Spatial regulation of Cdc55–PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast

Zds1/2 regulate mitotic progression by directing the nucleocytoplasmic distribution of Cdc55–PP2A.

[1]  Mark Skehel,et al.  Greatwall Phosphorylates an Inhibitor of Protein Phosphatase 2Α That Is Essential for Mitosis , 2010, Science.

[2]  Gary D Bader,et al.  Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry , 2002, Nature.

[3]  D. Hirata,et al.  Role of calcineurin and Mpk1 in regulating the onset of mitosis in budding yeast , 1998, Nature.

[4]  P. Bork,et al.  Functional organization of the yeast proteome by systematic analysis of protein complexes , 2002, Nature.

[5]  P. Philippsen,et al.  Additional modules for versatile and economical PCR‐based gene deletion and modification in Saccharomyces cerevisiae , 1998, Yeast.

[6]  Andrew Burgess,et al.  The Substrate of Greatwall Kinase, Arpp19, Controls Mitosis by Inhibiting Protein Phosphatase 2A , 2010, Science.

[7]  Giovanna Lucchini,et al.  The budding yeast PP2ACdc55 protein phosphatase prevents the onset of anaphase in response to morphogenetic defects , 2007, The Journal of cell biology.

[8]  Andrew W. Murray,et al.  Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast , 1996, Current Biology.

[9]  Sean R. Collins,et al.  Global landscape of protein complexes in the yeast Saccharomyces cerevisiae , 2006, Nature.

[10]  Y. Shu,et al.  Molecular genetic analysis of Rts1p, a B' regulatory subunit of Saccharomyces cerevisiae protein phosphatase 2A , 1997, Molecular and cellular biology.

[11]  D. Lew,et al.  Phosphorylation-Independent Inhibition of Cdc28p by the Tyrosine Kinase Swe1p in the Morphogenesis Checkpoint , 1999, Molecular and Cellular Biology.

[12]  Tim Hunt,et al.  Regulated activity of PP2A–B55δ is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts , 2009, The EMBO journal.

[13]  Matthew S. Gentry,et al.  Loss of a Protein Phosphatase 2A Regulatory Subunit (Cdc55p) Elicits Improper Regulation of Swe1p Degradation , 2000, Molecular and Cellular Biology.

[14]  D. Burke,et al.  The role of Cdc55 in the spindle checkpoint is through regulation of mitotic exit in Saccharomyces cerevisiae. , 2005, Molecular biology of the cell.

[15]  M. Stark,et al.  Mutations in the Saccharomyces cerevisiae type 2A protein phosphatase catalytic subunit reveal roles in cell wall integrity, actin cytoskeleton organization and mitosis. , 1997, Genetics.

[16]  D. Clift,et al.  Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase. , 2009, Genes & development.

[17]  Chandra L. Theesfeld,et al.  The Morphogenesis Checkpoint in Saccharomyces cerevisiae: Cell Cycle Control of Swe1p Degradation by Hsl1p and Hsl7p , 1999, Molecular and Cellular Biology.

[18]  K. Runge,et al.  Two paralogs involved in transcriptional silencing that antagonistically control yeast life span , 2000, Current Biology.

[19]  Shih-Yin Tsai,et al.  Interaction of Saccharomyces Cdc13p with Pol1p, Imp4p, Sir4p and Zds2p is involved in telomere replication, telomere maintenance and cell growth control. , 2004, Nucleic acids research.

[20]  Bela Novak,et al.  Downregulation of PP2ACdc55 Phosphatase by Separase Initiates Mitotic Exit in Budding Yeast , 2006, Cell.

[21]  Katsunori Tanaka,et al.  zds1, a Novel Gene Encoding an Ortholog of Zds1 and Zds2, Controls Sexual Differentiation, Cell Wall Integrity and Cell Morphology in Fission Yeast , 2006, Genetics.

[22]  D. Hirata,et al.  Involvement of calcineurin‐dependent degradation of Yap1p in Ca2+‐induced G2 cell‐cycle regulation in Saccharomyces cerevisiae , 2006, EMBO reports.

[23]  M. Tyers,et al.  The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. , 1998, Molecular cell.

[24]  Nilanjan Roy,et al.  The ZDS1 and ZDS2 proteins require the Sir3p component of yeast silent chromatin to enhance the stability of short linear centromeric plasmids , 1999, Chromosoma.

[25]  E. Bi,et al.  ZDS1 and ZDS2, genes whose products may regulate Cdc42p in Saccharomyces cerevisiae , 1996, Molecular and cellular biology.

[26]  Angelika Amon,et al.  Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus , 1999, Nature.

[27]  Steven A. Carr,et al.  Phosphorylation by Cyclin B-Cdk Underlies Release of Mitotic Exit Activator Cdc14 from the Nucleolus , 2004, Science.

[28]  Douglas R. Kellogg,et al.  Regulation of Mih1/Cdc25 by protein phosphatase 2A and casein kinase 1 , 2008, The Journal of cell biology.

[29]  Matthew S. Gentry,et al.  Localization of Saccharomyces cerevisiae protein phosphatase 2A subunits throughout mitotic cell cycle. , 2002, Molecular biology of the cell.

[30]  D. Burke,et al.  Cdc55p, the B-type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore/spindle checkpoint in Saccharomyces cerevisiae , 1997, Molecular and cellular biology.

[31]  S. Shuman,et al.  Effects of deletion mutations in the yeast Ces1 protein on cell growth and morphology and on high copy suppression of mutations in mRNA capping enzyme and translation initiation factor 4A. , 1998, Nucleic acids research.

[32]  Douglas R. Kellogg,et al.  The Zds proteins control entry into mitosis and target protein phosphatase 2A to the Cdc25 phosphatase , 2011, Molecular biology of the cell.

[33]  Angelika Amon,et al.  Separase, Polo Kinase, the Kinetochore Protein Slk19, and Spo12 Function in a Network that Controls Cdc14 Localization during Early Anaphase , 2002, Cell.

[34]  Otto Hudecz,et al.  Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cells , 2010, Nature Cell Biology.

[35]  Sergio Moreno,et al.  Conservation of mitotic controls in fission and budding yeasts , 1989, Cell.

[36]  J. Thevelein,et al.  Feedback Inhibition on Cell Wall Integrity Signaling by Zds1 Involves Gsk3 Phosphorylation of a cAMP-dependent Protein Kinase Regulatory Subunit* , 2003, Journal of Biological Chemistry.

[37]  D. Lew,et al.  Nucleocytoplasmic trafficking of G2/M regulators in yeast. , 2008, Molecular biology of the cell.

[38]  S. Valentini,et al.  Pkc1 Acts Through Zds1 and Gic1 to Suppress Growth and Cell Polarity Defects of a Yeast eIF5A Mutant , 2005, Genetics.

[39]  C. Cole,et al.  Physical and Genetic Interactions Link the Yeast Protein Zds1p with mRNA Nuclear Export* , 2005, Journal of Biological Chemistry.

[40]  J. Broach,et al.  Initiation of the TORC1-regulated G0 program requires Igo1/2, which license specific mRNAs to evade degradation via the 5'-3' mRNA decay pathway. , 2010, Molecular cell.

[41]  A. Straight,et al.  Net1, a Sir2-Associated Nucleolar Protein Required for rDNA Silencing and Nucleolar Integrity , 1999, Cell.

[42]  Yigong Shi Serine/Threonine Phosphatases: Mechanism through Structure , 2009, Cell.

[43]  Yanchang Wang,et al.  Phosphatase 2A negatively regulates mitotic exit in Saccharomyces cerevisiae. , 2005, Molecular biology of the cell.

[44]  F. Uhlmann,et al.  Separase cooperates with Zds1 and Zds2 to activate Cdc14 phosphatase in early anaphase , 2008, The Journal of cell biology.

[45]  Yu Jiang,et al.  Regulation of the Cell Cycle by Protein Phosphatase 2A in Saccharomyces cerevisiae , 2006, Microbiology and Molecular Biology Reviews.

[46]  A. Depaoli-Roach,et al.  Saccharomyces cerevisiae Homologs of Mammalian B and B′ Subunits of Protein Phosphatase 2A Direct the Enzyme to Distinct Cellular Functions* , 1997, The Journal of Biological Chemistry.

[47]  T. von der Haar,et al.  Optimized Protein Extraction for Quantitative Proteomics of Yeasts , 2007, PloS one.

[48]  J. Thorner,et al.  Hsl7 Localizes to a Septin Ring and Serves as an Adapter in a Regulatory Pathway That Relieves Tyrosine Phosphorylation of Cdc28 Protein Kinase inSaccharomyces cerevisiae , 1999, Molecular and Cellular Biology.

[49]  S. Ishihara,et al.  Dissection of upstream regulatory components of the Rho1p effector, 1,3-beta-glucan synthase, in Saccharomyces cerevisiae. , 2002, Genetics.

[50]  M. Hodel,et al.  Nuclear Localization Signal Receptor Affinity Correlates with in Vivo Localization in Saccharomyces cerevisiae* , 2006, Journal of Biological Chemistry.

[51]  Annalisa Ballarini,et al.  Nucleocytoplasmic Distribution of Budding Yeast Protein Kinase A Regulatory Subunit Bcy1 Requires Zds1 and Is Regulated by Yak1-Dependent Phosphorylation of Its Targeting Domain , 2001, Molecular and Cellular Biology.

[52]  K. Arndt,et al.  The role of Saccharomyces cerevisiae type 2A phosphatase in the actin cytoskeleton and in entry into mitosis. , 1995, The EMBO journal.

[53]  Sean R. Collins,et al.  Toward a Comprehensive Atlas of the Physical Interactome of Saccharomyces cerevisiae*S , 2007, Molecular & Cellular Proteomics.

[54]  S. Reed,et al.  Morphogenesis in the yeast cell cycle: regulation by Cdc28 and cyclins , 1993, The Journal of cell biology.

[55]  Paul Nurse,et al.  Genetic control of cell size at cell division in yeast , 1975, Nature.

[56]  M. Kirschner,et al.  Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins. , 1993, The EMBO journal.

[57]  D. Stillman,et al.  Mutations in the homologous ZDS1 and ZDS2 genes affect cell cycle progression , 1996, Molecular and Cellular Biology.

[58]  Jung-Eun Park,et al.  Concerted mechanism of Swe1/Wee1 regulation by multiple kinases in budding yeast , 2005, The EMBO journal.

[59]  S. Fields,et al.  A protein interaction map for cell polarity development , 2001, The Journal of cell biology.

[60]  M. Vignali,et al.  Zds2p Regulates Swe1p-dependent Polarized Cell Growth in Saccharomyces cerevisiae via a Novel Cdc55p Interaction Domain , 2010, Molecular biology of the cell.

[61]  M. Goebl,et al.  CDC55, a Saccharomyces cerevisiae gene involved in cellular morphogenesis: identification, characterization, and homology to the B subunit of mammalian type 2A protein phosphatase , 1991, Molecular and cellular biology.

[62]  P. Greengard,et al.  ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins. , 2001 .