High-definition fiber tractography for the evaluation of perilesional white matter tracts in high-grade glioma surgery.

Conventional white matter (WM) imaging approaches, such as diffusion tensor imaging (DTI), have been used to preoperatively identify the location of affected WM tracts in patients with intracranial tumors in order to maximize the extent of resection and potentially reduce postoperative morbidity. DTI, however, has limitations that include its inability to resolve multiple crossing fibers and its susceptibility to partial volume effects. Therefore, recent focus has shifted to more advanced WM imaging techniques such as high-definition fiber tractography (HDFT). In this paper, we illustrate the application of HDFT, which in our preliminary experience has enabled accurate depiction of perilesional tracts in a 3-dimensional manner in multiple anatomical compartments including edematous zones around high-grade gliomas. This has facilitated accurate surgical planning. This is illustrated by using case examples of patients with glioblastoma multiforme. We also discuss future directions in the role of these techniques in surgery for gliomas.

[1]  A. Brodbelt,et al.  Cellularity and apparent diffusion coefficient in oligodendroglial tumours characterized by genotype , 2010, Journal of Neuro-Oncology.

[2]  T. Hirai,et al.  Diffusion-weighted imaging of metastatic brain tumors: comparison with histologic type and tumor cellularity. , 2006, AJNR. American journal of neuroradiology.

[3]  Christopher Nimsky,et al.  Preoperative and Intraoperative Diffusion Tensor Imaging-based Fiber Tracking in Glioma Surgery , 2005, Neurosurgery.

[4]  T. Kapur,et al.  Fiber Tractography Based on Diffusion Tensor Imaging Compared with High-angular-resolution Diffusion Imaging with Compressed Sensing: Initial Experience , 2022 .

[5]  P. Hagmann,et al.  Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging , 2005, Magnetic resonance in medicine.

[6]  Jeremy D. Schmahmann,et al.  Diffusion spectrum magnetic resonance imaging (DSI) tractography of crossing fibers , 2008, NeuroImage.

[7]  Fang-Cheng Yeh,et al.  Rethinking the role of the middle longitudinal fascicle in language and auditory pathways. , 2013, Cerebral cortex.

[8]  D. Parker,et al.  Analysis of partial volume effects in diffusion‐tensor MRI , 2001, Magnetic resonance in medicine.

[9]  S. Higano,et al.  Minimum apparent diffusion coefficient is significantly correlated with cellularity in medulloblastomas , 2009, Neurological research.

[10]  M. Lipton,et al.  Utility of Diffusion Tensor Imaging in Evaluation of the Peritumoral Region in Patients with Primary and Metastatic Brain Tumors , 2014, American Journal of Neuroradiology.

[11]  A L Alexander,et al.  White matter reorganization after surgical resection of brain tumors and vascular malformations. , 2006, AJNR. American journal of neuroradiology.

[12]  Marie Vandekerckhove,et al.  Diffusion Tensor Imaging Provides an Insight Into the Microstructure of Meningiomas, High-Grade Gliomas, and Peritumoral Edema , 2012, Journal of computer assisted tomography.

[13]  P. Grenier,et al.  MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. , 1986, Radiology.

[14]  C. Filippi,et al.  Magnetic resonance diffusion tensor imaging and tractography of intracranial cavernous malformations: preliminary observations and characterization of the hemosiderin rim. , 2010, Journal of neurosurgery.

[15]  Timothy Verstynen,et al.  In vivo mapping of microstructural somatotopies in the human corticospinal pathways. , 2011, Journal of neurophysiology.

[16]  Susan M. Chang,et al.  Role of extent of resection in the long-term outcome of low-grade hemispheric gliomas. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[17]  Toshinori Hirai,et al.  Usefulness of diffusion‐weighted MRI with echo‐planar technique in the evaluation of cellularity in gliomas , 1999, Journal of magnetic resonance imaging : JMRI.

[18]  P. Basser,et al.  Diffusion tensor MR imaging of the human brain. , 1996, Radiology.

[19]  Yutaka Imai,et al.  Relation between cancer cellularity and apparent diffusion coefficient values using diffusion-weighted magnetic resonance imaging in breast cancer , 2008, Radiation Medicine.

[20]  D. Barone,et al.  Image guided surgery for the resection of brain tumours. , 2014, The Cochrane database of systematic reviews.

[21]  Steen Moeller,et al.  Advances in diffusion MRI acquisition and processing in the Human Connectome Project , 2013, NeuroImage.

[22]  Walter Schneider,et al.  High-definition fiber tractography of the human brain: neuroanatomical validation and neurosurgical applications. , 2012, Neurosurgery.

[23]  Peter McGraw,et al.  Peritumoral brain regions in gliomas and meningiomas: investigation with isotropic diffusion-weighted MR imaging and diffusion-tensor MR imaging. , 2004, Radiology.

[24]  Kaoru Kurisu,et al.  Apparent diffusion coefficient of human brain tumors at MR imaging. , 2005, Radiology.

[25]  J. Fernandez-Miranda,et al.  Asymmetry, connectivity, and segmentation of the arcuate fascicle in the human brain , 2014, Brain Structure and Function.

[26]  Fang-Cheng Yeh,et al.  Estimation of fiber orientation and spin density distribution by diffusion deconvolution , 2011, NeuroImage.

[27]  Neil J Sebire,et al.  Tumors in pediatric patients at diffusion-weighted MR imaging: apparent diffusion coefficient and tumor cellularity. , 2007, Radiology.

[28]  Mitchel S Berger,et al.  An extent of resection threshold for newly diagnosed glioblastomas. , 2011, Journal of neurosurgery.

[29]  P. Basser,et al.  Toward a quantitative assessment of diffusion anisotropy , 1996, Magnetic resonance in medicine.

[30]  Christopher Nimsky,et al.  Intraoperative Visualization of Fiber Tracking Based Reconstruction of Language Pathways in Glioma Surgery , 2012, Neurosurgery.

[31]  N. Makris,et al.  High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity , 2002, Magnetic resonance in medicine.

[32]  Derek K. Jones,et al.  How and how not to correct for CSF-contamination in diffusion MRI , 2012, NeuroImage.

[33]  Henry Brem,et al.  Independent association of extent of resection with survival in patients with malignant brain astrocytoma. , 2009, Journal of neurosurgery.

[34]  Li-Wei Kuo,et al.  Optimization of diffusion spectrum imaging and q-ball imaging on clinical MRI system , 2008, NeuroImage.

[35]  H. Duffau,et al.  The persistent crucial role of the left hemisphere for language in left-handers with a left low grade glioma: a stimulation mapping study , 2014, Acta Neurochirurgica.

[36]  Timothy D. Verstynen,et al.  Deterministic Diffusion Fiber Tracking Improved by Quantitative Anisotropy , 2013, PloS one.

[37]  H. Duffau,et al.  The Role of Left Inferior Fronto-Occipital Fascicle in Verbal Perseveration: A Brain Electrostimulation Mapping Study , 2013, Brain Topography.

[38]  C. Decaestecker,et al.  Apparent Diffusion Coefficient and Cerebral Blood Volume in Brain Gliomas: Relation to Tumor Cell Density and Tumor Microvessel Density Based on Stereotactic Biopsies , 2008, American Journal of Neuroradiology.

[39]  Yong Wang,et al.  Differences between generalized q-sampling imaging and diffusion tensor imaging in the preoperative visualization of the nerve fiber tracts within peritumoral edema in brain. , 2013, Neurosurgery.

[40]  N. Intrator,et al.  Free water elimination and mapping from diffusion MRI , 2009, Magnetic resonance in medicine.

[41]  C. Nimsky,et al.  Optic Radiation Fiber Tractography in Glioma Patients Based on High Angular Resolution Diffusion Imaging with Compressed Sensing Compared with Diffusion Tensor Imaging - Initial Experience , 2013, PloS one.

[42]  Fang-Cheng Yeh,et al.  Generalized ${ q}$-Sampling Imaging , 2010, IEEE Transactions on Medical Imaging.

[43]  D. Bihan Apparent Diffusion Coefficient and Beyond: What Diffusion MR Imaging Can Tell Us about Tissue Structure , 2013 .

[44]  Olav Haraldseth,et al.  Measurement of cell density and necrotic fraction in human melanoma xenografts by diffusion weighted magnetic resonance imaging , 2000, Magnetic resonance in medicine.

[45]  G. Johnson,et al.  Peritumoral diffusion tensor imaging of high-grade gliomas and metastatic brain tumors. , 2003, AJNR. American journal of neuroradiology.

[46]  Jacques-Donald Tournier,et al.  Diffusion tensor imaging and beyond , 2011, Magnetic resonance in medicine.

[47]  W. Tseng,et al.  Sparse Solution of Fiber Orientation Distribution Function by Diffusion Decomposition , 2013, PloS one.

[48]  Daniel C. Alexander,et al.  NODDI: Practical in vivo neurite orientation dispersion and density imaging of the human brain , 2012, NeuroImage.

[49]  P. Basser,et al.  Estimation of the effective self-diffusion tensor from the NMR spin echo. , 1994, Journal of magnetic resonance. Series B.

[50]  K. Kono,et al.  The role of diffusion-weighted imaging in patients with brain tumors. , 2001, AJNR. American journal of neuroradiology.

[51]  C. Beaulieu,et al.  The basis of anisotropic water diffusion in the nervous system – a technical review , 2002, NMR in biomedicine.

[52]  Hugues Duffau,et al.  Intraoperative subcortical electrical mapping of optic radiations in awake surgery for glioma involving visual pathways Clinical article , 2012 .

[53]  Fang-Cheng Yeh,et al.  Application of high-definition fiber tractography in the management of supratentorial cavernous malformations: a combined qualitative and quantitative approach. , 2014, Neurosurgery.

[54]  J. Fernandez-Miranda,et al.  Advanced diffusion MRI fiber tracking in neurosurgical and neurodegenerative disorders and neuroanatomical studies: A review. , 2014, Biochimica et biophysica acta.