Cancer in Cumbria and in the vicinity of the Sellafield nuclear installation, 1963-90.

OBJECTIVE--To reappraise the epidemiological findings reported by the Black Advisory Group concerning a possible excess of malignant disease, particularly of childhood acute lymphoid leukaemia and non-Hodgkin lymphomas, in the vicinity of the Sellafield nuclear installation, and to determine whether any excess of malignant disease had occurred among people aged 0-24 years in the area in the years after the Black report--that is, from 1984 to 1990. DESIGN--Calculation of incidence of cancer using data from population based cancer registries and special surveys. SETTING--England and Wales; county of Cumbria; county districts Allerdale and Copeland within Cumbria; Seascale ward within Copeland. SUBJECTS--All residents under the age of 75 years in the above areas, but with particular reference to those aged 0-24 years. MAIN OUTCOME MEASURES--Numbers of cases and incidence particularly of lymphoid leukaemia and non-Hodgkin lymphomas in those aged 0-24 years, but including other cancers and age groups. RESULTS--Previous reports of an increased incidence of cancer, especially of leukaemia, among those aged 0-24 years in Seascale during the period up to and including 1983 are confirmed. During 1984-90 there was an excess of total cancer among those aged 0-24 years. This was based on four cases including two cases of non-Hodgkin lymphoma but none of leukaemia. There was an increased, but nonsignificant, incidence of other cancers, based on two cases (one pinealoma and one Hodgkin's disease) occurring among those aged 15-24 years during 1984-90. This was not observed in the younger age group or in previous years. For the immediately surrounding area--that is, the county districts of Allerdale and Copeland excluding Seascale and in the remainder of Cumbria--there was no evidence of an increased incidence of cancer among those aged 0-24 years in either period. CONCLUSIONS--During 1963-83 and 1984-90 the incidence of malignant disease, particularly lymphoid leukaemia and non-Hodgkin lymphomas, in young people aged 0-24 in Seascale was higher than would be expected on the basis of either national rates or those for the surrounding areas. Although this increased risk is unlikely to be due to chance, the reasons for it are still unknown.

[1]  Anthony J. Swerdlow,et al.  Cancer Registration in England and Wales: Some Aspects Relevant to Interpretation of the Data , 1986 .

[2]  F. Alexander,et al.  Community lifestyle characteristics and risk of acute lymphoblastic leukaemia in children , 1990, The Lancet.

[3]  H. B. Marsden,et al.  A classification scheme for childhood cancer , 1987, International journal of cancer.

[4]  A. Craft,et al.  The Northern region Children's malignant disease registry 1968-82: incidence and survival. , 1987, British Journal of Cancer.

[5]  Cancer in young people in the north of England, 1968-85: analysis by census wards. , 1993, Journal of epidemiology and community health.

[6]  D. Black,et al.  Investigation of the possible increased incidence of cancer in West Cumbria , 1984 .

[7]  Terry J. Hamblin,et al.  Leukaemia and Lymphoma—an atlas of distribution within areas of England and Wales, 1984–1988 , 1990 .

[8]  M. Gardner,et al.  Follow up study of children born elsewhere but attending schools in Seascale, West Cumbria (schools cohort). , 1987, British medical journal.

[9]  J. Bithell,et al.  Pre-natal irradiation and childhood malignancy: a review of British data from the Oxford Survey. , 1975, British Journal of Cancer.

[10]  D. Parkin,et al.  The international incidence of childhood cancer , 1988, IARC scientific publications.

[11]  M. Gardner,et al.  Follow up study of children born to mothers resident in Seascale, West Cumbria (birth cohort). , 1987, British medical journal.

[12]  L. Kinlen,et al.  Childhood leukaemia and poliomyelitis in relation to military encampments in England and Wales in the period of national military service, 1950-63. , 1991, BMJ.

[13]  M. Bobrow,et al.  Committee on medical aspects of radiation in the environment (COMARE) : second report, investigation of the possible increased incidence of leukaemia in young people near the Dounreay Nuclear Establishment, Caithness, Scotland , 1988 .

[14]  S. C. Darby,et al.  Geographical variation in mortality from leukaemia and other cancers in England and Wales in relation to proximity to nuclear installations, 1969-78. , 1989, British Journal of Cancer.

[15]  L. Kinlen,et al.  Evidence from population mixing in British New Towns 1946-85 of an infective basis for childhood leukaemia , 1990, The Lancet.

[16]  A J Hall,et al.  Results of case-control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. , 1990, BMJ.