A Grand Challenge. 2. Phenotypic Profiling of a Natural Product Library on Parkinson's Patient-Derived Cells.
暂无分享,去创建一个
Tanja Grkovic | Alan Mackay-Sim | Ronald J Quinn | A. Mackay-Sim | S. Wood | A. Gorse | R. Quinn | T. Grkovic | G. Mellick | M. Vial | Stephen A Wood | D. Zencak | Dusan Zencak | Alain-Dominique Gorse | Marie-Laure Vial | George D Mellick | Marie-Laure Vial
[1] J. Paul Robinson,et al. Mitochondrial Complex I Inhibitor Rotenone Induces Apoptosis through Enhancing Mitochondrial Reactive Oxygen Species Production* , 2003, The Journal of Biological Chemistry.
[2] Rein Aasland,et al. Endosomal Localization of the Autoantigen EEA1 Is Mediated by a Zinc-binding FYVE Finger* , 1996, The Journal of Biological Chemistry.
[3] Lani F. Wu,et al. Multidimensional Drug Profiling By Automated Microscopy , 2004, Science.
[4] Christine A. Wells,et al. NRF2 Activation Restores Disease Related Metabolic Deficiencies in Olfactory Neurosphere-Derived Cells from Patients with Sporadic Parkinson's Disease , 2011, PloS one.
[5] Herbert Waldmann,et al. From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries. , 2002, Angewandte Chemie.
[6] M. Dym,et al. Colchicine-induced changes in the cytoskeleton of the golden-mantled ground squirrel (Spermophilus lateralis) Sertoli cells. , 1983, The American journal of anatomy.
[7] Herbert Waldmann,et al. Protein structure similarity clustering and natural product structure as guiding principles in drug discovery. , 2005, Drug discovery today.
[8] L. Gambini,et al. NMR Fingerprints of the Drug-like Natural-Product Space Identify Iotrochotazine A: A Chemical Probe to Study Parkinson’s Disease** , 2014, Angewandte Chemie.
[9] Roger G Linington,et al. Connecting phenotype and chemotype: high-content discovery strategies for natural products research. , 2015, Journal of natural products.
[10] Herbert Waldmann,et al. Compound library development guided by protein structure similarity clustering and natural product structure. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[11] F. Koehn,et al. The evolving role of natural products in drug discovery , 2005, Nature Reviews Drug Discovery.
[12] Pierre Baldi,et al. When is Chemical Similarity Significant? The Statistical Distribution of Chemical Similarity Scores and Its Extreme Values , 2010, J. Chem. Inf. Model..
[13] H. Tsuji,et al. Disruptive effect of chloroquine on lysosomes in cultured rat hepatocytes. , 2005, Biological & pharmaceutical bulletin.
[14] A. Wagemann,et al. Pharmacokinetics and antiarrhythmic efficacy of intravenous ajmaline in ventricular arrhythmia of acute onset , 1989, European Journal of Drug Metabolism and Pharmacokinetics.
[15] Anne E Carpenter,et al. Multiplex Cytological Profiling Assay to Measure Diverse Cellular States , 2013, PloS one.
[16] J. Olzmann,et al. High glucose‐induced oxidative stress and mitochondrial dysfunction in neurons , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[17] J. Reeves,et al. The lysosomal proton pump is electrogenic. , 1983, The Journal of biological chemistry.
[18] S. Wood,et al. A Grand Challenge: Unbiased Phenotypic Function of Metabolites from Jaspis splendens against Parkinson's Disease. , 2016, Journal of natural products.
[19] R. Wade,et al. How does taxol stabilize microtubules? , 1995, Current Biology.
[20] C. Dobson. Chemical space and biology , 2004, Nature.
[21] R. Teasdale,et al. The Vps35 D620N Mutation Linked to Parkinson's Disease Disrupts the Cargo Sorting Function of Retromer , 2014, Traffic.
[22] Daniel Rauh,et al. An Unbiased Cell Morphology–Based Screen for New, Biologically Active Small Molecules , 2005, PLoS biology.
[23] M. Schliwa. Action of cytochalasin D on cytoskeletal networks , 1982, The Journal of cell biology.
[24] L. Stefanis. α-Synuclein in Parkinson's disease. , 2012, Cold Spring Harbor perspectives in medicine.
[25] R. Kammerer,et al. The nuclear protein Waharan is required for endosomal-lysosomal trafficking in Drosophila , 2010, Journal of Cell Science.
[26] C. Wells,et al. Disease-specific, neurosphere-derived cells as models for brain disorders , 2010, Disease Models & Mechanisms.
[27] M. Farrer,et al. VPS35 mutations in Parkinson disease. , 2011, American journal of human genetics.
[28] K. Giuliano,et al. High-Content Profiling of Drug-Drug Interactions: Cellular Targets Involved in the Modulation of Microtubule Drug Action by the Antifungal Ketoconazole , 2003, Journal of biomolecular screening.
[29] Joshua M. Stuart,et al. "Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening. , 2013, Chemistry & biology.
[30] Rohan A Davis,et al. Drug-like properties: guiding principles for the design of natural product libraries. , 2012, Journal of natural products.
[31] Y. Ohsaki,et al. Lysosomal accumulation of mTOR is enhanced by rapamycin , 2010, Histochemistry and Cell Biology.
[32] J. Carpenter,et al. Autophagosome Formation during Varicella-Zoster Virus Infection following Endoplasmic Reticulum Stress and the Unfolded Protein Response , 2011, Journal of Virology.
[33] A. Harvey,et al. The re-emergence of natural products for drug discovery in the genomics era , 2015, Nature Reviews Drug Discovery.
[34] A. Dizhoor,et al. Binding of Guanylyl Cyclase Activating Protein 1 (GCAP1) to Retinal Guanylyl Cyclase (RetGC1) , 2008, Journal of Biological Chemistry.
[35] M. Berger,et al. Identification of Internalizing Human Single-Chain Antibodies Targeting Brain Tumor Sphere Cells , 2010, Molecular Cancer Therapeutics.
[36] Na-na Li,et al. Seven alkaloids and their antibacterial activity from Hypecoum erectum L. , 2011 .