论文信息 - Multiscale Fractal Analysis of Cortical Pyramidal Neurons

Multiscale Fractal Analysis of Cortical Pyramidal Neurons

The present study used 3D data on neuronal morphology images to quantitatively characterize the phenotype of transgenic neurons. We calculated the multiscale fractal dimension (MFD) of reconstructed neuronal cells. It was shown that in a specific mouse mutant changes in the complexity of neuronal morphology correlate with changes in the MFD of dendrites of pyramidal neurons. Neurons in the mutant strain have lower peak fractal dimension compared with the wildtype, and a greater variety of the cell morphological phenotype.

Luciano da Fontoura Costa | Andreas Schierwagen | Ulrich Gärtner | Alán Alpár

[1] Andreas Schierwagen,et al. Expression of constitutively active p21H‐rasval12 in postmitotic pyramidal neurons results in increased dendritic size and complexity , 2003, The Journal of comparative neurology.

[2] Andreas Schierwagen,et al. Active Percolation Analysis of Pyramidal Neurons of Somatosensory Cortex , 2005, q-bio/0501017.

[3] Luciano da Fontoura Costa,et al. Shape Analysis and Classification: Theory and Practice , 2000 .

[4] H F Jelinek,et al. Use of fractal theory in neuroscience: methods, advantages, and potential problems. , 2001, Methods.

[5] A. Schierwagen. Dendritic Branching Patterns , 1987 .

[6] E. Wagner,et al. Transgenic Activation of Ras in Neurons Promotes Hypertrophy and Protects from Lesion-Induced Degeneration , 2000, The Journal of cell biology.

[7] Jaap van Pelt,et al. A shape analysis framework for neuromorphometry , 2002, Network.

[8] L. Olsen,et al. Chaos in biological systems. , 1985 .