Infectious SIV resides in adipose tissue and induces metabolic defects in chronically infected rhesus macaques

[1]  L. Fritts,et al.  Lymphatic Dissemination of Simian Immunodeficiency Virus after Penile Inoculation , 2016, Journal of Virology.

[2]  Trevor Bedford,et al.  Persistent HIV-1 replication maintains the tissue reservoir during therapy , 2015, Nature.

[3]  C. Rouzioux,et al.  Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV Infection , 2015, PLoS pathogens.

[4]  D. Mathis,et al.  Immunological contributions to adipose tissue homeostasis. , 2015, Seminars in immunology.

[5]  R. Hickner,et al.  IL-15 concentrations in skeletal muscle and subcutaneous adipose tissue in lean and obese humans: local effects of IL-15 on adipose tissue lipolysis. , 2015, American journal of physiology. Endocrinology and metabolism.

[6]  T. Chun,et al.  HIV reservoirs as obstacles and opportunities for an HIV cure , 2015, Nature Immunology.

[7]  Jeremy M. Brown,et al.  Human adipose tissue as a reservoir for memory CD4+ T cells and HIV , 2015, AIDS.

[8]  A. Haase,et al.  Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption , 2015, Proceedings of the National Academy of Sciences.

[9]  Daniel Winer,et al.  T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[10]  J. Betts,et al.  The impact of adiposity on adipose tissue-resident lymphocyte activation in humans , 2014, International Journal of Obesity.

[11]  K. Cho,et al.  An MHC II-dependent activation loop between adipose tissue macrophages and CD4+ T cells controls obesity-induced inflammation. , 2014, Cell reports.

[12]  S. Jiang,et al.  Adipocyte IL-15 Regulates Local and Systemic NK Cell Development , 2014, The Journal of Immunology.

[13]  Jinyan Liu,et al.  Rapid Seeding of the Viral Reservoir Prior to SIV Viremia in Rhesus Monkeys , 2014, Nature.

[14]  Alan S Perelson,et al.  Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues , 2014, Proceedings of the National Academy of Sciences.

[15]  B. Siegmund,et al.  Bacterial Translocation – Impact on the Adipocyte Compartment , 2013, Front. Immunol..

[16]  S. Samson,et al.  HIV-1 Vpr Induces Adipose Dysfunction in Vivo Through Reciprocal Effects on PPAR/GR Co-Regulation , 2013, Science Translational Medicine.

[17]  T. Hulgan,et al.  Adipose tissue and immune function: a review of evidence relevant to HIV infection. , 2013, The Journal of infectious diseases.

[18]  L. Fritts,et al.  Viral RNA Levels and env Variants in Semen and Tissues of Mature Male Rhesus Macaques Infected with SIV by Penile Inoculation , 2013, PloS one.

[19]  A. Ferrante,et al.  The immune cells in adipose tissue , 2013, Diabetes, obesity & metabolism.

[20]  M. Colonna,et al.  Accepted Manuscript Association Between Specific Adipose Tissue CD 4 + T-Cell Populations and Insulin Resistance in Obese People , 2013 .

[21]  K. Cho,et al.  Adipose Tissue Macrophages Function As Antigen-Presenting Cells and Regulate Adipose Tissue CD4+ T Cells in Mice , 2013, Diabetes.

[22]  S. Walrand,et al.  Chemokine Expression in Inflamed Adipose Tissue Is Mainly Mediated by NF-κB , 2013, PloS one.

[23]  Stephen T. C. Wong,et al.  Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation. , 2013, Cell metabolism.

[24]  L. Weiss,et al.  The split personality of regulatory T cells in HIV infection. , 2013, Blood.

[25]  C. Benoist,et al.  PPARγ is a major driver of the accumulation and phenotype of adipose-tissue Treg cells , 2012, Nature.

[26]  F. Villarroya,et al.  Hiv-1 Tat Protein Impairs Adipogenesis and Induces the Expression and Secretion of Proinflammatory Cytokines in Human Sgbs Adipocytes , 2012, Antiviral therapy.

[27]  John P. Moore,et al.  SHIV-162P3 Infection of Rhesus Macaques Given Maraviroc Gel Vaginally Does Not Involve Resistant Viruses , 2011, PloS one.

[28]  J. Reynolds,et al.  T lymphocyte activation in visceral adipose tissue of patients with oesophageal adenocarcinoma , 2011, The British journal of surgery.

[29]  R. Steigbigel,et al.  Nef inhibits glucose uptake in adipocytes and contributes to insulin resistance in human immunodeficiency virus type I infection. , 2011, The Journal of infectious diseases.

[30]  F. Villarroya,et al.  Adipose tissue biology and HIV-infection. , 2011, Best practice & research. Clinical endocrinology & metabolism.

[31]  M. Dijkstra,et al.  Human Primary Adipocytes Exhibit Immune Cell Function: Adipocytes Prime Inflammation Independent of Macrophages , 2011, PloS one.

[32]  Michael D. George,et al.  The Gut Mucosal Viral Reservoir in HIV-Infected Patients Is Not the Major Source of Rebound Plasma Viremia following Interruption of Highly Active Antiretroviral Therapy , 2011, Journal of Virology.

[33]  P. Chieffi,et al.  Leptin Modulates the Survival of Autoreactive CD4+ T Cells through the Nutrient/Energy-Sensing Mammalian Target of Rapamycin Signaling Pathway , 2010, The Journal of Immunology.

[34]  K. Strissel,et al.  T‐Cell Recruitment and Th1 Polarization in Adipose Tissue During Diet‐Induced Obesity in C57BL/6 Mice , 2010, Obesity.

[35]  M. Bukrinsky,et al.  Circulating Nef induces dyslipidemia in simian immunodeficiency virus-infected macaques by suppressing cholesterol efflux. , 2010, The Journal of infectious diseases.

[36]  W. Borkowsky,et al.  Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infection. , 2010, The Journal of infectious diseases.

[37]  V. Bourlier,et al.  Interplay Between Human Adipocytes and T Lymphocytes in Obesity: CCL20 as an Adipochemokine and T Lymphocytes as Lipogenic Modulators , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[38]  V. Hombach,et al.  T-lymphocyte Infiltration in Visceral Adipose Tissue: A Primary Event in Adipose Tissue Inflammation and the Development of Obesity-Mediated Insulin Resistance , 2008, Arteriosclerosis, thrombosis, and vascular biology.

[39]  G. Chrousos,et al.  Human immunodeficiency virus (HIV)-1 viral protein R suppresses transcriptional activity of peroxisome proliferator-activated receptor {gamma} and inhibits adipocyte differentiation: implications for HIV-associated lipodystrophy. , 2008, Molecular endocrinology.

[40]  Suha M. Saleh,et al.  CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency. , 2007, Blood.

[41]  J. Falutz.  Therapy Insight: body-shape changes and metabolic complications associated with HIV and highly active antiretroviral therapy , 2007, Nature Clinical Practice Endocrinology &Metabolism.

[42]  Brigitte Gicquel,et al.  Is Adipose Tissue a Place for Mycobacterium tuberculosis Persistence? , 2006, PloS one.

[43]  Yan Zhou,et al.  Novel Pathway for Induction of Latent Virus from Resting CD4+ T Cells in the Simian Immunodeficiency Virus/Macaque Model of Human Immunodeficiency Virus Type 1 Latency , 2006, Journal of Virology.

[44]  J. Lifson,et al.  Highly sensitive SIV plasma viral load assay: practical considerations, realistic performance expectations, and application to reverse engineering of vaccines for AIDS , 2005, Journal of medical primatology.

[45]  C. Dani,et al.  Human Immunodeficiency Virus Protease Inhibitors Accumulate into Cultured Human Adipocytes and Alter Expression of Adipocytokines* , 2005, Journal of Biological Chemistry.

[46]  A. Landay,et al.  Dynamics of cytokine expression in HIV productively infected primary CD4+ T cells. , 2004, Blood.

[47]  S. Grinspoon,et al.  HIV-associated lipodystrophy: pathogenesis, prognosis, treatment, and controversies. , 2004, Annual review of medicine.

[48]  N. Saksena,et al.  HIV-1 Nef protein in the nucleus influences adipogenesis as well as viral transcription through the peroxisome proliferator-activated receptors , 2004, AIDS.

[49]  Alejandra Borjabad,et al.  In vitro infection of human primary adipose cells with HIV-1: a reassessment , 2003, AIDS.

[50]  V. Calvez,et al.  HIV and antiretroviral drug distribution in plasma and fat tissue of HIV-infected patients with lipodystrophy , 2002, AIDS.

[51]  D. Littman,et al.  Cytokine Signals Are Sufficient for HIV-1 Infection of Resting Human T Lymphocytes , 1999, The Journal of experimental medicine.

[52]  Anthony S. Fauci,et al.  Induction of HIV-1 Replication in Latently Infected CD4+ T Cells Using a Combination of Cytokines , 1998, The Journal of experimental medicine.

[53]  P. Henklein,et al.  Effects of transgenic expression of HIV-1 Vpr on lipid and energy metabolism in mice. , 2007, American journal of physiology. Endocrinology and metabolism.

[54]  C. Pond.  Paracrine relationships between adipose and lymphoid tissues: implications for the mechanism of HIV-associated adipose redistribution syndrome. , 2003, Trends in immunology.

[55]  P. Duesberg.  HIV Latency , 1993, Bio/Technology.