Non-invasive Estimation of Blood Glucose Level in Visible-NIR Spectrum: System and Software Design

We have designed and developed a non-invasive blood glucose level monitoring system. The electromagnetic spectrum of both visible and infrared region has been used for the study of absorption, refraction, and reflection of bio-molecules. In this article, we have shown the system model and data acquisition platform based on Android user interface. The system model includes a proposed multi-sensor signal processing sub-system, an embedded platform, and a Bluetooth wireless transmission subsystem. The proposed system has been investigated on normal and diabetic patients. The stability of the device is tested using a one-way ANOVA test. The result of the hypothesis test has shown in favour of acceptance of the datasets provided by the device.

[1]  Hassan Harb,et al.  An Enhanced K-Means and ANOVA-Based Clustering Approach for Similarity Aggregation in Underwater Wireless Sensor Networks , 2015, IEEE Sensors Journal.

[2]  Jun Chen,et al.  Scattering and absorption effects in the determination of glucose in whole blood by near-infrared spectroscopy. , 2005, Analytical chemistry.

[3]  Young Seol Kim,et al.  Clinical Experience of an Iontophoresis Based Glucose Measuring System , 2007, Journal of Korean medical science.

[4]  Kyoung Joung Lee,et al.  Design of a portable urine glucose monitoring system for health care , 2005, Comput. Biol. Medicine.

[5]  M A Arnold,et al.  Noninvasive blood glucose measurements by near-infrared transmission spectroscopy across human tongues. , 2000, Diabetes technology & therapeutics.

[6]  O. Khalil,et al.  Non-invasive glucose measurement technologies: an update from 1999 to the dawn of the new millennium. , 2004, Diabetes technology & therapeutics.

[7]  M A Arnold,et al.  Evaluation of measurement sites for noninvasive blood glucose sensing with near-infrared transmission spectroscopy. , 1999, Clinical chemistry.

[8]  G. Coté,et al.  Effect of temperature, pH, and corneal birefringence on polarimetric glucose monitoring in the eye. , 2002, Journal of biomedical optics.

[9]  Vijander Singh,et al.  Near-infrared LED based non-invasive blood glucose sensor , 2014, 2014 International Conference on Signal Processing and Integrated Networks (SPIN).

[10]  Pratyoosh Shukla,et al.  Non-Invasive Glucose Monitoring Techniques: A Review and current trends , 2008, 0810.5755.

[11]  Baruch Ben Dor,et al.  Development and validation of a multiwavelength spatial domain near-infrared oximeter to detect cerebral hypoxia-ischemia. , 2006, Journal of biomedical optics.

[12]  E. Chan,et al.  Pulse oximetry: understanding its basic principles facilitates appreciation of its limitations. , 2013, Respiratory medicine.

[13]  A. Maran,et al.  Non-invasive glucose monitoring: assessment of technologies and devices according to quantitative criteria. , 2007, Diabetes research and clinical practice.

[14]  C. Toumazou,et al.  Glucose sensors: a review of current and emerging technology , 2009, Diabetic medicine : a journal of the British Diabetic Association.

[15]  Lutz Heinemann,et al.  Continuous glucose monitoring by means of the microdialysis technique: underlying fundamental aspects. , 2003, Diabetes technology & therapeutics.

[16]  P. Abel,et al.  Assessment of subcutaneous glucose concentration: validation of the wick technique as a reference for implanted electrochemical sensors in normal and diabetic dogs , 1987, Diabetologia.

[17]  David C Klonoff,et al.  Microdialysis of interstitial fluid for continuous glucose measurement. , 2003, Diabetes technology & therapeutics.

[18]  Haobo Cheng,et al.  Determination of NIR informative wavebands for transmission non-invasive blood glucose measurement using a Fourier transform spectrometer , 2018 .

[19]  N. Evans,et al.  In vivo glucose monitoring: the clinical reality and the promise. , 2005, Biosensors & bioelectronics.

[20]  Carlos Eduardo Ferrante do Amaral,et al.  Current development in non-invasive glucose monitoring. , 2008, Medical engineering & physics.

[21]  D. W. Ball,et al.  Field Guide to Spectroscopy , 2006 .

[22]  R. Eaton,et al.  Non‐invasive glucose sensors and improved informatics – the future of diabetes management , 2003, Diabetes, obesity & metabolism.

[23]  S. Yao,et al.  Wearable multifunctional sensors using printed stretchable conductors made of silver nanowires. , 2014, Nanoscale.

[24]  Ganapati Mauze,et al.  In-vivo NIR diffuse-reflectance tissue spectroscopy of human subjects , 1999, Photonics West - Biomedical Optics.

[25]  U. Ungerstedt,et al.  Microdialysis measurement of the absolute glucose concentration in subcutaneous adipose tissue allowing glucose monitoring in diabetic patients , 1992, Diabetologia.

[26]  Richard H Guy,et al.  Reverse iontophoresis for non-invasive transdermal monitoring. , 2004, Physiological measurement.