Postoperative analgesia with intravenous fentanyl PCA vs epidural block after thoracoscopic pectus excavatum repair in children.

BACKGROUND The aim of this prospective, randomized trial was to compare analgesia, sedation, and cardiorespiratory function in children after thoracoscopic surgery for pectus excavatum repair, using two types of analgesia--epidural block with bupivacaine plus fentanyl vs patient-controlled analgesia (PCA) with fentanyl. METHODS Twenty-eight patients scheduled for thoracoscopic pectus excavatum surgery were randomly assigned to receive either thoracic epidural block or i.v. PCA for postoperative analgesia. Pain was assessed using a visual-analogue scale (VAS). The Ramsay sedation score, arterial pressure, ventilatory frequency, and heart rate were also measured, and blood gas analysis was performed regularly during the first 48 h after surgery. RESULTS A significant decrease in the VAS pain score, Ramsay sedation score, heart rate ventilatory frequency, systolic and diastolic blood pressure, and PaCO2, and a significant increase in PaO2 and oxygen saturation were found over time. Patients in the PCA group had significantly higher PaCO2 values. In addition, a significantly slower decline of systolic blood pressure and heart rate, and faster recovery of PaCO2 were found in PCA patients than in patients with epidural block. CONCLUSIONS I.V. fentanyl PCA is as effective as thoracic epidural for postoperative analgesia in children after thoracoscopic pectus excavatum repair. Bearing in mind the possible complications of epidural catheterization in children, the use of fentanyl PCA is recommended.

[1]  A. Auldist,et al.  THE LEARNING CURVE IN LEARNING THE CURVE: A REVIEW OF NUSS PROCEDURE IN TEENAGERS , 2005, ANZ journal of surgery.

[2]  B. Golianu,et al.  Pediatric thoracic anesthesia. , 2005, Current opinion in anaesthesiology.

[3]  M. Angst,et al.  The Site of Action of Epidural Fentanyl Infusions in the Presence of Local Anesthetics: A Minimum Local Analgesic Concentration Infusion Study in Nulliparous Labor , 2003, Anesthesia and analgesia.

[4]  R. Howard,et al.  Epidural analgesia in children. A survey of current opinions and practices amongst UK paediatric anaesthetists , 2003, Paediatric anaesthesia.

[5]  M. Angst,et al.  The Site of Action of Epidural Fentanyl in Humans: The Difference Between Infusion and Bolus Administration , 2003, Anesthesia and analgesia.

[6]  J. Tschopp,et al.  Influence of thoracic epidural analgesia on cardiovascular autonomic control after thoracic surgery. , 2003, British journal of anaesthesia.

[7]  T. Inge,et al.  Reduced hospitalization cost for patients with pectus excavatum treated using minimally invasive surgery , 2003, Surgical Endoscopy And Other Interventional Techniques.

[8]  A. Boyaci,et al.  Comparison of patient‐controlled analgesia with and without a background infusion after appendicectomy in children , 2003, Paediatric anaesthesia.

[9]  Robert E. Kelly,et al.  Review and Discussion of the Complications of Minimally Invasive Pectus Excavatum Repair , 2002, European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie.

[10]  J. Jacobs,et al.  Minimally invasive endoscopic repair of pectus excavatum. , 2002, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[11]  P. Bozkurt The analgesic efficacy and neuroendocrine response in paediatric patients treated with two analgesic techniques: using morphine‐epidural and patient‐controlled analgesia , 2002, Paediatric anaesthesia.

[12]  R. Dyer,et al.  Tramadol Infusion for Postthoracotomy Pain Relief: A Placebo-Controlled Comparison with Epidural Morphine , 2002, Anesthesia and analgesia.

[13]  M. Pinaud,et al.  Postoperative epidural analgesia with bupivacaine and fentanyl: hourly pain assessment in 348 paediatric cases , 2001, Paediatric anaesthesia.

[14]  G. Lederhaas,et al.  A Randomized Comparison of the Effects of Continuous Thoracic Epidural Analgesia and Intravenous Patient‐Controlled Analgesia After Posterior Spinal Fusion in Adolescents , 2000, Regional anesthesia and pain medicine.

[15]  S. Engum,et al.  Is the grass greener? Early results of the Nuss procedure. , 2000, Journal of pediatric surgery.

[16]  D. Tibboel,et al.  Patient controlled analgesia in children and adolescents: a randomized controlled trial , 1999, Paediatric anaesthesia.

[17]  N. Rawal Epidural and spinal agents for postoperative analgesia. , 1999, The Surgical clinics of North America.

[18]  C. Berde,et al.  The Risk of Infection from Epidural Analgesia in Children: A Review of 1620 Cases , 1995, Anesthesia and analgesia.

[19]  B. Kavanagh,et al.  Pain Control after Thoracic Surgery: A Review of Current Techniques , 1994, Anesthesiology.

[20]  C. Berde Epidural analgesia in children , 1994, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[21]  M. Hirose,et al.  Spinal cord injury in a child caused by an accidental dural puncture with a single-shot thoracic epidural needle. , 2003, Anesthesia and analgesia.

[22]  H. Lestin,et al.  [Postoperative epidural analgesia--current status, indications and management]. , 2002, Anaesthesiologie und Reanimation.

[23]  M. Cooper,et al.  Patient-controlled analgesia: an appropriate method of pain control in children. , 2001, Paediatric drugs.

[24]  B. Veering,et al.  Cardiovascular and pulmonary effects of epidural anaesthesia. , 2000, Anaesthesia and intensive care.

[25]  D. Benhamou,et al.  ESRA guidelines for the use of epidural opioids , 1997 .

[26]  D. Vane,et al.  Continuous thoracic epidural infusions for postoperative analgesia after pectus deformity repair. , 1996, Journal of pediatric surgery.