2003, Genome research.

[62]  W. Kraemer,et al.  The relationship of natural killer cell counts, perforin mRNA and CD2 expression to post-exercise natural killer cell activity in humans. , 2002, Acta physiologica Scandinavica.

[63]  L. Bégin,et al.  Vascular endothelial growth factor and signaling in the prostate: more than angiogenesis , 2002, Molecular and Cellular Endocrinology.

[64]  Noam Brown,et al.  The role of tumour‐associated macrophages in tumour progression: implications for new anticancer therapies , 2002, The Journal of pathology.

[65]  John R Mackey,et al.  Physical exercise and immune system function in cancer survivors , 2002, Cancer.

[66]  D. Tindall,et al.  Androgen receptor signaling in androgen-refractory prostate cancer. , 2001, Journal of the National Cancer Institute.

[67]  J. Haseman,et al.  A Retrospective Analysis of Background Lesions and Tissue Accountability for Male Accessory Sex Organs in Fischer-344 Rats , 2001, Toxicologic pathology.

[68]  F. Bethencourt,et al.  Estrogen receptors alpha and beta in the normal, hyperplastic and carcinomatous human prostate. , 2001, The Journal of endocrinology.

[69]  M. Ashburner,et al.  Gene Ontology: tool for the unification of biology , 2000, Nature Genetics.

[70]  Gary M Williams,et al.  Induction of proliferative lesions of ventral prostate, seminal vesicle, and other accessory sex glands in rats by N‐methyl‐N‐nitrosourea: Effect of castration, pretreatment with cyproterone acetate and testosterone propionate, and rat strain , 1992, The Prostate.