Personalized Medicine

Human differences in disease phenotype and treatment responses are well documented. Technological advances now allow healthcare providers to improve the prevention and treatment of chronic diseases by stratifying patient populations. Although personalized medicine has great promise, it has, so far, been primarily applied in oncology. Wider adoption requires changes in the healthcare system and in clinical decision-making, and early applications of personalized medicine appear to require strong clinical utility and sufficient value to drive adoption. Personalized medicine is likely to enter dentistry as patients start to demand it and as new drugs are developed for pathways common to oral diseases.

[1]  A. Silman,et al.  Combined sib-TDT and TDT provide evidence for linkage of the interleukin-1 gene cluster to erosive rheumatoid arthritis. , 1999, Human molecular genetics.

[2]  G. Hildebrandt,et al.  Management of rampant caries. , 2009, Northwest dentistry.

[3]  R. Page,et al.  Critical Issues in Periodontal Research , 1995, Journal of dental research.

[4]  Sarah J. Fansler,et al.  Identifying Low pH Active and Lactate-Utilizing Taxa within Oral Microbiome Communities from Healthy Children Using Stable Isotope Probing Techniques , 2012, PloS one.

[5]  K. Matsumoto,et al.  Cytokine profile in synovial fluid from patients with internal derangement of the temporomandibular joint: a preliminary study. , 2006, Dento maxillo facial radiology.

[6]  J. Brodeur,et al.  The High Incidence of Early Childhood Caries in Kindergarten-age Children , 2006 .

[7]  A. Garrod.  The Incidence of Alkaptonuria: A study in Chemical Individuality , 1996, Nutrition reviews.

[8]  J. Rudney,et al.  Potential biomarkers of human salivary function: a modified proteomic approach. , 2009, Archives of oral biology.

[9]  M. Pirmohamed,et al.  Pharmacogenetics of warfarin: current status and future challenges , 2007, The Pharmacogenomics Journal.

[10]  S. Dworkin,et al.  Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. , 1992, Journal of craniomandibular disorders : facial & oral pain.

[11]  B. Wasserman,et al.  A long-term survey of tooth loss in 600 treated periodontal patients. , 1978, Journal of periodontology.

[12]  V. Kraus,et al.  Summary of the OA biomarkers workshop 2010 - genetics and genomics: new targets in OA. , 2011, Osteoarthritis and cartilage.

[13]  P. Emery,et al.  Optimising treatment in rheumatoid arthritis: a review of potential biological markers of response , 2011, Annals of the rheumatic diseases.

[14]  H. Ayhan,et al.  The effect of nursing or rampant caries on height, body weight and head circumference. , 1996, The Journal of clinical pediatric dentistry.

[15]  F. Vogel.  Moderne Probleme der Humangenetik , 1959 .

[16]  J. Okeson.  Current terminology and diagnostic classification schemes. , 1997, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[17]  L. Edsberg,et al.  Potential biomarkers of temporomandibular joint disorders. , 2011, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[18]  Michael E Phelps,et al.  Systems Biology and New Technologies Enable Predictive and Preventative Medicine , 2004, Science.

[19]  R. Schilsky,et al.  Personalized cancer medicine – A strategy to counteract an increasing cancer challenge , 2012, Molecular oncology.

[20]  H. Löe,et al.  Natural history of periodontal disease in man. Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46 years of age. , 1986, Journal of clinical periodontology.

[21]  J. Lindhe,et al.  Long-term maintenance of patients treated for advanced periodontal disease. , 1984, Journal of clinical periodontology.

[22]  S. Bencharit,et al.  Defining salivary biomarkers using mass spectrometry-based proteomics: a systematic review. , 2011, Omics : a journal of integrative biology.

[23]  N. Saijo.  Present Status and Problems on Molecular Targeted Therapy of Cancer , 2012, Cancer research and treatment : official journal of Korean Cancer Association.