A new compound-specific pleiotropic effect of statins: modification of plasma gamma-tocopherol levels.

[1]  A. Gotto.  Statins, cardiovascular disease, and drug safety. , 2006, The American journal of cardiology.

[2]  D. Colquhoun,et al.  Effects of simvastatin on blood lipids, vitamin E, coenzyme Q10 levels and left ventricular function in humans , 2005, European journal of clinical investigation.

[3]  C. Cross,et al.  Studies in humans using deuterium-labeled α- and γ-tocopherols demonstrate faster plasma γ-tocopherol disappearance and greater γ-metabolite production , 2005 .

[4]  S. Yusuf,et al.  Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. , 2005, JAMA.

[5]  David E. Williams,et al.  α-Tocopherol modulates Cyp3a expression, increases γ-CEHC production, and limits tissue γ-tocopherol accumulation in mice fed high γ-tocopherol diets , 2005 .

[6]  Michael Schachter,et al.  Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update , 2005, Fundamental & clinical pharmacology.

[7]  J. Davignon.  Beneficial Cardiovascular Pleiotropic Effects of Statins , 2004, Circulation.

[8]  R. Rosenson.  Statins in atherosclerosis: lipid-lowering agents with antioxidant capabilities. , 2004, Atherosclerosis.

[9]  J. Viikari,et al.  Effect of 12‐month statin therapy on antioxidant potential of LDL and serum antioxidant vitamin concentrations , 2004, Annals of medicine.

[10]  S. Boddupalli,et al.  Alpha and gamma tocopherol metabolism in healthy subjects and patients with end-stage renal disease. , 2003, Kidney international.

[11]  B. Ames,et al.  γ‐Tocopherol, but not α‐tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats , 2003 .

[12]  M. Traber,et al.  γ-Tocopherol, the new vitamin E? , 2003 .

[13]  B. Ames,et al.  Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation. , 2002, Free radical biology & medicine.

[14]  P. Pfluger,et al.  Identities and differences in the metabolism of tocotrienols and tocopherols in HepG2 cells. , 2002, The Journal of nutrition.

[15]  K. Yamashita,et al.  Dietary sesame seed and its lignans inhibit 2,7,8-trimethyl- 2(2'-carboxyethyl)-6-hydroxychroman excretion into urine of rats fed gamma-tocopherol. , 2002, The Journal of nutrition.

[16]  J. Mehta,et al.  Mixed tocopherol preparation is superior to alpha-tocopherol alone against hypoxia-reoxygenation injury. , 2002, Biochemical and biophysical research communications.

[17]  B. Ames,et al.  gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. , 2001, The American journal of clinical nutrition.

[18]  R. Brigelius-Flohé,et al.  Tocopherols are metabolized in HepG2 cells by side chain ω-oxidation and consecutive β-oxidation , 2001 .

[19]  R. V. van Leeuwen,et al.  Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes , 2000, Biopharmaceutics & drug disposition.

[20]  R. Parker,et al.  Cytochrome P4503A-dependent metabolism of tocopherols and inhibition by sesamin. , 2000, Biochemical and biophysical research communications.

[21]  B. Ames,et al.  γ-Tocopherol and its major metabolite, in contrast to α-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells , 2000 .

[22]  U. Beisiegel,et al.  Lipophilic antioxidants in blood plasma as markers of atherosclerosis: the role of α-carotene and γ-tocopherol , 1999 .

[23]  S. Hall,et al.  The interaction of diltiazem with lovastatin and pravastatin , 1998, Clinical pharmacology and therapeutics.

[24]  M. Traber,et al.  Human plasma and tissue alpha-tocopherol concentrations in response to supplementation with deuterated natural and synthetic vitamin E. , 1998, The American journal of clinical nutrition.

[25]  Hiroyuki Arai,et al.  Affinity for α‐tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs , 1997, FEBS letters.

[26]  F. Bernini,et al.  Direct vascular effects of HMG-CoA reductase inhibitors. , 1997, Atherosclerosis.

[27]  B. Ames,et al.  γ-Tocopherol traps mutagenic electrophiles such as NOx and complements α-tocopherol: Physiological implications , 1997 .

[28]  B. Vessby,et al.  Gamma, but not alpha, tocopherol levels in serum are reduced in coronary heart disease patients , 1996, Journal of internal medicine.

[29]  M. Traber,et al.  Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans. , 1993, Journal of lipid research.

[30]  M. Goldberg,et al.  Inhibition of alfentanil metabolism by erythromycin , 1989, Clinical pharmacology and therapeutics.

[31]  M. Traber,et al.  Vitamin E is delivered to cells via the high affinity receptor for low-density lipoprotein. , 1984, The American journal of clinical nutrition.

[32]  S. Passi,et al.  Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA , 2003, BioFactors.

[33]  J. Feely,et al.  Pharmacokinetic-Pharmacodynamic Drug Interactions with HMG-CoA Reductase Inhibitors , 2002, Clinical pharmacokinetics.

[34]  Bordone,et al.  DISTRIBUTION OF LIPID-SOLUBLE ANTIOXIDANTS IN LIPOPROTEINS FROM HEALTHY SUBJECTS. II. EFFECTS OF IN VIVO SUPPLEMENTATION WITH alpha-TOCOPHEROL. , 2000, Pharmacological research.

[35]  Bordone,et al.  DISTRIBUTION OF LIPID-SOLUBLE ANTIOXIDANTS IN LIPOPROTEINS FROM HEALTHY SUBJECTS. I. CORRELATION WITH PLASMA ANTIOXIDANT LEVELS AND COMPOSITION OF LIPOPROTEINS. , 2000, Pharmacological research.