Follow-up of gestational trophoblastic disease by thyrotropin-releasing hormone test: a case study.

An alternative approach by thyrotropin-releasing hormone (TRH) stimulation test to assess the prognostic factor was described in a patient with trophoblastic disease. The serial changes in the prolactin (PRL) responses to TRH administration after evacuation of molar tissue were similar to those of normal term pregnant, immediate postpartum and nonpregnant women. The thyroid-stimulating hormone (TSH) response to TRH was, however, absent for over 3 weeks after evacuation. The lack of TSH response may reflect the high thyrotropic activity of human chorionic gonadotropin (hCG). It might be feasible that the occurrence of a hCG plateau after evacuation can be predicted by the absent TSH response to TRH administration in patients with trophoblastic disease.

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