TRESK channel as a potential target to treat T-cell mediated immune dysfunction.

[1]  S. Shabala,et al.  K(bg) and Kv1.3 channels mediate potassium efflux in the early phase of apoptosis in Jurkat T lymphocytes. , 2009, American journal of physiology. Cell physiology.

[2]  Dong-Hoon Shin,et al.  Identification of the large-conductance background K+ channel in mouse B cells as TREK-2. , 2009, American journal of physiology. Cell physiology.

[3]  Howard S. Smith,et al.  Calcineurin as a nociceptor modulator. , 2009, Pain physician.

[4]  Dongyue Huang,et al.  Roles of TRESK, a novel two-pore domain K+ channel, in pain pathway and general anesthesia , 2008, Neuroscience Bulletin.

[5]  G. Czirják,et al.  Phosphorylation-dependent Binding of 14-3-3 Proteins Controls TRESK Regulation* , 2008, Journal of Biological Chemistry.

[6]  O. Dobrovinskaya,et al.  TRESK-like potassium channels in leukemic T cells , 2008, Pflügers Archiv - European Journal of Physiology.

[7]  H. Wiendl,et al.  TWIK-related Acid-sensitive K+ Channel 1 (TASK1) and TASK3 Critically Influence T Lymphocyte Effector Functions* , 2008, Journal of Biological Chemistry.

[8]  J. La,et al.  Lamotrigine inhibits TRESK regulated by G-protein coupled receptor agonists. , 2008, Biochemical and biophysical research communications.

[9]  Y. Earm,et al.  Mechanosensitive activation of K+ channel via phospholipase C‐induced depletion of phosphatidylinositol 4,5‐bisphosphate in B lymphocytes , 2007, The Journal of physiology.

[10]  A. Rao,et al.  Linking calcineurin activity to leukemogenesis , 2007, Nature Medicine.

[11]  M. Savignac,et al.  Calcium-dependent transcription of cytokine genes in T lymphocytes , 2007, Pflügers Archiv - European Journal of Physiology.

[12]  R. C. Rodríguez de la Vega,et al.  K+ channel blockers: novel tools to inhibit T cell activation leading to specific immunosuppression. , 2006, Current pharmaceutical design.

[13]  G. Czirják,et al.  Targeting of Calcineurin to an NFAT-like Docking Site Is Required for the Calcium-dependent Activation of the Background K+ Channel, TRESK* , 2006, Journal of Biological Chemistry.

[14]  Christine Beeton,et al.  Potassium Channels, Memory T Cells, and Multiple Sclerosis , 2005, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[15]  Donghee Kim Physiology and pharmacology of two-pore domain potassium channels. , 2005, Current pharmaceutical design.

[16]  F. Macian,et al.  NFAT proteins: key regulators of T-cell development and function , 2005, Nature Reviews Immunology.

[17]  S. Korn,et al.  Potassium channels , 2005, IEEE Transactions on NanoBioscience.

[18]  G. Vámosi,et al.  Looking through ion channels: recharged concepts in T-cell signaling. , 2004, Trends in immunology.

[19]  Donghee Kim,et al.  Functional Expression of TRESK-2, a New Member of the Tandem-pore K+ Channel Family* , 2004, Journal of Biological Chemistry.

[20]  D. Uhm,et al.  Membrane-delimited Regulation of Novel Background K+ Channels by MgATP in Murine Immature B Cells* , 2004, Journal of Biological Chemistry.

[21]  Z. Tóth,et al.  The Two-pore Domain K+ Channel, TRESK, Is Activated by the Cytoplasmic Calcium Signal through Calcineurin* , 2004, Journal of Biological Chemistry.

[22]  Z. Varga,et al.  Ion channels and lymphocyte activation. , 2004, Immunology letters.

[23]  J. Neilson,et al.  Calcineurin B1 is essential for positive but not negative selection during thymocyte development. , 2004, Immunity.

[24]  L. Mátyus,et al.  Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[25]  Donghee Kim Fatty acid-sensitive two-pore domain K+ channels. , 2003, Trends in pharmacological sciences.

[26]  K. Chandy,et al.  Potassium channels as therapeutic targets for autoimmune disorders. , 2003, Current opinion in drug discovery & development.

[27]  P. Calabresi,et al.  The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS. , 2003, The Journal of clinical investigation.

[28]  Richard S Lewis,et al.  CRAC channels: activation, permeation, and the search for a molecular identity. , 2003, Cell calcium.

[29]  J. Molkentin,et al.  Defective T cell development and function in calcineurin Aβ-deficient mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[30]  K. Chandy,et al.  Selective blockade of T lymphocyte K+ channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[31]  K. Chandy,et al.  Molecular Properties and Physiological Roles of Ion Channels in the Immune System , 2001, Journal of Clinical Immunology.

[32]  P. Giraud,et al.  Selective Blocking of Voltage-Gated K+ Channels Improves Experimental Autoimmune Encephalomyelitis and Inhibits T Cell Activation1 , 2001, The Journal of Immunology.

[33]  K. Xu,et al.  Histamine induces nuclear factor of activated T cell-mediated transcription and cyclosporin A-sensitive interleukin-8 mRNA expression in human umbilical vein endothelial cells. , 1998, Molecular pharmacology.

[34]  E. Christian,et al.  A Novel Gene, hKCa4, Encodes the Calcium-activated Potassium Channel in Human T Lymphocytes* , 1997, The Journal of Biological Chemistry.

[35]  K. Chandy,et al.  Ion channels in the immune system as targets for immunosuppression. , 1997, Current opinion in biotechnology.

[36]  G. Crabtree,et al.  Molecular analysis of the interaction of calcineurin with drug-immunophilin complexes. , 1994, The Journal of biological chemistry.

[37]  P. Negulescu,et al.  Intracellular calcium dependence of gene expression in single T lymphocytes. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[38]  S. Grissmer,et al.  Calcium-activated potassium channels in resting and activated human T lymphocytes. Expression levels, calcium dependence, ion selectivity, and pharmacology , 1993, The Journal of general physiology.

[39]  S. Gollapudi,et al.  Effect of K+ channel blockers on anti-immunoglobulin-induced murine B cell proliferation. , 1988, Journal of clinical & laboratory immunology.

[40]  K. Chandy,et al.  Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis? , 1984, Nature.

[41]  A. Ichikawa,et al.  Recent advances in molecular pharmacology of the histamine systems: immune regulatory roles of histamine produced by leukocytes. , 2006, Journal of pharmacological sciences.

[42]  S. Snyder,et al.  Immunophilins and nervous system , 1995, Nature Medicine.

[43]  M. Cahalan,et al.  Potassium and calcium channels in lymphocytes. , 1995, Annual review of immunology.